{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T20:08:45Z","timestamp":1776024525924,"version":"3.50.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T00:00:00Z","timestamp":1417564800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0113197","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T18:56:02Z","timestamp":1417632962000},"page":"e113197","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Possible Single-Nucleotide Polymorphism Loci Associated with Systemic Sclerosis Susceptibility: A Genetic Association Study in a Chinese Han Population"],"prefix":"10.1371","volume":"9","author":[{"given":"Chang","family":"Shu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuming","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,12,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/rheumatology\/ker269","article-title":"Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies","volume":"51","author":"M Elhai","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/art.27303","article-title":"Association of the FAM167A-BLK region with systemic sclerosis","volume":"62","author":"I Ito","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaut.2009.08.014","article-title":"Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations","volume":"34","author":"P Gourh","year":"2010","journal-title":"J Autoimmun"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/ng.565","article-title":"Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus","volume":"42","author":"TR Radstake","year":"2010","journal-title":"Nat Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e1002091","DOI":"10.1371\/journal.pgen.1002091","article-title":"Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis","volume":"7","author":"Y Allanore","year":"2011","journal-title":"PLoS Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1002178","DOI":"10.1371\/journal.pgen.1002178","article-title":"Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy","volume":"7","author":"O Gorlova","year":"2011","journal-title":"PLoS Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1136\/annrheumdis-2012-201888","article-title":"Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study","volume":"72","author":"L Bossini-Castillo","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/sj.cr.7290272","article-title":"SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci","volume":"15","author":"YY Shi","year":"2005","journal-title":"Cell Res"},{"key":"ref10","first-page":"519","article-title":"Cell Res","volume":"19","author":"Z Li","year":"2009"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"6192","DOI":"10.1073\/pnas.111137198","article-title":"RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage","volume":"98","author":"A Liu","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6906","DOI":"10.1128\/MCB.21.20.6906-6912.2001","article-title":"RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells","volume":"21","author":"AX Liu","year":"2001","journal-title":"Mol Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1101\/gad.1134603","article-title":"RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development","volume":"17","author":"I Adini","year":"2003","journal-title":"Genes Dev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1016\/S0021-9258(18)42905-5","article-title":"Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk","volume":"267","author":"SM Dymecki","year":"1992","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1084\/jem.20030729","article-title":"Mimicry of pre\u2013B cell receptor signaling by activation of the tyrosine kinase Blk","volume":"198","author":"T Tretter","year":"2003","journal-title":"J Exp Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJMoa0707865","article-title":"Association of systemic lupus erythematosus with C8orf13\u2013BLK and ITGAM\u2013ITGAX","volume":"358","author":"G Hom","year":"2008","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/ng.2220","article-title":"A genome-wide association study identifies three new risk loci for Kawasaki disease","volume":"44","author":"Y Onouchi","year":"2012","journal-title":"Nat Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/gene.2010.44","article-title":"Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjogren&apos;s syndrome","volume":"12","author":"G Nordmark","year":"2011","journal-title":"Genes Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.2792","article-title":"Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren&apos;s syndrome","volume":"45","author":"CJ Lessard","year":"2013","journal-title":"Nat Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1177\/039463201302600318","article-title":"Association of HLA-DQB1* 0501 with scleroderma and its clinical features in Chinese population","volume":"26","author":"XD Zhou","year":"2012","journal-title":"Int J Immunopathol Pharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/039463201302600220","article-title":"STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population","volume":"26","author":"L Yi","year":"2013","journal-title":"Int J Immunopathol Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00439-011-1137-z","article-title":"Unraveling the genetic component of systemic sclerosis","volume":"131","author":"JE Mart\u00edn","year":"2012","journal-title":"Hum Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ajhg.2013.12.002","article-title":"Immunochip analysis identifies multiple susceptibility Loci for systemic sclerosis","volume":"94","author":"MD Mayes","year":"2014","journal-title":"The American Journal of Hum Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0113197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T20:49:32Z","timestamp":1650746972000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0113197"}},"subtitle":[],"editor":[{"given":"Shervin","family":"Assassi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,3]]},"references-count":23,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0113197","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,3]]}}}