{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:52:25Z","timestamp":1783648345949,"version":"3.55.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T00:00:00Z","timestamp":1414108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0111359","type":"journal-article","created":{"date-parts":[[2014,10,24]],"date-time":"2014-10-24T18:45:14Z","timestamp":1414176314000},"page":"e111359","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Associated Factors of Atrophic Gastritis Diagnosed by Double-Contrast Upper Gastrointestinal Barium X-Ray Radiography: A Cross-Sectional Study Analyzing 6,901 Healthy Subjects in Japan"],"prefix":"10.1371","volume":"9","author":[{"given":"Nobutake","family":"Yamamichi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chigaya","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Shimamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Minatsuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiemi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Fujishiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Konno-Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Kodashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsuko","family":"Asada-Hirayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Yakabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Kakimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Mitsushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,10,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3748\/wjg.v12.i3.354","article-title":"Epidemiology of gastric cancer","volume":"12","author":"KD Crew","year":"2006","journal-title":"World J Gastroenterol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"10727","DOI":"10.1158\/0008-5472.CAN-07-2601","article-title":"Frequent loss of Brm expression in gastric cancer correlates with histologic features and differentiation state","volume":"67","author":"N Yamamichi","year":"2007","journal-title":"Cancer Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1470-2045(08)70072-X","article-title":"Screening for gastric cancer in Asia: current evidence and practice","volume":"9","author":"WK Leung","year":"2008","journal-title":"Lancet Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/ijc.21664","article-title":"Gastric cancer screening and subsequent risk of gastric cancer: a large-scale population-based cohort study, with a 13-year follow-up in Japan","volume":"118","author":"KJ Lee","year":"2006","journal-title":"Int J Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/PL00011692","article-title":"Screening for gastric cancer in Japan","volume":"3","author":"Y Tsubono","year":"2000","journal-title":"Gastric Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/ijc.2910380608","article-title":"Evaluation of a mass screening program for stomach cancer with a case-control study design","volume":"38","author":"A Oshima","year":"1986","journal-title":"Int J Cancer"},{"key":"ref7","first-page":"211","article-title":"Mass screening for gastric cancer by X-ray examination","volume":"14","author":"S Hisamichi","year":"1984","journal-title":"Jpn J Clin Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/ijc.11183","article-title":"Prospective study of screening for stomach cancer in Japan","volume":"106","author":"T Mizoue","year":"2003","journal-title":"Int J Cancer"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/jjco\/hyn017","article-title":"The Japanese guidelines for gastric cancer screening","volume":"38","author":"C Hamashima","year":"2008","journal-title":"Jpn J Clin Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1080\/00365520802085395","article-title":"Decreased death from gastric cancer by endoscopic screening: association with a population-based cancer registry","volume":"43","author":"O Hosokawa","year":"2008","journal-title":"Scand J Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1572-0241.2003.07410.x","article-title":"Usefulness of gastric cancer screening using the serum pepsinogen test method","volume":"98","author":"K Miki","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1111\/j.1440-1746.2009.06214.x","article-title":"Changes in the prevalence of Helicobacter pylori infection and gastrointestinal diseases in the past 17 years","volume":"25","author":"S Nakajima","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"ref13","first-page":"630","article-title":"Decreasing prevalence of Helicobacter pylori infection: a 9-year observational study","volume":"54","author":"SY Lee","year":"2007","journal-title":"Hepatogastroenterology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/oxfordjournals.epirev.a018040","article-title":"Helicobacter pylori: epidemiology and routes of transmission","volume":"22","author":"LM Brown","year":"2000","journal-title":"Epidemiol Rev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.3748\/wjg.v18.i32.4412","article-title":"Significant decrease in prevalence of Helicobacter pylori in the Czech Republic","volume":"18","author":"J Bures","year":"2012","journal-title":"World J Gastroenterol"},{"key":"ref16","first-page":"1161","article-title":"Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994","volume":"20","author":"MF Dixon","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"N Uemura","year":"2001","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nrc2857","article-title":"Helicobacter pylori: gastric cancer and beyond","volume":"10","author":"DB Polk","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"ref19","first-page":"963","article-title":"Distribution of inflammation and atrophy in the stomach of Helicobacter pylori-positive and -negative patients with chronic gastritis","volume":"91","author":"K Satoh","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"380","DOI":"10.7326\/0003-4819-134-5-200103060-00010","article-title":"Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated","volume":"134","author":"T Ohkusa","year":"2001","journal-title":"Ann Intern Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1259\/bjr.75.898.750805","article-title":"Radiographically diagnosed antral gastritis: findings in patients with and without Helicobacter pylori infection","volume":"75","author":"S Dheer","year":"2002","journal-title":"Br J Radiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1148\/radiol.2461061245","article-title":"Double-contrast upper gastrointestinal radiography: a pattern approach for diseases of the stomach","volume":"246","author":"SE Rubesin","year":"2008","journal-title":"Radiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1471-230X-11-140","article-title":"Postprandial fullness correlates with rapid inflow of gastric content into duodenum but not with chronic gastritis","volume":"11","author":"N Yamamichi","year":"2011","journal-title":"BMC Gastroenterol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0016-5085(19)33241-X","article-title":"Chronological transition of the fundic-pyloric border determined by stepwise biopsy of the lesser and greater curvatures of the stomach","volume":"63","author":"K Kimura","year":"1972","journal-title":"Gastroenterology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1055\/s-0028-1098086","article-title":"An Endoscopic Recognition of the Atrophic Border and its Significance in Chronic Gastritis","volume":"3","author":"K Kimura","year":"1969","journal-title":"Endoscopy"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Takahashi Y, Yamamichi N, Shimamoto T, Mochizuki S, Fujishiro M, <etal>et al<\/etal>.. (2013) Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan. J Gastroenterol.","DOI":"10.1007\/s00535-013-0832-z"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e69891","DOI":"10.1371\/journal.pone.0069891","article-title":"Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan","volume":"8","author":"C Minatsuki","year":"2013","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e65996","DOI":"10.1371\/journal.pone.0065996","article-title":"No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan","volume":"8","author":"T Shimamoto","year":"2013","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1523-5378.2009.00681.x","article-title":"Clinical significance of IgG antibody titer against Helicobacter pylori","volume":"14","author":"M Tatemichi","year":"2009","journal-title":"Helicobacter"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/ijc.11680","article-title":"Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer","volume":"109","author":"H Ohata","year":"2004","journal-title":"Int J Cancer"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/aje\/kwj088","article-title":"The serum pepsinogen test as a predictor of gastric cancer: the Hisayama study","volume":"163","author":"Y Oishi","year":"2006","journal-title":"Am J Epidemiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/gut.2004.055400","article-title":"Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospective endoscopic cohort study","volume":"54","author":"H Watabe","year":"2005","journal-title":"Gut"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1586\/egh.10.7","article-title":"Population-based strategies for Helicobacter pylori-associated disease management: a Japanese perspective","volume":"4","author":"S Shiota","year":"2010","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1136\/gut.49.3.335","article-title":"Inverse background of Helicobacter pylori antibody and pepsinogen in reflux oesophagitis compared with gastric cancer: analysis of 5732 Japanese subjects","volume":"49","author":"Y Yamaji","year":"2001","journal-title":"Gut"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10120-006-0397-0","article-title":"Gastric cancer screening using the serum pepsinogen test method","volume":"9","author":"K Miki","year":"2006","journal-title":"Gastric Cancer"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1053\/gast.2000.8550","article-title":"Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study","volume":"119","author":"JJ Sung","year":"2000","journal-title":"Gastroenterology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1046\/j.1365-2036.2002.01311.x","article-title":"Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis","volume":"16","author":"M Ito","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1443-1661.2012.01385.x","article-title":"Changes in endoscopic findings of gastritis after cure of H. pylori infection: multicenter prospective trial","volume":"25","author":"M Kato","year":"2013","journal-title":"Dig Endosc"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/jnci\/92.23.1881","article-title":"Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-helicobacter pylori therapy","volume":"92","author":"P Correa","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.7326\/0003-4819-151-2-200907210-00009","article-title":"Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?","volume":"151","author":"L Fuccio","year":"2009","journal-title":"Ann Intern Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1001\/jama.291.2.187","article-title":"Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial","volume":"291","author":"BC Wong","year":"2004","journal-title":"JAMA"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1136\/gut.2003.034629","article-title":"Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication","volume":"53","author":"WK Leung","year":"2004","journal-title":"Gut"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1053\/j.gastro.2007.06.026","article-title":"Carcinogenesis of Helicobacter pylori","volume":"133","author":"P Correa","year":"2007","journal-title":"Gastroenterology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0111359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T16:17:31Z","timestamp":1565972251000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0111359"}},"subtitle":[],"editor":[{"given":"Mitsunobu R.","family":"Kano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,10,24]]},"references-count":43,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2014,10,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0111359","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,24]]}}}