{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:53:50Z","timestamp":1790045630122,"version":"4.0.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T00:00:00Z","timestamp":1413849600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0110543","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T18:17:14Z","timestamp":1413915434000},"page":"e110543","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Marked Cortisol Production by Intracrine ACTH in GIP-Treated Cultured Adrenal Cells in Which the GIP Receptor Was Exogenously Introduced"],"prefix":"10.1371","volume":"9","author":[{"given":"Hiroko","family":"Fujii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Tamamori-Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Susa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Nakakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Hagiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Iizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Okinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1210\/endo.132.1.8380389","article-title":"The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7\u201337)","volume":"132","author":"M Lu","year":"1993","journal-title":"Endocrinology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-5793(95)01006-Z","article-title":"Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma","volume":"373","author":"A Volz","year":"1995","journal-title":"FEBS Lett"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF02576685","article-title":"Comparison of ACTH and corticotropin-releasing hormone effects on rat adrenal steroidogenesis in vitro","volume":"191","author":"G Neri","year":"1991","journal-title":"Res Exp Med (Berl)"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF00318550","article-title":"Evidence that an extrahypothalamic pituitary corticotropin-releasing hormone (CRH)\/adrenocorticotropin (ACTH) system controls adrenal growth and secretion in rats","volume":"272","author":"A Markowska","year":"1993","journal-title":"Cell Tissue Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF01969708","article-title":"Increased plasma corticosterone levels in bovine growth hormone (bGH) transgenic mice: effects of ACTH, GH and IGF-I on in vitro adrenal corticosterone production","volume":"5","author":"M Cecim","year":"1996","journal-title":"Transgenic Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1210\/endo.141.5.7457","article-title":"Regulation by adrenocorticotropin (ACTH), angiotensin II, transforming growth factor-beta, and insulin-like growth factor I of bovine adrenal cell steroidogenic capacity and expression of ACTH receptor, steroidogenic acute regulatory protein, cytochrome P450c17, and 3beta-hydroxysteroid dehydrogenase","volume":"141","author":"C Le Roy","year":"2000","journal-title":"Endocrinology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1677\/joe.0.1680475","article-title":"The role of the pituitary gland and ACTH in the regulation of mRNAs encoding proteins essential for adrenal steroidogenesis in the late-gestation ovine fetus","volume":"168","author":"PJ Simmonds","year":"2001","journal-title":"J Endocrinol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/jemt.10339","article-title":"ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortex","volume":"61","author":"MB Sewer","year":"2003","journal-title":"Microsc Res Tech"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1210\/me.2004-0532","article-title":"Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought","volume":"19","author":"DM Stocco","year":"2005","journal-title":"Mol Endocrinol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/molehr\/gap025","article-title":"Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives","volume":"15","author":"PR Manna","year":"2009","journal-title":"Mol Hum Reprod"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1677\/JME-10-0006","article-title":"ACTH is a potent regulator of gene expression in human adrenal cells","volume":"45","author":"Y Xing","year":"2010","journal-title":"J Mol Endocrinol"},{"key":"ref12","first-page":"2414","article-title":"Abnormal adrenal and vascular responses to vasopressin mediated by a V1-vasopressin receptor in a patient with adrenocorticotropin-independent macronodular adrenal hyperplasia, Cushing\u2019s syndrome, and orthostatic hypotension","volume":"82","author":"A Lacroix","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJM199711133372004","article-title":"Propranolol therapy for ectopic beta-adrenergic receptors in adrenal Cushing\u2019s syndrome","volume":"337","author":"A Lacroix","year":"1997","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3109\/07435809809032696","article-title":"Gastric inhibitory polypeptide (GIP) stimulates cortisol secretion, cAMP production and DNA synthesis in an adrenal adenoma responsible for food-dependent Cushing\u2019s syndrome","volume":"24","author":"O Chabre","year":"1998","journal-title":"Endocr Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0196-9781(99)00011-X","article-title":"Gastric inhibitory polypeptide stimulates glucocorticoid secretion in rats, acting through specific receptors coupled with the adenylate cyclase-dependent signaling pathway","volume":"20","author":"G Mazzocchi","year":"1999","journal-title":"Peptides"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1210\/jc.2002-020067","article-title":"Eutopic overexpression of vasopressin v1a receptor in adrenocorticotropin-independent macronodular adrenal hyperplasia","volume":"87","author":"T Mune","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1043-2760(04)00188-2","article-title":"Cushing\u2019s syndrome variants secondary to aberrant hormone receptors","volume":"15","author":"A Lacroix","year":"2004","journal-title":"Trends Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.2009.03689.x","article-title":"Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction","volume":"73","author":"A Lacroix","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/EJE-10-0058","article-title":"Aberrant expression of multiple hormone receptors in ACTH-independent macronodular adrenal hyperplasia causing Cushing\u2019s syndrome","volume":"163","author":"JW de Groot","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1056\/NEJMoa1215245","article-title":"Intraadrenal corticotropin in bilateral macronodular adrenal hyperplasia","volume":"369","author":"E Louiset","year":"2013","journal-title":"N Engl J Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1056\/NEJM199210013271402","article-title":"Gastric inhibitory polypeptide-dependent cortisol hypersecretion\u2013a new cause of Cushing\u2019s syndrome","volume":"327","author":"A Lacroix","year":"1992","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJM199210013271403","article-title":"Food-dependent Cushing\u2019s syndrome mediated by aberrant adrenal sensitivity to gastric inhibitory polypeptide","volume":"327","author":"Y Reznik","year":"1992","journal-title":"N Engl J Med"},{"key":"ref23","first-page":"3168","article-title":"Food-dependent Cushing\u2019s syndrome resulting from abundant expression of gastric inhibitory polypeptide receptors in adrenal adenoma cells","volume":"81","author":"WW de Herder","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0248-8663(96)86438-1","article-title":"[Food-dependent Cushing syndrome: a new entity of organic hypercorticism]","volume":"17","author":"G Matejka","year":"1996","journal-title":"Rev Med Interne"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1210\/jcem.83.8.5038","article-title":"Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing\u2019s syndrome","volume":"83","author":"N N\u2019Diaye","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1210\/en.2005-0921","article-title":"Ectopic expression of the gastric inhibitory polypeptide receptor gene is a sufficient genetic event to induce benign adrenocortical tumor in a xenotransplantation model","volume":"147","author":"TL Mazzuco","year":"2006","journal-title":"Endocrinology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2337\/db11-1060","article-title":"Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(\u2212\/\u2212) mice","volume":"61","author":"HE Bates","year":"2012","journal-title":"Diabetes"},{"key":"ref28","first-page":"345","article-title":"Loss of expression of the ubiquitous transcription factor cAMP response element-binding protein (CREB) and compensatory overexpression of the activator CREMtau in the human adrenocortical cancer cell line H295R","volume":"85","author":"L Groussin","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.mce.2003.12.020","article-title":"Adrenocortical cell lines","volume":"228","author":"WE Rainey","year":"2004","journal-title":"Mol Cell Endocrinol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1158\/0008-5472.CAN-09-1601","article-title":"Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells","volume":"69","author":"B Ragazzon","year":"2009","journal-title":"Cancer Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1056\/NEJMoa1304603","article-title":"ARMC5 mutations in macronodular adrenal hyperplasia with Cushing\u2019s syndrome","volume":"369","author":"G Assie","year":"2013","journal-title":"N Engl J Med"},{"key":"ref32","first-page":"779","article-title":"A certain step of proteolytic processing of proopiomelanocortin occurs during the transition between two distinct stages of secretory granule maturation in rat anterior pituitary corticotrophs","volume":"131","author":"S Tanaka","year":"1992","journal-title":"Endocrinology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"7284","DOI":"10.1128\/MCB.00476-07","article-title":"Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of steroidogenic factor 1 (NR5A1)","volume":"27","author":"WY Chen","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1210\/en.2012-2153","article-title":"Excess androgens in utero alters fetal testis development","volume":"154","author":"F Connolly","year":"2013","journal-title":"Endocrinology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2144\/05382RR05","article-title":"Improved real-time RT-PCR method for high-throughput measurements using second derivative calculation and double correction","volume":"38","author":"V Luu-The","year":"2005","journal-title":"Biotechniques"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e68691","DOI":"10.1371\/journal.pone.0068691","article-title":"Differential regulation of human 3beta-hydroxysteroid dehydrogenase type 2 for steroid hormone biosynthesis by starvation and cyclic AMP stimulation: studies in the human adrenal NCI-H295R cell model","volume":"8","author":"S Udhane","year":"2013","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/frne.1994.1013","article-title":"Regulation of pituitary ACTH secretion during chronic stress","volume":"15","author":"G Aguilera","year":"1994","journal-title":"Front Neuroendocrinol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1172\/JCI118615","article-title":"Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway","volume":"97","author":"DW Ray","year":"1996","journal-title":"J Clin Invest"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1172\/JCI119541","article-title":"Cytokine-dependent gp130 receptor subunit regulates human fetal pituitary adrenocorticotropin hormone and growth hormone secretion","volume":"100","author":"I Shimon","year":"1997","journal-title":"J Clin Invest"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0166-2236(96)10069-2","article-title":"Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis","volume":"20","author":"JP Herman","year":"1997","journal-title":"Trends Neurosci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1210\/en.2009-0985","article-title":"Maternal leukemia inhibitory factor (LIF) promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway","volume":"151","author":"E Simamura","year":"2010","journal-title":"Endocrinology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000347130","article-title":"Laparoscopic enucleation of macronodules in a patient with ACTH-independent macronodular adrenal hyperplasia 7 years after unilateral adrenalectomy: consideration of operative procedure","volume":"90","author":"K Ito","year":"2013","journal-title":"Urol Int"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Assie G, Jouinot A, Bertherat J (2014) The \u2018omics\u2019 of adrenocortical tumours for personalized medicine. Nat Rev Endocrinol.","DOI":"10.1038\/nrendo.2013.272"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T06:38:59Z","timestamp":1717483139000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110543"}},"subtitle":[],"editor":[{"given":"Carlos M.","family":"Isales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,21]]},"references-count":44,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110543","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,21]]}}}