{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:21:32Z","timestamp":1769610092780,"version":"3.49.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0113296","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T14:35:03Z","timestamp":1416321303000},"page":"e113296","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Characterization of Albendazole-Randomly Methylated-\u03b2-Cyclodextrin Inclusion Complex and In Vivo Evaluation of Its Antihelmitic Activity in a Murine Model of Trichinellosis"],"prefix":"10.1371","volume":"9","author":[{"given":"Agustina","family":"Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dar\u00edo","family":"Leonardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda D.","family":"Vasconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucila I.","family":"Hinrichsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda C.","family":"Lamas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0304-4017(00)00341-1","article-title":"Trichinellosis: a worldwide zoonosis","volume":"93","author":"J Dupouy-Camet","year":"2000","journal-title":"Veterinary Parasitology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.parint.2011.01.007","article-title":"Trichinellosis, another helminthiasis affecting the central nervous system","volume":"60","author":"R Neghina","year":"2011","journal-title":"Parasitology International"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0304-4017(00)00352-6","article-title":"Trichinellosis: human disease, diagnosis and treatment","volume":"93","author":"W Kociecka","year":"2000","journal-title":"Veterinary Parasitology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0020-7519(97)00052-0","article-title":"Albendazole versus ricobendazole (albendazole-sulphoxide) against enteral and parenteral stages of <italic>Trichinella spiralis<\/italic> in mice","volume":"27","author":"ML Lopez-Garcia","year":"1997","journal-title":"International journal for parasitology"},{"key":"ref5","unstructured":"Piccirilli GN, Garc\u00eda A, Leonardi D, Mamprin ME, Bolmaro RE, <etal>et al<\/etal>. (2013) Chitosan microparticles: influence of the gelation process on the release profile and oral bioavailability of albendazole, a class II compound. Drug Dev. Ind. Pharm.: 1\u20138."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.parint.2013.08.009","article-title":"Novel albendazole formulations given during the intestinal phase of Trichinella spiralis infection reduce effectively parasitic muscle burden in mice","volume":"62","author":"A Garc\u00eda","year":"2013","journal-title":"Parasitology International"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1081\/DDC-100102294","article-title":"Preparation and Characterization of Albendazole \u03b2-Cyclodextrin Complexes","volume":"25","author":"JA Castillo","year":"1999","journal-title":"Drug Dev. Ind. Pharm"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"718791","DOI":"10.1100\/2012\/718791","article-title":"A study on solubilization of poorly soluble drugs by cyclodextrins and micelles: complexation and binding characteristics of sulfamethoxazole and trimethoprim","volume":"2012","author":"S G\u00f6kt\u00fcrk","year":"2012","journal-title":"The Scientific World Journal"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF01041557","article-title":"Enhanced water-solubility of albendazole by hydroxypropyl-\u03b2-cyclodextrin complexation","volume":"25","author":"VL Bassani","year":"1996","journal-title":"J Incl Phenom Macrocycl Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.jpba.2004.06.016","article-title":"Interaction of naproxen with ionic cyclodextrins in aqueous solution and in the solid state","volume":"37","author":"P Mura","year":"2005","journal-title":"J. Pharm. Biomed. Anal"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jpba.2008.11.003","article-title":"Physical-chemical characterization of binary and ternary systems of ketoprofen with cyclodextrins and phospholipids","volume":"50","author":"M Cirri","year":"2009","journal-title":"J. Pharm. Biomed. Anal"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0928-0987(01)00199-3","article-title":"Interaction of naproxen with noncrystalline acetyl \u03b2- and acetyl \u03b3-cyclodextrins in the solid and liquid state","volume":"15","author":"G Bettinetti","year":"2002","journal-title":"Eur. J. Pharm. Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jconrel.2007.07.018","article-title":"The utility of cyclodextrins for enhancing oral bioavailability","volume":"123","author":"RL Carrier","year":"2007","journal-title":"J. Controlled Release"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0378-5173(98)00390-1","article-title":"Influence of the preparation method on the physicochemical properties of ketoprofen-cyclodextrin binary systems","volume":"179","author":"P Mura","year":"1999","journal-title":"Int. J. Pharm"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jpba.2009.11.013","article-title":"Preparation and solid-state characterization of bupivacaine hydrochloride cyclodextrin complexes aimed for buccal delivery","volume":"52","author":"M Jug","year":"2010","journal-title":"J. Pharm. Biomed. Anal"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0169-409X(98)00053-2","article-title":"Cyclodextrins in targeting: Application to nanoparticles","volume":"36","author":"D Duch\u00eane","year":"1999","journal-title":"Adv. Drug Del. Rev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jconrel.2004.02.010","article-title":"Cyclodextrins as a potential carrier in drug nebulization","volume":"96","author":"B Evrard","year":"2004","journal-title":"J. Controlled Release"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijpharm.2012.06.055","article-title":"Cyclodextrins","volume":"453","author":"SV Kurkov","year":"2013","journal-title":"Int. J. Pharm"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0169-409X(98)00092-1","article-title":"Highly soluble cyclodextrin derivatives: chemistry, properties, and trends in development","volume":"36","author":"L Szente","year":"1999","journal-title":"Adv. Drug Del. Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1208\/s12249-013-9958-9","article-title":"Binding of Sulfamethazine to \u03b2-cyclodextrin and Methyl-\u03b2-cyclodextrin","volume":"14","author":"A Zoppi","year":"2013","journal-title":"AAPS PharmSciTech"},{"key":"ref21","unstructured":"Diaz D, Bernad Bernad Mj Fau - Gracia Mora J, Gracia Mora J Fau - Escobar Llanos CM, Escobar Llanos CM Complexation and solubility behavior of albendazole with some cyclodextrins."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.addr.2007.05.012","article-title":"Cyclodextrins as pharmaceutical solubilizers","volume":"59","author":"ME Brewster","year":"2007","journal-title":"Advanced Drug Delivery Reviews"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jconrel.2010.08.007","article-title":"Cyclodextrin complexed insulin encapsulated hydrogel microparticles: An oral delivery system for insulin","volume":"147","author":"S Sajeesh","year":"2010","journal-title":"J. Controlled Release"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.ejps.2010.07.013","article-title":"Enhanced oral absorption of saquinavir with Methyl-Beta-Cyclodextrin-Preparation and in vitro and in vivo evaluation","volume":"41","author":"SM Pathak","year":"2010","journal-title":"Eur. J. Pharm. Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.actatropica.2009.09.006","article-title":"Two novel ternary albendazole-cyclodextrin\u2013polymer systems: Dissolution, bioavailability and efficacy against Taenia crassiceps cysts","volume":"113","author":"F Palomares-Alonso","year":"2010","journal-title":"Acta Trop"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.carbpol.2013.08.078","article-title":"Cyclodextrins as encapsulation agents for plant bioactive compounds","volume":"101","author":"E Pinho","year":"2014","journal-title":"Carbohydr. Polym"},{"key":"ref27","first-page":"117","article-title":"Phase solubility techniques","volume":"4","author":"T Higuchi","year":"1965","journal-title":"Advances in Analytical Chemistry and Instrumentation"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.foodres.2009.09.025","article-title":"The use of 2D NMR to study \u03b2-cyclodextrin complexation and debittering of amino acids and peptides","volume":"43","author":"GA Linde","year":"2010","journal-title":"Food Res. Int"},{"key":"ref29","unstructured":"United States Pharmacopeial Convention (2012) The United States Pharmacopeia. Rockville, Maryland 35th ed."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.2042-7158.1976.tb02816.x","article-title":"Effect of disintegrant type upon the relationship between compressional pressure and dissolution efficiency","volume":"28","author":"KA Khan","year":"1976","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1017\/S0950268811000380","article-title":"Human beings are highly susceptible to low doses of Trichinella spp","volume":"140","author":"PF Teunis","year":"2012","journal-title":"Epidemiology Infection"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"6311","DOI":"10.1016\/j.bmc.2009.07.060","article-title":"Artemether\/hydroxypropyl-\u03b2-cyclodextrin host-guest system: Characterization, phase-solubility and inclusion mode","volume":"17","author":"B Yang","year":"2009","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ejpb.2008.09.027","article-title":"The influence of the preparation methods on the inclusion of model drugs in a \u03b2-cyclodextrin cavity","volume":"71","author":"PJ Sal\u00fastio","year":"2009","journal-title":"Eur. J. Pharm. Biopharm"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jpba.2008.10.032","article-title":"Physicochemical properties of antifungal drug-cyclodextrin complexes prepared by supercritical carbon dioxide and by conventional techniques","volume":"49","author":"AH Al-Marzouqi","year":"2009","journal-title":"J. Pharm. Biomed. Anal"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0113296","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T04:30:39Z","timestamp":1540009839000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0113296"}},"subtitle":[],"editor":[{"given":"M\u00e1ria A.","family":"Deli","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,18]]},"references-count":34,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0113296","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,18]]}}}