{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:34:23Z","timestamp":1760549663068},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:00:00Z","timestamp":1418083200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0114360","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T18:57:56Z","timestamp":1418151476000},"page":"e114360","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased Osteoclastogenesis in Mice Lacking the Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1"],"prefix":"10.1371","volume":"9","author":[{"given":"Timo","family":"Heckt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bickert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Jeschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wulf D.","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Schinke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Kristina","family":"Horst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,12,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature01660","article-title":"Control of osteoblast function and regulation of bone mass","volume":"423","author":"S Harada","year":"2003","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrg1122","article-title":"Genetic regulation of osteoclast development and function","volume":"4","author":"SL Teitelbaum","year":"2003","journal-title":"Nat Rev Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1593","article-title":"Skeletal remodeling in health and disease","volume":"7","author":"M Zaidi","year":"2007","journal-title":"Nat Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"57S","DOI":"10.1016\/8756-3282(95)00179-H","article-title":"Osteoclast function in Paget&apos;s disease and multiple myeloma","volume":"17","author":"GD Roodman","year":"1995","journal-title":"Bone"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI13073","article-title":"Osteolysis and Cancer","volume":"107","author":"D Goltzman","year":"2001","journal-title":"J Clin Invest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1084\/jem.173.1.269","article-title":"Congenital osteoclast deficiency in osteopetrotic (op\/op) mice is cured by injections of macrophage colony-stimulating factor","volume":"173","author":"H Kodama","year":"1991","journal-title":"J Exp Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood.V99.1.111","article-title":"Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects","volume":"99","author":"XM Dai","year":"2002","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"DL Lacey","year":"1998","journal-title":"Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3597","DOI":"10.1073\/pnas.95.7.3597","article-title":"Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL","volume":"95","author":"H Yasuda","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"YY Kong","year":"1999","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"10905","DOI":"10.1073\/pnas.200294797","article-title":"Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene","volume":"97","author":"N Kim","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"26475","DOI":"10.1074\/jbc.M313973200","article-title":"Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos","volume":"279","author":"K Matsuo","year":"2004","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S1534-5807(02)00369-6","article-title":"Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts","volume":"3","author":"H Takayanagi","year":"2002","journal-title":"Dev Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"WJ Boyle","year":"2003","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"13361","DOI":"10.1073\/pnas.95.23.13361","article-title":"Bone homeostasis","volume":"95","author":"GA Rodan","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S8756-3282(98)00118-5","article-title":"Three rules for bone adaptation to mechanical stimuli","volume":"23","author":"CH Turner","year":"1998","journal-title":"Bone"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1182\/blood.V96.5.1953","article-title":"Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity","volume":"96","author":"T Michigami","year":"2000","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"11581","DOI":"10.1073\/pnas.201394498","article-title":"Multiple myeloma disrupts the TRANCE\/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression","volume":"98","author":"RN Pearse","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1359\/jbmr.2000.15.10.1912","article-title":"Intercellular adhesion molecule 1 discriminates functionally different populations of human osteoblasts: characteristic involvement of cell cycle regulators","volume":"15","author":"Y Tanaka","year":"2000","journal-title":"J Bone Miner Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ceb.2006.08.008","article-title":"CEACAMs: their role in physiology and pathophysiology","volume":"18","author":"K Kuespert","year":"2006","journal-title":"Curr Opin Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1161\/ATVBAHA.112.300015","article-title":"Acceleration of collateral development by carcinoembryonic antigen-related cell adhesion molecule 1 expression on CD11b\/<sup>+<\/sup>Gr-1<sup>+<\/sup> myeloid cells\u2013brief report","volume":"32","author":"T Bickert","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1161\/CIRCRESAHA.113.301207","article-title":"Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Inhibits MMP-9-Mediated Blood-Brain-Barrier Breakdown in a Mouse Model for Ischemic Stroke","volume":"113","author":"P Ludewig","year":"2013","journal-title":"Circ Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1128\/MCB.23.1.272-279.2003","article-title":"Carcinoembryonic antigen-related cell adhesion molecule 10 expressed specifically early in pregnancy in the decidua is dispensable for normal murine development","volume":"23","author":"D Finkenzeller","year":"2003","journal-title":"Mol Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1083\/jcb.201008012","article-title":"Control of bone formation by the serpentine receptor Frizzled-9","volume":"192","author":"J Albers","year":"2011","journal-title":"J Cell Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1083\/jcb.201207142","article-title":"Canonical Wnt signaling inhibits osteoclastogenesis independent of osteoprotegerin","volume":"200","author":"J Albers","year":"2013","journal-title":"J Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.ygeno.2005.07.008","article-title":"Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine <italic>Cea<\/italic> family","volume":"86","author":"R Zebhauser","year":"2005","journal-title":"Genomics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6726","DOI":"10.1182\/blood-2008-10-184556","article-title":"CEACAM1+ myeloid cells control angiogenesis in inflammation","volume":"113","author":"AK Horst","year":"2009","journal-title":"Blood"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1172\/JCI36389","article-title":"Evidence that cytokines play a role in rheumatoid arthritis","volume":"118","author":"FM Brennan","year":"2008","journal-title":"J Clin Invest"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI5703","article-title":"IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis","volume":"103","author":"S Kotake","year":"1999","journal-title":"J Clin Invest"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1056\/NEJMoa030847","article-title":"The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma","volume":"349","author":"E Tian","year":"2003","journal-title":"N Engl J Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0889-8588(05)70115-5","article-title":"The role of interleukin-1 beta in the pathogenesis of multiple myeloma","volume":"13","author":"JA Lust","year":"1999","journal-title":"Hematol Oncol Clin North Am"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.immuni.2012.07.016","article-title":"The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction","volume":"37","author":"L Chen","year":"2012","journal-title":"Immunity"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.bone.2009.12.020","article-title":"Decreased osteoclastogenesis and high bone mass in mice with impaired insulin clearance due to liver-specific inactivation to CEACAM1","volume":"46","author":"S Huang","year":"2010","journal-title":"Bone"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0114360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T18:42:31Z","timestamp":1598553751000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0114360"}},"subtitle":[],"editor":[{"given":"Chi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,9]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0114360","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,9]]}}}