{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:51:25Z","timestamp":1791139885816,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0114137","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T20:25:57Z","timestamp":1417551957000},"page":"e114137","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["A New Model of Biodosimetry to Integrate Low and High Doses"],"prefix":"10.1371","volume":"9","author":[{"given":"M\u00f2nica","family":"Pujol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan-Francesc","family":"Barquinero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Puig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Rosa","family":"Caball\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"ref1","unstructured":"International Atomic Energy Agency (2011) Cytogenetic Dosimetry: Applications in Preparedness for and Response to Radiation Emergencies. Vienna."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1667\/RR2228.1","article-title":"Limitations associated with analysis of cytogenetic data for biological dosimetry","volume":"174","author":"VA Vinnikov","year":"2010","journal-title":"Radiat Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/095530097144058","article-title":"Biological dosimetry in simulated <italic>in vitro<\/italic> partial irradiations","volume":"71","author":"JF Barquinero","year":"1997","journal-title":"Int J Radiat Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1667\/0033-7587(2002)157[0461:SOFPTF]2.0.CO;2","article-title":"Suitability of FISH Painting Techniques for the Detection of Partial-Body Irradiations for Biological Dosimetry","volume":"157","author":"A Duran","year":"2002","journal-title":"Radiat Res"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.1269\/jrr.42.S149","article-title":"Cytogenetical dose estimation for 3 severely exposed patients in the JCO criticality accident in Tokai-mura","volume":"42","author":"I Hayata","year":"2001","journal-title":"J Radiat Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3109\/09553002.2010.481320","article-title":"Biological dose estimation for two severely exposed patients in a radiation accident in Shandong Jining, China, in 2004","volume":"86","author":"B Yao","year":"2010","journal-title":"Int J Radiat Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mrgentox.2012.11.005","article-title":"Estimation of the biological dose received by five victims of a radiation accident using three different cytogenetic tools","volume":"751","author":"B Yao","year":"2013","journal-title":"Mutat Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.mrfmmm.2009.07.003","article-title":"Cells bearing chromosome aberrations lacking one telomere are selectively blocked at the G2\/M checkpoint","volume":"670","author":"P Rodr\u00edguez","year":"2009","journal-title":"Mutat Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/0955300021000045655","article-title":"Chromosomal biodosimetry by unfolding a mixed Poisson distribution: a generalized model","volume":"79","author":"MS Sasaki","year":"2003","journal-title":"Int J Radiat Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/rpd\/ncs200","article-title":"Cytogenetic dose-response in vitro for biological dosimetry after exposure to high doses of gamma-rays","volume":"154","author":"VA Vinnikov","year":"2013","journal-title":"Radiat Prot Dosimetry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.radmeas.2011.04.001","article-title":"Biological dose estimation for accidental supra-high dose gamma-ray exposure","volume":"46","author":"Y Chen","year":"2011","journal-title":"Radiat Meas"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/rpd\/ncr326","article-title":"The use of caffeine to assess high dose exposures to ionising radiation by dicentric analysis","volume":"149","author":"M Pujol","year":"2012","journal-title":"Radiat Prot Dosimetry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.2307\/3576199","article-title":"Effect of caffeine on radiation-induced mitotic delay: delayed expression of G2 arrest","volume":"97","author":"R Rowley","year":"1984","journal-title":"Radiat Res"},{"key":"ref14","first-page":"4375","article-title":"Inhibition of ATM and ATR Kinase Activities by the Radiosensitizing Agent, Caffeine","volume":"59","author":"JN Sarkaria","year":"1999","journal-title":"Cancer Research"},{"key":"ref15","first-page":"1223","article-title":"G2-checkpoint abrogation in irradiated lymphocytes: A new cytogenetic approach to assess individual radiosensitivity and predisposition to cancer","volume":"35","author":"GI Terzoudi","year":"2009","journal-title":"International J Oncol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2307\/3001466","article-title":"Some small sample tests of significance for a Poisson distribution","volume":"12","author":"CR Rao","year":"1956","journal-title":"Biometrics"},{"key":"ref17","first-page":"331","article-title":"Distributions arising out of methods of ascertainment","volume":"2","author":"CR Rao","year":"1965","journal-title":"Sankhy\u0101 Series A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1080\/02664763.2013.800034","article-title":"Integer-valued autoregressive models for counts showing underdispersion","volume":"40","author":"CH Wei\u00df","year":"2013","journal-title":"J Appl Stat"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2307\/3576452","article-title":"The Use of Peripheral Blood Mononuclear Cell Prematurely Condensed Chromosomes for Biological Dosimetry","volume":"99","author":"GE Pantelias","year":"1984","journal-title":"Radiat Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/095530099140366","article-title":"Easy biodosimetry for high-dose radiation exposures using drug-induced, prematurely condensed chromosomes","volume":"75","author":"R Kanda","year":"1999","journal-title":"International J Radiat Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/09553000500092319","article-title":"Simple biodosimetry method for use in cases of high-dose radiation exposure that scores the chromosome number of Giemsa-stained drug-induced prematurely condensed chromosomes (PCC)","volume":"81","author":"E Gotoh","year":"2005","journal-title":"Int J Radiat Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mrgentox.2010.03.008","article-title":"Biodosimetry for high dose accidental exposures by drug induced premature chromosome condensation (PCC) assay","volume":"699","author":"S Balakrishnan","year":"2010","journal-title":"Mutat Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2013.03.013","article-title":"Suitability of scoring PCC rings and fragments for dose assessment after high-dose exposures to ionizing radiation","volume":"757","author":"R Puig","year":"2013","journal-title":"Mutat Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1269\/jrr.0625","article-title":"PCC-ring Induction in Human Lymphocytes Exposed to Gamma and Neutron Irradiation","volume":"48","author":"AI Lamadrid","year":"2007","journal-title":"J Radiat Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1667\/RR1843.1","article-title":"Premature chromosome condensation (PCC) assay for dose assessment in mass casualty accidents","volume":"173","author":"C Lindholm","year":"2010","journal-title":"Radiat Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1269\/jrr.10096","article-title":"Prematurely Condensed Chromosome Rings after Neutron Irradiation of Human Lymphocytes","volume":"535","author":"AI Lamadrid","year":"2011","journal-title":"J Radiat Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00411-005-0014-3","article-title":"Influence of mitotic delay on the results of biological dosimetry for high doses of ionizing radiation","volume":"44","author":"A Heimers","year":"2005","journal-title":"Radiat Environ Biophys"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1667\/RR1158.1","article-title":"Apoptosis Preferentially Eliminates Irradiated G0 Human Lymphocytes Bearing Dicentric Chromosomes","volume":"169","author":"AP Belloni","year":"2008","journal-title":"Radiat Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0027-5107(80)90092-5","article-title":"The use of harlequin staining to measure delay in the human lymphocyte cell cycle induced by in vitro X-irradiation","volume":"69","author":"RJ Purrott","year":"1980","journal-title":"Mutat Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF01323216","article-title":"Radiation induced chromosome aberrations and the Poisson distribution","volume":"16","author":"AA Edwards","year":"1979","journal-title":"Radiat Environ Biophys"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1080\/09553000050050909","article-title":"No dose-dependence of DNA double-strand break misrejoining following alpha-particle irradiation","volume":"76","author":"M K\u00fchne","year":"2000","journal-title":"Int J Radiat Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/(SICI)1098-2264(200001)27:1<59::AID-GCC8>3.0.CO;2-9","article-title":"Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts","volume":"27","author":"M L\u00f6brich","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1667\/RR1185.1","article-title":"Radiation-induced <italic>HPRT<\/italic> mutations resulting from misrejoined DNA double-strand breaks","volume":"169","author":"K Rothkamm","year":"2008","journal-title":"Radiat Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000077489","article-title":"Cytogenetic damage in lymphocytes for the purpose of dose reconstruction: a review of three recent radiation accidents","volume":"104","author":"A Wojcik","year":"2004","journal-title":"Cytogenet Genome Res"},{"key":"ref35","first-page":"321","article-title":"Chromosome-exchange aberrations in human lymphocytes","volume":"11","author":"A Norman","year":"1966","journal-title":"Int J Radiat Biol"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Jonhson NL, Kemp AW, Kotz S (2005) Mixture Distributions. In: Baldin DJ, Cressie NAC, Fisher NI, Johnstone IM, Kadane JB, Molenberghs G, Ryan LM, Scott DW, Smith AFM, Teugels JL, editors. Univariate Discrete Distributions. Wiley Interscience. 343\u2013380.","DOI":"10.1002\/0471715816.ch8"},{"key":"ref37","first-page":"45","article-title":"Radiation-induced chromosome aberration yields following an accidental non-uniform exposure","volume":"50","author":"B Sreedevi","year":"1993","journal-title":"Radiat Prot Dosimetry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1093\/oxfordjournals.rpd.a006090","article-title":"Cytogenic investigations of serious overexposures to an industrial gamma radiography source","volume":"102","author":"AV Sevan\u2019kaev","year":"2002","journal-title":"Radiat Prot Dosimetry"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1269\/jrr.07071","article-title":"Clinical Report of Three Cases of Acute Radiation Sickness from a 60Co Radiation Accident in Henan Province in China","volume":"49","author":"Q Liu","year":"2008","journal-title":"J Radiat Res"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0117767","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0114137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T12:41:48Z","timestamp":1589028108000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0114137"}},"subtitle":[],"editor":[{"given":"David O.","family":"Carpenter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,2]]},"references-count":39,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0114137","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0117767","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,2]]}}}