{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T12:04:27Z","timestamp":1782129867676,"version":"3.54.5"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0111004","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T18:05:17Z","timestamp":1414001117000},"page":"e111004","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Protocatechuic Acid, a Novel Active Substance against Avian Influenza Virus H9N2 Infection"],"prefix":"10.1371","volume":"9","author":[{"given":"Changbo","family":"Ou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunhui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongxue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Compans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1128\/JCM.43.11.5760-5767.2005","article-title":"Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003","volume":"43","author":"KM Butt","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jinf.2011.02.007","article-title":"Infection of immunocompromised patients by avian H9N2 influenza A virus","volume":"62","author":"VC Cheng","year":"2011","journal-title":"J Infect"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"9654","DOI":"10.1073\/pnas.160270697","article-title":"Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates","volume":"97","author":"YP Lin","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.vetmic.2011.10.003","article-title":"Evaluation of the protective efficacy of a commercial vaccine against different antigenic groups of H9N2 influenza viruses in chickens","volume":"156","author":"Y Sun","year":"2012","journal-title":"Vet Microbiol"},{"key":"ref5","first-page":"177","article-title":"Homologous recombination as an evolutionary force in the avian influenza A virus","volume":"26","author":"CQ He","year":"2009","journal-title":"Mol Biol Evol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3851\/IMP1656","article-title":"A comprehensive surveillance of adamantane resistance among human influenza A virus isolated from mainland China between 1956 and 2009","volume":"15","author":"Y Lan","year":"2010","journal-title":"Antivir Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11262-010-0534-z","article-title":"Emergence of amantadine-resistant avian influenza H5N1 virus in India","volume":"42","author":"C Tosh","year":"2011","journal-title":"Virus Genes"},{"key":"ref8","first-page":"179","article-title":"Antiviral activity of crude extracts of Eugenia jambolana Lam. against highly pathogenic avian influenza (H5N1) virus","volume":"50","author":"R Sood","year":"2012","journal-title":"Indian J Exp Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12250-010-3082-8","article-title":"In vivo inhibition of NAS preparation on H9N2 subtype AIV","volume":"25","author":"RF Shang","year":"2010","journal-title":"Virol Sin"},{"key":"ref10","first-page":"8","article-title":"Evaluation of the Histopathology of the Respiratory System in Essential Oil-Treated Broilers Following a Challenge With Mycoplasma gallisepticum and\/or H9N2 Influenza Virus","volume":"4","author":"EK Barbour","year":"2006","journal-title":"Intern J Appl Res Vet Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejps.2009.07.004","article-title":"Evaluation of the efficacy and safety of a statin\/caffeine combination against H5N1, H3N2 and H1N1 virus infection in BALB\/c mice","volume":"38","author":"Z Liu","year":"2009","journal-title":"Eur J Pharm Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.3382\/ps.2011-02069","article-title":"Protocatechuic acid, a new active substance against the challenge of avian infectious bursal disease virus","volume":"91","author":"CB Ou","year":"2012","journal-title":"Poult Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10787-011-0086-4","article-title":"Anti-inflammatory and analgesic activity of protocatechuic acid in rats and mice","volume":"19","author":"AB Lende","year":"2011","journal-title":"Inflammopharmacology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6661","DOI":"10.1021\/jf9015202","article-title":"Anticoagulatory, antiinflammatory, and antioxidative effects of protocatechuic acid in diabetic mice","volume":"57","author":"CY Lin","year":"2009","journal-title":"J Agric Food Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10565-006-0082-4","article-title":"Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism","volume":"22","author":"EC Yip","year":"2006","journal-title":"Cell Biol Toxicol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00705-009-0560-0","article-title":"Acute respiratory distress syndrome induced by H9N2 virus in mice","volume":"155","author":"G Deng","year":"2010","journal-title":"Arch Virol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.antiviral.2012.07.002","article-title":"Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents","volume":"96","author":"DF Smee","year":"2012","journal-title":"Antiviral Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.antiviral.2012.05.004","article-title":"Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice","volume":"95","author":"L Simeonova","year":"2012","journal-title":"Antiviral Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/jac\/44.4.561","article-title":"Modification of acquired immunity in mice by imipenem\/cilastatin","volume":"44","author":"E Ortega","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/jac\/dki457","article-title":"Genotypic resistance to lamivudine among hepatitis B virus isolates in Mexico","volume":"57","author":"C Alvarado-Esquivel","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e9332","DOI":"10.1371\/journal.pone.0009332","article-title":"Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro","volume":"5","author":"JT Nguyen","year":"2010","journal-title":"PLoS One"},{"key":"ref22","first-page":"5","article-title":"Effect of 4-Hydroxycinnamic Acid on Chickens Infected with Infectious Bursal Disease Virus","volume":"10","author":"CB Ou","year":"2011","journal-title":"Journal of Animal and Veterinary Advances"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s11259-010-9444-8","article-title":"Efficacy of mannanoligosaccharides and humate on immune response to Avian Influenza (H9) disease vaccination in broiler chickens","volume":"34","author":"T Tohid","year":"2010","journal-title":"Vet Res Commun"},{"key":"ref24","first-page":"1173","article-title":"Inhibition of several strains of influenza virus type A and B by phenolic polymers","volume":"45","author":"J Hils","year":"1986","journal-title":"Biomed Biochim Acta"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s705-002-8319-5","article-title":"In vitro anti-influenza virus activity of synthetic humate analogues derived from protocatechuic acid","volume":"147","author":"FJ Lu","year":"2002","journal-title":"Arch Virol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1164\/rccm.200511-1751OC","article-title":"Acute respiratory distress syndrome induced by avian influenza A (H5N1) virus in mice","volume":"174","author":"T Xu","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"R203","DOI":"10.1186\/cc9324","article-title":"Clinical aspects and cytokine response in severe H1N1 influenza A virus infection","volume":"14","author":"N Hagau","year":"2010","journal-title":"Crit Care"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2008.02.043","article-title":"Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury","volume":"133","author":"Y Imai","year":"2008","journal-title":"Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1385\/CRIAI:28:3:177","article-title":"IL-6: from laboratory to bedside","volume":"28","author":"T Kishimoto","year":"2005","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e29347","DOI":"10.1371\/journal.pone.0029347","article-title":"Acute respiratory distress syndrome induced by a swine 2009 H1N1 variant in mice","volume":"7","author":"Y Zhang","year":"2012","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nm.1929","article-title":"Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10","volume":"15","author":"J Sun","year":"2009","journal-title":"Nat Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/TA.0b013e318265d069","article-title":"Suppression of the p66shc adapter protein by protocatechuic acid prevents the development of lung injury induced by intestinal ischemia reperfusion in mice","volume":"73","author":"GZ Wang","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"6687","DOI":"10.1128\/JVI.75.14.6687-6691.2001","article-title":"Pathogenesis of influenza A (H5N1) virus infection in a primate model","volume":"75","author":"GF Rimmelzwaan","year":"2001","journal-title":"J Virol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1128\/JVI.76.9.4420-4429.2002","article-title":"Pathogenesis of avian influenza A (H5N1) viruses in ferrets","volume":"76","author":"LA Zitzow","year":"2002","journal-title":"J Virol"},{"key":"ref35","first-page":"3273","article-title":"Toward a broadly protective influenza vaccine","volume":"118","author":"PC Doherty","year":"2008","journal-title":"J Clin Invest"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4049\/jimmunol.1200571","article-title":"Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection","volume":"190","author":"H Hamada","year":"2013","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1164\/rccm.201207-1245OC","article-title":"High levels of virus-specific CD4+ T cells predict severe pandemic influenza A virus infection","volume":"186","author":"Y Zhao","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e4122","DOI":"10.1371\/journal.pone.0004122","article-title":"Influenza a virus induces an immediate cytotoxic activity in all major subsets of peripheral blood mononuclear cells","volume":"4","author":"S Sturlan","year":"2009","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s10753-011-9425-2","article-title":"Protocatechuic acid attenuates lipolysaccharide-induced acute lung injury","volume":"35","author":"M Wei","year":"2012","journal-title":"Inflammation"},{"key":"ref40","first-page":"3908","article-title":"Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid: suppressing effects on tumor development and biomarkers expression of colon tumorigenesis","volume":"53","author":"T Tanaka","year":"1993","journal-title":"Cancer Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1177\/0748233712442735","article-title":"Protective effects of protocatechuic acid on TCDD-induced oxidative and histopathological damage in the heart tissue of rats","volume":"29","author":"O Ciftci","year":"2013","journal-title":"Toxicol Ind Health"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0111004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T06:54:18Z","timestamp":1540277658000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0111004"}},"subtitle":[],"editor":[{"given":"Meijia","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,22]]},"references-count":41,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0111004","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,22]]}}}