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Correlation between latent toxoplasmosis and specific disease burden \u2013 a WHO data-based study of 29 European and 59 non-European countries","volume":"9(3)","author":"J Flegr","year":"2014","journal-title":"PLoS ONE"},{"key":"ref17","first-page":"657","article-title":"<italic>Toxoplasmic<\/italic> encephalomyelititis. III. A new case of granulomatoces encephalomyelititis due to a protozoon","volume":"15","author":"A Wolf","year":"1939","journal-title":"Am J Pathol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1017\/S0031182007004064","article-title":"Sex-dependent toxoplasmosis-associated differences in testosterone concentration in humans","volume":"135","author":"J Flegr","year":"2008","journal-title":"Parasitology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.exppara.2011.03.014","article-title":"Direct evidence of Toxoplasma-induced changes in serum testosterone in mice","volume":"128","author":"\u0160 Ka\u0148kov\u00e1","year":"2011","journal-title":"Exp Parasitol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1017\/S003118209800300X","article-title":"Impaired thyroid function in murine toxoplasmosis","volume":"3)","author":"W Stahl","year":"1998","journal-title":"Parasitology 117(Pt"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1017\/S0031182098003035","article-title":"Aetiology of thyroidal dysfunction in murine toxoplasmosis","volume":"3)","author":"W Stahl","year":"1998","journal-title":"Parasitology 117(Pt"},{"key":"ref22","first-page":"20","article-title":"Difference of neuro- and immunomodulatory steroids and selected hormone and lipid concentrations between <italic>Toxoplasma<\/italic>-free and Toxoplasma-infected schizophrenia patients","volume":"35","author":"J Flegr","year":"2014","journal-title":"Neuroendocrinol Lett"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00436-010-2013-9","article-title":"Modulation of immunity in mice with latent toxoplasmosis\u2013the experimental support for the immunosuppression hypothesis of <italic>Toxoplasma<\/italic>-induced changes in reproduction of mice and humans","volume":"107","author":"S Kankova","year":"2010","journal-title":"Parasitol res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/1471-2334-11-274","article-title":"Potential immunomodulatory effects of latent toxoplasmosis in humans","volume":"11","author":"J Flegr","year":"2011","journal-title":"BMC Infect Dis"},{"key":"ref25","unstructured":"CDC. Toxoplasmosis: epidemiology &amp; risk factors. 2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cdc.gov\/toxoplasmosis\/epi.html\" xlink:type=\"simple\">http:\/\/www.cdc.gov\/toxoplasmosis\/epi.html<\/ext-link>. Accessed 2014 October 2."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/j.1469-0691.2007.01771.x","article-title":"New and old risk-factors for <italic>Toxoplasma gondii<\/italic> infection: prospective cross-sectional study among military personnel in the Czech Republic","volume":"13","author":"P Kolbekov\u00e1","year":"2007","journal-title":"Clin Microb Inf"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.autrev.2008.07.013","article-title":"Infections and autoimmune thyroid diseases: Parallel detection of antibodies against pathogens with proteomic technology","volume":"8","author":"R Tozzoli","year":"2008","journal-title":"Autoimmun Rev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1469-0691.2006.01564.x","article-title":"Evaluation of a commercial IgE ELISA in comparison with IgA and IgM ELISAs, IgG avidity assay and complement fixation for the diagnosis of acute toxoplasmosis","volume":"13","author":"P Kodym","year":"2007","journal-title":"Clin Microb Inf"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s12016-010-8241-z","article-title":"Geographical differences in autoantibodies and antiinfectious agents antibodies among healthy adults","volume":"42","author":"Y Shapira","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1210\/jcem-71-2-276","article-title":"Regulation of maternal thyroid during pregnancy","volume":"71","author":"D Glinoer","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1177\/1933719108329095","article-title":"Inflammation and pregnancy","volume":"16(2)","author":"JR Challis","year":"2009","journal-title":"Reprod Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1128\/CMR.11.4.569","article-title":"Regulation and fuction of T-cell-mediated imunity during <italic>Toxoplasma gondii<\/italic> infection","volume":"11(4)","author":"EY Denkers","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"ref33","first-page":"139","article-title":"Host resistance to <italic>Toxoplasma gondii<\/italic>: model for studying the selective induction of cell-mediated immunity by intracellular parasites","volume":"2","author":"RT Gazzinelli","year":"1993","journal-title":"Infect Agents Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1530\/eje.1.01906","article-title":"Defect of a subpopulation of natural killer immune cells in Graves\u2019 disease and Hashimoto\u2019s thyroiditis: normalizing effect of dehydroepiandrosterone sulfate","volume":"152","author":"SB Solerte","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"899","DOI":"10.4049\/jimmunol.175.2.899","article-title":"NKT cells are critical for the initiation of an inflammatory bowel response against <italic>Toxoplasma gondii<\/italic>","volume":"175(2)","author":"C Ronet","year":"2005","journal-title":"J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1086\/595793","article-title":"Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review","volume":"199(2)","author":"A Elbez-Rubinstein","year":"2009","journal-title":"J Infect Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.it.2012.03.002","article-title":"The otherness of self: microchimerism in health and disease","volume":"33","author":"JL Nelson","year":"2012","journal-title":"Trends Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1210\/jc.2011-3160","article-title":"Microchimerism and endocrine disorders","volume":"97","author":"L Fugazzola","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref39","unstructured":"Prandota J (2012). Increased generation of antibodies and autoantibodies directed against brain proteins in patients with autism and their families may be caused by <italic>T. gondii<\/italic> infection. Maternal and fetal microchimerisms probably play an important role in these processes acting as a \u201cTrojan horse\u201d in dissemination of the parasite. In: Gemma C, editor. Neuroinflammation Pathogenesis, Mechanisms and Management. New York: Nova Science Publishers. 447\u2013638."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e1003051","DOI":"10.1371\/journal.ppat.1003051","article-title":"GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by <italic>Toxoplasma gondii<\/italic>","volume":"8","author":"JM Fuks","year":"2012","journal-title":"PLoS Pathog"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T15:47:22Z","timestamp":1589039242000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110878"}},"subtitle":[],"editor":[{"given":"David J.","family":"Sullivan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,28]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110878","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,28]]}}}