{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:32:41Z","timestamp":1789943561008,"version":"4.0.1"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0110873","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T22:17:41Z","timestamp":1413843461000},"page":"e110873","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Whole Proteome Analysis of Mouse Lymph Nodes in Cutaneous Anthrax"],"prefix":"10.1371","volume":"9","author":[{"given":"Taissia G.","family":"Popova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Espina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudius","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Liotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serguei G.","family":"Popov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1089\/lrb.2008.1008","article-title":"The lymphatic system in health and disease","volume":"6","author":"LN Cueni","year":"2008","journal-title":"Lymphat Res Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/pmic.200300573","article-title":"Proteomic analysis of lymph","volume":"4","author":"LV Leak","year":"2004","journal-title":"Proteomics"},{"key":"ref3","first-page":"65","article-title":"Profiling of normal human leg lymph proteins using the 2-D electrophoresis and SELDI-TOF mass spectrophotometry approach","volume":"37","author":"B Interewicz","year":"2004","journal-title":"Lymphology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/S0022-2275(20)33440-4","article-title":"Lipid and apolipoprotein concentrations in prenodal leg lymph of fasted humans. Associations with plasma concentrations in normal subjects, lipoprotein lipase deficiency, and LCAT deficiency","volume":"41","author":"MN Nanjee","year":"2000","journal-title":"J Lipid Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/1529-0131(200103)44:3<541::AID-ANR102>3.0.CO;2-6","article-title":"Lymph draining from foot joints in rheumatoid arthritis provides insight into local cytokine and chemokine production and transport to lymph nodes","volume":"44","author":"WL Olszewski","year":"2001","journal-title":"Arthritis Rheum"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"G895","DOI":"10.1152\/ajpgi.90378.2008","article-title":"The proteome of rodent mesenteric lymph","volume":"295","author":"A Mittal","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1021\/pr060327k","article-title":"Sepsis plasma protein profiling with immunodepletion, three-dimensional liquid chromatography tandem mass spectrometry, and spectrum counting","volume":"5","author":"Z Shen","year":"2006","journal-title":"J Proteome Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1002\/pmic.200401228","article-title":"Depletion of multiple high-abundance proteins improves protein profiling capacities of human serum and plasma","volume":"5","author":"LA Echan","year":"2005","journal-title":"Proteomics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1471-2172-11-51","article-title":"The gastrointestinal nematode Trichostrongylus colubriformis down-regulates immune gene expression in migratory cells in afferent lymph","volume":"11","author":"JS Knight","year":"2010","journal-title":"BMC Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.surg.2009.02.022","article-title":"Proteome and system ontology of hemorrhagic shock: exploring early constitutive changes in postshock mesenteric lymph","volume":"146","author":"ED Peltz","year":"2009","journal-title":"Surgery"},{"key":"ref11","first-page":"130","article-title":"The proteome of mesenteric lymph during acute pancreatitis and implications for treatment","volume":"10","author":"A Mittal","year":"2009","journal-title":"JOP"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"G895","DOI":"10.1152\/ajpgi.90378.2008","article-title":"The proteome of rodent mesenteric lymph","volume":"295","author":"A Mittal","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/SHK.0b013e3181cd8631","article-title":"Changes in the mesenteric lymph proteome induced by hemorrhagic shock","volume":"34","author":"A Mittal","year":"2010","journal-title":"Shock"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/pmic.200700531","article-title":"The proteome of gastric lymph in normal and nematode infected sheep","volume":"8","author":"GM Goldfinch","year":"2008","journal-title":"Proteomics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e9863","DOI":"10.1371\/journal.pone.0009863","article-title":"An Expanded Self-Antigen Peptidome Is Carried by the Human Lymph As Compared to the Plasma","volume":"5","author":"CC Clement","year":"2010","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3389\/fimmu.2013.00424","article-title":"The Lymph Self-Antigen Repertoire","volume":"4","author":"CC Clement","year":"2013","journal-title":"Front Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/pmic.200700664","article-title":"Application of proteomics technology for analyzing the interactions between host cells and intracellular infectious agents","volume":"8","author":"M Coiras","year":"2008","journal-title":"Proteomics"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/pmic.201000610","article-title":"Quantitative proteomics by 2-DE, 16O\/18O labelling and linear ion trap mass spectrometry analysis of lymph nodes from piglets inoculated by porcine circovirus type 2","volume":"11","author":"M Ram\u00edrez-Boo","year":"2011","journal-title":"Proteomics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cimid.2012.11.003","article-title":"Exploring the immune response of porcine mesenteric lymph nodes to Salmonella enterica serovar Typhimurium: an analysis of transcriptional changes, morphological alterations and pathogen burden","volume":"36","author":"RP Martins","year":"2013","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1128\/IAI.06061-11","article-title":"Updating perspectives on the initiation of Bacillus anthracis growth and dissemination through its host","volume":"80(5)","author":"ZP Weiner","year":"2012","journal-title":"Infection and Immunity"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.4172\/jpb.1000101","article-title":"Discovery of Infectious Disease Biomarkers in Murine Anthrax Model Using Mass Spectrometry of the Low-Molecular-Mass Serum Proteome","volume":"2","author":"A Narayanan","year":"2009","journal-title":"J Proteomics Bioinform"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-61779-286-1_1","article-title":"Reverse phase protein microarrays for clinical applications","volume":"785","author":"M Pierobon","year":"2011","journal-title":"Methods Mol Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1097\/JTO.0b013e3182725fc7","article-title":"A pilot characterization of human lung NSCLC by protein pathway activation mapping","volume":"7","author":"A Zupa","year":"2012","journal-title":"J Thorac Oncol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e13805","DOI":"10.1371\/journal.pone.0013805","article-title":"Reverse-phase phosphoproteome analysis of signaling pathways induced by Rift valley fever virus in human small airway epithelial cells","volume":"5","author":"TG Popova","year":"2010","journal-title":"PLoS One"},{"key":"ref25","article-title":"Application of molecular technologies for phosphoproteomic analysis of clinical samples","author":"M Pierobon","year":"2014","journal-title":"Oncogene"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/978-1-61779-043-0_18","article-title":"Reverse phase protein microarrays: fluorometric and colorimetric detection","volume":"723","author":"RI Gallagher","year":"2011","journal-title":"Methods Mol Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1586\/14789450.2014.893193","article-title":"Stratification of clear cell renal cell carcinoma by signaling pathway analysis","volume":"11","author":"M Cremona","year":"2014","journal-title":"Expert Rev Proteomics"},{"key":"ref28","article-title":"Feedbacks and adaptive capabilities of the PI3K\/Akt\/mTOR axis in Acute Myeloid Leukemia revealed by pathway selective inhibition and phosphoproteome analysis","author":"J Bertacchini","year":"2014","journal-title":"Leukemia"},{"key":"ref29","article-title":"Realizing the promise of reverse phase protein arrays for clinical, translational and basic research: a workshop report","author":"R Akbani","year":"2014","journal-title":"Mol Cell Proteomics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1371\/journal.pmed.0050123","article-title":"A mouse to human search for plasma proteome changes associated with pancreatic tumor development","volume":"5","author":"VM Faca","year":"2008","journal-title":"PLoS Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery","volume":"4","author":"G Dennis","year":"2003","journal-title":"Genome Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.micinf.2011.08.016","article-title":"New insights into the biological effects of anthrax toxins: linking cellular to arganismal responses","volume":"14","author":"A Guichard","year":"2011","journal-title":"Microbe Infect"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1574-695X.2008.00480.x","article-title":"Neutrophil elastase and syndecan shedding contribute to antithrombin depletion in murine anthrax","volume":"54","author":"M-C Chung","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1099\/jmm.0.007427-0","article-title":"Activation of plasminogen activator inhibitor implicates protease InhA in the acute-phase response to Bacillus anthracis infection","volume":"58","author":"M-C Chung","year":"2009","journal-title":"J Med Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"9531","DOI":"10.1074\/jbc.M705871200","article-title":"Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy","volume":"283","author":"M-C Chung","year":"2008","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"31408","DOI":"10.1074\/jbc.M605526200","article-title":"Secreted neutral metalloproteases of Bacillus anthracis as candidate pathogenic factors","volume":"281","author":"M-C Chung","year":"2006","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e18119","DOI":"10.1371\/journal.pone.0018119","article-title":"Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity","volume":"6","author":"M-C Chung","year":"2011","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2334-5-25","article-title":"Effective antiprotease-antibiotic treatment of experimental anthrax","volume":"5","author":"SG Popov","year":"2005","journal-title":"BMC Infect Dis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/MOH.0b013e32833338f3","article-title":"Effects of sepsis on neutrophil chemotaxis","volume":"17","author":"RC Reddy","year":"2010","journal-title":"Curr Opin Hematol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ceb.2009.01.028","article-title":"Tyrosine phosphorylation: thirty years and counting","volume":"21","author":"T Hunter","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.molonc.2010.09.004","article-title":"Phosphoproteomics in cancer","volume":"4","author":"HC Harsha","year":"2010","journal-title":"Mol Oncol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0006-291X(02)00227-9","article-title":"Lethal toxin of Bacillus anthracis causes apoptosis of macrophages","volume":"293","author":"SG Popov","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1574-695X.2009.00558.x","article-title":"Anthrax infection inhibits the AKT signaling involved in the E-cadherin-mediated adhesion of lung epithelial cells","volume":"56","author":"T Popova","year":"2009","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"M110.000927","DOI":"10.1074\/mcp.M110.000927","article-title":"Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry","volume":"10","author":"NP Manes","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/sj.bjc.6605734","article-title":"Increased circulating cell signalling phosphoproteins in sera are useful for the detection of pancreatic cancer","volume":"103","author":"S Takano","year":"2010","journal-title":"Br J Cancer"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.1021\/pr900603n","article-title":"An initial characterization of the serum phosphoproteome","volume":"8","author":"W Zhou","year":"2009","journal-title":"J Proteome Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1158\/1940-6207.CAPR-11-0427","article-title":"Functional protein pathway activation mapping of the progression of normal skin to squamous cell carcinoma","volume":"5","author":"JG Einspahr","year":"2012","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jprot.2012.11.013","article-title":"Protein expression profiles of human lymph and plasma mapped by 2D\u2013DIGE and 1D SDS-PAGE coupled with nanoLC-ESI-MS\/MS bottom-up proteomics","volume":"78","author":"CC Clement","year":"2013","journal-title":"J Proteomics"},{"key":"ref49","first-page":"163","article-title":"Comparative proteomic analysis of rodent plasma and mesenteric lymph","volume":"56","author":"K-C Yuan","year":"2013","journal-title":"Chin J Physiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/SHK.0b013e318206f654","article-title":"Proteomic analysis of human mesenteric lymph","volume":"35","author":"M Dzieciatkowska","year":"2011","journal-title":"Shock"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2741\/1816","article-title":"Role of the gut in the development of injury- and shock induced SIRS and MODS: the gut-lymph hypothesis, a review","volume":"11","author":"EA Deitch","year":"2006","journal-title":"Front Biosci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1152\/japplphysiol.00022.2007","article-title":"Arachidonic acid in postshock mesenteric lymph induces pulmonary synthesis of leukotriene B4","volume":"104","author":"JR Jordan","year":"2008","journal-title":"J Appl Physiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/01.shk.0000160524.14235.6c","article-title":"Trauma-hemorrhagic shock mesenteric lymph from rat contains a modified form of albumin that is implicated in endothelial cell toxicity","volume":"23","author":"VL Kaiser","year":"2005","journal-title":"Shock"},{"key":"ref54","first-page":"4009","article-title":"Anthrax-associated shock","volume":"13","author":"DL Goldman","year":"2008","journal-title":"Front Biosci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/jlb.47.2.142","article-title":"Specific binding of haptoglobin to human neutrophils and its functional consequences","volume":"47","author":"SK Oh","year":"1990","journal-title":"J Leukoc Biol"},{"key":"ref56","first-page":"504","article-title":"Circulating lethal toxin decreases the ability of neutrophils to respond to Bacillus anthracis","volume":"Microbiol16","author":"ZP Weiner","year":"2013","journal-title":"Cell"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1574-695X.2010.00740.x","article-title":"Anthrolysin O and fermentation products mediate the toxicity of Bacillus anthracis to lung epithelial cells under microaerobic conditions","volume":"61","author":"TG Popova","year":"2011","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0006-291X(03)00440-6","article-title":"Anaerobic induction of Bacillus anthracis hemolytic activity","volume":"303","author":"VI Klichko","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2180-6-8","article-title":"Acceleration of epithelial cell syndecan-1 shedding by anthrax hemolytic virulence factors","volume":"6","author":"TG Popova","year":"2006","journal-title":"BMC Microbiol"},{"key":"ref60","article-title":"Bacillus anthracis-derived Nitric oxide Induces Protein S-nitrosylation Contributing to Macrophage Death","author":"M-C Chung","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e17921","DOI":"10.1371\/journal.pone.0017921","article-title":"Bacillus anthracis protease InhA increases blood-brain barrier permeability and contributes to cerebral hemorrhages","volume":"6","author":"V Mukherjee D","year":"2011","journal-title":"PLoS One"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1993.73.1.1","article-title":"Interstitial-lymphatic mechanisms in the control of extracellular fluid volume","volume":"73","author":"K Aukland","year":"1993","journal-title":"Physiol Rev"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1016\/j.peptides.2005.05.001","article-title":"Albumin peptide: a molecular marker for trauma\/hemorrhagic-shock in rat mesenteric lymph","volume":"26","author":"VL Kaiser","year":"2005","journal-title":"Peptides"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/SHK.0b013e3181ceef5e","article-title":"Proteomic analysis of post-hemorrhagic shock mesenteric lymph","volume":"34","author":"J-F Fang","year":"2010","journal-title":"Shock"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.immuni.2011.04.015","article-title":"Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage","volume":"35","author":"SR Ali","year":"2011","journal-title":"Immunity"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"734","DOI":"10.4161\/auto.5.5.8567","article-title":"Implications of autophagy in anthrax pathogenicity","volume":"5","author":"YK Tan","year":"2009","journal-title":"Autophagy"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.immuni.2005.08.010","article-title":"Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis\u2013CREB and NF-kappaB as key regulators","volume":"23","author":"JM Park","year":"2005","journal-title":"Immunity"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e25530","DOI":"10.4161\/jkst.25530","article-title":"JAK-STAT and intestinal mucosal immunology","volume":"2","author":"AF Heneghan","year":"2013","journal-title":"JAK-STAT"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T05:16:46Z","timestamp":1650431806000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110873"}},"subtitle":[],"editor":[{"given":"Adam","family":"Driks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,20]]},"references-count":68,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110873","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,20]]}}}