{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:25:40Z","timestamp":1792520740561,"version":"4.5.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T00:00:00Z","timestamp":1413504000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0111039","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T21:58:11Z","timestamp":1413842291000},"page":"e111039","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":80,"title":["Autoimmunity as a Candidate for the Etiopathogenesis of Meniere's Disease: Detection of Autoimmune Reactions and Diagnostic Biomarker Candidate"],"prefix":"10.1371","volume":"9","author":[{"given":"Sung Huhn","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Gi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Gyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.otc.2010.05.001","article-title":"Current Epidemiology of Meniere&apos;s Syndrome","volume":"43","author":"TH Alexander","year":"2010","journal-title":"Otolaryngologic Clinics of North America"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/00129492-200111000-00030","article-title":"Impact of Meniere&apos;s disease on quality of life","volume":"22","author":"JP Anderson","year":"2001","journal-title":"Otol Neurotol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0140-6736(08)61161-7","article-title":"Meniere&apos;s disease","volume":"372","author":"H Sajjadi","year":"2008","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s11882-012-0258-3","article-title":"Is allergy related to Meniere&apos;s disease?","volume":"12","author":"C Banks","year":"2012","journal-title":"Curr Allergy Asthma Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1055\/s-0033-1354599","article-title":"Posttraumatic vertigo and dizziness","volume":"33","author":"TD Fife","year":"2013","journal-title":"Semin Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ejmg.2013.03.010","article-title":"High incidence of Meniere-like symptoms in relatives of Meniere patients in the areas of Oulu University Hospital and Kainuu Central Hospital in Finland","volume":"56","author":"E Hietikko","year":"2013","journal-title":"Eur J Med Genet"},{"key":"ref7","first-page":"9","article-title":"Meniere&apos;s disease","volume":"17","author":"LB Minor","year":"2004","journal-title":"Curr Opin Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/cge.12150","article-title":"Familial clustering and genetic heterogeneity in Meniere&apos;s disease","volume":"85","author":"T Requena","year":"2014","journal-title":"Clin Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0030-6665(20)30138-9","article-title":"Molecular and cellular pathology of Meniere&apos;s disease","volume":"30","author":"PA Wackym","year":"1997","journal-title":"Otolaryngol Clin North Am"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e26759","DOI":"10.1371\/journal.pone.0026759","article-title":"High prevalence of systemic autoimmune diseases in patients with Meniere&apos;s disease","volume":"6","author":"I Gazquez","year":"2011","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2249.2008.03595.x","article-title":"Possible association between thyroid autoimmunity and Meniere&apos;s disease","volume":"152","author":"B Fattori","year":"2008","journal-title":"Clinical and Experimental Immunology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1177\/000348941112001004","article-title":"HSP70 Antibodies in 80 Patients With \u201cClinically Certain\u201d Meniere&apos;s Disease","volume":"120","author":"J Hornibrook","year":"2011","journal-title":"Annals of Otology Rhinology and Laryngology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1080\/08916930701248555","article-title":"Antibodies to myelin protein zero (P0) protein as markers of auto-immune inner ear diseases","volume":"40","author":"BN Pham","year":"2007","journal-title":"Autoimmunity"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/00005537-199702000-00015","article-title":"Comparison of anti-heat shock protein 70 (anti-hsp70) and anti-68-kDa inner ear protein in the sera of patients with Meniere&apos;s disease","volume":"107","author":"SO Shin","year":"1997","journal-title":"Laryngoscope"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/jcp.22737","article-title":"Proteomics in Meniere disease","volume":"227","author":"G Chiarella","year":"2012","journal-title":"J Cell Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere&apos;s disease. American Academy of Otolaryngology-Head and Neck Foundation, Inc","volume":"113","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Kim SH, Kim UK, Lee WS, Bok J, Song JW, et al. (2011) Albumin-Like Protein is the Major Protein Constituent of Luminal Fluid in the Human Endolymphatic Sac. Plos One 6.","DOI":"10.1371\/journal.pone.0021656"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.autrev.2012.01.004","article-title":"Meniere&apos;s disease might be an autoimmune condition?","volume":"11","author":"A Greco","year":"2012","journal-title":"Autoimmunity Reviews"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000276124","article-title":"Human endolymphatic sac: evidence for a role in inner ear immune defence","volume":"52","author":"HJ Altermatt","year":"1990","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/00016488009127140","article-title":"Immunodefence of the inner ear? Lymphocyte-macrophage interaction in the endolymphatic sac","volume":"89","author":"H Rask-Andersen","year":"1980","journal-title":"Acta Otolaryngol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3109\/00016488709107271","article-title":"The role of the endolymphatic sac in inner ear immunity","volume":"103","author":"S Tomiyama","year":"1987","journal-title":"Acta Otolaryngol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/000348949710600303","article-title":"\u201cEndolymphatic sacitis\u201d in a case of active Meniere&apos;s disease \u2013 An ultrastructural histopathologic investigation","volume":"106","author":"N DanckwardtLilliestrom","year":"1997","journal-title":"Annals of Otology Rhinology and Laryngology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00005537-199702000-00013","article-title":"Demonstration of autoantibodies to the endolymphatic sac in Meniere&apos;s disease","volume":"107","author":"AM Alleman","year":"1997","journal-title":"Laryngoscope"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/jcb.24747","article-title":"A proteomics-driven assay defines specific plasma protein signatures in different stages of Meniere&apos;s disease","volume":"115","author":"G Chiarella","year":"2014","journal-title":"J Cell Biochem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e18195","DOI":"10.1371\/journal.pone.0018195","article-title":"Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear","volume":"6","author":"T Elkan-Miller","year":"2011","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.neuroscience.2006.05.057","article-title":"Synaptic organization in cochlear inner hair cells deficient for the CaV1.3 (alpha1D) subunit of L-type Ca2+ channels","volume":"141","author":"NR Nemzou","year":"2006","journal-title":"Neuroscience"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e70373","DOI":"10.1371\/journal.pone.0070373","article-title":"Identification and immunocytochemical characterization of Piccolino, a novel Piccolo splice variant selectively expressed at sensory ribbon synapses of the eye and ear","volume":"8","author":"H Regus-Leidig","year":"2013","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/archotol.1986.03780050060010","article-title":"Circulating immune complexes in Meniere&apos;s disease","volume":"112","author":"GB Brookes","year":"1986","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1288\/00005537-199103000-00001","article-title":"Meniere&apos;s disease: an immune complex-mediated illness?","volume":"101","author":"MJ Derebery","year":"1991","journal-title":"Laryngoscope"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2350-12-2","article-title":"Polymorphisms of CD16A and CD32 Fcgamma receptors and circulating immune complexes in Meniere&apos;s disease: a case-control study","volume":"12","author":"JA Lopez-Escamez","year":"2011","journal-title":"BMC Med Genet"},{"key":"ref31","first-page":"225","article-title":"Circulating auto-antibodies in Meniere&apos;s disease","volume":"112","author":"H Perez Garrigues","year":"1995","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"ref32","first-page":"116","article-title":"C3 and C1q complement deposits in the membranous labyrinth of patients with Meniere&apos;s disease","volume":"42","author":"R Hausler","year":"1988","journal-title":"Adv Otorhinolaryngol"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Yazawa Y, Kitahara M (1989) Immunofluorescent study of the endolymphatic sac in Meniere&apos;s disease. Acta Otolaryngol Suppl 468: 71\u201376.","DOI":"10.3109\/00016488909139024"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/lary.20650","article-title":"Association of a functional polymorphism of PTPN22 encoding a lymphoid protein phosphatase in bilateral Meniere&apos;s disease","volume":"120","author":"JA Lopez-Escamez","year":"2010","journal-title":"Laryngoscope"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1097\/MAO.0b013e3180dca1cc","article-title":"HLA-DRB1*1101 allele may be associated with bilateral Meniere&apos;s disease in southern European population","volume":"28","author":"JA Lopez-Escamez","year":"2007","journal-title":"Otol Neurotol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00251-013-0683-z","article-title":"Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere&apos;s disease","volume":"65","author":"T Requena","year":"2013","journal-title":"Immunogenetics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0111039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T04:14:03Z","timestamp":1717474443000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0111039"}},"subtitle":[],"editor":[{"given":"Bernd","family":"Sokolowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,17]]},"references-count":36,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0111039","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,17]]}}}