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Methods of Enzymatic Analysis. 3rd Edition - Varlag Chemie, Wehnheim: 636."},{"key":"ref17","unstructured":"Kornberg A (1955) Methods in Enzymology 1. Academic Press, New York: 323."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e36308","DOI":"10.1371\/journal.pone.0036308","article-title":"Haematological and Biochemical Reference Values for Healthy Adults in the Middle Belt of Ghana","volume":"7","author":"DK Dosoo","year":"2012","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1182\/blood-2009-09-241844","article-title":"Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth","volume":"115","author":"B Kreuels","year":"2010","journal-title":"Blood"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/0035-9203(92)90083-O","article-title":"Morbidity from malaria and immune responses to defined<italic>Plasmodium falciparum<\/italic> antigens in children with sickle cell trait in The Gambia","volume":"86","author":"S Allen","year":"1992","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/1475-2875-12-317","article-title":"Biochemical and immunological mechanisms by which sickle cell trait protects against malaria","volume":"12","author":"L Gong","year":"2013","journal-title":"Malaria Journal"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1182\/blood-2003-11-3820","article-title":"Enhanced phagocytosis of ring-parasitizedmutant erythrocytes A common mechanism that may explain protection against falciparum malaria in sickle trait and beta-thalassemia trait","volume":"104","author":"K Ayi","year":"2004","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2174\/156652406776055212","article-title":"Immune responses to asexual blood-stages of malaria parasite","volume":"6","author":"SS Yazdani","year":"2006","journal-title":"Curr Mol Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.chom.2012.06.007","article-title":"Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance","volume":"12","author":"G LaMonte","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0140-6736(67)91037-9","article-title":"Glucose-6-phosphate-dehydrogenase deficiency, sickling, and malaria in African children in South Western Nigeria","volume":"1","author":"H Gilles","year":"1967","journal-title":"Lancet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0001-706X(97)00089-2","article-title":"A comparison of the incidence of severe malaria in Malian children with normal and C-trait hemoglobin profiles","volume":"68","author":"F Guinet","year":"1997","journal-title":"Acta tropica"},{"key":"ref27","first-page":"2358","article-title":"Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S. 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