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Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.surgery.org\" xlink:type=\"simple\">www.surgery.org<\/ext-link>."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1471-2202-9-105","article-title":"The role of the t-SNARE SNAP-25 in action potential-dependent calcium signaling and expression in GABAergic and glutamatergic neurons","volume":"9","author":"LC Tafoya","year":"2008","journal-title":"BMC Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1073\/pnas.0706211105","article-title":"Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels","volume":"105","author":"D Pozzi","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"419","DOI":"10.2170\/physiolsci.RP000908","article-title":"Improved calcium utilization at 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