{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:48:15Z","timestamp":1791215295031,"version":"4.1.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0113554","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T19:45:26Z","timestamp":1417722326000},"page":"e113554","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protein Z Exerts Pro-Angiogenic Effects and Upregulates CXCR4"],"prefix":"10.1371","volume":"9","author":[{"given":"Antje","family":"Butschkau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana-Maria","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Genz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Vollmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1021\/bi972002a","article-title":"The gene for human protein Z is localized to chromosome 13 at band q34 and is coded by eight regular exons and one alternative exon","volume":"37","author":"K Fujimaki","year":"1998","journal-title":"Biochemistry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1172\/JCI111317","article-title":"Human Protein Z","volume":"73","author":"GJ Broze Jr","year":"1984","journal-title":"J Clin Invest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1042\/bst0050255","article-title":"The isolation of a new warfarin-sensitive protein from bovine plasma","volume":"5","author":"CV Prowse","year":"1977","journal-title":"Biochem Soc Trans"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1055\/s-0037-1616195","article-title":"Protein Z-dependent regulation of coagulation","volume":"86","author":"GJ Broze Jr","year":"2001","journal-title":"Thromb Haemost"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"9250","DOI":"10.1073\/pnas.95.16.9250","article-title":"Isolation of a protein Z-dependent plasma protease inhibitor","volume":"95","author":"X Han","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"11073","DOI":"10.1021\/bi990641a","article-title":"The protein Z-dependent protease inhibitor is a serpin","volume":"38","author":"X Han","year":"1999","journal-title":"Biochemistry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1073\/pnas.120081897","article-title":"Prothrombotic phenotype of protein Z deficiency","volume":"97","author":"ZF Yin","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1182\/blood-2007-12-126391","article-title":"Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency","volume":"111","author":"J Zhang","year":"2008","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1111\/j.1538-7836.2006.02186.x","article-title":"Low protein Z levels and risk of occurrence of deep vein thrombosis","volume":"4","author":"R Santacroce","year":"2006","journal-title":"J Thromb Haemost"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0140-6736(00)04218-5","article-title":"Frequency of protein Z deficiency in patients with ischaemic stroke","volume":"357","author":"M Vasse","year":"2001","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1160\/TH07-04-0300","article-title":"Low protein Z levels in patients with peripheral arterial disease","volume":"98","author":"F Sofi","year":"2007","journal-title":"Thromb Haemost"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1538-7836.2009.03325.x","article-title":"Protein Z-dependent protease inhibitor and protein Z in peripheral arterial disease patients","volume":"7","author":"F Sofi","year":"2009","journal-title":"J Thromb Haemost"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1161\/01.CIR.0000129968.46095.F3","article-title":"Heparin cofactor II is a novel protective factor against carotid atherosclerosis in elderly individuals","volume":"109","author":"K Aihara","year":"2004","journal-title":"Circulation"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"34256","DOI":"10.1074\/jbc.M112.353532","article-title":"Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMP-activated protein kinase-endothelial nitric-oxide synthase signaling pathway","volume":"287","author":"Y Ikeda","year":"2012","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"719570","DOI":"10.1155\/2013\/719570","article-title":"Low circulating protein C levels are associated with lower leg ulcers in patients with diabetes","volume":"2013","author":"K Whitmont","year":"2013","journal-title":"Biomed Res Int"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/oxfordjournals.jbchem.a123481","article-title":"Synthesis of protein C in human umbilical vein endothelial cells","volume":"109","author":"S Tanabe","year":"1991","journal-title":"J Biochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1161\/01.RES.0000133680.87668.FA","article-title":"Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo","volume":"95","author":"M Uchiba","year":"2004","journal-title":"Circ Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1096\/fj.09-134445","article-title":"Activated protein C utilizes the angiopoietin\/Tie2 axis to promote endothelial barrier function","volume":"24","author":"N Minhas","year":"2010","journal-title":"FASEB J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1074\/jbc.M110.181388","article-title":"Activated protein C enhances human keratinocyte barrier integrity via sequential activation of epidermal growth factor receptor and Tie2","volume":"286","author":"M Xue","year":"2011","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1160\/TH05-11-0723","article-title":"Human endothelial cells synthesize protein Z, but not the protein Z dependent inhibitor","volume":"95","author":"M Vasse","year":"2006","journal-title":"Thromb Haemost"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/ATVBAHA.109.192807","article-title":"Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity","volume":"30","author":"NM Heida","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1038\/nprot.2009.185","article-title":"Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia","volume":"4","author":"A Limbourg","year":"2009","journal-title":"Nat Protoc"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1161\/ATVBAHA.113.301783","article-title":"Toll-like receptor 2-blocking antibodies promote angiogenesis and induce ERK1\/2 and AKT signaling via CXCR4 in endothelial cells","volume":"33","author":"NM Wagner","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/74651","article-title":"Mechanisms of angiogenesis and arteriogenesis","volume":"6","author":"P Carmeliet","year":"2000","journal-title":"Nat Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nm1075","article-title":"Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1","volume":"108","author":"DJ Ceradini","year":"2004","journal-title":"Nat Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jvs.2009.10.044","article-title":"Angiogenic effects of stromal cell-derived factor-1 (SDF-1\/CXCL12) variants in vitro and the in vivo expressions of CXCL12 variants and CXCR4 in human critical leg ischemia","volume":"51","author":"TK Ho","year":"2010","journal-title":"J Vasc Surg"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1160\/TH09-09-0645","article-title":"A meta-analysis of potential risks of low levels of protein Z for diseases related to vascular thrombosis","volume":"103","author":"F Sofi","year":"2010","journal-title":"Thromb Haemost"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1160\/TH03-04-0237","article-title":"Low protein Z plasma levels are independently associated with acute coronary syndromes","volume":"90","author":"S Fedi","year":"2003","journal-title":"Thromb Haemost"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1111\/j.1538-7836.2005.01536.x","article-title":"Protein Z plasma levels in different phases of activity of coronary atherosclerosis","volume":"3","author":"F Sofi","year":"2005","journal-title":"J Thromb Haemost"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nm0603-653","article-title":"Angiogenesis in health and disease","volume":"9","author":"P Carmeliet","year":"2003","journal-title":"Nat Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1126\/science.1064981","article-title":"Biomedicine. Clotting factors build blood vessels","volume":"293","author":"P Carmeliet","year":"2001","journal-title":"Science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.yexcr.2009.10.024","article-title":"Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction","volume":"316","author":"MW Gramling","year":"2010","journal-title":"Exp Cell Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0113554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:24:12Z","timestamp":1589041452000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0113554"}},"subtitle":[],"editor":[{"given":"Ingo","family":"Ahrens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,4]]},"references-count":32,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0113554","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,4]]}}}