{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T18:14:52Z","timestamp":1781201692170,"version":"3.54.1"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T00:00:00Z","timestamp":1418947200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0115164","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T23:30:41Z","timestamp":1419031841000},"page":"e115164","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["A Multiplex Immunoassay Method for Simultaneous Quantification of Iron, Vitamin A and Inflammation Status Markers"],"prefix":"10.1371","volume":"9","author":[{"given":"Eleanor","family":"Brindle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Crudder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol E.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean","family":"Garrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Lyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1024\/0300-9831\/a000129","article-title":"Vitamins for the first 1000 days: preparing for life","volume":"82","author":"I Elmadfa","year":"2012","journal-title":"Int J Vitam Nutr Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e755","DOI":"10.1542\/peds.2011-3513","article-title":"Effect of iron deficiency anemia in pregnancy on child mental development in rural China","volume":"131","author":"S Chang","year":"2013","journal-title":"Pediatrics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1001\/jama.2013.7239","article-title":"Even mild iodine deficiency during gestation may impair brain function in children","volume":"309","author":"M Mitka","year":"2013","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e67860","DOI":"10.1371\/journal.pone.0067860","article-title":"The global hidden hunger indices and maps: an advocacy tool for action","volume":"8","author":"S Muthayya","year":"2013","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000345165","article-title":"Global burden of maternal and child undernutrition and micronutrient deficiencies","volume":"61","author":"T Ahmed","year":"2012","journal-title":"Ann Nutr Metab"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Bender D (2003) Vitamin A: retinoids and carotenoids. Nutritional Biochemistry of the Vitamins. Cambridge: Cambridge University Press. pp. 30\u201376.","DOI":"10.1017\/CBO9780511615191.003"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0140-6736(02)11403-6","article-title":"Selected major risk factors and global and regional burden of disease","volume":"360","author":"M Ezzati","year":"2002","journal-title":"Lancet"},{"key":"ref8","unstructured":"WHO (2009) Global prevalence of vitamin A deficiency in populations at risk 1995\u20132005. WHO Global Database on Vitamin A Deficiency. Geneva. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/whqlibdoc.who.int\/publications\/2009\/9789241598019_eng.pdf?ua=1\" xlink:type=\"simple\">http:\/\/whqlibdoc.who.int\/publications\/2009\/9789241598019_eng.pdf?ua=1<\/ext-link>."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0140-6736(13)60937-X","article-title":"Maternal and child undernutrition and overweight in low-income and middle-income countries","volume":"382","author":"RE Black","year":"2013","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1136\/archdischild-2011-300093","article-title":"Visual impairment in children in middle- and lower-income countries","volume":"96","author":"P Courtright","year":"2011","journal-title":"Arch Dis Child"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Cascella M, B\u00e4rfuss S, Stocker A (2013) Cis-retinoids and the chemistry of vision. Arch Biochem Biophys. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23791723\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23791723<\/ext-link>. Accessed 15 August 2013.","DOI":"10.1016\/j.abb.2013.06.003"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/clinchem\/22.10.1593","article-title":"Determination of serum retinol (vitamin A) by high-speed liquid chromatography","volume":"22","author":"MG De Ruyter","year":"1976","journal-title":"Clin Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.clinbiochem.2011.05.023","article-title":"Performance of the CRAFTi portable fluorometer comparing with the HPLC method for determining serum retinol","volume":"44","author":"L Chaimongkol","year":"2011","journal-title":"Clin Biochem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/ajcn\/73.3.594","article-title":"Retinol binding protein as a surrogate measure for serum retinol: studies in vitamin A-deficient children from the Republic of the Marshall Islands","volume":"73","author":"MV Gamble","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"658S","DOI":"10.3945\/ajcn.110.005777","article-title":"Vitamin A: biomarkers of nutrition for development","volume":"94","author":"a Tanumihardjo S","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2895S","DOI":"10.1093\/jn\/132.9.2895S","article-title":"Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein","volume":"132","author":"S de Pee","year":"2002","journal-title":"J Nutr"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Miller JL (2013) Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med 3. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23613366\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23613366<\/ext-link>. Accessed 15 August 2013.","DOI":"10.1101\/cshperspect.a011866"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1017\/S1368980008002401","article-title":"Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993\u20132005","volume":"12","author":"E McLean","year":"2009","journal-title":"Public Health Nutr"},{"key":"ref19","unstructured":"Stoltzfus R, Mullany L, Black R (2004) Iron Deficiency Anaemia. In: Ezzati M, Lopez AD, Rodgers A, Murray CJL, editors. Comparative quantification of health risks: The global and regional burden of disease attributable to selected major risk factors. Geneva: World Health Organization."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0009-8981(82)90115-2","article-title":"Determination of ferritin in urine and in serum of normal adults with a sensitive enzyme immunoassay","volume":"123","author":"K Ishikawa","year":"1982","journal-title":"Clin Chim Acta"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0009-8981(96)06375-9","article-title":"Soluble transferrin receptor-transferrin complex in serum: measurement by latex agglutination nephelometric immunoassay","volume":"254","author":"A Hikawa","year":"1996","journal-title":"Clin Chim Acta"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/00365519950185788","article-title":"Evaluation of kits for measurement of the soluble transferrin receptor","volume":"59","author":"A Akesson","year":"1999","journal-title":"Scand J Clin Lab Invest"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1093\/clinchem\/29.6.1109","article-title":"Three commercial methods for serum ferritin compared and the high-dose \u201chook effect\u201d eliminated","volume":"29","author":"RH Ng","year":"1983","journal-title":"Clin Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.beha.2004.08.022","article-title":"Diagnosis and management of iron-deficiency anaemia","volume":"18","author":"JD Cook","year":"2005","journal-title":"Best Pract Res Clin Haematol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/01.MIB.0000199223.27595.e3","article-title":"Ferritin as a simple indicator of iron deficiency in anemic IBD patients","volume":"12","author":"D Guagnozzi","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0009-8981(03)00005-6","article-title":"Soluble transferrin receptor for the evaluation of erythropoiesis and iron status","volume":"329","author":"Y Beguin","year":"2003","journal-title":"Clin Chim Acta"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1365-2257.2004.00600.x","article-title":"In patients who have stainable iron in the bone marrow an elevated plasma transferrin receptor value may reflect functional iron deficiency","volume":"26","author":"M Ervasti","year":"2004","journal-title":"Clin Lab Haematol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1365-2141.2001.03063.x","article-title":"The ratio of serum transferrin receptor and serum ferritin in the diagnosis of iron status","volume":"115","author":"BI Malope","year":"2001","journal-title":"Br J Haematol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/archinte.162.4.445","article-title":"Diagnosis of iron deficiency anemia in the elderly by transferrin receptor-ferritin index","volume":"162","author":"E Rimon","year":"2002","journal-title":"Arch Intern Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1600-0609.1998.tb01086.x","article-title":"Transferrin receptor-ferritin index: a useful parameter in differential diagnosis of iron deficiency and hyperplastic erythropoiesis","volume":"61","author":"J Cermak","year":"1998","journal-title":"Eur J Haematol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1258\/acb.2007.007167","article-title":"Interpreting indicators of iron status during an acute phase response\u2014lessons from malaria and human immunodeficiency virus","volume":"45","author":"CA Northrop-Clewes","year":"2008","journal-title":"Ann Clin Biochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3945\/ajcn.2010.29284","article-title":"Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis","volume":"92","author":"DI Thurnham","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0029665113003662","article-title":"Interactions between nutrition and immune function: using inflammation biomarkers to interpret micronutrient status","volume":"73","author":"DI Thurnham","year":"2014","journal-title":"Proc Nutr Soc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1093\/jn\/134.11.3127","article-title":"Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique","volume":"134","author":"JG Erhardt","year":"2004","journal-title":"J Nutr"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1177\/156482650802900406","article-title":"Application of retinol-binding protein enzyme immunoassay to dried blood spots to assess vitamin A deficiency in a population-based survey: the Uganda Demographic and Health Survey 2006","volume":"29","author":"RK Baingana","year":"2008","journal-title":"Food Nutr Bull"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1373\/clinchem.2009.127514","article-title":"Antibody-based protein multiplex platforms: technical and operational challenges","volume":"56","author":"a Ellington A","year":"2010","journal-title":"Clin Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1186\/ar3683","article-title":"A 4-trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation","volume":"14","author":"A Chiba","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.bbi.2012.02.008","article-title":"Stress management skills, neuroimmune processes and fatigue levels in persons with chronic fatigue syndrome","volume":"26","author":"EG Lattie","year":"2012","journal-title":"Brain Behav Immun"},{"key":"ref39","unstructured":"Davies C (2005) Introduction to Immunoassay Principles. In: Wild D, editor. The Immunoassay Handbook. Oxford, UK: Elsevier. pp. 3\u201340."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"685S","DOI":"10.3945\/ajcn.110.005751","article-title":"Field-friendly techniques for assessment of biomarkers of nutrition for development","volume":"94","author":"DA Garrett","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/ajcn\/79.1.93","article-title":"Development of a rapid enzyme immunoassay for the detection of retinol-binding protein","volume":"79","author":"J Hix","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jim.2010.09.014","article-title":"Serum, plasma, and dried blood spot high-sensitivity C-reactive protein enzyme immunoassay for population research","volume":"362","author":"E Brindle","year":"2010","journal-title":"J Immunol Methods"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"JM Bland","year":"1986","journal-title":"Lancet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1191\/096228099673819272","article-title":"Measuring agreement in method comparison studies","volume":"8","author":"JM Bland","year":"1999","journal-title":"Stat Methods Med Res"},{"key":"ref45","unstructured":"Baingana RK, Matovu-Kasozi D, Garrett DA (2012) The importance of controlling for the acute-phase response in the population-based assessment of vitamin A status: a study in children of pre-school age in Uganda. Public Health Nutr: 1\u20138. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23021569\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23021569<\/ext-link>. Accessed 2 January 2013."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1182\/blood.V92.5.1807","article-title":"An assessment of dried blood-spot technology for identifying iron deficiency","volume":"92","author":"JD Cook","year":"1998","journal-title":"Blood"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1182\/blood-2011-11-391219","article-title":"Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children","volume":"119","author":"AM Prentice","year":"2012","journal-title":"Blood"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0115164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T03:12:32Z","timestamp":1598584352000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0115164"}},"subtitle":[],"editor":[{"given":"Shantanu","family":"Sengupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,19]]},"references-count":47,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0115164","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,19]]}}}