{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T05:54:15Z","timestamp":1771048455384,"version":"3.50.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0113763","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T19:36:31Z","timestamp":1416857791000},"page":"e113763","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Orally Administered Melatonin Prevents Lipopolysaccharide-Induced Neural Tube Defects in Mice"],"prefix":"10.1371","volume":"9","author":[{"given":"Lin","family":"Fu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Zhen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Biao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Xiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/S0016-5085(77)80025-5","article-title":"Endotoxin and bacteria in portal blood","volume":"72","author":"AI Jacob","year":"1977","journal-title":"Gastroenterology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0002-9440(10)63473-6","article-title":"A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production","volume":"163","author":"Z Zhou","year":"2003","journal-title":"Am J Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1530\/rep.0.1250095","article-title":"The fundamental role of increased production of nitric oxide in lipopolysaccharide-induced embryonic resorption in mice","volume":"125","author":"DG Ogando","year":"2003","journal-title":"Reproduction"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1096\/fasebj.12.2.189","article-title":"Interleukin-10 attenuates experimental fetal growth restriction and demise","volume":"12","author":"DL Rivera","year":"1998","journal-title":"FASEB J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1067\/mob.2003.112","article-title":"Protective effect of N-acetylcysteine against fetal death and preterm labor induced by maternal inflammation","volume":"188","author":"IA Buhimschi","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/toxsci\/kfi300","article-title":"Effect of N-acetylcysteine on lipopolysaccharide-induced intra-uterine fetal death and intra-uterine growth retardation in mice","volume":"88","author":"DX Xu","year":"2005","journal-title":"Toxicol Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tox.2007.02.010","article-title":"Effects of low-dose lipopolysaccharide (LPS) pretreatment on LPS-induced intra-uterine fetal death and preterm labor","volume":"234","author":"DX Xu","year":"2007","journal-title":"Toxicology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.ajog.2006.03.047","article-title":"Reactive oxygen species are involved in lipopolysaccharide-induced intrauterine growth restriction and skeletal development retardation in mice","volume":"195","author":"DX Xu","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.toxlet.2013.10.021","article-title":"Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice","volume":"224","author":"M Zhao","year":"2014","journal-title":"Toxicol Lett"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/toxsci\/kfn027","article-title":"Reactive oxygen species contribute to lipopolysaccharide-induced teratogenesis in mice","volume":"103","author":"L Zhao","year":"2008","journal-title":"Toxicol Sci"},{"key":"ref11","first-page":"173","article-title":"Role of the maternal acute phase response and tumor necrosis factor alpha in the developmental toxicity of lipopolysaccharide in the CD-1 mouse","volume":"16","author":"TM Leazer","year":"2002","journal-title":"Reprod Toxicol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxlet.2005.09.009","article-title":"Tumor necrosis factor alpha partially contributes to lipopolysaccharide-induced intra-uterine fetal growth restriction and skeletal development retardation in mice","volume":"163","author":"DX Xu","year":"2006","journal-title":"Toxicol Lett"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1179\/135100003225002709","article-title":"Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction","volume":"8","author":"AR Ressmeyer","year":"2003","journal-title":"Redox Rep"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1600-079X.2009.00701.x","article-title":"Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines","volume":"47","author":"R Hardeland","year":"2009","journal-title":"J Pineal Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1749-6632.1994.tb21831.x","article-title":"Melatonin\u2013a highly potent endogenous radical scavenger and electron donor: new aspects of the oxidation chemistry of this indole accessed in vitro","volume":"738","author":"B Poeggeler","year":"1994","journal-title":"Ann N Y Acad Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/jpi.12010","article-title":"On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK","volume":"54","author":"A Galano","year":"2013","journal-title":"J Pineal Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1600-079X.2006.00407.x","article-title":"One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?","volume":"42","author":"DX Tan","year":"2007","journal-title":"J Pineal Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1600-079X.2008.00614.x","article-title":"The melatonin metabolite N-acetyl-5-methoxykynuramine is a potent singlet oxygen scavenger","volume":"46","author":"M Schaefer","year":"2009","journal-title":"J Pineal Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1600-079X.2011.00943.x","article-title":"Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-kappaB and STAT\/GAS activity","volume":"52","author":"KJ Min","year":"2012","journal-title":"J Pineal Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1600-079X.2007.00445.x","article-title":"Maternally administered melatonin differentially regulates lipopolysaccharide-induced proinflammatory and anti-inflammatory cytokines in maternal serum, amniotic fluid, fetal liver, and fetal brain","volume":"43","author":"DX Xu","year":"2007","journal-title":"J Pineal Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-079X.2008.00621.x","article-title":"Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice","volume":"46","author":"YD Lee","year":"2009","journal-title":"J Pineal Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1600-079X.2012.01002.x","article-title":"Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells","volume":"53","author":"MZ Xia","year":"2012","journal-title":"J Pineal Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1600-079X.2012.00982.x","article-title":"Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-kappaB, c\/EBPbeta, and p300 signaling","volume":"53","author":"D Shi","year":"2012","journal-title":"J Pineal Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1600-079X.2005.00274.x","article-title":"Melatonin protects against lipopolysaccharide-induced intra-uterine fetal death and growth retardation in mice","volume":"40","author":"YH Chen","year":"2006","journal-title":"J Pineal Res"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Dominguez Rubio AP, Sordelli M, Salazar AI, Aisemberg J, Bariani MV, et al.. (2013) Melatonin Prevents Experimental Preterm Labor And Increases Offspring Survival. J Pineal Res. doi: 10.1111\/jpi.12108.","DOI":"10.1111\/jpi.12108"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1600-079X.2011.00945.x","article-title":"Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and alpha-synuclein aggregation","volume":"52","author":"CF Chang","year":"2012","journal-title":"J Pineal Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(08)00401-9","article-title":"Folate-mediated one-carbon metabolism","volume":"79","author":"JT Fox","year":"2008","journal-title":"Vitam Horm"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1126\/science.280.5372.2107","article-title":"Embryonic folate metabolism and mouse neural tube defects","volume":"280","author":"A Fleming","year":"1998","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4161\/epi.23988","article-title":"Epigenetic alterations in folate transport genes in placental tissue from fetuses with neural tube defects and in leukocytes from subjects with hyperhomocysteinemia","volume":"8","author":"SA Farkas","year":"2013","journal-title":"Epigenetics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev-nutr-072610-145133","article-title":"Mechanisms of membrane transport of folates into cells and across epithelia","volume":"31","author":"R Zhao","year":"2011","journal-title":"Annu Rev Nutr"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.placenta.2009.11.017","article-title":"Expression of folate transporters in human placenta and implications for homocysteine metabolism","volume":"31","author":"N Solanky","year":"2010","journal-title":"Placenta"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.placenta.2012.02.005","article-title":"Spatial and temporal expression of folate-related transporters and metabolic enzymes during mouse placental development","volume":"33","author":"J Cherukad","year":"2012","journal-title":"Placenta"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/jpi.12084","article-title":"Insulin and IGF1 enhance IL-17-induced chemokine expression through a GSK3B-dependent mechanism: a new target for melatonin's anti-inflammatory action","volume":"55","author":"D Ge","year":"2013","journal-title":"J Pineal Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/jpi.12087","article-title":"Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway","volume":"55","author":"Z Wang","year":"2013","journal-title":"J Pineal Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/jpi.12085","article-title":"Melatonin ameliorates vascular endothelial dysfunction, inflammation, and atherosclerosis by suppressing the TLR4\/NF-kappaB system in high-fat-fed rabbits","volume":"55","author":"ZP Hu","year":"2013","journal-title":"J Pineal Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/jpi.12045","article-title":"Melatonin mediates protective effects on inflammatory response induced by interleukin-1 beta in human mesenchymal stem cells","volume":"55","author":"X Liu","year":"2013","journal-title":"J Pineal Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/pr.2013.14","article-title":"Folic acid uptake by the human syncytiotrophoblast is affected by gestational diabetes, hyperleptinemia, and TNF-alpha","volume":"73","author":"JR Araujo","year":"2013","journal-title":"Pediatr Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1600-079X.2008.00586.x","article-title":"Melatonin preserves fetal growth in rats by protecting against ischemia\/reperfusion-induced oxidative\/nitrosative mitochondrial damage in the placenta","volume":"45","author":"R Nagai","year":"2008","journal-title":"J Pineal Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1600-079X.2009.00671.x","article-title":"Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy","volume":"46","author":"HG Richter","year":"2009","journal-title":"J Pineal Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/jpi.12121","article-title":"Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction","volume":"56","author":"SL Miller","year":"2014","journal-title":"J Pineal Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0113763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T05:02:49Z","timestamp":1650690169000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0113763"}},"subtitle":[],"editor":[{"given":"Zoha","family":"Kibar","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,11,24]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2014,11,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0113763","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,24]]}}}