{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:22:19Z","timestamp":1779103339662,"version":"3.51.4"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0113613","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T18:54:40Z","timestamp":1416855280000},"page":"e113613","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Antagonism of Ionotropic Glutamate Receptors Attenuates Chemical Ischemia-Induced Injury in Rat Primary Cultured Myenteric Ganglia"],"prefix":"10.1371","volume":"9","author":[{"given":"Elisa","family":"Carpanese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Moretto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviana","family":"Filpa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Marchet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Moro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Crema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianmario","family":"Frigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Giaroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s004230050197","article-title":"Intestinal ischemia - the basics","volume":"384","author":"U Haglund","year":"1999","journal-title":"Langenbeck's Arch Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s00384-002-0408-5","article-title":"Crohn&apos;s disease: in defense of a microvascular aetiology","volume":"17","author":"M Thornton","year":"2002","journal-title":"Int J Colorectal Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1053\/j.sempedsurg.2005.05.003","article-title":"Ischemia and necrotizing enterocolitis: where, when, and how","volume":"14","author":"PT Nowicki","year":"2005","journal-title":"Semin Pediatr Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1023\/A:1012782321827","article-title":"Small bowel review. Diseases of the small intestine","volume":"46","author":"ABR Thomson","year":"2001","journal-title":"Dig Dis Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1023\/B:DDAS.0000037815.63547.08","article-title":"Structural and neuronal changes in rat ileum after ischemia with reperfusion","volume":"49","author":"LM Lindestr\u00f6m","year":"2004","journal-title":"Dig Dis Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00401-009-0549-5","article-title":"The reactions of specific neuron types to intestinal ischemia in the guinea pig enteric nervous system","volume":"118","author":"LR Rivera","year":"2009","journal-title":"Acta Neuropathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00441-010-1126-x","article-title":"Deleterious effects of intestinal ischemia\/reperfusion injury in the mouse enteric nervous system are associated with protein nitrosylation","volume":"344","author":"LR Rivera","year":"2011","journal-title":"Cell Tissue Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/S0024-3205(02)01966-5","article-title":"Alterations of intestinal motor responsiveness in a model of mild mesenteric ischemia\/reperfusion in rats","volume":"71","author":"V Ballabeni","year":"2002","journal-title":"Life Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2005.03.052","article-title":"Effect of N-methyl-<sc>d<\/sc>-aspartate receptor blockade on neuronal plasticity and gastrointestinal transit delay induced by ischemia\/reperfusion in rats","volume":"134","author":"F Calcina","year":"2005","journal-title":"Neuroscience"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuint.2005.10.005","article-title":"Involvement of glutamate receptors of the NMDA type in the modulation of acetylcholine and glutamate overflow from the guinea pig ileum during in vitro hypoxia and hypoglycaemia","volume":"48","author":"D Giuliani","year":"2006","journal-title":"Neurochem Int"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1111\/j.1365-2982.2010.01644.x","article-title":"Protein kinase C modulates NMDA receptors in the myenteric plexus of the guinea pig ileum during in vitro ischemia and reperfusion","volume":"23","author":"C Giaroni","year":"2011","journal-title":"Neurogastroenterol Motil"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00424-010-0809-1","article-title":"Glutamate receptors, neurotoxicity and neurodegeneration","volume":"460","author":"A Lau","year":"2001","journal-title":"Pflugers Arch"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1023\/A:1018899927786","article-title":"Intestinal motility during hypoxia and reoxygenation in vitro","volume":"42","author":"K Bielefeldt","year":"1997","journal-title":"Dig Dis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1471-4892(01)00101-1","article-title":"Glutamate in the enteric nervous system","volume":"1","author":"AL Kirchgessner","year":"2001","journal-title":"Curr Opin Pharmacol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1523\/JNEUROSCI.17-12-04764.1997","article-title":"Glutamatergic enteric neurons","volume":"17","author":"MT Liu","year":"1997","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0014-2999(03)02147-2","article-title":"Evidence for a glutamatergic modulation of the cholinergic function in the human enteric nervous system via NMDA receptors","volume":"476","author":"C Giarossni","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"8804","DOI":"10.1523\/JNEUROSCI.17-22-08804.1997","article-title":"Excitotoxicity in the enteric nervous system","volume":"17","author":"AL Kirchgessner","year":"1997","journal-title":"J Neurosci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejphar.2009.08.038","article-title":"The effects of NMDA receptor antagonists over intestinal ischemia\/reperfusion injury in rats","volume":"621","author":"CR C\u00e1mara-Lemarroy","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.neuro.2007.01.005","article-title":"Mechanisms of sodium azide-induced changes in intracellular calcium concentration in rat primary cortical neurons","volume":"28","author":"S Marino","year":"2007","journal-title":"Neurotoxicol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1074\/jbc.M209264200","article-title":"Development of novel fluorescence probes that can reliably detect reactive oxygen species and distinguish specific species","volume":"278","author":"K Setsukinai","year":"2003","journal-title":"J Biol Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.mito.2006.11.026","article-title":"Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage","volume":"7","author":"HP Indo","year":"2007","journal-title":"Mitochondrion"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s11064-008-9852-0","article-title":"Sodium azide induced neuronal damage in vitro: evidence for non-apoptotic cell death","volume":"34","author":"R Selvatici","year":"2009","journal-title":"Neurochem Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejphar.2008.12.010","article-title":"DDPH ameliorated oxygen and glucose deprivation-induced injury in rat hippocampal neurons via interrupting Ca<sup>2+<\/sup>overload and glutamate release","volume":"603","author":"Z He","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/(SICI)1097-4547(19990515)56:4<358::AID-JNR4>3.0.CO;2-G","article-title":"Increases in [Ca<sup>2+<\/sup>]<sub>i<\/sub> and changes in intracellular pH during chemical anoxia in mouse neocortical neurons in primary culture","volume":"56","author":"NK J\u00f8rgensen","year":"1999","journal-title":"J Neurosci Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/(SICI)1097-4547(19960401)44:1<40::AID-JNR5>3.0.CO;2-I","article-title":"Characterization of a chemical anoxia model in cerebellar granule neurons using sodium azide: protection by nifedipine and MK-801","volume":"44","author":"T Varming","year":"1996","journal-title":"J Neurosci Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neures.2004.07.010","article-title":"Angiotensin type 2 receptor neuroprotection against chemical hypoxia is dependent on the delayed rectifier K<sup>+<\/sup> channel, Na<sup>+<\/sup>\/Ca<sup>2+<\/sup> exchanger and Na<sup>+<\/sup>\/K<sup>+<\/sup> ATPase in primary cortical cultures","volume":"50","author":"TN Grammatopoulos","year":"2004","journal-title":"Neurosci Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/BF01181314","article-title":"Neurotrophic effects of NMDA activation on developing cerebellar granule cells","volume":"22","author":"RD Burgoyne","year":"1993","journal-title":"J Neurocytol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/jphysiol.1985.sp015633","article-title":"The action of N-methyl-D-apartic acid on mouse spinal neurones in culture","volume":"361","author":"ML Mayer","year":"1985","journal-title":"J Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1365-2982.1994.tb00178.x","article-title":"Myenteric ganglia from the adult guinea-pig small intestine in tissue culture","volume":"6","author":"M Hanani","year":"1994","journal-title":"Neurogastroenterol Motil"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.tins.2011.11.010","article-title":"GluN<sub>3<\/sub> subunit-containing NMDA receptors: not just one-trick ponies","volume":"35","author":"S Pachernegg","year":"2012","journal-title":"Trends Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2174\/1570159X11209040354","article-title":"Redox signaling pathways involved in neuronal ischemic preconditioning","volume":"10","author":"JW Thompson","year":"2012","journal-title":"Curr Neuropharmacol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.brainresbull.2004.06.001","article-title":"Differential effects of NMDA and AMPA\/kainate receptor antagonists on superoxide production and MnSOD activity in rat brain following intrahippocampal injection","volume":"64","author":"L Radenovic","year":"2004","journal-title":"Brain Res Bull"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0022-510X(95)00217-6","article-title":"CNQX prevents spinal motor neuron death following sciatic nerve transection in newborn rats","volume":"134","author":"Y Iwasaki","year":"1995","journal-title":"J Neurol Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"7727","DOI":"10.1523\/JNEUROSCI.18-19-07727.1998","article-title":"Rapid Ca<sup>2+<\/sup> entry through Ca<sup>2+<\/sup>-Permeable AMPA\/Kainate channels triggers marked intracellular Ca<sup>2+<\/sup> rises and consequent oxygen radical production","volume":"18","author":"SG Carriedo","year":"1998","journal-title":"J Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1523\/JNEUROSCI.20-01-00240.2000","article-title":"AMPA Exposure Induce Mitochondrial Ca<sup>2+<\/sup> overload and ROS generation in spinal motor neurons <italic>In Vitro<\/italic>","volume":"20","author":"SG Carriedo","year":"2000","journal-title":"J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0306-4522(94)90494-4","article-title":"Basal forebrain and cholinergic neurons are selectively vulnerable to AMPA\/Kainate receptor-mediated neurotoxicity","volume":"60","author":"JH Weiss","year":"1994","journal-title":"Neuroscience"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1474-9726.2006.00214.x","article-title":"Reactive oxygen species, dietary restriction and neurotrophic factors in age-related loss of myenteric neurons","volume":"5","author":"C Thrasivoulou","year":"2006","journal-title":"Aging Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/nmo.12061","article-title":"Role of neuronal and inducible nitric oxide synthases in the guinea pig ileum myenteric plexus during in vitro ischemia and reperfusion","volume":"25","author":"C Giaroni","year":"2013","journal-title":"Neurogastroenterol Motil"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0126418","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T00:00:00Z","timestamp":1428883200000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0113613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T11:29:24Z","timestamp":1589023764000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0113613"}},"subtitle":[],"editor":[{"given":"Nikos K.","family":"Karamanos","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,24]]},"references-count":38,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0113613","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0126418","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,24]]}}}