{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:19:09Z","timestamp":1791425949471,"version":"4.3.3"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T00:00:00Z","timestamp":1415059200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0111880","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T19:14:25Z","timestamp":1415128465000},"page":"e111880","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["Identification of Peptidoglycan-Associated Proteins as Vaccine Candidates for Enterococcal Infections"],"prefix":"10.1371","volume":"9","author":[{"given":"Felipe","family":"Romero-Saavedra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Laverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Wobser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Michaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Budin-Verneuil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Bernay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellah","family":"Benachour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Hartke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Huebner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,11,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1056\/NEJM200003093421007","article-title":"Vancomycin-resistant enterococcal infections","volume":"342","author":"BE Murray","year":"2000","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.2807\/ese.17.46.20316-en","article-title":"The European Centre for Disease Prevention and Control (ECDC) pilot point prevalence survey of healthcare-associated infections and antimicrobial use","volume":"17","author":"P Zarb","year":"2012","journal-title":"Euro Surveill"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/668770","article-title":"Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009\u20132010","volume":"34","author":"DM Sievert","year":"2013","journal-title":"Infect Control Hosp Epidemiol"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.2807\/ese.13.47.19046-en","article-title":"Emergence and spread of vancomycin resistance among enterococci in Europe","volume":"13","author":"G Werner","year":"2008","journal-title":"Euro Surveill"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1056\/NEJMp0804651","article-title":"Antibiotic-resistant bugs in the 21st century\u2013a clinical super-challenge","volume":"360","author":"a Arias C","year":"2009","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1128\/JCM.01351-07","article-title":"Emergence of clonal complex 17 Enterococcus faecium in The Netherlands","volume":"46","author":"J Top","year":"2008","journal-title":"J Clin Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1128\/JCM.43.1.462-463.2005","article-title":"Emerging incidence of Enterococcus faecium among hospital isolates (1993 to 2002)","volume":"43","author":"A Treitman","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1099\/mic.0.026385-0","article-title":"The ecology, epidemiology and virulence of Enterococcus","volume":"155","author":"K Fisher","year":"2009","journal-title":"Microbiology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1469-0691.2010.03213.x","article-title":"Pathogenesis and immunity in enterococcal infections","volume":"16","author":"IG Sava","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"ref10","unstructured":"Repp C, Huebner J (2012) Protective Immune Response. In: Semedo-Lemsaddek T, Barreto-Crespo MT, Tenreiro R, editors. Enterococcus and Safety. Lisbone: Nova Science Publishers, Incorporated. pp. 305\u2013317."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1098\/rstb.2011.0210","article-title":"Protein secretion and surface display in Gram-positive bacteria","volume":"367","author":"O Schneewind","year":"2012","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1128\/CMR.18.1.102-127.2005","article-title":"Surface proteins of Streptococcus agalactiae and related proteins in other bacterial pathogens","volume":"18","author":"G Lindahl","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbamcr.2004.04.014","article-title":"Protein sorting to the cell wall envelope of Gram-positive bacteria","volume":"1694","author":"H Ton-That","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1286-4579(02)01545-9","article-title":"Outer membrane proteins: key players for bacterial adaptation in host niches","volume":"4","author":"J Lin","year":"2002","journal-title":"Microbes Infect"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1128\/IAI.69.6.4019-4026.2001","article-title":"Improved Pattern for Genome-Based Screening Identifies Novel Cell Wall-Attached Proteins in Gram-Positive Bacteria","volume":"69","author":"R Janulczyk","year":"2001","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"12478","DOI":"10.3390\/molecules171112478","article-title":"Development of new drugs for an old target: the penicillin binding proteins","volume":"17","author":"A Zervosen","year":"2012","journal-title":"Molecules"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2958.2012.08199.x","article-title":"Meropenem inhibits D,D-carboxypeptidase activity in Mycobacterium tuberculosis","volume":"86","author":"P Kumar","year":"2012","journal-title":"Mol Microbiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e70365","DOI":"10.1371\/journal.pone.0070365","article-title":"Identification of potential new protein vaccine candidates through pan-surfomic analysis of pneumococcal clinical isolates from adults","volume":"8","author":"A Olaya-Abril","year":"2013","journal-title":"PLoS One"},{"key":"ref19","first-page":"453","article-title":"Pneumonia immunization in older adults: review of vaccine effectiveness and strategies","volume":"7","author":"U Assaad","year":"2012","journal-title":"Clin Interv Aging"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1146\/annurev.iy.13.040195.003255","article-title":"T cell-independent antigens type 2","volume":"13","author":"JJ Mond","year":"1995","journal-title":"Annu Rev Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1000716","DOI":"10.1371\/journal.ppat.1000716","article-title":"Importance of the collagen adhesin ace in pathogenesis and protection against Enterococcus faecalis experimental endocarditis","volume":"6","author":"V Singh K","year":"2010","journal-title":"PLoS Pathog"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/IAI.69.5.3305-3314.2001","article-title":"Antibodies to a surface-exposed, N-terminal domain of aggregation substance are not protective in the rabbit model of Enterococcus faecalis infective endocarditis","volume":"69","author":"JK McCormick","year":"2001","journal-title":"Infect Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1099\/mic.0.053207-0","article-title":"Identification of SagA as a novel vaccine target for the prevention of Enterococcus faecium infections","volume":"157","author":"A Kropec","year":"2011","journal-title":"Microbiology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1574-695X.2002.tb00589.x","article-title":"Identification of ABC transporters in vancomycin-resistant Enterococcus faecium as potential targets for antibody therapy","volume":"33","author":"J Burnie","year":"2002","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1099\/jmm.0.020578-0","article-title":"Enterococcal surface protein contributes to persistence in the host but is not a target of opsonic and protective antibodies in Enterococcus faecium infection","volume":"59","author":"IG Sava","year":"2010","journal-title":"J Med Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nbt1179","article-title":"Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome","volume":"24","author":"MJ Rodr\u00edguez-Ortega","year":"2006","journal-title":"Nat Biotechnol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1021\/pr1009838","article-title":"Quantitative proteomic view on secreted, cell surface-associated, and cytoplasmic proteins of the methicillin-resistant human pathogen Staphylococcus aureus under iron-limited conditions","volume":"10","author":"K Hempel","year":"2011","journal-title":"J Proteome Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2105-11-39","article-title":"An automatic method for identifying surface proteins in bacteria: SLEP","volume":"11","author":"E Giombini","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/1471-2105-9-173","article-title":"LocateP: genome-scale subcellular-location predictor for bacterial proteins","volume":"9","author":"M Zhou","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/pmic.200800195","article-title":"Prediction of surface exposed proteins in Streptococcus pyogenes, with a potential application to other Gram-positive bacteria","volume":"9","author":"A Barinov","year":"2009","journal-title":"Proteomics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1128\/IAI.73.5.3137-3146.2005","article-title":"Surface Analyses and Immune Reactivities of Major Cell Wall-Associated Proteins of Group A Streptococcus","volume":"75","author":"JN Cole","year":"2005","journal-title":"Infect Immun"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1002\/pmic.200500253","article-title":"Proteomic profiling of cell envelope-associated proteins from Staphylococcus aureus","volume":"6","author":"CL Gatlin","year":"2006","journal-title":"Proteomics"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1139\/W09-052","article-title":"Identification of secreted and surface proteins from Enterococcus faecalis","volume":"55","author":"A Benachour","year":"2009","journal-title":"Can J Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1002\/pmic.200700550","article-title":"Shedding &amp; shaving: disclosure of proteomic expressions on a bacterial face","volume":"8","author":"H Tjalsma","year":"2008","journal-title":"Proteomics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1371\/journal.ppat.0030007","article-title":"Insertion sequence-driven diversification creates a globally dispersed emerging multiresistant subspecies of E. faecium","volume":"3","author":"HL Leavis","year":"2007","journal-title":"PLoS Pathog"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1021\/pr901143a","article-title":"Quantitative cell surface proteome profiling for SigB-dependent protein expression in the human pathogen Staphylococcus aureus via biotinylation approach","volume":"9","author":"K Hempel","year":"2010","journal-title":"J Proteome Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1469-0691.2007.01878.x","article-title":"Streptococcus pneumoniae: proteomics of surface proteins for vaccine development","volume":"14","author":"C Morsczeck","year":"2008","journal-title":"Clin Microbiol Infect"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1099\/mic.0.055319-0","article-title":"The prolipoprotein diacylglyceryl transferase (Lgt) of Enterococcus faecalis contributes to virulence","volume":"158","author":"F Reffuveille","year":"2012","journal-title":"Microbiology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/prot.21018","article-title":"Prediction of Protein Subcellular Localization","volume":"651","author":"C Yu","year":"2006","journal-title":"Proteins"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nprot.2007.494","article-title":"Cell-PLoc: a package of Web servers for predicting subcellular localization of proteins in various organisms","volume":"3","author":"K-C Chou","year":"2008","journal-title":"Nat Protoc"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.2174\/092986609789839322","article-title":"Gpos-mPLoc: A Top-Down Approach to Improve the Quality of Predicting Subcellular Localization of Gram-Positive Bacterial Proteins","volume":"16","author":"H-B Shen","year":"2009","journal-title":"Protein Pept Lett"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/protein\/gzl053","article-title":"Gpos-PLoc: an ensemble classifier for predicting subcellular localization of Gram-positive bacterial proteins","volume":"20","author":"H-B Shen","year":"2007","journal-title":"Protein Eng Des Sel"},{"key":"ref43","unstructured":"Sambrook J, Russell DW (2001) Molecular Cloning: A Laboratory Manual, Volume 1. 3rd ed. Cold Spring Harbor, NY: CSHL Press."},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1128\/IAI.67.3.1213-1219.1999","article-title":"Isolation and chemical characterization of a capsular polysaccharide antigen shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium","volume":"67","author":"J Huebner","year":"1999","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1128\/IAI.68.8.4631-4636.2000","article-title":"Prophylactic and Therapeutic Efficacy of Antibodies to a Capsular Polysaccharide Shared among Vancomycin-Sensitive and -Resistant Enterococci","volume":"68","author":"J Huebner","year":"2000","journal-title":"Infect Immun"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e17839","DOI":"10.1371\/journal.pone.0017839","article-title":"Serodiversity of opsonic antibodies against Enterococcus faecalis\u2013glycans of the cell wall revisited","volume":"6","author":"C Theilacker","year":"2011","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1365-2958.2008.06211.x","article-title":"LysM, a widely distributed protein motif for binding to (peptido)glycans","volume":"68","author":"G Buist","year":"2008","journal-title":"Mol Microbiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1128\/MMBR.63.1.174-229.1999","article-title":"Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope","volume":"63","author":"WW Navarre","year":"1999","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1574-6976.2008.00105.x","article-title":"The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis","volume":"32","author":"E Sauvage","year":"2008","journal-title":"FEMS Microbiol Rev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s00018-002-8500-0","article-title":"The 2.4-\u00c5 crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin","volume":"59","author":"E Sauvage","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e1002804","DOI":"10.1371\/journal.pgen.1002804","article-title":"Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium","volume":"8","author":"X Zhang","year":"2012","journal-title":"PLoS Genet"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1365-2958.2010.07188.x","article-title":"Penicillin-binding protein folding is dependent on the PrsA peptidyl-prolyl cis-trans isomerase in Bacillus subtilis","volume":"77","author":"H-L Hyyryl\u00e4inen","year":"2010","journal-title":"Mol Microbiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1128\/JCM.42.6.2548-2557.2004","article-title":"Serological and genetic diversity of capsular polysaccharides in Enterococcus faecalis","volume":"42","author":"M Hufnagel","year":"2004","journal-title":"J Clin Microbiol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1126\/science.1109869","article-title":"Identification of a universal Group B streptococcus vaccine by multiple genome screen","volume":"309","author":"D Maione","year":"2005","journal-title":"Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1126\/science.287.5459.1816","article-title":"Identification of Vaccine Candidates Against Serogroup B Meningococcus by Whole-Genome Sequencing","volume":"(80-) 287","author":"M Pizza","year":"2000","journal-title":"Science"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0168-9525(03)00167-7","article-title":"Moonlighting proteins: old proteins learning new tricks","volume":"19","author":"CJ Jeffery","year":"2003","journal-title":"Trends Genet"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jprot.2013.03.035","article-title":"Surfomics: shaving live organisms for a fast proteomic identification of surface proteins","volume":"97","author":"A Olaya-Abril","year":"2014","journal-title":"J Proteomics"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.micinf.2004.02.003","article-title":"Identification of enolase as a laminin-binding protein on the surface of Staphylococcus aureus","volume":"6","author":"CRW Carneiro","year":"2004","journal-title":"Microbes Infect"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"14503","DOI":"10.1074\/jbc.273.23.14503","article-title":"{alpha}-Enolase, a Novel Strong Plasmin(ogen) Binding Protein on the Surface of Pathogenic Streptococci","volume":"273","author":"V Pancholi","year":"1998","journal-title":"J Biol Chem"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/S146625230999003X","article-title":"Surface-associated and secreted factors of Streptococcus suis in epidemiology, pathogenesis and vaccine development","volume":"10","author":"CG Baums","year":"2009","journal-title":"Anim Health Res Rev"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1128\/IAI.67.3.1086-1092.1999","article-title":"The staphylococcal transferrin-binding protein is a cell wall glyceraldehyde-3-phosphate dehydrogenase","volume":"67","author":"B Modun","year":"1999","journal-title":"Infect Immun"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1046\/j.1365-2958.2002.03207.x","article-title":"Elongation factor Tu and E1 beta subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in Mycoplasma pneumoniae","volume":"46","author":"SF Dallo","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1002\/pmic.200400928","article-title":"The cell wall subproteome of Listeria monocytogenes","volume":"4","author":"J Schaumburg","year":"2004","journal-title":"Proteomics"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1128\/IAI.68.6.3740-3743.2000","article-title":"Detection of 23 Immunogenic Pneumococcal Proteins Using Convalescent-Phase Serum","volume":"68","author":"G Zysk","year":"2000","journal-title":"Infect Immun"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/1615-9861(200205)2:5<580::AID-PROT580>3.0.CO;2-G","article-title":"Identification of vaccine candidate antigens of Staphylococcus aureus by serological proteome analysis","volume":"2","author":"O Vytvytska","year":"2002","journal-title":"Proteomics"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1128\/IAI.49.2.371-377.1985","article-title":"Immunochemical characterization of a protein associated with Mycobacterium leprae cell wall","volume":"49","author":"TP Gillis","year":"1985","journal-title":"Infect Immun"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/mpat.2001.0468","article-title":"Analysis of expression of GroEL (Hsp60) of Clostridium difficile in response to stress","volume":"31","author":"C Hennequin","year":"2001","journal-title":"Microb Pathog"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1128\/IAI.06251-11","article-title":"Involvement of peptidylprolyl cis\/trans isomerases in Enterococcus faecalis virulence","volume":"80","author":"F Reffuveille","year":"2012","journal-title":"Infect Immun"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1128\/AAC.49.6.2246-2259.2005","article-title":"Transcriptional response of Enterococcus faecalis V583 to erythromycin","volume":"49","author":"A Aakra","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3201\/1106.041204","article-title":"Global spread of vancomycin-resistant Enterococcus faecium from distinct nosocomial genetic complex","volume":"11","author":"RJL Willems","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0168-1605(03)00189-2","article-title":"Opsonophagocytic assay as a potentially useful tool for assessing safety of enterococcal preparations","volume":"88","author":"M Hufnagel","year":"2003","journal-title":"Int J Food Microbiol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/jac\/40.3.454","article-title":"High prevalence of colonization with vancomycin- and pristinamycin- resistant enterococci in healthy humans and pigs in The Netherlands: is the addition of antibiotics to animal feeds to blame?","volume":"40","author":"A Van den Bogaard","year":"1997","journal-title":"J Antimicrob Chemother"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1348-0421.1992.tb02070.x","article-title":"Proposal of a New Scheme for the Serological Typing of Enterococcus faecalis Strains","volume":"36","author":"S Maekawa","year":"1992","journal-title":"Microbiol Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0111880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T05:46:40Z","timestamp":1650520000000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0111880"}},"subtitle":[],"editor":[{"given":"Patrick C. Y.","family":"Woo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,4]]},"references-count":73,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0111880","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,4]]}}}