{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:30:40Z","timestamp":1792161040279,"version":"4.4.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0114575","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T16:04:55Z","timestamp":1419350695000},"page":"e114575","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Accumulation of Self-Reactive Na\u00efve and Memory B Cell Reveals Sequential Defects in B Cell Tolerance Checkpoints in Sj\u00f6gren\u2019s Syndrome"],"prefix":"10.1371","volume":"9","author":[{"given":"Elisa","family":"Corsiero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurhan","family":"Sutcliffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Pitzalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bombardieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1002\/art.27564","article-title":"Significance of B cells and B cell clonality in Sjogren's syndrome","volume":"62","author":"P Youinou","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1365-2362.2010.02342.x","article-title":"Autoimmune response and target autoantigens in Sjogren's syndrome","volume":"40","author":"JG Routsias","year":"2010","journal-title":"Eur J Clin Invest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1002\/art.21347","article-title":"Antimuscarinic antibodies in Sjogren's syndrome: where are we, and where are we going?","volume":"52","author":"L Dawson","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"p63","DOI":"10.1159\/000104873","article-title":"Induction of anti-carbonic-anhydrase-II antibody causes renal tubular acidosis in a mouse model of Sjogren's syndrome","volume":"106","author":"F Takemoto","year":"2007","journal-title":"Nephron Physiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1126\/science.276.5312.604","article-title":"Identification of alpha-fodrin as a candidate autoantigen in primary Sjogren's syndrome","volume":"276","author":"N Haneji","year":"1997","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3109\/s10165-011-0514-8","article-title":"Generation and functional analysis of monoclonal antibodies against the second extracellular loop of human M3 muscarinic acetylcholine receptor","volume":"22","author":"H Tsuboi","year":"2012","journal-title":"Mod Rheumatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1002\/art.10445","article-title":"Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjogren's syndrome","volume":"46","author":"A Hansen","year":"2002","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.4049\/jimmunol.0803588","article-title":"Ectopic germinal centers are rare in Sjogren's syndrome salivary glands and do not exclude autoreactive B cells","volume":"182","author":"L Le Pottier","year":"2009","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.4049\/jimmunol.179.7.4929","article-title":"Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune sialoadenitis and MALT lymphoma in Sjogren's syndrome","volume":"179","author":"M Bombardieri","year":"2007","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1002\/art.11311","article-title":"Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjogren's syndrome","volume":"48","author":"S Salomonsson","year":"2003","journal-title":"Arthritis Rheum"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/art.21062","article-title":"Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjogren's syndrome","volume":"52","author":"F Barone","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1136\/ard.2010.144782","article-title":"Lymphoid organisation in labial salivary gland biopsies is a possible predictor for the development of malignant lymphoma in primary Sjogren's syndrome","volume":"70","author":"E Theander","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1084\/jem.20042321","article-title":"Impaired early B cell tolerance in patients with rheumatoid arthritis","volume":"201","author":"J Samuels","year":"2005","journal-title":"J Exp Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"H Wardemann","year":"2003","journal-title":"Science"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.coi.2008.09.001","article-title":"B-cell tolerance checkpoints in health and autoimmunity","volume":"20","author":"E Meffre","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1084\/jem.20042251","article-title":"Defective B cell tolerance checkpoints in systemic lupus erythematosus","volume":"201","author":"S Yurasov","year":"2005","journal-title":"J Exp Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jim.2007.09.017","article-title":"Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning","volume":"329","author":"T Tiller","year":"2008","journal-title":"J Immunol Methods"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"C Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"9727","DOI":"10.1073\/pnas.0803644105","article-title":"Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors","volume":"105","author":"B Mietzner","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1084\/jem.20052033","article-title":"A checkpoint for autoreactivity in human IgM+ memory B cell development","volume":"203","author":"M Tsuiji","year":"2006","journal-title":"J Exp Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.immuni.2007.01.009","article-title":"Autoreactivity in human IgG+ memory B cells","volume":"26","author":"T Tiller","year":"2007","journal-title":"Immunity"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fimmu.2012.00176","article-title":"Immunoglobulin analysis tool: a novel tool for the analysis of human and mouse heavy and light chain transcripts","volume":"3","author":"T Rogosch","year":"2012","journal-title":"Front Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0167-5699(94)90175-9","article-title":"The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement","volume":"15","author":"B Chang","year":"1994","journal-title":"Immunol Today"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5122","DOI":"10.4049\/jimmunol.165.9.5122","article-title":"The inference of antigen selection on Ig genes","volume":"165","author":"IS Lossos","year":"2000","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1046\/j.1365-3083.2003.01226.x","article-title":"Comparison of immunoglobulin heavy chain rearrangements between peripheral and glandular B cells in a patient with primary Sjogren's syndrome","volume":"57","author":"A Hansen","year":"2003","journal-title":"Scand J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s00018-011-0872-6","article-title":"Polyreactive antibodies in adaptive immune responses to viruses","volume":"69","author":"H Mouquet","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/ar2210","article-title":"B cells in Sjogren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue","volume":"9","author":"A Hansen","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.autrev.2010.05.005","article-title":"What do we know about memory B cells in primary Sjogren's syndrome?","volume":"9","author":"A Hansen","year":"2010","journal-title":"Autoimmun Rev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nri1838","article-title":"B-cell targeting in rheumatoid arthritis and other autoimmune diseases","volume":"6","author":"JC Edwards","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1002\/art.21260","article-title":"Rituximab treatment in patients with primary Sjogren's syndrome: an open-label phase II study","volume":"52","author":"J Pijpe","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"18044","DOI":"10.1073\/pnas.1113395108","article-title":"Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells","volume":"108","author":"JF Scheid","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Mouquet H, Nussenzweig MC (2011) Polyreactive antibodies in adaptive immune responses to viruses. Cell Mol Life Sci.","DOI":"10.1007\/s00018-011-0872-6"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1172\/JCI24179","article-title":"Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus","volume":"115","author":"A Cappione 3rd","year":"2005","journal-title":"J Clin Invest"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.autrev.2011.11.018","article-title":"Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells","volume":"11","author":"A Kessel","year":"2012","journal-title":"Autoimmun Rev"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1172\/JCI3234","article-title":"Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjogren's syndrome","volume":"102","author":"DI Stott","year":"1998","journal-title":"J Clin Invest"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0114575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,18]],"date-time":"2019-08-18T15:42:38Z","timestamp":1566142958000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0114575"}},"subtitle":[],"editor":[{"given":"Jay","family":"Reddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,23]]},"references-count":35,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0114575","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,23]]}}}