{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:52:53Z","timestamp":1790805173917,"version":"4.1.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T00:00:00Z","timestamp":1415923200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0112877","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T20:14:15Z","timestamp":1415996055000},"page":"e112877","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":70,"title":["PR3-ANCA: A Promising Biomarker in Primary Sclerosing Cholangitis (PSC)"],"prefix":"10.1371","volume":"9","author":[{"given":"Laura M.","family":"Stinton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea","family":"Bentow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mahler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary L.","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertus","family":"Eksteen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilaad G.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Lindkvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon M.","family":"Hirschfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Milkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry L. A.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin J.","family":"Fritzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,11,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/hep.1840100406","article-title":"Primary sclerosing cholangitis: natural history, prognostic factors and survival analysis","volume":"10","author":"RH Wiesner","year":"1989","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0140-6736(13)60096-3","article-title":"Primary sclerosing cholangitis","volume":"382","author":"GM Hirschfield","year":"2013","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0168-8278(00)80061-6","article-title":"Serum autoantibodies in patients with primary sclerosing cholangitis","volume":"32","author":"P Angulo","year":"2000","journal-title":"J Hepatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0168-8278(00)80241-X","article-title":"Clinical significance of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver diseases","volume":"32","author":"C Roozendaal","year":"2000","journal-title":"J Hepatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/0016-5085(91)70028-V","article-title":"Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis","volume":"100","author":"RH Duerr","year":"1991","journal-title":"Gastroenterology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.clinre.2012.07.008","article-title":"Antineutrophil cytoplasmic auto-antibodies (ANCA) in autoimmune hepatitis and primary sclerosing cholangitis","volume":"37","author":"G Deniziaut","year":"2013","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/ajcp\/111.4.507","article-title":"International Consensus Statement on Testing and Reporting of Antineutrophil Cytoplasmic Antibodies (ANCA)","volume":"111","author":"J Savige","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/j.1478-3231.2009.01989.x","article-title":"What is behind the presence of anti-neutrophil cytoplasmatic antibodies in chronic liver disease?","volume":"29","author":"V De Riva","year":"2009","journal-title":"Liver Int"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1046\/j.1440-1746.2000.02173.x","article-title":"Anti-neutrophil cytoplasmic antibodies in hepatobiliary disease","volume":"15","author":"DA Fulcher","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/00313029400169451","article-title":"Anti-neutrophil cytoplasmic antibodies (ANCA): their detection and significance: report from workshops","volume":"26","author":"JA Savige","year":"1994","journal-title":"Pathology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1365-2249.2007.03453.x","article-title":"Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA)","volume":"150","author":"MV Talor","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3748\/wjg.v9.i7.1487","article-title":"Gastric autoimmune disorders in patients with chronic hepatitis C before, during and after interferon-alpha therapy","volume":"9","author":"C Fabbri","year":"2003","journal-title":"World J Gastroenterol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/gut.44.6.867","article-title":"High mobility group (HMG) non-histone chromosomal proteins HMG1 and HMG2 are significant target antigens of perinuclear anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis","volume":"44","author":"J Sobajima","year":"1999","journal-title":"Gut"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1053\/gast.2000.9366","article-title":"&quot;Atypical p-ANCA&quot; in IBD and hepatobiliary disorders react with a 50-kilodalton nuclear envelope protein of neutrophils and myeloid cell lines","volume":"119","author":"B Terjung","year":"2000","journal-title":"Gastroenterology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1136\/gut.2008.157818","article-title":"p-ANCAs in autoimmune liver disorders recognise human beta-tubulin isotype 5 and cross-react with microbial protein FtsZ","volume":"59","author":"B Terjung","year":"2010","journal-title":"Gut"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1749-6632.2009.04752.x","article-title":"DNA-bound lactoferrin is the major target for antineutrophil perinuclear cytoplasmic antibodies in ulcerative colitis","volume":"1173","author":"B Teegen","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"ref17","first-page":"704","article-title":"Antineutrophil cytoplasmic antibodies (ANCAs) in patients with inflammatory bowel disease show no correlation with proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G and lysozyme: a Singapore study","volume":"29","author":"CJ Ooi","year":"2000","journal-title":"Ann Acad Med Singapore"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.cca.2013.06.005","article-title":"PR3-ANCA: A promising biomarker for ulcerative colitis with extensive disease","volume":"424C","author":"M Mahler","year":"2013","journal-title":"Clin Chim Acta"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12016-012-8349-4","article-title":"Presence of Anti-proteinase 3 Antineutrophil Cytoplasmic Antibodies (Anti-PR3 ANCA) as Serologic Markers in Inflammatory Bowel Disease","volume":"45","author":"MT Arias-Loste","year":"2013","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/ard.2009.109868","article-title":"Clinical evaluation of hsPR3-ANCA ELISA for detection of antineutrophil cytoplasmatic antibodies directed against proteinase 3","volume":"69","author":"JU Holle","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0002-9343(98)00294-0","article-title":"Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features","volume":"105","author":"C Roozendaal","year":"1998","journal-title":"Am J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cca.2012.01.004","article-title":"Development and performance evaluation of novel chemiluminescence assays for detection of anti-PR3 and anti-MPO antibodies","volume":"413","author":"M Mahler","year":"2012","journal-title":"Clin Chim Acta"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1568-9972(01)00020-9","article-title":"Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics","volume":"1","author":"SA Long","year":"2002","journal-title":"Autoimmun Rev"},{"key":"ref24","article-title":"Presence of Anti-proteinase 3 Antineutrophil Cytoplasmic Antibodies (Anti-PR3 ANCA) as Serologic Markers in Inflammatory Bowel Disease","author":"MT Arias-Loste","year":"2013","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.gastro.2003.07.011","article-title":"Incidence, clinical spectrum, and outcomes of primary sclerosing cholangitis in a United States community","volume":"125","author":"K Bambha","year":"2003","journal-title":"Gastroenterology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1053\/bega.2001.0209","article-title":"Anti-neutrophil antibodies in primary sclerosing cholangitis","volume":"15","author":"B Terjung","year":"2001","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1309\/F6L4C48RHFMT4AAU","article-title":"Antigen-specific ANCA ELISAs have different sensitivities for active and treated vasculitis and for nonvasculitic disease","volume":"129","author":"M Trevisin","year":"2008","journal-title":"Am J Clin Pathol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1136\/jcp.55.9.680","article-title":"Immunofluorescent patterns produced by antineutrophil cytoplasmic antibodies (ANCA) vary depending on neutrophil substrate and conjugate","volume":"55","author":"W Pollock","year":"2002","journal-title":"J Clin Pathol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1136\/jcp.2003.009332","article-title":"The binding of proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) varies in different ELISAs","volume":"57","author":"M Trevisin","year":"2004","journal-title":"J Clin Pathol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1309\/WAEPADW0K4LPUHFN","article-title":"Addendum to the International Consensus Statement on testing and reporting of antineutrophil cytoplasmic antibodies. Quality control guidelines, comments, and recommendations for testing in other autoimmune diseases","volume":"120","author":"J Savige","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jim.2009.05.008","article-title":"Antineutrophil cytoplasmic antibody (ANCA) testing of routine sera varies in different laboratories but concordance is greater for cytoplasmic fluorescence (C-ANCA) and myeloperoxidase specificity (MPO-ANCA)","volume":"347","author":"W Pollock","year":"2009","journal-title":"J Immunol Methods"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1373\/clinchem.2004.032318","article-title":"Interassay and interobserver variability in the detection of anti-neutrophil cytoplasmic antibodies in patients with ulcerative colitis","volume":"50","author":"S Joossens","year":"2004","journal-title":"Clin Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1053\/jhep.2002.34944","article-title":"Diagnosis and treatment of autoimmune hepatitis","volume":"36","author":"AJ Czaja","year":"2002","journal-title":"Hepatology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MOG.0b013e328324ed06","article-title":"Autoimmune liver disease","volume":"25","author":"AJ Czaja","year":"2009","journal-title":"Curr Opin Gastroenterol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00004836-200310000-00011","article-title":"Autoantibodies in the diagnosis and management of liver disease","volume":"37","author":"AJ Czaja","year":"2003","journal-title":"J Clin Gastroenterol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jim.2008.03.012","article-title":"Evaluation of a multiplex flow cytometric immunoassay to detect PR3- and MPO-ANCA in active and treated vasculitis, and in inflammatory bowel disease (IBD)","volume":"336","author":"M Trevisin","year":"2008","journal-title":"J Immunol Methods"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1517\/17530050802651561","article-title":"Microbead-based technologies in diagnostic autoantibody detection","volume":"3","author":"MJ Fritzler","year":"2009","journal-title":"Expert Opin Med Diagn"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1053\/jhep.2003.50049","article-title":"Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease","volume":"37","author":"M Vidali","year":"2003","journal-title":"Hepatology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0112877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T04:26:36Z","timestamp":1540009596000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0112877"}},"subtitle":[],"editor":[{"given":"Niklas K.","family":"Bj\u00f6rkstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,14]]},"references-count":38,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0112877","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725236425.793518877","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,14]]}}}