{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:21:14Z","timestamp":1791908474535,"version":"4.3.4"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0114229","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T15:11:41Z","timestamp":1417705901000},"page":"e114229","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Galectin-1 Overexpression in Endometriosis and Its Regulation by Neuropeptides (CRH, UCN) Indicating Its Important Role in Reproduction and Inflammation"],"prefix":"10.1371","volume":"9","author":[{"given":"Aikaterini","family":"Vergetaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Jeschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Vrekoussis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Taliouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Sabatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia A.","family":"Papakonstanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonis","family":"Makrigiannakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,12,4]]},"reference":[{"key":"ref1","first-page":"183","article-title":"[Endometrial biopsy]","volume":"11","author":"R Palmer","year":"1950","journal-title":"Ann Endocrinol (Paris)"},{"key":"ref2","unstructured":"Sampson JA (1927) Metastatic or Embolic Endometriosis, due to the Menstrual Dissemination of Endometrial Tissue into the Venous Circulation. Am J Pathol 3: 93\u2013110 143."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"SE Bulun","year":"2009","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"LC Giudice","year":"2004","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","article-title":"Clinical practice. Endometriosis","volume":"362","author":"LC Giudice","year":"2010","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0165-0378(98)00019-9","article-title":"The hormonal control of endometrial receptivity: estrogen (E2) and progesterone","volume":"39","author":"D de Ziegler","year":"1998","journal-title":"J Reprod Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00281-007-0077-0","article-title":"Neuroendocrine-immune disequilibrium and endometriosis: an interdisciplinary approach","volume":"29","author":"N Tariverdian","year":"2007","journal-title":"Semin Immunopathol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00109-009-0559-8","article-title":"Neuroendocrine circuitry and endometriosis: progesterone derivative dampens corticotropin-releasing hormone-induced inflammation by peritoneal cells in vitro","volume":"88","author":"N Tariverdian","year":"2010","journal-title":"J Mol Med (Berl)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1080\/09513590701581721","article-title":"Paracrine regulation of endometriotic tissue","volume":"23","author":"F Minici","year":"2007","journal-title":"Gynecol Endocrinol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0304-4165(02)00310-0","article-title":"Galectinomics: finding themes in complexity","volume":"1572","author":"DN Cooper","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/sj.cdd.4400535","article-title":"Galectins: an evolutionarily conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy","volume":"6","author":"GA Rabinovich","year":"1999","journal-title":"Cell Death Differ"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1507\/endocrj.K08E-111","article-title":"Expression and localization of galectin-9 in the human uterodome","volume":"55","author":"Y Shimizu","year":"2008","journal-title":"Endocr J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/molehr\/gah144","article-title":"Galectin fingerprinting in human endometrium and decidua during the menstrual cycle and in early gestation","volume":"11","author":"M von Wolff","year":"2005","journal-title":"Mol Hum Reprod"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1210\/me.2007-0243","article-title":"The membrane-spanning domain of CD98 heavy chain promotes alpha(v)beta3 integrin signals in human extravillous trophoblasts","volume":"22","author":"M Kabir-Salmani","year":"2008","journal-title":"Mol Endocrinol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/14767050802041961","article-title":"Severe preeclampsia is characterized by increased placental expression of galectin-1","volume":"21","author":"NG Than","year":"2008","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e28514","DOI":"10.1371\/journal.pone.0028514","article-title":"Galectin-1 is part of human trophoblast invasion machinery\u2013a functional study in vitro","volume":"6","author":"N Kolundzic","year":"2011","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/PAI.0b013e3181f5a05e","article-title":"Galectin-3 is overexpressed in various forms of endometriosis","volume":"19","author":"JC Noel","year":"2011","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"S249","DOI":"10.1016\/S0002-9378(99)70710-6","article-title":"Reproductive placental corticotropin-releasing hormone and its clinical implications","volume":"180","author":"GP Chrousos","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.7326\/0003-4819-129-3-199808010-00012","article-title":"Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: clinical implications","volume":"129","author":"GP Chrousos","year":"1998","journal-title":"Ann Intern Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1210\/er.2005-0034","article-title":"The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology","volume":"27","author":"EW Hillhouse","year":"2006","journal-title":"Endocr Rev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/10408360701548468","article-title":"Reproductive corticotropin releasing hormone, implantation, and fetal immunotolerance","volume":"44","author":"SN Kalantaridou","year":"2007","journal-title":"Crit Rev Clin Lab Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S1043-2760(02)00670-7","article-title":"Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists","volume":"13","author":"DK Grammatopoulos","year":"2002","journal-title":"Trends Endocrinol Metab"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1677\/joe.0.173R009","article-title":"Identification of urocortin mRNA and peptide in the human endometrium","volume":"173","author":"P Florio","year":"2002","journal-title":"J Endocrinol"},{"key":"ref24","first-page":"1427","article-title":"Human decidua and in vitro decidualized endometrial stromal cells at term contain immunoreactive corticotropin-releasing factor (CRF) and CRF messenger ribonucleic acid","volume":"74","author":"F Petraglia","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.peptides.2004.05.026","article-title":"Urocortins in human reproduction","volume":"25","author":"P Florio","year":"2004","journal-title":"Peptides"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1210\/jcem.82.5.3923","article-title":"Expression of corticotropin-releasing hormone and its R1 receptor in human endometrial stromal cells","volume":"82","author":"AM Di Blasio","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000127103","article-title":"Regulation of the promoter of the human corticotropin-releasing hormone gene in transfected human endometrial cells","volume":"64","author":"A Makrigiannakis","year":"1996","journal-title":"Neuroendocrinology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1749-6632.1997.tb52135.x","article-title":"Endometrial corticotropin-releasing hormone: expression, regulation, and potential physiological implications","volume":"816","author":"A Makrigiannakis","year":"1997","journal-title":"Ann N Y Acad Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.14310\/horm.2002.1161","article-title":"Stress neuropeptides in the human endometrium: paracrine effects on cell differentiation and apoptosis","volume":"1","author":"A Gravanis","year":"2002","journal-title":"Hormones (Athens)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/humrep\/del331","article-title":"Secretory endometrium highly expresses urocortin messenger RNA and peptide: possible role in the decidualization process","volume":"22","author":"M Torricelli","year":"2007","journal-title":"Hum Reprod"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1073\/pnas.0530162100","article-title":"Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation","volume":"100","author":"WG Ma","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/molehr\/5.9.789","article-title":"The decidualizing effect of progesterone may involve direct transcriptional activation of corticotrophin-releasing hormone from human endometrial stromal cells","volume":"5","author":"A Makrigiannakis","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1159\/000054507","article-title":"The transcription of corticotropin-releasing hormone in human endometrial cells is regulated by cytokines","volume":"70","author":"A Makrigiannakis","year":"1999","journal-title":"Neuroendocrinology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/molehr\/6.4.344","article-title":"Corticotrophin-releasing hormone (CRH) interacts with inflammatory prostaglandins and interleukins and affects the decidualization of human endometrial stroma","volume":"6","author":"E Zoumakis","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/ni719","article-title":"Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance","volume":"2","author":"A Makrigiannakis","year":"2001","journal-title":"Nat Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2353\/ajpath.2006.050167","article-title":"Corticotropin-releasing hormone modulates human trophoblast invasion through carcinoembryonic antigen-related cell adhesion molecule-1 regulation","volume":"168","author":"AM Bamberger","year":"2006","journal-title":"Am J Pathol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","volume":"25","author":"SK Dey","year":"2004","journal-title":"Endocr Rev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1472-6483(10)60942-X","article-title":"Factors controlling blastocyst implantation","volume":"10","author":"V Minas","year":"2005","journal-title":"Reprod Biomed Online"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0143-4004(05)80226-7","article-title":"Human trophoblast-endometrial interactions in an in vitro suspension culture system","volume":"11","author":"HJ Kliman","year":"1990","journal-title":"Placenta"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-0897.2004.00224.x","article-title":"Increased numbers of activated mast cells in endometriosis lesions positive for corticotropin-releasing hormone and urocortin","volume":"52","author":"D Kempuraj","year":"2004","journal-title":"Am J Reprod Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1210\/jc.2010-2263","article-title":"Impaired CRH and urocortin expression and function in eutopic endometrium of women with endometriosis","volume":"96","author":"R Novembri","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e62313","DOI":"10.1371\/journal.pone.0062313","article-title":"Differential expression of CRH, UCN, CRHR1 and CRHR2 in eutopic and ectopic endometrium of women with endometriosis","volume":"8","author":"A Vergetaki","year":"2013","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1210\/endo.137.12.8940412","article-title":"In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation","volume":"137","author":"EL Webster","year":"1996","journal-title":"Endocrinology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cellimm.2011.06.003","article-title":"Galectins distinctively regulate central monocyte and macrophage function","volume":"271","author":"D Paclik","year":"2011","journal-title":"Cell Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/oxfordjournals.jbchem.a021762","article-title":"Specific inhibition of lymphocyte proliferation and induction of apoptosis by CLL-I, a beta-galactoside-binding lectin","volume":"122","author":"GA Rabinovich","year":"1997","journal-title":"J Biochem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S1471-4906(02)02232-9","article-title":"Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?","volume":"23","author":"GA Rabinovich","year":"2002","journal-title":"Trends Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1023\/B:GLYC.0000014088.21242.e0","article-title":"Galectins as inflammatory mediators","volume":"19","author":"J Almkvist","year":"2004","journal-title":"Glycoconj J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nri2536","article-title":"Turning \u2018sweet\u2019 on immunity: galectin-glycan interactions in immune tolerance and inflammation","volume":"9","author":"GA Rabinovich","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(00)01630-7","article-title":"Immunobiology of endometriosis","volume":"75","author":"DI Lebovic","year":"2001","journal-title":"Fertil Steril"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"137R","DOI":"10.1093\/glycob\/cwl025","article-title":"Galectin-1: a small protein with major functions","volume":"16","author":"I Camby","year":"2006","journal-title":"Glycobiology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0304-4165(02)00314-8","article-title":"Role of galectins in inflammatory and immunomodulatory processes","volume":"1572","author":"GA Rabinovich","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/00001703-199810000-00003","article-title":"Endometriosis: abnormal endometrium and dysfunctional immune response","volume":"10","author":"DP Braun","year":"1998","journal-title":"Curr Opin Obstet Gynecol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1098-2795(199710)48:2<261::AID-MRD14>3.0.CO;2-0","article-title":"Expression of galectin-1 mRNA in the mouse uterus is under the control of ovarian steroids during blastocyst implantation","volume":"48","author":"YS Choe","year":"1997","journal-title":"Mol Reprod Dev"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/molehr\/gas043","article-title":"Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy","volume":"19","author":"I Tirado-Gonzalez","year":"2013","journal-title":"Mol Hum Reprod"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jri.2009.10.012","article-title":"Glycoprotein and carbohydrate binding protein expression in the placenta in early pregnancy loss","volume":"85","author":"U Jeschke","year":"2010","journal-title":"J Reprod Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/nm1680","article-title":"A pivotal role for galectin-1 in fetomaternal tolerance","volume":"13","author":"SM Blois","year":"2007","journal-title":"Nat Med"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0015-0282(01)01816-7","article-title":"Role of cytokines in endometriosis","volume":"76","author":"T Harada","year":"2001","journal-title":"Fertil Steril"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0015-0282(01)01878-7","article-title":"Treating endometriosis as an autoimmune disease","volume":"76","author":"WB Nothnick","year":"2001","journal-title":"Fertil Steril"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0114229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T00:32:34Z","timestamp":1566088354000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0114229"}},"subtitle":[],"editor":[{"given":"Renping","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,4]]},"references-count":58,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0114229","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,4]]}}}