{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:16:32Z","timestamp":1790669792677,"version":"4.1.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T00:00:00Z","timestamp":1417737600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0114445","type":"journal-article","created":{"date-parts":[[2014,12,5]],"date-time":"2014-12-05T19:00:01Z","timestamp":1417806001000},"page":"e114445","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Non-Vitamin K Antagonist Oral Anticoagulants and the Treatment of Venous Thromboembolism in Cancer Patients: A Semi Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes"],"prefix":"10.1371","volume":"9","author":[{"given":"Torben Bjerregaard","family":"Larsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Br\u00f8nnum","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Skj\u00f8th","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Hvilsted","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/0002-8703(87)90212-2","article-title":"Pulmonary embolism and thrombophlebitis in the United States, 1970\u20131985","volume":"114","author":"RF Gillum","year":"1987","journal-title":"Am Heart J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/ajh.20983","article-title":"Estimated annual numbers of US acute-care hospital patients at risk for venous thromboembolism","volume":"82","author":"FA Anderson","year":"2007","journal-title":"Am J Hematol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1160\/TH07-03-0212","article-title":"Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality","volume":"98","author":"AT Cohen","year":"2007","journal-title":"Thromb Haemost"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1182\/blood-2002-01-0108","article-title":"Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis","volume":"100","author":"P Prandoni","year":"2002","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-125-1-199607010-00001","article-title":"The long-term clinical course of acute deep venous thrombosis","volume":"125","author":"P Prandoni","year":"1996","journal-title":"Ann Intern Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1001\/archinte.162.11.1245","article-title":"Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study","volume":"162","author":"JA Heit","year":"2002","journal-title":"Arch Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1056\/NEJM199804233381701","article-title":"The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism","volume":"338","author":"HT S\u00f8rensen","year":"1998","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0140-6736(97)10018-6","article-title":"Venous thromboembolism and cancer","volume":"351","author":"JA Baron","year":"1998","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/MBC.0b013e328341f030","article-title":"Risk of recurrent venous thromboembolism according to malignancy characteristics in patients with cancer-associated thrombosis: a systematic review of observational and intervention studies","volume":"22","author":"ML Louzada","year":"2011","journal-title":"Blood Coagul Fibrinolysis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1056\/NEJM200012213432504","article-title":"Prognosis of cancers associated with venous thromboembolism","volume":"343","author":"HT S\u00f8rensen","year":"2000","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Agnelli G, Verso M, Mandal\u00e0 M, Gallus S, Cimminiello C, et al. (2013) A prospective study on survival in cancer patients with and without venous thromboembolism. Intern Emerg Med. doi:10.1007\/s11739-013-0985-z.","DOI":"10.1007\/s11739-013-0985-z"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1038\/sj.bjc.6605601","article-title":"Treatment and secondary prevention of venous thromboembolism in cancer","volume":"102","author":"R Coleman","year":"2010","journal-title":"Br J Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1160\/TH13-06-0443","article-title":"Vitamin K antagonists in heart disease: current status and perspectives (Section III). Position paper of the ESC Working Group on Thrombosis\u2013Task Force on Anticoagulants in Heart Disease","volume":"110","author":"R De Caterina","year":"2013","journal-title":"Thromb Haemost"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1160\/TH13-07-0556","article-title":"Cessation of oral anticoagulation in relation to mortality and the risk of thrombotic events in patients with atrial fibrillation","volume":"110","author":"P Gallego","year":"2013","journal-title":"Thromb Haemost"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e419S","DOI":"10.1378\/chest.11-2301","article-title":"Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"C Kearon","year":"2012","journal-title":"Chest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1056\/NEJMoa025313","article-title":"Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer","volume":"349","author":"AYY Lee","year":"2003","journal-title":"N Engl J Med"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Husted S, De Caterina R, Andreotti F, Arnesen H, Bachmann F, et al. (2014) Non-vitamin K antagonist oral anticoagulants (NOACs): No longer new or novel. Thromb Haemost 111. doi:10.1160\/TH14-03-0228.","DOI":"10.1160\/TH14-03-0228"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1056\/NEJMoa0906598","article-title":"Dabigatran versus warfarin in the treatment of acute venous thromboembolism","volume":"361","author":"S Schulman","year":"2009","journal-title":"N Engl J Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1007903","article-title":"Oral rivaroxaban for symptomatic venous thromboembolism","volume":"363","author":"R Bauersachs","year":"2010","journal-title":"N Engl J Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJMoa1113572","article-title":"Oral rivaroxaban for the treatment of symptomatic pulmonary embolism","volume":"366","author":"HR B\u00fcller","year":"2012","journal-title":"N Engl J Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1056\/NEJMoa1306638","article-title":"Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism","volume":"369","author":"HR B\u00fcller","year":"2013","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1302507","article-title":"Oral apixaban for the treatment of acute venous thromboembolism","volume":"369","author":"G Agnelli","year":"2013","journal-title":"N Engl J Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"62","author":"D Moher","year":"2009","journal-title":"J Clin Epidemiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"A Liberati","year":"2009","journal-title":"BMJ"},{"key":"ref25","unstructured":"The Cochrane Collaboration (2011) Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/handbook.cochrane.org\/\" xlink:type=\"simple\">http:\/\/handbook.cochrane.org\/<\/ext-link>. Accessed 5 August 2013."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"R DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients","volume":"3","author":"S Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1056\/NEJMoa025313","article-title":"Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer","volume":"349","author":"AYY Lee","year":"2003","journal-title":"N Engl J Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.amjmed.2006.02.022","article-title":"Long-term low-molecular-weight heparin versus usual care in proximal-vein thrombosis patients with cancer","volume":"119","author":"RD Hull","year":"2006","journal-title":"Am J Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/1076029606293692","article-title":"Secondary prevention of venous thromboembolic events in patients with active cancer: enoxaparin alone versus initial enoxaparin followed by warfarin for a 180-day period","volume":"12","author":"SR Deitcher","year":"2006","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1001\/archinte.162.15.1729","article-title":"Comparison of Low-Molecular-Weight Heparin and Warfarin for the Secondary Prevention of Venous Thromboembolism in Patients With Cancer","volume":"162","author":"G Meyer","year":"2002","journal-title":"Arch Intern Med"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Akl EA, Barba M, Rohilla S, Terrenato I, Sperati F, et al. (2008) Anticoagulation for the long term treatment of venous thromboembolism in patients with cancer. Cochrane database Syst Rev: CD006650. doi:10.1002\/14651858.CD006650.pub2.","DOI":"10.1002\/14651858.CD006650.pub2"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0114445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T01:36:38Z","timestamp":1566092198000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0114445"}},"subtitle":[],"editor":[{"given":"Yoshihiro","family":"Fukumoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,5]]},"references-count":32,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0114445","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,5]]}}}