{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T21:54:19Z","timestamp":1719438859369},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T00:00:00Z","timestamp":1414627200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0111248","type":"journal-article","created":{"date-parts":[[2014,10,30]],"date-time":"2014-10-30T14:14:14Z","timestamp":1414678454000},"page":"e111248","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Eplerenone on Adenosine Formation in Humans In Vivo: A Double-Blinded Randomised Controlled Study"],"prefix":"10.1371","volume":"9","clinical-trial-number":[{"clinical-trial-number":"nct01837108","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"T. N. A.","family":"van den Berg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap","family":"Deinum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Bilos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Rogier T.","family":"Donders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard A.","family":"Rongen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels P.","family":"Riksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,10,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1056\/NEJMra071667","article-title":"Myocardial reperfusion injury","volume":"357","author":"DM Yellon","year":"2007","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators","volume":"341","author":"B Pitt","year":"1999","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa030207","article-title":"Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction","volume":"348","author":"B Pitt","year":"2003","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1009492","article-title":"Eplerenone in patients with systolic heart failure and mild symptoms","volume":"364","author":"F Zannad","year":"2011","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/HYPERTENSIONAHA.111.190488","article-title":"Low-dose spironolactone prevents apoptosis repressor with caspase recruitment domain degradation during myocardial infarction","volume":"59","author":"TY Loan Le","year":"2012","journal-title":"Hypertension"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/eurheartj\/ehp555","article-title":"Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion","volume":"31","author":"K Schmidt","year":"2010","journal-title":"Eur Heart J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1161\/HYPERTENSIONAHA.109.136242","article-title":"Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction","volume":"54","author":"AS Mihailidou","year":"2009","journal-title":"Hypertension"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/01.HYP.0000205831.39339.a5","article-title":"Cardioprotective effects of eplerenone in the rat heart: interaction with locally synthesized or blood-derived aldosterone?","volume":"47","author":"W Chai","year":"2006","journal-title":"Hypertension"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jcmg.2008.11.011","article-title":"Molecular imaging for efficacy of pharmacologic intervention in myocardial remodeling","volume":"2","author":"SW van den Borne","year":"2009","journal-title":"JACC Cardiovasc Imaging"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.biocel.2005.10.007","article-title":"Expression of procollagen C-proteinase enhancer-1 in the remodeling rat heart is stimulated by aldosterone","volume":"38","author":"G Kessler-Icekson","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1586\/ecp.12.8","article-title":"Targeting adenosine receptors in the development of cardiovascular therapeutics","volume":"5","author":"NP Riksen","year":"2012","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/FJC.0b013e31819fd4e7","article-title":"Metformin prevents myocardial reperfusion injury by activating the adenosine receptor","volume":"53","author":"M Paiva","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/HYPERTENSIONAHA.110.155689","article-title":"Upregulation of ecto-5'-nucleotidase by rosuvastatin increases the vasodilator response to ischemia","volume":"56","author":"P Meijer","year":"2010","journal-title":"Hypertension"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2174\/138920008786049249","article-title":"Measurement of the endogenous adenosine concentration in humans in vivo: methodological considerations","volume":"9","author":"BP Ramakers","year":"2008","journal-title":"Curr Drug Metab"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"C799","DOI":"10.1152\/ajpcell.1989.256.4.C799","article-title":"Turnover of adenosine in plasma of human and dog blood","volume":"256","author":"GH Moser","year":"1989","journal-title":"Am J Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ejphar.2008.01.053","article-title":"Human in vivo research on the vascular effects of adenosine","volume":"585","author":"NP Riksen","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1161\/ATVBAHA.108.179622","article-title":"Rosuvastatin increases extracellular adenosine formation in humans in vivo: a new perspective on cardiovascular protection","volume":"29","author":"P Meijer","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/bjp.2008.10","article-title":"Dipyridamole enhances ischaemia-induced reactive hyperaemia by increased adenosine receptor stimulation","volume":"153","author":"P Meijer","year":"2008","journal-title":"Br J Pharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0378-4347(95)00383-5","article-title":"Simultaneous high-performance liquid chromatographic determination of caffeine and theophylline for routine drug monitoring in human plasma","volume":"677","author":"E Schreiber-Deturmeny","year":"1996","journal-title":"J Chromatogr B Biomed Appl"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.pharmthera.2013.11.006","article-title":"The cardioprotective effects of mineralocorticoid receptor antagonists","volume":"142","author":"TN van den Berg","year":"2014","journal-title":"Pharmacol Ther"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/01.CIR.0000143830.59419.73","article-title":"Optimal windows of statin use for immediate infarct limitation: 5'-nucleotidase as another downstream molecule of phosphatidylinositol 3-kinase","volume":"110","author":"S Sanada","year":"2004","journal-title":"Circulation"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/00005344-200404000-00013","article-title":"Methotrexate and MX-68, a new derivative of methotrexate, limit infarct size via adenosine-dependent mechanisms in canine hearts","volume":"43","author":"H Asanuma","year":"2004","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s002100000318","article-title":"Metabolic flux rates of adenosine in the heart","volume":"362","author":"A Deussen","year":"2000","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1152\/japplphysiol.00108.2005","article-title":"In vivo evidence against a role for adenosine in the exercise pressor reflex in humans","volume":"99","author":"NP Riksen","year":"2005","journal-title":"J Appl Physiol (1985)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1000245","DOI":"10.1371\/journal.pmed.1000245","article-title":"Can animal models of disease reliably inform human studies?","volume":"7","author":"HB van der Worp","year":"2010","journal-title":"PLoS Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"28423","DOI":"10.1074\/jbc.272.45.28423","article-title":"Molecular cloning and functional characterization of nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative nucleoside transporter proteins (rENT1 and rENT2) from rat tissues","volume":"272","author":"SY Yao","year":"1997","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/ard.2005.048637","article-title":"Methotrexate modulates the kinetics of adenosine in humans in vivo","volume":"65","author":"NP Riksen","year":"2006","journal-title":"Ann Rheum Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0111248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:43:52Z","timestamp":1588963432000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0111248"}},"subtitle":[],"editor":[{"given":"Yoshihiro","family":"Fukumoto","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,30]]},"references-count":27,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0111248","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,30]]}}}