{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T21:16:28Z","timestamp":1720818988863},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T00:00:00Z","timestamp":1415577600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0112509","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T19:16:49Z","timestamp":1415647009000},"page":"e112509","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["High Levels of Soluble Ctla-4 Are Present in Anti-Mitochondrial Antibody Positive, but Not in Antibody Negative Patients with Primary Biliary Cirrhosis"],"prefix":"10.1371","volume":"9","author":[{"given":"Daniele","family":"Saverino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaola","family":"Pesce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Princey","family":"Antola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunetta","family":"Porcelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"Brusca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo","family":"Villalta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilina","family":"Tampoia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Tozzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio","family":"Tonutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Alessio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Bagnasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Bizzaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,11,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/hep.20907","article-title":"Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients","volume":"42","author":"ME Gershwin","year":"2005","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jhep.2008.06.006","article-title":"The unfinished business of primary biliary cirrhosis","volume":"49","author":"C Selmi","year":"2008","journal-title":"J Hepatology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jaut.2008.05.002","article-title":"Polyautoimmunity and familial autoimmunity in systemic sclerosis","volume":"31","author":"M Hudson","year":"2008","journal-title":"J Autoimmun"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cld.2008.02.014","article-title":"Presentation and diagnosis of primary biliary cirrhosis in the 21st century","volume":"12","author":"T Kumagi","year":"2008","journal-title":"Clinical Liver Disease"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00281-009-0164-5","article-title":"Primary biliary cirrhosis","volume":"31","author":"S Hohenester","year":"2009","journal-title":"Semininars Immunopathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cld.2008.02.015","article-title":"Liver transplantation in primary biliary cirrhosis","volume":"12","author":"P Milkiewicz","year":"2008","journal-title":"Clin Liver Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2006.12.004","article-title":"Gender as risk factor for autoimmune diseases","volume":"28","author":"N Gleicher","year":"2007","journal-title":"J Autoimmun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1056\/NEJMra043898","article-title":"Primary biliary cirrhosis","volume":"353","author":"MM Kaplan","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1053\/j.gastro.2005.12.029","article-title":"Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic Acid","volume":"130","author":"A Pares","year":"2006","journal-title":"Gastroenterol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.dld.2010.02.014","article-title":"Update on primary biliary cirrhosis","volume":"42","author":"P Invernizzi","year":"2010","journal-title":"Dig Liver Disease"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jhep.2008.05.022","article-title":"Primary biliary cirrhosis following Lactobacillus vaccination for recurrent vaginitis","volume":"49","author":"D Bogdanos","year":"2008","journal-title":"J Hepatol"},{"key":"ref12","first-page":"189585","article-title":"Primary biliary cirrhosis: family stories","volume":"2011","author":"D Smyk","year":"2011","journal-title":"Autoimmune Dis"},{"key":"ref13","first-page":"55","article-title":"Primary biliary cirrhosis: one disease with many faces","volume":"13","author":"GM Hirschfield","year":"2011","journal-title":"The Israel Medical Association Journal"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13317-011-0023-y","article-title":"Towards systemic sclerosis and away from primary biliary cirrhosis: the case of PTPN22","volume":"3","author":"DS Smyk","year":"2012","journal-title":"Autoimmun Highligths"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jaut.2010.06.004","article-title":"Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis","volume":"35","author":"F Bernuzzi","year":"2010","journal-title":"J Autoimmun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jhep.2004.03.008","article-title":"Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease","volume":"41","author":"MS Longhi","year":"2004","journal-title":"J Hepatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jaut.2010.09.005","article-title":"PBC screen: an IgG\/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis","volume":"35","author":"H Liu","year":"2010","journal-title":"J Autoimmun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.cca.2010.12.019","article-title":"Disease-specific autoantibodies in primary biliary cirrhosis","volume":"412","author":"DP Bogdanos","year":"2011","journal-title":"Clinica Chimica Acta"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s12016-010-8234-y","article-title":"Overcoming a \u201cprobable\u201d diagnosis in antimitochondrial antibody negative primary biliary cirrhosis: study of 100 sera and review of the literature","volume":"42","author":"N Bizzaro","year":"2012","journal-title":"Clin Reviews Allergy Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.autrev.2012.03.005","article-title":"Primary biliary cirrhosis and the nuclear pore complex","volume":"11","author":"C Duarte-Rey","year":"2012","journal-title":"Autoimmun Rev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1055\/s-2007-1007185","article-title":"Nuclear envelope protein autoantibodies in primary biliary cirrhosis","volume":"17","author":"JC Courvalin","year":"1977","journal-title":"Seminar Liver Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4049\/jimmunol.147.3.1037","article-title":"CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence message expression gene structure and chromosomal location","volume":"147","author":"K Harper","year":"1991","journal-title":"J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1084\/jem.184.2.783","article-title":"CTLA-4: a negative regulator of autoimmune disease","volume":"184","author":"NJ Karandikar","year":"1996","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.19.1.225","article-title":"Complexities of CD28\/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation","volume":"19","author":"B Salomon","year":"2001","journal-title":"Annual Rev Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1002\/(SICI)1521-4141(199911)29:11<3596::AID-IMMU3596>3.0.CO;2-Y","article-title":"A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells","volume":"29","author":"G Magistrelli","year":"1999","journal-title":"Eur J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.4049\/jimmunol.164.10.5015","article-title":"A soluble form of CTLA-4 in patients with autoimmune thyroid disease","volume":"164","author":"MK Oaks","year":"2000","journal-title":"J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.clim.2007.01.003","article-title":"Soluble CTLA-4 in autoimmune thyroid diseases: Relationship with clinical status and possible role in the immune response dysregulation","volume":"123","author":"D Saverino","year":"2007","journal-title":"Clin Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/rheumatology\/keh303","article-title":"Serum soluble CTLA-4 levels are increased in diffuse cutaneous systemic sclerosis","volume":"43","author":"S Sato","year":"2004","journal-title":"Rheumatol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/rheumatology\/keh663","article-title":"Aberrant production of soluble costimulatory molecules CTLA-4. CD28. CD80 and CD86 in patients with systemic lupus erythematosus","volume":"44","author":"CK Wong","year":"2005","journal-title":"Rheumatol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0165-5728(02)00228-X","article-title":"Abnormal expression of CTLA-4 by T cells from patients with myasthenia gravis: effect of an AT-rich gene sequence","volume":"130","author":"XB Wang","year":"2002","journal-title":"J Neuroimmunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s13317-010-0011-7","article-title":"The soluble CTLA-4 receptor and its role in autoimmune diseases: an update","volume":"1","author":"D Saverino","year":"2010","journal-title":"Autoimmun Highlights"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Simone R, Pesce G, Antola G, Rumbullaku M, Bagnasco M, <etal>et al<\/etal>.. (2014) The Soluble Form of CTLA-4 from Serum of Patients with Autoimmune Diseases Regulates T-Cell Responses, BioMed Res Int: 215763.","DOI":"10.1155\/2014\/215763"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1751-2980.2011.00537.x","article-title":"Cytotoxic T-lymphocyte antigen 4 gene +49A\/G polymorphism significantly associated with susceptibility to primary biliary cirrhosis: a meta-analysis","volume":"12","author":"RR Chen","year":"2011","journal-title":"J Dig Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/intimm\/dxp069","article-title":"A functional soluble form of CTLA-4 is present in the serum of celiac patients and correlates with mucosal injury","volume":"21","author":"R Simone","year":"2009","journal-title":"Int Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e37980","DOI":"10.1371\/journal.pone.0037980","article-title":"Effects of different up-dosing regimens for hymenoptera venom immunotherapy on serum CTLA-4 and IL-10","volume":"7","author":"AM Riccio","year":"2012","journal-title":"PLoS One"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e44654","DOI":"10.1371\/journal.pone.0044654","article-title":"A Soluble Form of CTLA-4 Is Present in Paediatric Patients with Acute Lymphoblastic Leukaemia and Correlates with CD1d(+) Expression","volume":"7","author":"R Simone","year":"2012","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.autrev.2013.01.001","article-title":"Advances in CTLA-4-Ig-mediated modulation of inflammatory cell and immune response activation in rheumatoid arthritis","volume":"12","author":"M Cutolo","year":"2013","journal-title":"Autoimmun Rev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/hep.26067","article-title":"Therapeutic effect of cytotoxic T lymphocyte antigen 4\/immunoglobulin on a murine model of primary biliary cirrhosis","volume":"57","author":"A Dhirapong","year":"2012","journal-title":"Hepatology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1477-5751-7-8","article-title":"Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms","volume":"7","author":"A Berry","year":"2008","journal-title":"J Neg Res Biomed"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0112509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:59:42Z","timestamp":1689641982000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0112509"}},"subtitle":[],"editor":[{"given":"Aftab A.","family":"Ansari","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,10]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0112509","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,10]]}}}