{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:36:56Z","timestamp":1761964616274},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0112109","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T20:40:20Z","timestamp":1417034420000},"page":"e112109","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms"],"prefix":"10.1371","volume":"9","author":[{"given":"Christopher J.","family":"Lelliott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ahnmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Therese","family":"Admyre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingela","family":"Ahlstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Irving","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feenagh","family":"Keyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurel","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Mumphrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Bjursell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Bohlooly-Y","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Rudolf","family":"Berthoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lind\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,11,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"E962","DOI":"10.1210\/jc.2010-2639","article-title":"Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity","volume":"96","author":"H Jiao","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nrd2792","article-title":"The FGF family: Biology, pathophysiology and therapy","volume":"8","author":"A Beenken","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/jb\/mvq121","article-title":"Fibroblast growth factors: From molecular evolution to roles in development, metabolism and disease","volume":"149","author":"N Itoh","year":"2011","journal-title":"J Biochem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"E964","DOI":"10.1152\/ajpendo.00089.2006","article-title":"Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys","volume":"292","author":"HD Sun","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref5","first-page":"113ra126","article-title":"Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1","volume":"3","author":"AL Wu","year":"2011","journal-title":"Sci Transl Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4161\/mabs.1.6.10057","article-title":"Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism","volume":"1","author":"CL Dobson","year":"2009","journal-title":"MAbs"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0092-8674(00)81865-6","article-title":"Targeted disruption of the melanocortin-4 receptor results in obesity in mice","volume":"88","author":"D Huszar","year":"1997","journal-title":"Cell"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"R749","DOI":"10.1152\/ajpregu.00134.2004","article-title":"Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity","volume":"287","author":"A Astrand","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.bbrc.2006.08.103","article-title":"Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice","volume":"349","author":"AK Gerdin","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/s00125-010-1692-1","article-title":"Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.cre neurons suppresses insulin release in vivo","volume":"53","author":"G Sun","year":"2010","journal-title":"Diabetologia"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.physbeh.2010.03.011","article-title":"Hypothalamic mechanisms in cachexia","volume":"100","author":"AJ Grossberg","year":"2010","journal-title":"Physiol Behav"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.cmet.2008.10.004","article-title":"Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis","volume":"8","author":"C Blouet","year":"2008","journal-title":"Cell Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"R340","DOI":"10.1152\/ajpregu.00380.2011","article-title":"Involvement of the extracellular signal-regulated kinase 1\/2 signaling pathway in amylin's eating inhibitory effect","volume":"302","author":"CS Potes","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"536","DOI":"10.2337\/db08-0822","article-title":"Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin","volume":"58","author":"K Rahmouni","year":"2009","journal-title":"Diabetes"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"10240","DOI":"10.1523\/JNEUROSCI.2764-04.2004","article-title":"Extracellular signal-regulated kinase 1\/2 signaling pathway in solitary nucleus mediates cholecystokinin-induced suppression of food intake in rats","volume":"24","author":"GM Sutton","year":"2004","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.bbrc.2011.05.085","article-title":"Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family","volume":"409","author":"W Romero-Fernandez","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"162ra153","DOI":"10.1126\/scitranslmed.3004690","article-title":"Treating diabetes and obesity with an FGF21-mimetic antibody activating the betaKlotho\/FGFR1c receptor complex","volume":"4","author":"IN Foltz","year":"2012","journal-title":"Sci Transl Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0006-8993(95)01002-X","article-title":"A comprehensive analysis of the distribution of FGF-2 and FGFR1 in the rat brain","volume":"701","author":"AM Gonzalez","year":"1995","journal-title":"Brain Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"MW Schwartz","year":"2000","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.yfrne.2009.10.002","article-title":"Hypothalamic inflammation and energy homeostasis: Resolving the paradox","volume":"31","author":"JP Thaler","year":"2010","journal-title":"Front Neuroendocrinol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1210\/en.2004-1520","article-title":"Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus","volume":"146","author":"CT De Souza","year":"2005","journal-title":"Endocrinology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cmet.2009.08.013","article-title":"MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity","volume":"10","author":"A Kleinridders","year":"2009","journal-title":"Cell Metab"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity","volume":"29","author":"M Milanski","year":"2009","journal-title":"J Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"E1003","DOI":"10.1152\/ajpendo.90377.2008","article-title":"Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet","volume":"296","author":"KA Posey","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2008.07.043","article-title":"Hypothalamic IKKbeta\/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity","volume":"135","author":"X Zhang","year":"2008","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"JP Thaler","year":"2012","journal-title":"J Clin Invest"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0006-8993(98)00280-7","article-title":"Lipopolysaccharide (LPS)- and muramyl dipeptide (MDP)-induced anorexia during refeeding following acute fasting: Characterization of brain cytokine and neuropeptide systems mRNAs","volume":"795","author":"D Gayle","year":"1998","journal-title":"Brain Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.peptides.2008.10.019","article-title":"Administration of IL-1beta to the 4th ventricle causes anorexia that is blocked by agouti-related peptide and that coincides with activation of tyrosine-hydroxylase neurons in the nucleus of the solitary tract","volume":"30","author":"MD DeBoer","year":"2009","journal-title":"Peptides"},{"key":"ref29","first-page":"R1711","article-title":"Chemokines\/intercrines and central regulation of feeding","volume":"266","author":"CR Plata-Salaman","year":"1994","journal-title":"Am J Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/cne.20598","article-title":"Highly regionalized neuronal expression of monocyte chemoattractant protein-1 (MCP-1\/CCL2) in rat brain: Evidence for its colocalization with neurotransmitters and neuropeptides","volume":"489","author":"G Banisadr","year":"2005","journal-title":"J Comp Neurol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1046\/j.1471-4159.2002.00809.x","article-title":"Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain","volume":"81","author":"G Banisadr","year":"2002","journal-title":"J Neurochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"16199","DOI":"10.1073\/pnas.1306799110","article-title":"Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6","volume":"110","author":"R Shirazi","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","first-page":"R217","article-title":"Central action of acidic fibroblast growth factor in feeding regulation","volume":"256","author":"K Hanai","year":"1989","journal-title":"Am J Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0014-2999(01)00767-1","article-title":"Fibroblast growth factor inhibits locomotor activity as well as feeding behavior of rats","volume":"416","author":"M Hotta","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"278S","DOI":"10.1093\/ajcn\/55.1.278s","article-title":"A new brain glucosensor and its physiological significance","volume":"55","author":"Y Oomura","year":"1992","journal-title":"Am J Clin Nutr"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1006\/exnr.1996.0032","article-title":"Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake","volume":"137","author":"AJ Li","year":"1996","journal-title":"Exp Neurol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/jcp.20483","article-title":"Ligand concentration is a driver of divergent signaling and pleiotropic cellular responses to FGF","volume":"206","author":"M Garcia-Maya","year":"2006","journal-title":"J Cell Physiol"},{"key":"ref38","first-page":"14","article-title":"Making sense of it: Roles of the sensory circumventricular organs in feeding and regulation of energy homeostasis","volume":"232","author":"M Fry","year":"2007","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"R512","DOI":"10.1152\/ajpregu.90858.2008","article-title":"The subfornical organ: A central nervous system site for actions of circulating leptin","volume":"296","author":"PM Smith","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.physbeh.2010.01.013","article-title":"Acute electrical stimulation of the subfornical organ induces feeding in satiated rats","volume":"99","author":"PM Smith","year":"2010","journal-title":"Physiol Behav"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1038\/ncomms3049","article-title":"Alpha-tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors","volume":"4","author":"SC Robins","year":"2013","journal-title":"Nat Commun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cmet.2013.12.015","article-title":"Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain","volume":"19","author":"E Balland","year":"2014","journal-title":"Cell Metab"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/35048589","article-title":"Attenuation of FGF signalling in mouse beta-cells leads to diabetes","volume":"408","author":"AW Hart","year":"2000","journal-title":"Nature"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0112109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T21:35:15Z","timestamp":1566077715000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0112109"}},"subtitle":[],"editor":[{"given":"Marc","family":"Claret","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,26]]},"references-count":43,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0112109","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,26]]}}}