{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:57:23Z","timestamp":1791406643294,"version":"4.3.3"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0110653","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T13:59:40Z","timestamp":1413986380000},"page":"e110653","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":101,"title":["Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans"],"prefix":"10.1371","volume":"9","author":[{"given":"David","family":"Patsouris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei-Ji","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Vial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelie","family":"Bravard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Lefai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Agn\u00e9s","family":"Chauvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Laugerette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille","family":"Debard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Caroline","family":"Michalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Laville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Rieusset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.2337\/db10-0281","article-title":"FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction","volume":"60","author":"A Bravard","year":"2011","journal-title":"Diabetes"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.2337\/diabetes.50.5.1134","article-title":"Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes","volume":"50","author":"PH Ducluzeau","year":"2001","journal-title":"Diabetes"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1194\/jlr.M200169-JLR200","article-title":"Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone","volume":"43","author":"SM Watkins","year":"2002","journal-title":"J Lipid Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"E374","DOI":"10.1152\/ajpendo.00314.2011","article-title":"Oil composition of high-fat diet affects metabolic inflammation differently in connection with endotoxin receptors in mice","volume":"302","author":"F Laugerette","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/dvg.22364","article-title":"Generation of transgenic mice expressing EGFP protein fused to NP68 MHC class I epitope using lentivirus vectors","volume":"51","author":"M Tomkowiak","year":"2013","journal-title":"Genesis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.bbrc.2011.11.135","article-title":"Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance","volume":"417","author":"J Rieusset","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/jbm.a.32237","article-title":"In vivo analysis of biocompatibility and vascularization of the synthetic bone grafting substitute NanoBone","volume":"91","author":"K Abshagen","year":"2009","journal-title":"J Biomed Mater Res A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1128\/MCB.00690-09","article-title":"A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation","volume":"30","author":"V Lecomte","year":"2010","journal-title":"Mol Cell Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e34976","DOI":"10.1371\/journal.pone.0034976","article-title":"Regulation of chemokine and chemokine receptor expression by PPARgamma in adipocytes and macrophages","volume":"7","author":"MT Nguyen","year":"2012","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1161\/01.ATV.0000183883.72263.13","article-title":"A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha","volume":"25","author":"T Suganami","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"E1118","DOI":"10.1152\/ajpendo.00435.2007","article-title":"Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob\/ob and dietary obese mice","volume":"293","author":"J Ye","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1172\/JCI29881","article-title":"Obesity induces a phenotypic switch in adipose tissue macrophage polarization","volume":"117","author":"CN Lumeng","year":"2007","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1172\/JCI200319451","article-title":"Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance","volume":"112","author":"H Xu","year":"2003","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1084\/jem.20070075","article-title":"Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis","volume":"204","author":"L Arnold","year":"2007","journal-title":"J Exp Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2337\/db07-1344","article-title":"Obesity-related upregulation of monocyte chemotactic factors in adipocytes: involvement of nuclear factor-kappaB and c-Jun NH2-terminal kinase pathways","volume":"58","author":"P Jiao","year":"2009","journal-title":"Diabetes"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"E898","DOI":"10.1152\/ajpendo.00131.2007","article-title":"JNK- and IkappaB-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro","volume":"294","author":"K Takahashi","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cmet.2012.01.023","article-title":"Saturated fatty acid and TLR signaling link beta cell dysfunction and islet inflammation","volume":"15","author":"K Eguchi","year":"2012","journal-title":"Cell Metab"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/oby.2012.24","article-title":"Low macrophage accumulation in skeletal muscle of obese type 2 diabetics and elderly subjects","volume":"20","author":"CS Tam","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2337\/db10-1178","article-title":"Bimodal effect on pancreatic beta-cells of secretory products from normal or insulin-resistant human skeletal muscle","volume":"60","author":"K Bouzakri","year":"2011","journal-title":"Diabetes"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"E174","DOI":"10.1152\/ajpendo.90632.2008","article-title":"PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle","volume":"297","author":"AH Remels","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cell.2009.06.046","article-title":"The protein kinase IKKepsilon regulates energy balance in obese mice","volume":"138","author":"SH Chiang","year":"2009","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"E1300","DOI":"10.1152\/ajpendo.90885.2008","article-title":"Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action","volume":"296","author":"V Varma","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s00125-013-2897-x","article-title":"Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes","volume":"56","author":"LN Fink","year":"2013","journal-title":"Diabetologia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1038\/oby.2012.24","article-title":"Low macrophage accumulation in skeletal muscle of obese type 2 diabetics and elderly subjects","volume":"20","author":"CS Tam","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1172\/JCI34260","article-title":"Insulin sensitivity: modulation by nutrients and inflammation","volume":"118","author":"S Schenk","year":"2008","journal-title":"J Clin Invest"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.2337\/db11-1402","article-title":"Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels","volume":"61","author":"M Bosma","year":"2012","journal-title":"Diabetes"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1172\/JCI30565","article-title":"Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance","volume":"117","author":"L Liu","year":"2007","journal-title":"J Clin Invest"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/3018","article-title":"Type 2 diabetes\u2013who is conducting the orchestra?","volume":"20","author":"BB Kahn","year":"1998","journal-title":"Nat Genet"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"CN Lumeng","year":"2011","journal-title":"J Clin Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e64","DOI":"10.1371\/journal.pgen.0030064","article-title":"PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism","volume":"3","author":"G Medina-Gomez","year":"2007","journal-title":"PLoS Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1096\/fj.10-171579","article-title":"Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury","volume":"25","author":"H Lu","year":"2011","journal-title":"FASEB J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1172\/JCI26498","article-title":"MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity","volume":"116","author":"H Kanda","year":"2006","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"26602","DOI":"10.1074\/jbc.M601284200","article-title":"Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance","volume":"281","author":"N Kamei","year":"2006","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cmet.2009.03.002","article-title":"CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance","volume":"9","author":"C Chavey","year":"2009","journal-title":"Cell Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"20692","DOI":"10.1074\/jbc.M109.018556","article-title":"Keratinocyte-derived chemokine in obesity: expression, regulation, and role in adipose macrophage infiltration and glucose homeostasis","volume":"284","author":"JG Neels","year":"2009","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1161\/ATVBAHA.109.197442","article-title":"CCL5 promotes macrophage recruitment and survival in human adipose tissue","volume":"30","author":"M Keophiphath","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"E831","DOI":"10.1152\/ajpendo.00339.2011","article-title":"Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle","volume":"302","author":"L Pedersen","year":"2012","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1096\/fj.04-2870fje","article-title":"Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction","volume":"19","author":"T Phillips","year":"2005","journal-title":"FASEB J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.2337\/dc06-2537","article-title":"Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study","volume":"30","author":"SW Park","year":"2007","journal-title":"Diabetes Care"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1146\/annurev-physiol-021909-135846","article-title":"Macrophages, inflammation, and insulin resistance","volume":"72","author":"JM Olefsky","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jnutbio.2005.11.002","article-title":"Tumor necrosis factor alpha signaling in skeletal muscle: effects of age and caloric restriction","volume":"17","author":"AJ Dirks","year":"2006","journal-title":"J Nutr Biochem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T09:55:36Z","timestamp":1565949336000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110653"}},"subtitle":[],"editor":[{"given":"Makoto","family":"Kanzaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,22]]},"references-count":41,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110653","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,22]]}}}