{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:38:05Z","timestamp":1780425485868,"version":"3.54.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0113961","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T19:38:37Z","timestamp":1422646717000},"page":"e0113961","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Baseline Magnetic Resonance Imaging of the Optic Nerve Provides Limited Predictive Information on Short-Term Recovery after Acute Optic Neuritis"],"prefix":"10.1371","volume":"10","author":[{"given":"Sebastian","family":"Berg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Kaschka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin S.","family":"Utz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Huhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"L\u00e4mmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"L\u00e4mmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Waschbisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kloska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Hyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"Doerfler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf A.","family":"Linker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1745-6215-13-94","article-title":"Efficacy of vision restoration therapy after optic neuritis (VISION study): study protocol for a randomized controlled trial","volume":"13","author":"J Schinzel","year":"2012","journal-title":"Trials"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1874364101206010065","article-title":"Optic neuritis, its differential diagnosis and management","volume":"6","author":"H Hoorbakht","year":"2012","journal-title":"Open Ophthalmol J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/ICU.0b013e328358b202","article-title":"Management of optic neuritis as a clinically first event of multiple sclerosis","volume":"23","author":"N Kale","year":"2012","journal-title":"Curr Opin Ophthalmol"},{"key":"ref4","first-page":"182","article-title":"Optic neuritis","volume":"5","author":"MC Dooley","year":"2010","journal-title":"J Ophthalmic Vis Res"},{"key":"ref5","first-page":"1273","article-title":"Clinical practice","volume":"354","author":"LJ Balcer","year":"2006","journal-title":"Optic neuritis. N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neurol.2012.07.013","article-title":"Atypical forms of optic neuritis","volume":"168","author":"J de Seze","year":"2012","journal-title":"Rev Neurol (Paris)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.ajo.2005.01.031","article-title":"Evolving management of optic neuritis and multiple sclerosis","volume":"139","author":"AC Arnold","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1474-4422(05)00992-0","article-title":"The neuro-ophthalmology of multiple sclerosis","volume":"4","author":"EM Frohman","year":"2005","journal-title":"Lancet Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00055735-200212000-00006","article-title":"Acute demyelinating optic neuritis","volume":"13","author":"R Foroozan","year":"2002","journal-title":"Curr Opin Ophthalmol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(13)70259-X","article-title":"Optic neuritis","volume":"13","author":"AT Toosy","year":"2014","journal-title":"Lancet Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.ophtha.2007.08.004","article-title":"Visual function 15 years after optic neuritis: a final follow-up report from the Optic Neuritis Treatment Trial","volume":"115","year":"2008","journal-title":"Ophthalmology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/1352458509353650","article-title":"Early MRI in optic neuritis: the risk for clinically definite multiple sclerosis","volume":"16","author":"JK Swanton","year":"2010","journal-title":"Mult Scler"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s00415-005-0655-9","article-title":"Predicting the outcome of optic neuritis: evaluation of risk factors after 30 years of follow-up","volume":"252","author":"P Nilsson","year":"2005","journal-title":"J Neurol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1001\/archneur.61.9.1401","article-title":"The natural history of recurrent optic neuritis","volume":"61","author":"I Pirko","year":"2004","journal-title":"Arch Neurol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.neurol.2012.07.012","article-title":"Contribution of imaging to the diagnosis of optic neuropathies","volume":"168","author":"A Tourbah","year":"2012","journal-title":"Rev Neurol (Paris)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF00596577","article-title":"Lesion discrimination in optic neuritis using high-resolution fat-suppressed fast spin-echo MRI","volume":"38","author":"A Gass","year":"1996","journal-title":"Neuroradiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1007\/s00415-004-0477-1","article-title":"Visual recovery following acute optic neuritis--a clinical, electrophysiological and magnetic resonance imaging study","volume":"251","author":"SJ Hickman","year":"2004","journal-title":"J Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1093\/brain\/awf087","article-title":"Contrast-enhanced MRI in acute optic neuritis: relationship to visual performance","volume":"125","author":"MJ Kupersmith","year":"2002","journal-title":"Brain"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00004728-199103000-00006","article-title":"MR fat suppression combined with Gd-DTPA enhancement in optic neuritis and perineuritis","volume":"15","author":"RD Tien","year":"1991","journal-title":"J Comput Assist Tomogr"},{"key":"ref20","first-page":"713","article-title":"Enhancement and demyelination of the intraorbital optic nerve","volume":"99","author":"J Guy","year":"1992","journal-title":"Fat suppression magnetic resonance imaging. Ophthalmology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1212\/WNL.38.2.175","article-title":"Magnetic resonance imaging of the optic nerve in optic neuritis","volume":"38","author":"DH Miller","year":"1988","journal-title":"Neurology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/S0161-6420(96)30429-6","article-title":"Prognostic value of magnetic resonance imaging in monosymptomatic optic neuritis","volume":"103","author":"S Dunker","year":"1996","journal-title":"Ophthalmology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/1352458508091367","article-title":"Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography","volume":"14","author":"F Costello","year":"2008","journal-title":"Mult Scler"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ana.20575","article-title":"Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis","volume":"58","author":"SA Trip","year":"2005","journal-title":"Ann Neurol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1167\/iovs.07-0381","article-title":"Electrophysiological evidence for heterogeneity of lesions in optic neuritis","volume":"48","author":"A Klistorner","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/ana.21474","article-title":"Axonal loss and myelin in early ON loss in postacute optic neuritis","volume":"64","author":"A Klistorner","year":"2008","journal-title":"Ann Neurol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1212\/01.WNL.0000138437.99046.6B","article-title":"Plasma exchange for severe optic neuritis: treatment of 10 patients","volume":"63","author":"K Ruprecht","year":"2004","journal-title":"Neurology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1600-0404.2011.01612.x","article-title":"Treatment of steroid-unresponsive optic neuritis with plasma exchange","volume":"126","author":"S Roesner","year":"2012","journal-title":"Acta Neurol Scand"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1474-4422(07)70176-X","article-title":"MRI criteria for multiple sclerosis in patients presenting with clinically isolated syndromes: a multicentre retrospective study","volume":"6","author":"JK Swanton","year":"2007","journal-title":"Lancet Neurol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/ana.410340507","article-title":"Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis","volume":"34","author":"D Katz","year":"1993","journal-title":"Ann Neurol"},{"issue":"Pt 6","key":"ref31","first-page":"2437","article-title":"The pathophysiology of acute optic neuritis. An association of gadolinium leakage with clinical and electrophysiological deficits","volume":"114","author":"BD Youl","year":"1991","journal-title":"Brain"},{"key":"ref32","first-page":"446","article-title":"[Acute optic neuritis: clinical and MRI prognostic factors","volume":"158","author":"R Deschamps","year":"2002","journal-title":"Study of fifty patients]. Rev Neurol (Paris)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"821","DOI":"10.47102\/annals-acadmedsg.V38N9p821","article-title":"Magnetic resonance imaging in acute optic neuritis in Singapore","volume":"38","author":"SA Lim","year":"2009","journal-title":"Ann Acad Med Singapore"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00234-004-1308-x","article-title":"The optic nerve sheath on MRI in acute optic neuritis","volume":"47","author":"SJ Hickman","year":"2005","journal-title":"Neuroradiology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2415-12-36","article-title":"Assessment of visual disability using visual evoked potentials","volume":"12","author":"J Jeon","year":"2012","journal-title":"BMC Ophthalmol"},{"issue":"Suppl 1","key":"ref36","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1016\/S0039-6257(99)00095-8","article-title":"Serial visual evoked potentials in 90 untreated patients with acute optic neuritis","volume":"44","author":"JL Frederiksen","year":"1999","journal-title":"Surv Ophthalmol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10633-007-9072-y","article-title":"Correlation between full-field and multifocal VEPs in optic neuritis","volume":"116","author":"A Klistorner","year":"2008","journal-title":"Doc Ophthalmol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.3174\/ajnr.A2574","article-title":"Diffusion tensor imaging of the optic nerve in multiple sclerosis: association with retinal damage and visual disability","volume":"32","author":"SA Smith","year":"2011","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.neuroimage.2008.12.047","article-title":"Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis","volume":"45","author":"S Kolbe","year":"2009","journal-title":"Neuroimage"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuroimage.2005.09.024","article-title":"Optic nerve diffusion tensor imaging in optic neuritis","volume":"30","author":"SA Trip","year":"2006","journal-title":"Neuroimage"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1212\/01.wnl.0000335766.22758.cd","article-title":"Disability in optic neuritis correlates with diffusion tensor-derived directional diffusivities","volume":"72","author":"RT Naismith","year":"2009","journal-title":"Neurology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archneurol.2011.243","article-title":"Diffusion tensor imaging in acute optic neuropathies: predictor of clinical outcomes","volume":"69","author":"RT Naismith","year":"2012","journal-title":"Arch Neurol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e83825","DOI":"10.1371\/journal.pone.0083825","article-title":"Optic nerve diffusion tensor imaging after acute optic neuritis predicts axonal and visual outcomes","volume":"8","author":"A van der Walt","year":"2013","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1093\/brain\/awh076","article-title":"Serial magnetization transfer imaging in acute optic neuritis","volume":"127","author":"SJ Hickman","year":"2004","journal-title":"Brain"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e52291","DOI":"10.1371\/journal.pone.0052291","article-title":"Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes","volume":"7","author":"Y Wang","year":"2012","journal-title":"PLoS One"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1093\/brain\/awh284","article-title":"A serial MRI study following optic nerve mean area in acute optic neuritis","volume":"127","author":"SJ Hickman","year":"2004","journal-title":"Brain"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0113961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T09:14:48Z","timestamp":1690967688000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0113961"}},"subtitle":[],"editor":[{"given":"Markus","family":"Reindl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0113961","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]}}}