{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:24:41Z","timestamp":1785731081578,"version":"3.56.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T00:00:00Z","timestamp":1414540800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0110946","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T18:34:34Z","timestamp":1414607674000},"page":"e110946","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Posterior Cerebral Artery Angle and the Rupture of Basilar Tip Aneurysms"],"prefix":"10.1371","volume":"9","author":[{"given":"Allen L.","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Mouminah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/S1474-4422(11)70109-0","article-title":"Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis","volume":"10","author":"MH Vlak","year":"2011","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/STROKEAHA.109.566018","article-title":"Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined population","volume":"41","author":"RA Gabriel","year":"2010","journal-title":"Stroke"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1161\/STROKEAHA.110.603803","article-title":"Paradoxical trends in the management of unruptured cerebral aneurysms in the United States: analysis of nationwide database over a 10-year period","volume":"42","author":"MC Huang","year":"2011","journal-title":"Stroke"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1227\/01.NEU.0000311076.64109.2E","article-title":"Guidelines for the surgical treatment of unruptured intracranial aneurysms: the first annual J. Lawrence pool memorial research symposium\u2013controversies in the management of cerebral aneurysms","volume":"62","author":"RJ Komotar","year":"2008","journal-title":"Neurosurgery"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(03)13860-3","article-title":"Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment","volume":"362","author":"DO Wiebers","year":"2003","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.3171\/foc.2004.17.5.3","article-title":"The natural history of unruptured intracranial aneurysms","volume":"17","author":"J Mocco","year":"2004","journal-title":"Neurosurg Focus"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.3171\/foc.2004.17.5.4","article-title":"Natural history of unruptured intracranial aneurysms","volume":"17","author":"RD Ecker","year":"2004","journal-title":"Neurosurg Focus"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1056\/NEJMoa1113260","article-title":"The natural course of unruptured cerebral aneurysms in a Japanese cohort","volume":"366","author":"A Morita","year":"2012","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3171\/2012.7.JNS111766","article-title":"Differences in simple morphological variables in ruptured and unruptured middle cerebral artery aneurysms","volume":"117","author":"N Lin","year":"2012","journal-title":"J Neurosurg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3171\/2013.9.JNS13921","article-title":"Morphological and clinical risk factors for posterior communicating artery aneurysm rupture","volume":"120","author":"H Matsukawa","year":"2014","journal-title":"J Neurosurg"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Matsukawa H, Uemura A, Fujii M, Kamo M, Takahashi O, <etal>et al<\/etal>.. (2012) Morphological and clinical risk factors for the rupture of anterior communicating artery aneurysms. J Neurosurg.","DOI":"10.3171\/2012.11.JNS121210"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e79635","DOI":"10.1371\/journal.pone.0079635","article-title":"Analysis of morphological parameters to differentiate rupture status in anterior communicating artery aneurysms","volume":"8","author":"N Lin","year":"2013","journal-title":"PLoS One"},{"key":"ref13","unstructured":"Drake CGP, S.J.; Hernesniemi J. (1996) Surgery of Vertebrobasilar: London, Ontario, Experience on 1767 Patients. New York: Springer-Verlag."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(02)11314-6","article-title":"International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial","volume":"360","author":"A Molyneux","year":"2002","journal-title":"Lancet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1056\/NEJM199812103392401","article-title":"Unruptured intracranial aneurysms\u2013risk of rupture and risks of surgical intervention. International Study of Unruptured Intracranial Aneurysms Investigators","volume":"339","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(03)13860-3","article-title":"Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment","volume":"362","author":"DO Wiebers","year":"2003","journal-title":"Lancet"},{"key":"ref17","first-page":"632","article-title":"3D SLICER","volume":"1","author":"S Pieper","year":"2004","journal-title":"Proceedings of the 1st IEEE International Symposium on Biomedical Imaging: From Nano to Macro"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Pieper S, Lorensen B, Schroeder W, Kikinis R (2006) The NA-MIC Kit: ITK, VTK, Pipelines, Grids and 3D Slicer as An Open Platform for the Medical Image Computing Community. Proceedings of the 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro: 698\u2013701.","DOI":"10.1109\/ISBI.2006.1625012"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3171\/jns.2005.102.2.0355","article-title":"Quantified aneurysm shape and rupture risk","volume":"102","author":"ML Raghavan","year":"2005","journal-title":"J Neurosurg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1227\/01.NEU.0000316847.64140.81","article-title":"Morphology parameters for intracranial aneurysm rupture risk assessment","volume":"63","author":"S Dhar","year":"2008","journal-title":"Neurosurgery"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00006123-200103000-00007","article-title":"Is the aspect ratio a reliable index for predicting the rupture of a saccular aneurysm?","volume":"48","author":"H Ujiie","year":"2001","journal-title":"Neurosurgery"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1023\/B:ABME.0000012746.31343.92","article-title":"Three-dimensional geometrical characterization of cerebral aneurysms","volume":"32","author":"B Ma","year":"2004","journal-title":"Ann Biomed Eng"},{"key":"ref23","first-page":"1079","article-title":"An analysis of the geometry of saccular intracranial aneurysms","volume":"20","author":"L Parlea","year":"1999","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref24","first-page":"119","article-title":"Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: a possible index for surgical treatment of intracranial aneurysms","volume":"45","author":"H Ujiie","year":"1999","journal-title":"Neurosurgery"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1179\/016164109X12581096796558","article-title":"Size ratio for clinical assessment of intracranial aneurysm rupture risk","volume":"32","author":"D Ma","year":"2010","journal-title":"Neurol Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1161\/STROKEAHA.109.570770","article-title":"Aneurysm inflow-angle as a discriminant for rupture in sidewall cerebral aneurysms: morphometric and computational fluid dynamic analysis","volume":"41","author":"MI Baharoglu","year":"2010","journal-title":"Stroke"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jbiomech.2007.09.032","article-title":"On the effect of parent-aneurysm angle on flow patterns in basilar tip aneurysms: towards a surrogate geometric marker of intra-aneurismal hemodynamics","volume":"41","author":"MD Ford","year":"2008","journal-title":"J Biomech"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s00701-003-0124-0","article-title":"Difference in configuration of ruptured and unruptured intracranial aneurysms determined by biplanar digital subtraction angiography","volume":"145","author":"J Beck","year":"2003","journal-title":"Acta Neurochir (Wien)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00415-009-0028-x","article-title":"Configuration of the circle of Willis, direction of flow, and shape of the aneurysm as risk factors for rupture of intracranial aneurysms","volume":"256","author":"NK de Rooij","year":"2009","journal-title":"J Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1227\/NEU.0b013e3182503bf9","article-title":"Ruptured status discrimination performance of aspect ratio, height\/width, and bottleneck factor is highly dependent on aneurysm sizing methodology","volume":"71","author":"A Lauric","year":"2012","journal-title":"Neurosurgery"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1227\/01.NEU.0000124482.03676.8B","article-title":"Is aspect ratio a reliable predictor of intracranial aneurysm rupture?","volume":"54","author":"A Nader-Sepahi","year":"2004","journal-title":"Neurosurgery"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00234-010-0804-4","article-title":"Analysis of aneurysm rupture in relation to the geometric indices: aspect ratio, volume, and volume-to-neck ratio","volume":"53","author":"C-W Ryu","year":"2011","journal-title":"Neuroradiology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1227\/01.NEU.0000311347.35583.0C","article-title":"Morphological differences between ruptured and unruptured cases in middle cerebral artery aneurysms","volume":"62","author":"T Sadatomo","year":"2008","journal-title":"Neurosurgery"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1227\/01.NEU.0000298899.77097.BF","article-title":"Bottleneck factor and height-width ratio: association with ruptured aneurysms in patients with multiple cerebral aneurysms","volume":"61","author":"BL Hoh","year":"2007","journal-title":"Neurosurgery"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1227\/NEU.0b013e31824c057e","article-title":"Intracellular signaling pathways and size, shape, and rupture history of human intracranial aneurysms","volume":"70","author":"E Laaksamo","year":"2012","journal-title":"Neurosurgery"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Backes D, Vergouwen MD, Velthuis BK, van der Schaaf IC, Bor AS, <etal>et al<\/etal>.. (2014) Difference in Aneurysm Characteristics Between Ruptured and Unruptured Aneurysms in Patients With Multiple Intracranial Aneurysms. Stroke.","DOI":"10.1161\/STROKEAHA.113.004421"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1161\/STROKEAHA.113.001838","article-title":"Natural history of unruptured intracranial aneurysms: a long-term follow-up study","volume":"44","author":"S Juvela","year":"2013","journal-title":"Stroke"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1161\/STROKEAHA.110.585059","article-title":"Small unruptured intracranial aneurysm verification study: SUAVe study, Japan","volume":"41","author":"M Sonobe","year":"2010","journal-title":"Stroke"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1161\/STROKEAHA.108.521674","article-title":"Unruptured intracranial aneurysms: incidence of rupture and risk factors","volume":"40","author":"T Ishibashi","year":"2009","journal-title":"Stroke"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1474-4422(13)70263-1","article-title":"Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies","volume":"13","author":"JP Greving","year":"2014","journal-title":"Lancet Neurol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e94837","DOI":"10.1371\/journal.pone.0094837","article-title":"Morphological parameters associated with ruptured posterior communicating aneurysms","volume":"9","author":"A Ho","year":"2014","journal-title":"PLoS One"},{"key":"ref42","first-page":"195","article-title":"Numerical investigation of pulsatile blood flow in a bifurcation model with a non-planar branch: the effect of different bifurcation angles and non-planar branch","volume":"2","author":"O Arjmandi Tash","year":"2012","journal-title":"Bioimpacts"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0141-5425(91)90100-L","article-title":"Pulsatile non-Newtonian blood flow in three-dimensional carotid bifurcation models: a numerical study of flow phenomena under different bifurcation angles","volume":"13","author":"K Perktold","year":"1991","journal-title":"J Biomed Eng"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0741-5214(96)80048-6","article-title":"Effect of carotid artery geometry on the magnitude and distribution of wall shear stress gradients","volume":"23","author":"DR Wells","year":"1996","journal-title":"J Vasc Surg"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jbiomech.2007.08.012","article-title":"Carotid geometry effects on blood flow and on risk for vascular disease","volume":"41","author":"KT Nguyen","year":"2008","journal-title":"J Biomech"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1001\/jama.282.21.2035","article-title":"Hemodynamic shear stress and its role in atherosclerosis","volume":"282","author":"AM Malek","year":"1999","journal-title":"JAMA"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"H1535","DOI":"10.1152\/ajpheart.00510.2009","article-title":"Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis","volume":"297","author":"D Nam","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"58S","DOI":"10.1378\/chest.114.1_Supplement.58S","article-title":"Mechanisms of shear stress transmission and transduction in endothelial cells","volume":"114","author":"AI Barakat","year":"1998","journal-title":"Chest"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1161\/01.STR.0000144648.89172.0f","article-title":"Magnitude and role of wall shear stress on cerebral aneurysm: computational fluid dynamic study of 20 middle cerebral artery aneurysms","volume":"35","author":"M Shojima","year":"2004","journal-title":"Stroke"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1161\/STROKEAHA.106.481234","article-title":"Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation","volume":"38","author":"H Meng","year":"2007","journal-title":"Stroke"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1006\/bbrc.1997.6146","article-title":"Lack of hemodynamic forces triggers apoptosis in vascular endothelial cells","volume":"231","author":"D Kaiser","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1007\/s10439-012-0577-5","article-title":"Automatic neck plane detection and 3D geometric characterization of aneurysmal sacs","volume":"40","author":"M Piccinelli","year":"2012","journal-title":"Ann Biomed Eng"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0110946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T20:03:48Z","timestamp":1565985828000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0110946"}},"subtitle":[],"editor":[{"given":"Jinglu","family":"Ai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,29]]},"references-count":52,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0110946","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,29]]}}}