{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:32:22Z","timestamp":1773880342888,"version":"3.50.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T00:00:00Z","timestamp":1416355200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0113057","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T05:10:27Z","timestamp":1416460227000},"page":"e113057","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Capsaicin Cough Sensitivity and the Association with Clinical Parameters in Bronchiectasis"],"prefix":"10.1371","volume":"9","author":[{"given":"Wei-jie","family":"Guan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-hua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-ya","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-min","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-ping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan-shan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,11,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMra012519","article-title":"Bronchiectasis","volume":"346","author":"AF Baker","year":"2002","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1440-1843.2009.01569.x","article-title":"Clinical challenges in managing bronchiectasis","volume":"14","author":"KW Tsang","year":"2009","journal-title":"Respirology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1164\/ajrccm.163.4.9909121","article-title":"The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia","volume":"163","author":"JC Ho","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1440-1843.2000.00233.x","article-title":"Ciliary assessment in bronchiectasis","volume":"5","author":"KW Tsang","year":"2000","journal-title":"Respirology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1136\/thx.2005.049767","article-title":"Capsaicin cough sensitivity in bronchiectasis","volume":"61","author":"A Torrego","year":"2006","journal-title":"Thorax"},{"key":"ref6","first-page":"289","article-title":"Cough reflex testing with inhaled capsaicin and TRPV1 activation in asthma and comorbid conditions","volume":"23","author":"M Couto","year":"2013","journal-title":"J Investig Allergol Clin Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.jaci.2013.04.042","article-title":"Pharmacodynamic modeling of cough responses to capsaicin inhalation calls into question the utility of the C5 endpoint","volume":"132","author":"EC Hilton","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1745-9974-9-14","article-title":"Chronic cough hypersensitivity syndrome","volume":"9","author":"AH Morice","year":"2013","journal-title":"Cough"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5415\/apallergy.2014.4.1.3","article-title":"Changing the paradigm for cough: does \u2018cough hypersensitivity\u2019 aid our understanding?","volume":"4","author":"WJ Song","year":"2014","journal-title":"Asia Pac Allergy"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1378\/chest.105.1.151","article-title":"The relation of sleep complaints to respiratory symptoms in a general population","volume":"105","author":"ME Klink","year":"1994","journal-title":"Chest"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1183\/09031936.00110409","article-title":"Chronic cough in patients with sleep-disordered breathing","volume":"35","author":"KK Chan","year":"2010","journal-title":"Eur Respir J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1389-9457(01)00157-5","article-title":"Subjective sleep quality in cystic fibrosis","volume":"3","author":"MA Milross","year":"2002","journal-title":"Sleep Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11136-012-0188-5","article-title":"Depression and anxiety symptoms in bronchiectasis: associations with health-related quality of life","volume":"22","author":"C Olveira","year":"2013","journal-title":"Qual Life Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.pupt.2010.12.003","article-title":"TRPV1 as a cough sensor and its temperature-sensitive properties","volume":"3","author":"LY Lee","year":"2011","journal-title":"Pulm Pharmacol Ther"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1136\/thx.2005.054429","article-title":"Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough","volume":"12","author":"HK Park","year":"2006","journal-title":"Thorax"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1152\/physiol.00026.2008","article-title":"Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control","volume":"23","author":"BF Bessac","year":"2008","journal-title":"Physiology (Bathesda)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.pupt.2011.01.012","article-title":"Chronic \u201ccough hypersensitivity syndrome\u201d: a more precise label for chronic cough","volume":"24","author":"KF Chung","year":"2011","journal-title":"Pulm Pharmacol Thera"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1378\/chest.117.2.420","article-title":"Sputum Elastase in Steady-s<italic>tate Bronchiectasis.<\/italic>","volume":"117","author":"KW Tsang","year":"2000","journal-title":"Chest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1183\/09031936.00160508","article-title":"Validation of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis","volume":"34","author":"MP Murray","year":"2009","journal-title":"Eur Respir J"},{"key":"ref20","first-page":"5","article-title":"Changes in health-related quality of life and clinical implications in Chinese patients with chronic cough","volume":"25","author":"W Ma","year":"2009","journal-title":"Cough"},{"key":"ref21","first-page":"319","article-title":"ATS\/ERS task force: Standardization of spirometry","volume":"26","author":"G Laszio","year":"2005","journal-title":"Eur Respir J"},{"key":"ref22","first-page":"50","article-title":"Normative values of pulmonary function testing in Chinese adults","volume":"115","author":"JP Zheng","year":"2002","journal-title":"Chin Med J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1164\/rccm.201210-1937OC","article-title":"Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation","volume":"187","author":"MM Tunney","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1164\/ajrccm.162.4.9906120","article-title":"An Investigation into Causative Factors in Patients with Bronchiectasis","volume":"162","author":"MC Pasteur","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.rmed.2013.04.013","article-title":"Phenotyping adults with non-cystic fibrosis bronchiectasis: A prospective observational cohort study","volume":"107","author":"GA Anwar","year":"2013","journal-title":"Respir Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/thx.2010.136119","article-title":"British Thoracic Society guidelines for non-CF bronchiectasis","volume":"65","author":"MC Pasteur","year":"2010","journal-title":"Thorax"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The bronchiectasis severity index: An international derivation and validation study","volume":"189","author":"JD Chalmers","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1183\/09031936.00003709","article-title":"Mortality in bronchiectasis: a long-term study assessing the factors influencing survival","volume":"34","author":"MR Loebinger","year":"2009","journal-title":"Eur Respir J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.rmed.2013.12.015","article-title":"Mortality in non-cystic fibrosis bronchiectasis: a prospective cohort analysis","volume":"108","author":"PC Goeminne","year":"2014","journal-title":"Respir Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S2213-2600(14)70050-5","article-title":"Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled study","volume":"2","author":"P Mandal","year":"2014","journal-title":"Lancet Respir Med"},{"key":"ref31","first-page":"719","article-title":"Role of gender and pubertal stage on cough sensitivity in childhood and adolescence","volume":"59","author":"S Varechova","year":"2008","journal-title":"J Physiol Pharmacol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/resp.12219","article-title":"The sptuum color chart as a predictor of lung inflammation, proteolytics and damage in non-cystic fibrosis bronchiectasis: a case-control analysis","volume":"19","author":"PC Goeminne","year":"2014","journal-title":"Respirology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.molimm.2012.09.011","article-title":"Mechanisms of immune dysfunction and bacterial persistence in non-cystic fibrosis bronchiectasis","volume":"55","author":"JD Chalmers","year":"2013","journal-title":"Mol Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0113057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T06:03:03Z","timestamp":1540274583000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0113057"}},"subtitle":[],"editor":[{"given":"James D.","family":"Chalmers","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,19]]},"references-count":33,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0113057","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,19]]}}}