{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:12:57Z","timestamp":1792793577374,"version":"4.5.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T00:00:00Z","timestamp":1418342400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0115209","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T22:01:05Z","timestamp":1418421665000},"page":"e115209","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":105,"title":["Decreased Serum Level of miR-146a as Sign of Chronic Inflammation in Type 2 Diabetic Patients"],"prefix":"10.1371","volume":"9","author":[{"given":"Lucy","family":"Balde\u00f3n R.","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Weigelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harm","family":"de Wit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behiye","family":"Ozcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri","family":"van Oudenaren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Semp\u00e9rtegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sijbrands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Grosse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilma","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemmo A.","family":"Drexhage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J. M.","family":"Leenen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,12,12]]},"reference":[{"issue":"5091","key":"ref1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance","volume":"259","author":"GS Hotamisligil","year":"1993","journal-title":"Science"},{"issue":"5249","key":"ref2","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.271.5249.665","article-title":"IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance","volume":"271","author":"GS Hotamisligil","year":"1996","journal-title":"Science"},{"issue":"22","key":"ref3","first-page":"13018","article-title":"Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase","volume":"271","author":"P Peraldi","year":"1996","journal-title":"The Journal of biological chemistry 1996"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1194\/jlr.M800402-JLR200","article-title":"Oxidized LDL impair adipocyte response to insulin by activating serine\/threonine kinases","volume":"50","author":"B Scazzocchio","year":"2009","journal-title":"Journal of lipid research"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"a000158","DOI":"10.1101\/cshperspect.a000158","article-title":"The IKK complex, a central regulator of NF-kappaB activation","volume":"2","author":"A Israel","year":"2010","journal-title":"Cold Spring Harbor perspectives in biology"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1083\/jcb.200601065","article-title":"Myosin motor Myo1c and its receptor NEMO\/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1","volume":"173","author":"Y Nakamori","year":"2006","journal-title":"The Journal of cell biology"},{"issue":"1","key":"ref7","first-page":"4","article-title":"Recent advances in the relationship between obesity, inflammation, and insulin resistance","volume":"17","author":"JP Bastard","year":"2006","journal-title":"European cytokine network"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12192-008-0073-x","article-title":"Inflammation, heat shock proteins, and type 2 diabetes","volume":"14","author":"PL Hooper","year":"2009","journal-title":"Cell stress & chaperones"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"e28146","DOI":"10.1371\/journal.pone.0028146","article-title":"The multi-level action of fatty acids on adiponectin production by fat cells","volume":"6","author":"S Karki","year":"2011","journal-title":"PloS one"},{"key":"ref10","first-page":"150","article-title":"Dyslipidemia in type 2 diabetes mellitus","volume":"5(3)","author":"AD Mooradian"},{"issue":"2","key":"ref11","first-page":"19","article-title":"Insulin and insulin resistance","volume":"26","author":"G Wilcox","year":"2005","journal-title":"The Clinical biochemist Reviews\/Australian Association of Clinical Biochemists"},{"issue":"24","key":"ref12","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1093\/eurheartj\/ehn387","article-title":"Adipose tissue dysfunction in obesity, diabetes, and vascular diseases","volume":"29","author":"GR Hajer","year":"2008","journal-title":"European heart journal"},{"key":"ref13","article-title":"Interleukin-6 in diabetes and cardiovascular complications","author":"D Qu","year":"2014","journal-title":"British journal of pharmacology"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Febbraio MA (2014) Role of interleukins in obesity: implications for metabolic disease. Trends in endocrinology and metabolism: TEM.","DOI":"10.1016\/j.tem.2014.02.004"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2337\/diacare.27.3.813","article-title":"Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes","volume":"27","author":"JC Pickup","year":"2004","journal-title":"Diabetes care"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"812","DOI":"10.2337\/diabetes.52.3.812","article-title":"Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study","volume":"52","author":"J Spranger","year":"2003","journal-title":"Diabetes"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2337\/diabetes.53.3.693","article-title":"Inflammatory markers and risk of developing type 2 diabetes in women","volume":"53","author":"FB Hu","year":"2004","journal-title":"Diabetes"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1463-1326.2009.01118.x","article-title":"Role and therapeutic potential of microRNAs in diabetes","volume":"11","author":"IG Kolfschoten","year":"2009","journal-title":"Diabetes, obesity & metabolism"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/CS20130079","article-title":"microRNA in the development of diabetic complications","volume":"126","author":"AD McClelland","year":"2014","journal-title":"Clin Sci (Lond)"},{"issue":"1\u20132","key":"ref20","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11010-011-0727-3","article-title":"Impaired miR-146a expression links subclinical inflammation and insulin resistance in Type 2 diabetes","volume":"351","author":"M Balasubramanyam","year":"2011","journal-title":"Molecular and cellular biochemistry"},{"issue":"50","key":"ref21","doi-asserted-by":"crossref","first-page":"38951","DOI":"10.1074\/jbc.M110.178848","article-title":"Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease","volume":"285","author":"JG Cui","year":"2010","journal-title":"The Journal of biological chemistry"},{"issue":"9","key":"ref22","first-page":"540","article-title":"[Expression of microRNA-146a in lipopolysaccharide challenged alveolar macrophages in vitro]","volume":"22","author":"F Liu","year":"2010","journal-title":"Zhongguo wei zhong bing ji jiu yi xue \u200a=\u200a Chinese critical care medicine \u200a=\u200a Zhongguo weizhongbing jijiuyixue"},{"issue":"50","key":"ref23","doi-asserted-by":"crossref","first-page":"34590","DOI":"10.1074\/jbc.M109.056317","article-title":"miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY","volume":"284","author":"MA Nahid","year":"2009","journal-title":"The Journal of biological chemistry"},{"issue":"33","key":"ref24","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"KD Taganov","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s10753-012-9467-0","article-title":"Association of MicroRNA-146a with autoimmune diseases","volume":"35","author":"WD Xu","year":"2012","journal-title":"Inflammation"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/jcp.21639","article-title":"MicroRNAs: novel regulators during the immune response","volume":"218","author":"Y Bi","year":"2009","journal-title":"Journal of cellular physiology"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"e35877","DOI":"10.1371\/journal.pone.0035877","article-title":"Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice","volume":"7","author":"MM Donners","year":"2012","journal-title":"PloS one"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.fob.2012.07.005","article-title":"Repressed induction of interferon-related microRNAs miR-146a and miR-155 in peripheral blood mononuclear cells infected with HCV genotype 4","volume":"2","author":"N El-Ekiaby","year":"2012","journal-title":"FEBS open bio"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.0610731104","article-title":"MicroRNA-155 is induced during the macrophage inflammatory response","volume":"104","author":"RM O'Connell","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.immuni.2010.09.009","article-title":"MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development","volume":"33","author":"RM O'Connell","year":"2010","journal-title":"Immunity"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/cvr\/cvn156","article-title":"Role of microRNAs in vascular diseases, inflammation, and angiogenesis","volume":"79","author":"C Urbich","year":"2008","journal-title":"Cardiovascular research"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1055\/s-0033-1341516","article-title":"Dysregulated miR-155 expression in peripheral blood mononuclear cells from patients with type 2 diabetes","volume":"121","author":"NE Corral-Fernandez","year":"2013","journal-title":"Experimental and clinical endocrinology & diabetes: official journal, German Society of Endocrinology [and] German Diabetes Association"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1038\/leu.2012.106","article-title":"Impact of serum storage conditions on microRNA stability","volume":"26","author":"S Grasedieck","year":"2012","journal-title":"Leukemia"},{"key":"ref34","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v3.23743","article-title":"Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood","volume":"3","author":"L Cheng","year":"2014","journal-title":"Journal of extracellular vesicles"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases","volume":"18","author":"X Chen","year":"2008","journal-title":"Cell research"},{"issue":"30","key":"ref36","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"PS Mitchell","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neulet.2009.04.052","article-title":"Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer&apos;s disease temporal lobe neocortex","volume":"459","author":"P Sethi","year":"2009","journal-title":"Neuroscience letters"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00592-010-0226-0","article-title":"Significance of serum microRNAs in pre-diabetes and newly diagnosed type 2 diabetes: a clinical study","volume":"48","author":"L Kong","year":"2011","journal-title":"Acta diabetologica"},{"key":"ref39","first-page":"S62","article-title":"Diabetes care","volume":"34","year":"2011"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1084\/jem.20101823","article-title":"miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice","volume":"208","author":"MP Boldin","year":"2011","journal-title":"The Journal of experimental medicine"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.4049\/jimmunol.180.8.5689","article-title":"Rapid changes in microRNA-146a expression negatively regulate the IL-1beta-induced inflammatory response in human lung alveolar epithelial cells","volume":"180","author":"MM Perry","year":"2008","journal-title":"J Immunol"},{"issue":"9","key":"ref42","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1161\/01.ATV.0000235691.84430.86","article-title":"Chemokines and incident coronary heart disease: results from the MONICA\/KORA Augsburg case-cohort study, 1984\u20132002","volume":"26","author":"C Herder","year":"2006","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"e39486","DOI":"10.1371\/journal.pone.0039486","article-title":"Cytokinome profile of patients with type 2 diabetes and\/or chronic hepatitis C infection","volume":"7","author":"S Costantini","year":"2012","journal-title":"PloS one"},{"key":"ref44","unstructured":"Freire WR, Ramirez MJ, Belmont P, Mendieta M, Silva K, <etal>et al<\/etal>. (2013) RESUMEN EJECUTIVO, TOMO I. Encuesta Nacional de Salud y Nutrici\u00f3n Ecuador. ENSANUT-ECU 2011\u20132013. In: Ministerio de Salud P\u00fablica\/Instituto Nacional de Estad\u00edstica y Censos Quito- Ecuador."},{"issue":"12","key":"ref45","doi-asserted-by":"crossref","first-page":"833","DOI":"10.5483\/BMBRep.2008.41.12.833","article-title":"The hepatocyte growth factor\/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis","volume":"41","author":"WK You","year":"2008","journal-title":"BMB reports"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/sj.ijo.0803316","article-title":"Hepatocyte growth factor secreted by cultured adipocytes promotes tube formation of vascular endothelial cells in vitro","volume":"30","author":"A Saiki","year":"2006","journal-title":"Int J Obes (Lond)"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1161\/ATVBAHA.107.157537","article-title":"Regulation of endothelial cell proliferation by primary monocytes","volume":"28","author":"SY Schubert","year":"2008","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2337\/db13-0333","article-title":"Hepatocyte growth factor\/c-Met signaling is required for beta-cell regeneration","volume":"63","author":"JC Alvarez-Perez","year":"2014","journal-title":"Diabetes"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1464-5491.2006.01849.x","article-title":"Clinical significance of circulating hepatocyte growth factor, a new risk marker of carotid atherosclerosis in patients with Type 2 diabetes","volume":"23","author":"K Satani","year":"2006","journal-title":"Diabetic medicine: a journal of the British Diabetic Association"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.cmet.2014.01.013","article-title":"Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes","volume":"19","author":"S Lee","year":"2014","journal-title":"Cell metabolism"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1371\/journal.pone.0000031","article-title":"Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes","volume":"1","author":"I Nagaev","year":"2006","journal-title":"PloS one"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.atherosclerosis.2005.02.014","article-title":"The potential role of resistin in atherogenesis","volume":"182","author":"MS Burnett","year":"2005","journal-title":"Atherosclerosis"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Rashid S (2013) Mechanism by which Elevated Resistin Levels Accelerate Atherosclerotic Cardiovascular Disease. Rheumatol Curr Res 3(115).","DOI":"10.4172\/2161-1149.1000115"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0115209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:30:20Z","timestamp":1589041820000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0115209"}},"subtitle":[],"editor":[{"given":"Walter","family":"Lukiw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,12]]},"references-count":53,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0115209","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,12]]}}}