{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:05:48Z","timestamp":1791320748507,"version":"4.3.1"},"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T00:00:00Z","timestamp":1415836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0112397","type":"journal-article","created":{"date-parts":[[2014,11,13]],"date-time":"2014-11-13T19:26:00Z","timestamp":1415906760000},"page":"e112397","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":71,"title":["Low Dose Cranial Irradiation-Induced Cerebrovascular Damage Is Reversible in Mice"],"prefix":"10.1371","volume":"9","author":[{"given":"Nikolett","family":"S\u00e1ndor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fruzsina R.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bocsik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"S\u00e1ntha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogl\u00e1rka","family":"Schilling-T\u00f3th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violetta","family":"L\u00e9ner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Kah\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1ria A.","family":"Deli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9za","family":"S\u00e1fr\u00e1ny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hargita","family":"Hegyesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/0360-3016(80)90175-3","article-title":"Therapeutic irradiation and brain injury","volume":"6","author":"GE Sheline","year":"1980","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/bjc.1996.145","article-title":"Risk factors for intellectual and educational sequelae of cranial irradiation in childhood acute lymphoblastic leukemia","volume":"73","author":"E Smibert","year":"1996","journal-title":"Br J Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1200\/JCO.2004.05.186","article-title":"Change in neurocognitive functioning after treatment with cranial radiation in childhood","volume":"22","author":"BJ Spiegler","year":"2004","journal-title":"J Clin Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1136\/jnnp.45.2.166","article-title":"Long-lasting cerebral functional changes following moderate dose x-radiation treatment to the scalp in childhood: an electroencephalographic power spectral study","volume":"45","author":"I Yaar","year":"1982","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(12)60815-0","article-title":"Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study","volume":"380","author":"MS Pearce","year":"2012","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0013-4694(67)90189-7","article-title":"Spectrum analysis of residual EEG changes following post-natal x-irradiation in rats","volume":"23","author":"S Kobayashi","year":"1967","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.14219\/jada.archive.1967.0354","article-title":"Hazards of radiation from x-ray exposure","volume":"75","author":"HH Hicks","year":"1967","journal-title":"J Am Dent Assoc"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF01405622","article-title":"Late vascular effects of whole brain X-irradiation in the mouse","volume":"64","author":"Y Yoshii","year":"1982","journal-title":"Acta Neurochir"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3109\/09553002.2014.859761","article-title":"Radiation exposure prior to traumatic brain injury induces responses that differ as a function of animal age","volume":"90","author":"AR Allen","year":"2014","journal-title":"Int J Radiat Biol"},{"key":"ref10","first-page":"273","article-title":"Mechanisms of radiation injury to the central nervous system: Implications for neuroprotection. Mol Interventions","volume":"4","author":"CS Wong","year":"2004"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1167.2012.03696.x","article-title":"Overview and introduction: the blood-brain barrier in health and disease","volume":"53","author":"NJ Abbott","year":"2012","journal-title":"Epilepsia"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/jcbfm.2013.135","article-title":"Blood-brain barrier dysfunction as a cause and consequence of Alzheimer&apos;s disease","volume":"33","author":"MA Erickson","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ijrobp.2005.01.039","article-title":"Molecular targets in radiation-induced blood-brain barrier disruption","volume":"62","author":"RA Nordal","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref14","first-page":"683","article-title":"Changes in blood-brain barrier permeability induced by radiotherapy: implications for timing of chemotherapy?","volume":"9","author":"M van Vulpen","year":"2002","journal-title":"Oncol Rep"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e38366","DOI":"10.1371\/journal.pone.0038366","article-title":"High-resolution in-vivo analysis of normal brain response to cranial irradiation","volume":"7","author":"K Burrell","year":"2012","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/ATVBAHA.111.237651","article-title":"Effect of ionizing Radiation-induced damage of endothelial progenitor cells in vascular regeneration","volume":"32","author":"MO Lee","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1002\/stem.745","article-title":"Circulating endothelial progenitor cells for vascular medicine","volume":"11","author":"T Asahara","year":"2011","journal-title":"Stem Cells"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/07357907.2013.789903","article-title":"Endothelial colony forming cells (ECFCs) as a model for studying effects of low-dose ionizing radiation: growth inhibition by a single dose","volume":"31","author":"VA Kinev","year":"2013","journal-title":"Cancer Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1259\/0007-1285-61-731-1043","article-title":"Time- and dose-related changes in the white matter of the rat brain after single doses of X rays","volume":"61","author":"W Calvo","year":"1988","journal-title":"Br J Radiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0360-3016(90)90264-K","article-title":"Development of blood vessel-related radiation damage in the fimbria of the central nervous system","volume":"18","author":"HS Reinhold","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0167-8140(94)90413-8","article-title":"Disruption of the blood-brain barrier as the primary effect of CNS irradiation","volume":"31","author":"P Rubin","year":"1994","journal-title":"Radiother Oncol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3174\/ajnr.A1801","article-title":"An experimental study of acute radiation-induced cognitive dysfunction in a young rat model","volume":"31","author":"Y Liu","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neulet.2011.04.067","article-title":"X-irradiation reduces the proliferation of astrocytes by cell cycle arrest","volume":"498","author":"Q Wang","year":"2011","journal-title":"Neurosci Lett"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-5728(98)00270-7","article-title":"TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury","volume":"95","author":"S1 Kyrkanides","year":"1999","journal-title":"J Neuroimmunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.nbd.2005.08.006","article-title":"Ionizing radiation induces astrocyte gliosis through microglia activation","volume":"21","author":"SY Hwang","year":"2006","journal-title":"Neurobiol Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.brainres.2011.11.022","article-title":"Radiation-induced blood-brain barrier damages: an in vitro study","volume":"1433","author":"W Fauquette","year":"2012","journal-title":"Brain Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"L Hayflick","year":"1961","journal-title":"Exp Cell Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1084\/jem.20050959","article-title":"Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization","volume":"202","author":"B Heissig","year":"2005","journal-title":"J Exp Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/gerona\/glt057","article-title":"Ionizing radiation promotes the acquisition of a senescence-associated secretory phenotype and impairs angiogenic capacity in cerebromicrovascular endothelial cells: role of increased DNA damage and decreased DNA repair capacity in microvascular radiosensitivity","volume":"68","author":"Z Ungvari","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e70024","DOI":"10.1371\/journal.pone.0070024","article-title":"The PI3K\/Akt\/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation","volume":"8","author":"R Yentrapalli","year":"2013","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1097\/00001756-200011270-00064","article-title":"PrP fragment 106\u2013126 is toxic to cerebral endothelial cells expressing PrP(C)","volume":"11","author":"MA Deli","year":"2000","journal-title":"Neuroreport"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10571-007-9195-4","article-title":"Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells","volume":"27","author":"S Nakagawa","year":"2007","journal-title":"Cell Mol Neurobiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neuint.2008.12.002","article-title":"A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes","volume":"54","author":"S Nakagawa","year":"2009","journal-title":"Neurochem Int"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0304-3940(96)12546-5","article-title":"Intracarotid tumor necrosis factor-alpha administration increases the blood-brain barrier permeability in cerebral cortex of the newborn pig: quantitative aspects of double-labelling studies and confocal laser scanning analysis","volume":"208","author":"CS \u00c1brah\u00e1m","year":"1996","journal-title":"Neurosci Lett"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.brainres.2011.07.013","article-title":"Methamphetamine transiently increases the blood-brain barrier permeability in the hippocampus: role of tight junction proteins and matrix metalloproteinase-9","volume":"1411","author":"T Martins","year":"2011","journal-title":"Brain Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/10623320009072215","article-title":"Regulation of endothelial barrier function by the cAMP-dependent protein kinase","volume":"4","author":"CE Patterson","year":"2000","journal-title":"Endothelium"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/01.PRS.0000091169.51035.A5","article-title":"Selective recruitment of endothelial progenitor cells to ischemic tissues with increased neovascularization","volume":"113","author":"S Park","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuint.2006.08.006","article-title":"Pentosan polysulfate protects brain endothelial cells against bacterial lipopolysaccharide-induced damages","volume":"50","author":"S Veszelka","year":"2007","journal-title":"Neurochem Int"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3233\/JAD-120163","article-title":"Docosahexaenoic acid reduces amyloid-\u03b2 induced toxicity in cells of the neurovascular unit","volume":"36","author":"S Veszelka","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1471-4159.2004.03020.x","article-title":"Puromycin-based purification of rat brain capillary endothelial cell cultures. Effect on the expression of blood-brain barrier-specific properties","volume":"93","author":"N Perri\u00e8re","year":"2005","journal-title":"J Neurochem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/2045-8118-10-33","article-title":"Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC\/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies","volume":"10","author":"DE Eigenmann","year":"2013","journal-title":"Fluids Barriers CNS"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10571-004-1377-8","article-title":"Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology","volume":"25","author":"MA Deli","year":"2005","journal-title":"Cell Mol Neurobiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"GP Dimri","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"T Asahara","year":"1997","journal-title":"Science"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJMoa022287","article-title":"Circulating endothelial progenitor cells, vascular function, and cardiovascular risk","volume":"348","author":"JM Hill","year":"2003","journal-title":"N Engl J Med"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/0360-3016(86)90133-1","article-title":"The late effects of radiation on the blood brain barrier","volume":"12","author":"MP Remler","year":"1986","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/0360-3016(94)00655-5","article-title":"Radiation response of the central nervous system","volume":"31","author":"TE Schultheiss","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ijrobp.2009.08.029","article-title":"Simultaneous integrated boost intensity-modulated radiotherapy in patients with high-grade gliomas","volume":"78","author":"KH Cho","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2174\/157488709787047567","article-title":"A literature review of the recent radiotherapy clinical trials in pediatric brain tumors","volume":"4","author":"A Skowro\u0144ska-Gardas","year":"2009","journal-title":"Rev Recent Clin Trials"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11060-008-9520-x","article-title":"Mechanisms of radiation-induced brain toxicity and implications for future clinical trials","volume":"87","author":"JH Kim","year":"2008","journal-title":"J Neurooncol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1667\/RR3049","article-title":"Studies of mortality of atomic bomb survivors. Report 13: Solid cancer and noncancer disease mortality: 1950\u20131997","volume":"160","author":"DL Preston","year":"2003","journal-title":"Radiat Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1667\/RR1728.1","article-title":"High-LET radiation-induced response of microvessels in the Hippocampus","volume":"173","author":"XW Mao","year":"2010","journal-title":"Radiat Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1139\/y02-070","article-title":"Blood-brain barrier permeability after gamma whole-body irradiation: an in vivo microdialysis study","volume":"80","author":"M Diserbo","year":"2002","journal-title":"Can J Physiol Pharmacol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/jcbfm.2009.39","article-title":"Newborn- and adult-derived brain microvascular endothelial cells show age-related differences in phenotype and glutamate-evoked protease release","volume":"29","author":"H Legros","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/BF01411440","article-title":"Early blood-brain barrier disruption after high-dose single-fraction irradiation in rats","volume":"136","author":"H Nakata","year":"1995","journal-title":"Acta Neurochir (Wien)"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"401261","DOI":"10.1155\/2013\/401261","article-title":"The treatment outcome and radiation-induced toxicity for patients with head and neck carcinoma in the IMRT era: a systematic review with dosimetric and clinical parameters","volume":"2013","author":"V Kouloulias","year":"2013","journal-title":"Biomed Res Int"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainres.2004.05.102","article-title":"Effects of lipopolysaccharide on the radiation-induced changes in the blood-brain barrier and the astrocytes","volume":"1019","author":"M Kaya","year":"2004","journal-title":"Brain Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1667\/RR2030.1","article-title":"Prevention and mitigation of acute death of mice after abdominal irradiation by the antioxidant N-acetyl-cysteine (NAC)","volume":"173","author":"D Jia","year":"2010","journal-title":"Radiat Res"},{"key":"ref59","first-page":"301","article-title":"Endothelial regeneration. III. Time course of intimal changes after small defined injury to rat aortic endothelium","volume":"44","author":"MA Reidy","year":"1981","journal-title":"Lab Invest"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1073\/pnas.92.19.8783","article-title":"Subacute neuropathologicaleffects of microplanar beams of x-rays from a synchrotron wiggler","volume":"92","author":"DN Slatkin","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1152\/physiol.00033.2004","article-title":"Endothelial progenitor cells for vasculogenesis","volume":"20","author":"S Murasawa","year":"2005","journal-title":"Physiology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1182\/blood.V95.3.952.003k27_952_958","article-title":"Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors","volume":"95","author":"M Peichev","year":"2000","journal-title":"Blood"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.4049\/jimmunol.178.10.6482","article-title":"Th1- and Th2-dependent endothelial progenitor cell recruitment and angiogenic switch in asthma","volume":"178","author":"K Asosingh","year":"2007","journal-title":"J Immunol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1182\/blood-2005-04-1418","article-title":"Total body irradiation selectively induces murine hematopoietic stem cell senescence","volume":"107","author":"Y Wang","year":"2006","journal-title":"Blood"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"777","DOI":"10.3233\/JAD-2010-100759","article-title":"Protection of the blood-brain barrier by pentosan against amyloid-\u03b2-induced toxicity","volume":"22","author":"MA Deli","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1083\/jcb.200806024","article-title":"Wnt\/beta-catenin signaling controls development of the blood-brain barrier","volume":"183","author":"S Liebner","year":"2008","journal-title":"J Cell Biol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"NJ Abbott","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1259\/0007-1285-64-766-934","article-title":"Endothelial cell population dynamics in rat brain after local irradiation","volume":"64","author":"NV Ljubimova","year":"1991","journal-title":"Br J Radiol"},{"key":"ref69","first-page":"5417","article-title":"Oligodendrocytes in the adult rat spinal cord undergo radiation-induced apoptosis","volume":"56","author":"YQ Li","year":"1996","journal-title":"Cancer Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2307\/3577346","article-title":"Hypertrophy of cultured bovine aortic endothelium following irradiation","volume":"117","author":"EM Rosen","year":"1989","journal-title":"Radiat Res"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.ijrobp.2005.11.047","article-title":"In vivo two-photon microscopy study of short-term effects of microbeam irradiation on normal mouse brain microvasculature","volume":"64","author":"R Serduc","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cardiores.2004.12.027","article-title":"Endothelial aging","volume":"66","author":"RP Brandes","year":"2005","journal-title":"Cardiovasc Res"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.2741\/2902","article-title":"Role of telomeres in vascular senescence","volume":"13","author":"T Minamino","year":"2008","journal-title":"Front Biosci"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1113\/expphysiol.2008.043133","article-title":"Mechanisms of endothelial senescence","volume":"94","author":"JD Erusalimsky","year":"2009","journal-title":"Exp Physiol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fphys.2012.00132","article-title":"Mechanisms involved in the aging-induced vascular dysfunction","volume":"3","author":"M El Assar","year":"2012","journal-title":"Front Physiol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"EP Rogakou","year":"1998","journal-title":"J Biol Chem"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.canlet.2005.07.016","article-title":"Does gammaH2AX foci formation depend on the presence of DNA double strand breaks?","volume":"229","author":"A Takahashi","year":"2005","journal-title":"Cancer Lett"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1073\/pnas.0830918100","article-title":"Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses","volume":"100","author":"K Rothkamm","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1269\/jrr.0628","article-title":"Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells","volume":"47","author":"Y Kataoka","year":"2006","journal-title":"J Radiat Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0112397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T19:12:49Z","timestamp":1598469169000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0112397"}},"subtitle":[],"editor":[{"given":"Philip J.","family":"Tofilon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,13]]},"references-count":79,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0112397","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,13]]}}}