{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:25:45Z","timestamp":1791919545896,"version":"4.3.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0112354","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T18:44:42Z","timestamp":1416595482000},"page":"e112354","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical Application of Micronucleus Test: A Case-Control Study on the Prediction of Breast Cancer Risk\/Susceptibility"],"prefix":"10.1371","volume":"9","author":[{"given":"Claudia","family":"Bolognesi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bruzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Gismondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Volpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Viassolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Pedemonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Varesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,11,21]]},"reference":[{"key":"ref1","unstructured":"OECD Library, Test No. 487: In Vitro Mammalian Cell Micronucleus Test. (2010) OECD Guidelines for the Testing of Chemicals, Section 4. Health Effects."},{"key":"ref2","unstructured":"IAEA, Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies, in: EPR-Biodosimetry (2011) International Atomic Energy Agency, Vienna."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/carcin\/bgl177","article-title":"An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans","volume":"28","author":"S Bonassi","year":"2007","journal-title":"Carcinogenesis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.mrfmmm.2007.10.010","article-title":"Validation of micronuclei frequency in peripheral blood lymphocytes as early cancer risk biomarker in a nested case\u2013control study","volume":"639","author":"E Murgia","year":"2008","journal-title":"Mutat Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/mutage\/geq075","article-title":"Micronuclei frequency in peripheral blood lymphocytes and cancer risk: evidence from human studies","volume":"26","author":"S Bonassi","year":"2011","journal-title":"Mutagenesis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/mutage\/geq071","article-title":"Cytokinesis-blocked micronucleus assay and cancer risk assessment","volume":"26","author":"R El-Zein","year":"2011","journal-title":"Mutagenesis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/bjc.2011.567","article-title":"Role of micronucleus test in predicting breast cancer susceptibility: a systematic review and meta-analysis","volume":"106","author":"F Cardinale","year":"2012","journal-title":"Br J Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1158\/0008-5472.CAN-06-0326","article-title":"Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk","volume":"66","author":"RA El-Zein","year":"2006","journal-title":"Cancer Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1158\/1055-9965.EPI-12-0435","article-title":"Use of the cytokinesis-blocked micronucleus assay to detect gender differences and genetic instability in a lung cancer case-control study","volume":"22","author":"MK McHugh","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/mutage\/geu007","article-title":"Micronucleus frequency in human peripheral blood lymphocytes as a biomarker for the early detection of colorectal cancer risk","volume":"29","author":"F Maffei","year":"2014","journal-title":"Mutagenesis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/mutage\/geq067","article-title":"Association of micronucleus frequency with neurodegenerative diseases","volume":"26","author":"L Migliore","year":"2011","journal-title":"Mutagenesis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/mutage\/geq077","article-title":"The association of micronucleus frequency with obesity, diabetes and cardiovascular disease","volume":"26","author":"MG Andreassi","year":"2011","journal-title":"Mutagenesis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0165-4608(00)00322-8","article-title":"Genomic instability in Down syndrome and Fanconi anemia assessed by micronucleus analysis and single-cell gel electrophoresis","volume":"124","author":"SW Maluf","year":"2001","journal-title":"Cancer Genet Cytogenet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/095530096144725","article-title":"Dose-rate sparing for micronucleus induction in lymphocytes of controls and ataxia-telangiectasia heterozygotes exposed to 60Co gamma-irradiation in vitro","volume":"70","author":"D Scott","year":"1996","journal-title":"Int J Radiat Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/1098-2280(2001)37:1<31::AID-EM1004>3.0.CO;2-P","article-title":"HUman MicroNucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria, and host factors on the frequency of micronuclei","volume":"37","author":"S Bonassi","year":"2001","journal-title":"Environ Mol Mutagen"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1383-5718(02)00248-6","article-title":"HUman MicroNucleus project. Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project","volume":"534","author":"M Fenech","year":"2003","journal-title":"Mutat Res"},{"key":"ref17","first-page":"43","article-title":"The effect of age, gender, diet and lifestyle on DNA damage measured using micronucleus frequency in human peripheral blood lymphocytes. Mutagenesis","volume":"26","author":"M Fenech","year":"2011"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1038\/sj.onc.1206678","article-title":"Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation","volume":"22","author":"SN Powell","year":"2003","journal-title":"Oncogene"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev.pathol.3.121806.151422","article-title":"Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment","volume":"4","author":"AR Venkitaraman","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1111\/j.1349-7006.2004.tb02195.x","article-title":"Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage","volume":"95","author":"K Yoshida","year":"2004","journal-title":"Cancer Sci"},{"key":"ref21","first-page":"390","article-title":"Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families","volume":"60","author":"A Rothfus","year":"2000","journal-title":"Cancer Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0027-5107(01)00300-1","article-title":"Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation","volume":"500","author":"K Trenz","year":"2002","journal-title":"Mutat Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.mrrev.2003.06.011","article-title":"Enhanced sensitivity of peripheral blood lymphocytes from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics","volume":"544","author":"K Trenz","year":"2003","journal-title":"Mutat Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/humu.20880","article-title":"Sequence variant classification and reporting: recommendation for improving the interpretation of cancer susceptibility genetic test results","volume":"29","author":"SE Plon","year":"2008","journal-title":"Hum Mutat"},{"key":"ref25","first-page":"1084","article-title":"Cytokinesis-block micronucleus cytome assay","volume":"2","author":"M Fenech","year":"2007","journal-title":"Nat"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/bjc.1998.98","article-title":"Radiation-induced micronucleus induction in lymphocytes identifies a high frequency of radiosensitive cases among breast cancer patients: a test for predisposition?","volume":"77","author":"D Scott","year":"1998","journal-title":"Br J Cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/095530099140744","article-title":"Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays","volume":"75","author":"D Scott","year":"1999","journal-title":"Int J Radiat Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1080\/09553000050201109","article-title":"Heritability of chromosomal radiosensitivity in breast cancer patients: a pilot study with the lymphocyte micronucleus assay","volume":"76","author":"W Burrill","year":"2000","journal-title":"Int J Radiat Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/sj.bjc.6600628","article-title":"Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition","volume":"87","author":"A Baeyens","year":"2002","journal-title":"Br J Cancer"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/09553000400017937","article-title":"Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers","volume":"80","author":"A Baeyens","year":"2004","journal-title":"Int J Radiat Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/mutage\/gel035","article-title":"On the difference of micronucleus frequencies in peripheral blood lymphocytes between breast cancer patients and controls","volume":"21","author":"D Varga","year":"2006","journal-title":"Mutagenesis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.radonc.2012.10.007","article-title":"Correlation of in vitro lymphocyte radiosensitivity and gene expression with late normal tissue reactions following curative radiotherapy for breast cancer","volume":"105","author":"P Finnon","year":"2012","journal-title":"Radiother Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3109\/09553002.2013.782447","article-title":"Relative biological effectiveness of mammography X-rays at the level of DNA and chromosomes in lymphocytes","volume":"89","author":"J Depuydt","year":"2013","journal-title":"Int J Radiat Biol"},{"key":"ref34","first-page":"2983","article-title":"Sensitivity to five mutagens in Fanconi&apos;s anemia as measured by the micronucleus method","volume":"38","author":"JA Heddle","year":"1978","journal-title":"Cancer Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/095530000138268","article-title":"Increased G2 chromosomal radiosensitivity in cancer patients: the role of cdk1\/cyclin-B activity level in the mechanisms involved","volume":"76","author":"GI Terzoudi","year":"2000","journal-title":"Int J Radiat Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1054\/bjoc.2000.1701","article-title":"Chromosomal radiosensitivity as a marker of predisposition to common cancers?","volume":"84","author":"K Baria","year":"2001","journal-title":"Br J Cancer"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s10549-011-1940-1","article-title":"Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study","volume":"132","author":"LE Wang","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/(SICI)1097-0215(19970926)73:1<20::AID-IJC4>3.0.CO;2-3","article-title":"DNA repair proficiency in breast cancer patients and their first-degree relatives","volume":"73","author":"RK Patel","year":"1997","journal-title":"Int J Cancer"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/ijc.22915","article-title":"Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility","volume":"121","author":"J Barwell","year":"2007","journal-title":"Int J Cancer"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0112354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T22:29:31Z","timestamp":1588976971000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0112354"}},"subtitle":[],"editor":[{"given":"Maria Rosaria","family":"Scarfi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,21]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0112354","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,21]]}}}