{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:05:18Z","timestamp":1791234318174,"version":"4.1.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0110429","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T21:20:13Z","timestamp":1413840013000},"page":"e110429","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":86,"title":["Apigenin Inhibits Enterovirus-71 Infection by Disrupting Viral RNA Association with trans-Acting Factors"],"prefix":"10.1371","volume":"9","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haishi","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayi","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxiang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S1473-3099(10)70194-8","article-title":"Virology, epidemiology, pathogenesis, and control of enterovirus 71","volume":"10","author":"T Solomon","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1128\/JCM.00563-09","article-title":"Enterovirus 71 outbreak in the People's Republic of China in 2008","volume":"47","author":"F Yang","year":"2009","journal-title":"J Clin Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1743-422X-10-28","article-title":"Strategies to develop antivirals against enterovirus 71","volume":"10","author":"RL Kuo","year":"2013","journal-title":"Virol J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0042-6822(03)00544-0","article-title":"Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved","volume":"315","author":"SR Thompson","year":"2003","journal-title":"Virology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1074\/jbc.M608750200","article-title":"Picornavirus internal ribosome entry site elements can stimulate translation of upstream genes","volume":"282","author":"C Junemann","year":"2007","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"9658","DOI":"10.1128\/JVI.05063-11","article-title":"Host factors in enterovirus 71 replication","volume":"85","author":"SR Shih","year":"2011","journal-title":"J Virol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6106","DOI":"10.1128\/JVI.02476-08","article-title":"hnRNP A1 interacts with the 5' untranslated regions of enterovirus 71 and Sindbis virus RNA and is required for viral replication","volume":"83","author":"JY Lin","year":"2009","journal-title":"J Virol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1128\/JVI.02278-12","article-title":"Enterovirus 71 infection cleaves a negative regulator for viral internal ribosomal entry site-driven translation","volume":"87","author":"LL Chen","year":"2013","journal-title":"J Virol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1099\/vir.0.2008\/003673-0","article-title":"Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication","volume":"89","author":"JY Lin","year":"2008","journal-title":"J Gen Virol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.4161\/rna.25107","article-title":"High-affinity interaction of hnRNP A1 with conserved RNA structural elements is required for translation and replication of enterovirus 71","volume":"10","author":"JD Levengood","year":"2013","journal-title":"RNA Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.foodchem.2011.03.022","article-title":"Kaempferol inhibits enterovirus 71 replication and internal ribosome entry site (IRES) activity through FUBP and HNRP proteins","volume":"128","author":"FJ Tsai","year":"2011","journal-title":"Food Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"18999","DOI":"10.3390\/ijms140918999","article-title":"hnRNP A1: the Swiss army knife of gene expression","volume":"14","author":"J Jean-Philippe","year":"2013","journal-title":"Int J Mol Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.molmed.2012.06.006","article-title":"Pre-mRNA splicing in disease and therapeutics","volume":"18","author":"RK Singh","year":"2012","journal-title":"Trends Mol Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1158\/2159-8290.CD-13-0253","article-title":"Misregulation of pre-mRNA alternative splicing in cancer","volume":"3","author":"J Zhang","year":"2013","journal-title":"Cancer Discov"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.mcn.2012.12.002","article-title":"Heterogeneous nuclear ribonucleoprotein A1 in health and neurodegenerative disease: from structural insights to post-transcriptional regulatory roles","volume":"56","author":"U Bekenstein","year":"2013","journal-title":"Mol Cell Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.2337\/db11-1349","article-title":"Heterogeneous nuclear ribonucleoprotein F suppresses angiotensinogen gene expression and attenuates hypertension and kidney injury in diabetic mice","volume":"61","author":"CS Lo","year":"2012","journal-title":"Diabetes"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"E2153","DOI":"10.1073\/pnas.1303726110","article-title":"Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets","volume":"110","author":"D Arango","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"LJ Reed","year":"1938","journal-title":"Am J Epidemiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1046-2023(02)00021-X","article-title":"Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo","volume":"26","author":"S Niranjanakumari","year":"2002","journal-title":"Methods"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1086\/527326","article-title":"Ribavirin reduces mortality in enterovirus 71-infected mice by decreasing viral replication","volume":"197","author":"ZH Li","year":"2008","journal-title":"J Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1093\/nar\/22.11.1996","article-title":"Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1","volume":"22","author":"G Biamonti","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrm760","article-title":"Messenger-RNA-binding proteins and the messages they carry","volume":"3","author":"G Dreyfuss","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0168-1702(95)00087-9","article-title":"Complete nucleotide sequence of enterovirus 71 is distinct from poliovirus","volume":"39","author":"BA Brown","year":"1995","journal-title":"Virus Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jcla.2063","article-title":"Variability in molecular typing of Coxsackie A viruses by RFLP analysis and sequencing","volume":"16","author":"N Siafakas","year":"2002","journal-title":"J Clin Lab Anal"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e27082","DOI":"10.1371\/journal.pone.0027082","article-title":"A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in mice","volume":"6","author":"MT Yeh","year":"2011","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/0929867013373723","article-title":"Biological properties of citrus flavonoids pertaining to cancer and inflammation","volume":"8","author":"JA Manthey","year":"2001","journal-title":"Curr Med Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.micres.2009.09.002","article-title":"Antibacterial, antifungal, and antiviral activities of some flavonoids","volume":"165","author":"DD Orhan","year":"2010","journal-title":"Microbiol Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"162750","DOI":"10.1155\/2013\/162750","article-title":"Chemistry and biological activities of flavonoids: an overview","volume":"2013","author":"S Kumar","year":"2013","journal-title":"The Scientific World Journal"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1128\/AAC.34.3.460","article-title":"Activities and mechanisms of action of halogen-substituted flavanoids against poliovirus type 2 infection in vitro","volume":"34","author":"C Conti","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0166-3542(89)90034-X","article-title":"Effect of isoflavans and isoflavenes on the infection of Frp\/3 cells by hepatitis A virus","volume":"11","author":"F Superti","year":"1989","journal-title":"Antiviral Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.antiviral.2006.07.003","article-title":"Antiviral activity of substituted homoisoflavonoids on enteroviruses","volume":"72","author":"S Tait","year":"2006","journal-title":"Antiviral Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:29:54Z","timestamp":1588998594000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110429"}},"subtitle":[],"editor":[{"given":"Jianming","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,16]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110429","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,16]]}}}