{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T10:52:55Z","timestamp":1770288775907,"version":"3.49.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T00:00:00Z","timestamp":1415923200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0113022","type":"journal-article","created":{"date-parts":[[2014,11,15]],"date-time":"2014-11-15T01:15:44Z","timestamp":1416014144000},"page":"e113022","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Generation of Insulin-Producing Cells from the Mouse Liver Using \u03b2 Cell-Related Gene Transfer Including Mafa and Mafb"],"prefix":"10.1371","volume":"9","author":[{"given":"Haruka","family":"Nagasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokio","family":"Katsumata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Han","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryusuke","family":"Koshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunshin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,11,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.devcel.2007.06.001","article-title":"A multipotent progenitor domain guides pancreatic organogenesis","volume":"13","author":"Q Zhou","year":"2007","journal-title":"Dev Cell"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.devcel.2010.02.005","article-title":"Cellular plasticity within the pancreas \u2013 lessons learned from development","volume":"18","author":"S Puri","year":"2010","journal-title":"Dev Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1073\/pnas.86.20.7711","article-title":"v-maf, a viral oncogene that encodes a \u201cleucine zipper\u201d motif","volume":"86","author":"M Nishizawa","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/jb\/mvm105","article-title":"Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes","volume":"141","author":"K Kataoka","year":"2007","journal-title":"J Biochem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.tem.2011.05.003","article-title":"MafA and MafB activity in pancreatic \u03b2 cells","volume":"22","author":"Y Hang","year":"2011","journal-title":"Trends Endocrinol Metab"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1128\/MCB.06543-11","article-title":"Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins","volume":"32","author":"H Yamazaki","year":"2012","journal-title":"Mol Cell Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ydbio.2006.02.028","article-title":"A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells","volume":"293","author":"W Nishimura","year":"2006","journal-title":"Dev Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nbt1393","article-title":"Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo","volume":"26","author":"E Kroon","year":"2008","journal-title":"Nat Biotechnol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/ilar.49.1.103","article-title":"Noninvasive bioluminescence imaging in small animals","volume":"49","author":"KR Zinn","year":"2008","journal-title":"ILAR J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11307-009-0240-1","article-title":"Bioluminescence imaging in mouse models quantifies beta cell mass in the pancreas and after islet transplantation","volume":"12","author":"J Virostko","year":"2010","journal-title":"Mol Imaging Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ymthe.2004.01.008","article-title":"Bioluminescent monitoring of islet graft survival after transplantation","volume":"9","author":"Y Lu","year":"2004","journal-title":"Mol Ther"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/978-1-60327-517-0_29","article-title":"Bioluminescence: imaging modality for in vitro and in vivo gene expression","volume":"477","author":"RT Sadikot","year":"2008","journal-title":"Methods Mol Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1538\/expanim.61.445","article-title":"Noninvasive monitoring of \u03b2-cell mass and fetal \u03b2-cell genesis in mice using bioluminescence imaging","volume":"61","author":"Y Sekiguchi","year":"2012","journal-title":"Exp Anim"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e60411","DOI":"10.1371\/journal.pone.0060411","article-title":"Bioluminescence imaging of \u03b2 cells and intrahepatic insulin gene activity under normal and pathological conditions","volume":"8","author":"T Katsumata","year":"2013","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.2337\/db05-1651","article-title":"Isolation and characterization of proinsulin-producing medullary thymic epithelial cell clones","volume":"55","author":"MO Palumbo","year":"2006","journal-title":"Diabetes"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/S0024-3205(02)01918-5","article-title":"Molecular target structures in alloxan-induced diabetes in mice","volume":"71","author":"SS im Walde","year":"2002","journal-title":"Life Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.devcel.2009.01.012","article-title":"Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes","volume":"16","author":"V Yechoor","year":"2009","journal-title":"Dev Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15047","DOI":"10.1074\/jbc.M412013200","article-title":"A crucial role of MafA as a novel therapeutic target for diabetes","volume":"280","author":"H Kaneto","year":"2005","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1677\/JOE-08-0063","article-title":"MafA is a dedicated activator of the insulin gene in vivo","volume":"198","author":"I Artner","year":"2008","journal-title":"J Endocrinol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"15116","DOI":"10.1073\/pnas.0507567102","article-title":"Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells","volume":"102","author":"K Minami","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nbt.2141","article-title":"Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3","volume":"30","author":"B Blum","year":"2012","journal-title":"Nat Biotechnol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.2337\/db12-0849","article-title":"Thyroid hormone promotes postnatal rat pancreatic \u03b2-cell development and glucose-responsive insulin secretion through MAFA","volume":"62","author":"C Aguayo-Mazzucato","year":"2013","journal-title":"Diabetes"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.2337\/db11-1361","article-title":"Maintenance of \u03b2-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology","volume":"61","author":"M Szabat","year":"2012","journal-title":"Diabetes"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.bbrc.2003.10.196","article-title":"Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter","volume":"312","author":"M Kajihara","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.1128\/MCB.21.14.4441-4452.2001","article-title":"Phosphorylation of MafA is essential for its transcriptional and biological properties","volume":"21","author":"S Benkhelifa","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.molcel.2007.11.009","article-title":"GSK-3-mediated phosphorylation enhances Maf-transforming activity","volume":"28","author":"N Rocques","year":"2007","journal-title":"Mol Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.1128\/MCB.01573-06","article-title":"MafA stability in pancreatic beta cells is regulated by glucose and is dependent on its constitutive phosphorylation at multiple sites by glycogen synthase kinase 3","volume":"27","author":"SI Han","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1074\/jbc.M806286200","article-title":"Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cells","volume":"284","author":"C Shao","year":"2009","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1074\/jbc.M806314200","article-title":"The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation","volume":"284","author":"S Guo","year":"2009","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"12655","DOI":"10.1074\/jbc.M110.105759","article-title":"Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding","volume":"285","author":"S Guo","year":"2010","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.2337\/db10-0190","article-title":"MafA and MafB regulate genes critical to beta-cells in a unique temporal manner","volume":"59","author":"I Artner","year":"2010","journal-title":"Diabetes"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/75050","article-title":"Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia","volume":"6","author":"S Ferber","year":"2000","journal-title":"Nat Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nm867","article-title":"NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice","volume":"9","author":"H Kojima","year":"2003","journal-title":"Nat Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"15336","DOI":"10.1073\/pnas.1201701109","article-title":"In vivo reprogramming of Sox9+ cells in the liver to insulin-secreting ducts","volume":"109","author":"A Banga","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0960-9822(02)01434-3","article-title":"Experimental conversion of liver to pancreas","volume":"13","author":"ME Horb","year":"2003","journal-title":"Curr Biol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e79076","DOI":"10.1371\/journal.pone.0079076","article-title":"Generation of functional insulin-producing cells from neonatal porcine liver-derived cells by PDX1\/VP16, BETA2\/NeuroD and MafA","volume":"8","author":"DS Ham","year":"2013","journal-title":"PLoS One"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0113022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T03:44:59Z","timestamp":1588995899000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0113022"}},"subtitle":[],"editor":[{"given":"Bridget","family":"Wagner","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,14]]},"references-count":36,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0113022","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,14]]}}}