{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:16:09Z","timestamp":1766733369145,"version":"3.40.5"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0112695","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T20:20:46Z","timestamp":1417551646000},"page":"e112695","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["BMP4 Increases the Expression of TRPC and Basal [Ca2+]i via the p38MAPK and ERK1\/2 Pathways Independent of BMPRII in PASMCs"],"prefix":"10.1371","volume":"9","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lichun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueqian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenju","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tcm.2007.09.003","article-title":"Transforming growth factor beta\/bone morphogenic protein signaling in pulmonary arterial hypertension: remodeling revisited","volume":"17","author":"O Eickelberg","year":"2007","journal-title":"Trends Cardiovasc Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"L841","DOI":"10.1152\/ajplung.00158.2005","article-title":"BMP signaling controls PASMC KV channel expression in vitro and in vivo","volume":"290","author":"KA Young","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1210\/en.2004-0234","article-title":"Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action","volume":"145","author":"M Takeda","year":"2004","journal-title":"Endocrinology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/01.RES.00000175571.53833.6c","article-title":"Bone morphogenetic proteins in vascular calcification","volume":"97","author":"KA Hruska","year":"2005","journal-title":"Circ Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2214\/ajr.135.1.177","article-title":"Pulmonary arterial calcification with reversible pulmonary hypertension","volume":"135","author":"FR Gutierrez","year":"1980","journal-title":"AJR Am J Roentgenol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1161\/01.CIR.0000012754.72951.3D","article-title":"Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor","volume":"105","author":"C Atkinson","year":"2002","journal-title":"Circulation"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/ATVBAHA.107.141200","article-title":"Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension","volume":"27","author":"RE Morty","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/01.RES.0000181152.65534.07","article-title":"Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension","volume":"97","author":"DB Frank","year":"2005","journal-title":"Circ Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"L450","DOI":"10.1152\/ajplung.00206.2005","article-title":"Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension","volume":"290","author":"H Takahashi","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"L1556","DOI":"10.1152\/ajplung.00305.2006","article-title":"Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH","volume":"292","author":"Y Tada","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1086\/316947","article-title":"BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension","volume":"68","author":"RD Machado","year":"2001","journal-title":"Am J Hum Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"L1182","DOI":"10.1152\/ajplung.00020.2006","article-title":"Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension","volume":"292","author":"AM Reynolds","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1378\/chest.08-1341","article-title":"Molecular mechanisms of pulmonary arterial hypertension: role of mutations in the bone morphogenetic protein type II receptor","volume":"134","author":"RJ Davies","year":"2008","journal-title":"Chest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1161\/01.RES.0000215809.47923.fd","article-title":"Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice","volume":"98","author":"L Long","year":"2006","journal-title":"Circ Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/79226","article-title":"Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension","volume":"26","author":"KB Lane","year":"2000","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/jmg.37.10.741","article-title":"Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family","volume":"37","author":"JR Thomson","year":"2000","journal-title":"J Med Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1161\/01.RES.0000166926.54293.68","article-title":"Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension","volume":"96","author":"X Yang","year":"2005","journal-title":"Circ Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1165\/rcmb.2006-0360OC","article-title":"BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes","volume":"37","author":"X Yang","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cellsig.2003.08.011","article-title":"Signal transduction of bone morphogenetic protein receptors","volume":"16","author":"A Nohe","year":"2004","journal-title":"Cell Signal"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"C1370","DOI":"10.1152\/ajpcell.00040.2010","article-title":"Bone morphogenetic protein 4 enhances canonical transient receptor potential expression, store-operated Ca2+ entry, and basal [Ca2+]i in rat distal pulmonary arterial smooth muscle cells","volume":"299","author":"W Lu","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"L848","DOI":"10.1152\/ajplung.00319.2003","article-title":"Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle","volume":"286","author":"J Wang","year":"2004","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"L1059","DOI":"10.1152\/ajplung.00448.2004","article-title":"Acute hypoxia increases intracellular [Ca2+] in pulmonary arterial smooth muscle by enhancing capacitative Ca2+ entry","volume":"288","author":"J Wang","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"24443","DOI":"10.1074\/jbc.M502825200","article-title":"Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells","volume":"280","author":"PB Yu","year":"2005","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1128\/MCB.15.7.3479","article-title":"Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs","volume":"15","author":"F Liu","year":"1995","journal-title":"Mol Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"22522","DOI":"10.1074\/jbc.270.38.22522","article-title":"Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors","volume":"270","author":"T Nohno","year":"1995","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1073\/pnas.92.17.7632","article-title":"Cloning and characterization of a human type II receptor for bone morphogenetic proteins","volume":"92","author":"BL Rosenzweig","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"32122","DOI":"10.1074\/jbc.M504629200","article-title":"Identification of receptors and signaling pathways for orphan bone morphogenetic protein\/growth differentiation factor ligands based on genomic analyses","volume":"280","author":"S Mazerbourg","year":"2005","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"585S","DOI":"10.1378\/chest.128.6_suppl.585S","article-title":"Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders","volume":"128","author":"P Bertolino","year":"2005","journal-title":"Chest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"A Leask","year":"2004","journal-title":"FASEB J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1101\/gad.1167003","article-title":"Integration of Smad and MAPK pathways: a link and a linker revisited","volume":"17","author":"J Massague","year":"2003","journal-title":"Genes Dev"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/bies.950170605","article-title":"Calcium signalling and cell proliferation","volume":"17","author":"MJ Berridge","year":"1995","journal-title":"Bioessays"},{"key":"ref32","first-page":"L269","article-title":"Cellular mechanisms and role of endothelin-1-induced calcium oscillations in pulmonary arterial myocytes","volume":"275","author":"JM Hyvelin","year":"1998","journal-title":"Am J Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"L870","DOI":"10.1152\/ajplung.2001.280.5.L870","article-title":"Capacitative Ca(<sup>2+<\/sup>) entry in agonist-induced pulmonary vasoconstriction","volume":"280","author":"SS McDaniel","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nrm1679","article-title":"Plants, symbiosis and parasites: a calcium signalling connection","volume":"6","author":"JF Harper","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"MJ Berridge","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1161\/01.RES.0000138952.16382.ad","article-title":"Chronic hypoxia-induced upregulation of store-operated and receptor-operated Ca<sup>2+<\/sup> channels in pulmonary arterial smooth muscle cells: a novel mechanism of hypoxic pulmonary hypertension","volume":"95","author":"MJ Lin","year":"2004","journal-title":"Circ Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1161\/01.RES.0000227551.68124.98","article-title":"Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca<sup>2+<\/sup> in pulmonary arterial smooth muscle cells","volume":"98","author":"J Wang","year":"2006","journal-title":"Circ Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"C114","DOI":"10.1152\/ajpcell.00629.2008","article-title":"Sildenafil inhibits chronically hypoxic upregulation of canonical transient receptor potential expression in rat pulmonary arterial smooth muscle","volume":"298","author":"W Lu","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"L144","DOI":"10.1152\/ajplung.00412.2001","article-title":"Inhibition of endogenous TRP1 decreases capacitative Ca<sup>2+<\/sup> entry and attenuates pulmonary artery smooth muscle cell proliferation","volume":"283","author":"M Sweeney","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"H746","DOI":"10.1152\/ajpheart.2001.280.2.H746","article-title":"Upregulated TRP and enhanced capacitative Ca(<sup>2+<\/sup>) entry in human pulmonary artery myocytes during proliferation","volume":"280","author":"VA Golovina","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0031-6997(24)01321-8","article-title":"Calcium movements, distribution, and functions in smooth muscle","volume":"49","author":"H Karaki","year":"1997","journal-title":"Pharmacol Rev"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ceca.2011.03.007","article-title":"TRPC channels are involved in calcium-dependent migration and proliferation in immortalized GnRH neurons","volume":"49","author":"P Ariano","year":"2011","journal-title":"Cell Calcium"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ceca.2009.07.008","article-title":"TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP\/MPP(+)","volume":"46","author":"S Selvaraj","year":"2009","journal-title":"Cell Calcium"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1093\/hmg\/11.13.1517","article-title":"Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension","volume":"11","author":"N Rudarakanchana","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"18129","DOI":"10.1074\/jbc.M701679200","article-title":"Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4","volume":"282","author":"Y Xia","year":"2007","journal-title":"J Biol Chem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0112695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T22:37:08Z","timestamp":1747175828000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0112695"}},"subtitle":[],"editor":[{"given":"James","family":"West","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,2]]},"references-count":45,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0112695","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2014,12,2]]}}}