{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:05:25Z","timestamp":1792249525785,"version":"4.4.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0113266","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T19:33:31Z","timestamp":1416339211000},"page":"e113266","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":117,"title":["Melanin Photosensitization and the Effect of Visible Light on Epithelial Cells"],"prefix":"10.1371","volume":"9","author":[{"given":"Orlando","family":"Chiarelli-Neto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan Silva","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleska Kerllen","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Pavani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divinomar","family":"Severino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Fai\u00e3o-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvya Stuchi","family":"Maria-Engler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Aliprandini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glaucia R.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Di Mascio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa H. G.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio S.","family":"Baptista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1096\/fj.06-5725fje","article-title":"Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis","volume":"20","author":"Y Yamaguchi","year":"2006","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/0891-5849(94)00192-M","article-title":"UVA radiation-induced oxidative damage to lipids and proteins in vitro and in human skin fibroblasts is dependent on iron and singlet oxygen","volume":"18","author":"GF Vile","year":"1995","journal-title":"Free radical biology & medicine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"15345","DOI":"10.1074\/jbc.274.22.15345","article-title":"Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion","volume":"274","author":"M Berneburg","year":"1999","journal-title":"The Journal of biological chemistry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/jid.2011.51","article-title":"Oxidatively generated damage to DNA by UVA radiation in cells and human skin","volume":"131","author":"J Cadet","year":"2011","journal-title":"The Journal of investigative dermatology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1073\/pnas.0401141101","article-title":"The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis","volume":"101","author":"NS Agar","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/phpp.12111","article-title":"Photoprotection of human skin beyond ultraviolet radiation","volume":"30","author":"S Grether-Beck","year":"2014","journal-title":"Photodermatology, photoimmunology & photomedicine"},{"key":"ref7","first-page":"450","article-title":"Mahmoud BH, Hexsel CL, Hamzavi IH, Lim HW (n.d.) Effects of visible light on the skin","volume":"84","journal-title":"Photochemistry and photobiology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/carcin\/18.4.811","article-title":"Wavelength dependence of oxidative DNA damage induced by UV and visible light","volume":"18","author":"C Kielbassa","year":"1997","journal-title":"Carcinogenesis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1093\/carcin\/18.12.2379","article-title":"Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation","volume":"18","author":"E Kvam","year":"1997","journal-title":"Carcinogenesis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/jid.2011.476","article-title":"Irradiation of skin with visible light induces reactive oxygen species and matrix-degrading enzymes","volume":"132","author":"F Liebel","year":"2012","journal-title":"The Journal of investigative dermatology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/jid.2010.95","article-title":"Impact of long-wavelength UVA and visible light on melanocompetent skin","volume":"130","author":"BH Mahmoud","year":"2010","journal-title":"The Journal of investigative dermatology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/jid.2012.148","article-title":"How much sun protection is needed?: Are we on the way to full-spectrum protection?","volume":"132","author":"L Kolbe","year":"2012","journal-title":"The Journal of investigative dermatology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.0022-202X.2005.23760.x","article-title":"Mechanisms of skin tanning in different racial\/ethnic groups in response to ultraviolet radiation","volume":"124","author":"T Tadokoro","year":"2005","journal-title":"The Journal of investigative dermatology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.freeradbiomed.2012.02.039","article-title":"Novel properties of melanins include promotion of DNA strand breaks, impairment of repair, and reduced ability to damage DNA after quenching of singlet oxygen","volume":"52","author":"AA Suzukawa","year":"2012","journal-title":"Free radical biology & medicine"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1096\/fj.02-0865fje","article-title":"UV-induced DNA damage and melanin content in human skin differing in racial\/ethnic origin","volume":"17","author":"T Tadokoro","year":"2003","journal-title":"FASEB J"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Setlow RB, Grist E, Thompson K, Woodhead AD (1993) Wavelengths Effective in Induction of Malignant-Melanoma. Proceedings of the National Academy of Sciences of the United States of America 90: 6666\u20136670. Available: &lt;Go to ISI&gt;:\/\/A1993LM68100060.","DOI":"10.1073\/pnas.90.14.6666"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1073\/pnas.0511248103","article-title":"UV causation of melanoma in Xiphophorus is dominated by melanin photosensitized oxidant production","volume":"103","author":"SR Wood","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.freeradbiomed.2011.06.013","article-title":"Generation and suppression of singlet oxygen in hair by photosensitization of melanin","volume":"51","author":"O Chiarelli-Neto","year":"2011","journal-title":"Free radical biology & medicine"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1039\/b926014p","article-title":"Singlet oxygen: there is indeed something new under the sun","volume":"39","author":"PR Ogilby","year":"2010","journal-title":"Chemical Society reviews"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(00)19003-2","article-title":"Naphthalene endoperoxides as generators of singlet oxygen in biological media","volume":"319","author":"C Pierlot","year":"2000","journal-title":"Methods in enzymology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1751-1097.2008.00343.x","article-title":"Comparable photoreactivity of hair melanosomes, eu- and pheomelanins at low concentrations: low melanin a risk factor for UVA damage and melanoma?","volume":"84","author":"RM Haywood","year":"2008","journal-title":"Photochemistry and photobiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1034\/j.1600-0749.2003.00072.x","article-title":"Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals: a comparative review","volume":"16","author":"S Ito","year":"2003","journal-title":"Pigment Cell Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s00249-008-0287-y","article-title":"Singlet oxygen generation in the reaction centers of Rhodobacter sphaeroides","volume":"37","author":"AF Uchoa","year":"2008","journal-title":"Eur Biophys J"},{"key":"ref24","first-page":"218","article-title":"Biological behavior of malignant melanoma cells correlated to their survival in vivo","volume":"35","author":"IJ Fidler","year":"1975","journal-title":"Cancer research"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.106.3.761","article-title":"Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line","volume":"106","author":"P Boukamp","year":"1988","journal-title":"The Journal of cell biology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/257393a0","article-title":"Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line","volume":"257","author":"P Ralph","year":"1975","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1073\/pnas.73.9.3278","article-title":"Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells","volume":"73","author":"TE Carey","year":"1976","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1755-148X.2012.00992.x","article-title":"Proteasome inhibition and ROS generation by 4-nerolidylcatechol induces melanoma cell death","volume":"25","author":"CA Brohem","year":"2012","journal-title":"Pigment cell & melanoma research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0006-2952(03)00240-5","article-title":"The mitochondrial uncoupler dicumarol disrupts the MTT assay","volume":"66","author":"AC Collier","year":"2003","journal-title":"Biochemical pharmacology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.tiv.2009.05.013","article-title":"Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation","volume":"23","author":"S-J Heo","year":"2009","journal-title":"Toxicology in vitro: an international journal published in association with BIBRA"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"MM Bradford","year":"1976","journal-title":"Analytical biochemistry"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1021\/tx000020e","article-title":"DNA damage induced in cells by gamma and UVA radiation as measured by HPLC\/GC-MS and HPLC-EC and Comet assay","volume":"13","author":"JP Pouget","year":"2000","journal-title":"Chemical research in toxicology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/abio.2001.5559","article-title":"Comet assay coupled to repair enzymes for the detection of oxidative damage to DNA induced by low doses of gamma-radiation: use of YOYO-1, low-background slides, and optimized electrophoresis conditions","volume":"303","author":"S Sauvaigo","year":"2002","journal-title":"Analytical biochemistry"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nprot.2006.5","article-title":"The comet assay: a method to measure DNA damage in individual cells","volume":"1","author":"PL Olive","year":"2006","journal-title":"Nature protocols"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1034\/j.1600-0749.13.s8.7.x","article-title":"The melanosome: the perfect model for cellular responses to the environment","volume":"13","author":"VJ Hearing","year":"2000","journal-title":"Pigment cell research\/sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature05660","article-title":"Melanocyte biology and skin pigmentation","volume":"445","author":"JY Lin","year":"2007","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1146\/annurev.genet.37.110801.143233","article-title":"Genetics of hair and skin color","volume":"37","author":"JL Rees","year":"2003","journal-title":"Annual review of genetics"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Beltr\u00e1n-Garc\u00eda MJ, Prado FM, Oliveira MS, Ortiz-Mendoza D, Scalfo AC, <etal>et al<\/etal>. (2014) Singlet molecular oxygen generation by light-activated DHN-melanin of the fungal pathogen Mycosphaerella fijiensis in black Sigatoka disease of bananas. PloS one 9: e91616. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3960117&tool=pmcentrez&rendertype=abstract\" xlink:type=\"simple\">http:\/\/www.pubmedcentral.nih.gov\/articlerender.fcgi?artid=3960117&amp;tool=pmcentrez&amp;rendertype=abstract<\/ext-link>. ccessed 2014 June 19.","DOI":"10.1371\/journal.pone.0091616"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1128\/MCB.24.1.465-474.2004","article-title":"The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells","volume":"24","author":"MT Russo","year":"2004","journal-title":"Molecular and cellular biology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"18814","DOI":"10.1016\/S0021-9258(17)32239-1","article-title":"New substrates for old enzymes. 5-Hydroxy-2\u2032-deoxycytidine and 5-hydroxy-2\u2032-deoxyuridine are substrates for Escherichia coli endonuclease III and formamidopyrimidine DNA N-glycosylase, while 5-hydroxy-2\u2032-deoxyuridine is a substrate for uracil DNA N-glycos","volume":"269","author":"Z Hatahet","year":"1994","journal-title":"The Journal of biological chemistry"},{"key":"ref41","first-page":"1464","article-title":"Induction of delayed mutations and chromosomal instability in fibroblasts after UVA-, UVB-, and X-radiation","volume":"63","author":"J Dahle","year":"2003","journal-title":"Cancer research"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1562\/2004-07-27-IR-247.1","article-title":"UV-A fingerprint mutations in human skin cancer","volume":"81","author":"GM Halliday","year":"2005","journal-title":"Photochemistry and photobiology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1751-1097.2007.00286.x","article-title":"Effects of visible light on the skin","volume":"84","author":"BH Mahmoud","year":"2007","journal-title":"Photochemistry and photobiology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1034\/j.1600-0781.2003.00054.x","article-title":"Cutaneous effects of infrared radiation: from clinical observations to molecular response mechanisms","volume":"19","author":"SM Schieke","year":"2003","journal-title":"Photodermatology, photoimmunology & photomedicine"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jphotobiol.2011.02.018","article-title":"Effects of blue light irradiation on human dermal fibroblasts","volume":"103","author":"C Opl\u00e4nder","year":"2011","journal-title":"Journal of photochemistry and photobiology B, Biology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/eye.2010.149","article-title":"Retinal light toxicity","volume":"25","author":"PN Youssef","year":"2011","journal-title":"Eye (London, England)"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1056\/NEJMp1005999","article-title":"Indoor tanning\u2013science, behavior, and policy","volume":"363","author":"DE Fisher","year":"2010","journal-title":"The New England journal of medicine"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0113266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T20:28:18Z","timestamp":1650659298000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0113266"}},"subtitle":[],"editor":[{"given":"John R.","family":"Battista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,18]]},"references-count":47,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0113266","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,18]]}}}