{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:16:09Z","timestamp":1792664169075,"version":"4.5.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T00:00:00Z","timestamp":1415232000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0111453","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T19:20:48Z","timestamp":1415301648000},"page":"e111453","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["Cell Proliferation and Neurogenesis in Adult Mouse Brain"],"prefix":"10.1371","volume":"9","author":[{"given":"Olivia L.","family":"Bordiuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Morin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail V.","family":"Sem\u00ebnov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,11,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1126\/science.1173215","article-title":"A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation","volume":"325","author":"CD Clelland","year":"2009","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/4151030a","article-title":"Functional neurogenesis in the adult hippocampus","volume":"415","author":"H Van Praag","year":"2002","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature09817","article-title":"Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation","volume":"472","author":"A Sahay","year":"2011","journal-title":"Nature"},{"key":"ref4","first-page":"1983","article-title":"Adult neurogenesis: mechanisms and functional significance","volume":"141","author":"SMG Braun","year":"2014","journal-title":"Dev Camb Engl"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.neuron.2011.05.004","article-title":"Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain","volume":"70","author":"RA Ihrie","year":"2011","journal-title":"Neuron"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2011.05.001","article-title":"Adult neurogenesis in the mammalian brain: significant answers and significant questions","volume":"70","author":"G-L Ming","year":"2011","journal-title":"Neuron"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tins.2012.09.004","article-title":"Newborn cortical neurons: only for neonates?","volume":"36","author":"DM Feliciano","year":"2013","journal-title":"Trends Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrn2147","article-title":"How widespread is adult neurogenesis in mammals?","volume":"8","author":"E Gould","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1073\/pnas.0712168105","article-title":"A chemical method for fast and sensitive detection of DNA synthesis in vivo","volume":"105","author":"A Salic","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.brainres.2009.12.092","article-title":"Evaluation of 5-ethynyl-2\u2032-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system","volume":"1319","author":"C Zeng","year":"2010","journal-title":"Brain Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1152\/physrev.00055.2003","article-title":"Adult Neurogenesis: From Precursors to Network and Physiology","volume":"85","author":"DN Abrous","year":"2005","journal-title":"Physiol Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10874","article-title":"Transient expression of doublecortin during adult neurogenesis","volume":"467","author":"JP Brown","year":"2003","journal-title":"J Comp Neurol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1460-9568.2004.03813.x","article-title":"Doublecortin expression levels in adult brain reflect neurogenesis","volume":"21","author":"S Couillard-Despres","year":"2005","journal-title":"Eur J Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1523\/JNEUROSCI.5060-06.2007","article-title":"The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells","volume":"27","author":"TL Walker","year":"2007","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"ref15","first-page":"2120","article-title":"A subpopulation of dorsal lateral\/caudal ganglionic eminence-derived neocortical interneurons expresses the transcription factor Sp8","volume":"22","author":"T Ma","year":"2012","journal-title":"Cereb Cortex N Y N 1991"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1242\/dev.128.19.3759","article-title":"In utero fate mapping reveals distinct migratory pathways and fates of neurons born in the mammalian basal forebrain","volume":"128","author":"H Wichterle","year":"2001","journal-title":"Development"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4161\/cam.4.3.11640","article-title":"Ephrins guide migrating cortical interneurons in the basal telencephalon","volume":"4","author":"J Rudolph","year":"2010","journal-title":"Cell Adhes Migr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1469-7580.2007.00750.x","article-title":"Slit-Robo interactions during cortical development","volume":"211","author":"WD Andrews","year":"2007","journal-title":"J Anat"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1093\/brain\/awr052","article-title":"Cell proliferation in human ganglionic eminence and suppression after prematurity-associated haemorrhage","volume":"134","author":"MR Del Bigio","year":"2011","journal-title":"Brain J Neurol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1053\/j.semperi.2009.04.003","article-title":"Insights from in vitro fetal magnetic resonance imaging of cerebral development","volume":"33","author":"I Kostovic","year":"2009","journal-title":"Semin Perinatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1096-7192(02)00126-9","article-title":"Human ARX gene: genomic characterization and expression","volume":"77","author":"R Ohira","year":"2002","journal-title":"Mol Genet Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0092-8674(02)00862-0","article-title":"Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors","volume":"110","author":"H Nakatomi","year":"2002","journal-title":"Cell"},{"key":"ref23","first-page":"i103","article-title":"Composition and organization of the SCZ: a large germinal layer containing neural stem cells in the adult mammalian brain","volume":"16","author":"B Seri","year":"2006","journal-title":"Cereb Cortex N Y N 1991"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"11464","DOI":"10.1073\/pnas.172403999","article-title":"Newly generated neurons in the amygdala and adjoining cortex of adult primates","volume":"99","author":"PJ Bernier","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1159\/000320210","article-title":"Hippocampal neurogenesis and cortical cellular plasticity in Wahlberg's epauletted fruit bat: a qualitative and quantitative study","volume":"76","author":"CW Gatome","year":"2010","journal-title":"Brain Behav Evol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"13036","DOI":"10.1073\/pnas.1735482100","article-title":"Glia-independent chains of neuroblasts through the subcortical parenchyma of the adult rabbit brain","volume":"100","author":"F Luzzati","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00429-007-0151-3","article-title":"Origin, migration and fate of newly generated neurons in the adult rodent piriform cortex","volume":"212","author":"LA Shapiro","year":"2007","journal-title":"Brain Struct Funct"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuroscience.2005.04.033","article-title":"Evidence for neurogenesis within the white matter beneath the temporal neocortex of the adult rat brain","volume":"134","author":"NU Takemura","year":"2005","journal-title":"Neuroscience"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1460-9568.2010.07557.x","article-title":"Evidence for the spontaneous production but massive programmed cell death of new neurons in the subcallosal zone of the postnatal mouse brain","volume":"33","author":"WR Kim","year":"2011","journal-title":"Eur J Neurosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"6170","DOI":"10.1523\/JNEUROSCI.2437-12.2013","article-title":"Fgf10-Expressing Tanycytes Add New Neurons to the Appetite\/Energy-Balance Regulating Centers of the Postnatal and Adult Hypothalamus","volume":"33","author":"N Haan","year":"2013","journal-title":"J Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nn.3079","article-title":"Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche","volume":"15","author":"DA Lee","year":"2012","journal-title":"Nat Neurosci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1172\/JCI43134","article-title":"Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice","volume":"122","author":"DEG McNay","year":"2012","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Sousa-Ferreira L, Almeida LP de, Cavadas C (2013) Role of hypothalamic neurogenesis in feeding regulation. Trends Endocrinol Metab TEM. doi:10.1016\/j.tem.2013.10.005.","DOI":"10.1016\/j.tem.2013.10.005"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0166-2236(00)01691-X","article-title":"The oligodendrocyte precursor cell in health and disease","volume":"24","author":"JM Levine","year":"2001","journal-title":"Trends Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nn.2220","article-title":"PDGFRA\/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice","volume":"11","author":"LE Rivers","year":"2008","journal-title":"Nat Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/nn2014","article-title":"Local self-renewal can sustain CNS microglia maintenance and function throughout adult life","volume":"10","author":"B Ajami","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.biopsych.2007.09.023","article-title":"New interneurons in the adult neocortex: small, sparse, but significant?","volume":"63","author":"HA Cameron","year":"2008","journal-title":"Biol Psychiatry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1523\/JNEUROSCI.12-01-00249.1992","article-title":"Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain","volume":"12","author":"CM Morshead","year":"1992","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/cne.902860404","article-title":"Density of neurons and synapses in the cerebral cortex of the mouse","volume":"286","author":"A Sch\u00fcz","year":"1989","journal-title":"J Comp Neurol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1440-169X.2010.01226.x","article-title":"Programmed cell death during postnatal development of the rodent nervous system","volume":"53","author":"WR Kim","year":"2011","journal-title":"Dev Growth Differ"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/bioinformatics\/btp184","article-title":"Globally optimal stitching of tiled 3D microscopic image acquisitions","volume":"25","author":"S Preibisch","year":"2009","journal-title":"Bioinforma Oxf Engl"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nbt.1612","article-title":"V3D enables real-time 3D visualization and quantitative analysis of large-scale biological image data sets","volume":"28","author":"H Peng","year":"2010","journal-title":"Nat Biotechnol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0111453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T15:54:04Z","timestamp":1650556444000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0111453"}},"subtitle":[],"editor":[{"given":"Gary L.","family":"Dunbar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,6]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0111453","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,6]]}}}