{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T06:08:39Z","timestamp":1744178919217},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0115356","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T08:10:40Z","timestamp":1418976640000},"page":"e115356","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Different Arms of the Adaptive Immune System Induced by a Combination Vaccine Work in Concert to Provide Enhanced Clearance of Influenza"],"prefix":"10.1371","volume":"9","author":[{"given":"Joanna C. A.","family":"Cobbin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena E.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,12,18]]},"reference":[{"key":"ref1","unstructured":"Osterholm M, Kelley NS, Manske JM, Ballering KS, Leighton TR, <etal>et al<\/etal>. (October 2012) The compelling need for game-changing influenza vaccines: An analysis of the influenza vaccine enterprise and recommendations for the future. Comprehensive Influenza Vaccine Initiative (CCIVI), Center for Infectious Disease Research &amp; Policy. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cidrap.umn.edu\/cidrap\/files\/80\/ccivi\" xlink:type=\"simple\">http:\/\/www.cidrap.umn.edu\/cidrap\/files\/80\/ccivi<\/ext-link> report.pdf. Accessed 2014 December 1."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S1473-3099(11)70295-X","article-title":"Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis","volume":"12","author":"MT Osterholm","year":"2012","journal-title":"The Lancet Infectious Diseases"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/0264-410X(95)92777-Y","article-title":"Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein","volume":"13","author":"VA Slepushkin","year":"1995","journal-title":"Vaccine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/13484","article-title":"A universal influenza A vaccine based on the extracellular domain of the M2 protein","volume":"5","author":"W Fiers","year":"1999","journal-title":"Nature Medicine"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1016\/S0264-410X(03)00040-9","article-title":"Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2","volume":"21","author":"K Mozdzanowska","year":"2003","journal-title":"Vaccine"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/icb.2010.15","article-title":"A lipopeptide based on the M2 and HA proteins of influenza A viruses induces protective antibody","volume":"88","author":"D Pejoski","year":"2010","journal-title":"Immunology and Cell Biology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1126\/science.1171491","article-title":"Antibody recognition of a highly conserved influenza virus epitope","volume":"324","author":"DC Ekiert","year":"2009","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"18979","DOI":"10.1073\/pnas.1013387107","article-title":"Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes","volume":"107","author":"TT Wang","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e00018","DOI":"10.1128\/mBio.00018-10","article-title":"Influenza virus vaccine based on the conserved hemagglutinin stalk domain","volume":"1","author":"J Steel","year":"2010","journal-title":"mBio"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1126\/science.1192517","article-title":"Induction of broadly neutralizing H1N1 influenza antibodies by vaccination","volume":"329","author":"C-J Wei","year":"2010","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1128\/JVI.76.9.4212-4221.2002","article-title":"Induction of long-term memory CD8(+) T cells for recall of viral clearing responses against influenza virus","volume":"76","author":"G Deliyannis","year":"2002","journal-title":"Journal of Virology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"15440","DOI":"10.1073\/pnas.0406740101","article-title":"A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses","volume":"101","author":"DC Jackson","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.antiviral.2012.03.009","article-title":"Polyfunctional CD8(+) T cells are associated with the vaccination-induced control of a novel recombinant influenza virus expressing an HCV epitope","volume":"94","author":"ACL Tan","year":"2012","journal-title":"Antiviral Research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1128\/CVI.05441-11","article-title":"Effects of different adjuvants in the context of intramuscular and intranasal routes on humoral and cellular immune responses induced by detergent-split A\/H3N2 influenza vaccines in mice","volume":"19","author":"M Baz","year":"2012","journal-title":"Clinical and Vaccine Immunology"},{"key":"ref15","first-page":"276","article-title":"The human cytotoxic T cell response to influenza A vaccination","volume":"43","author":"AJ McMichael","year":"1981","journal-title":"Clinical and Experimental Immunology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/nm.3350","article-title":"Cellular immune correlates of protection against symptomatic pandemic influenza","volume":"19","author":"S Sridhar","year":"2013","journal-title":"Nature Medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/cid\/cis327","article-title":"Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans","volume":"55","author":"PJ Lillie","year":"2012","journal-title":"Clinical Infectious Diseases"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/eji.200535217","article-title":"Intranasal lipopeptide primes lung-resident memory CD8+ T cells for long-term pulmonary protection against influenza","volume":"36","author":"G Deliyannis","year":"2006","journal-title":"European Journal of Immunology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/intimm\/dxl114","article-title":"Lipid-containing mimetics of natural triggers of innate immunity as CTL-inducing influenza vaccines","volume":"18","author":"YF Lau","year":"2006","journal-title":"International Immunology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1750-2659.2009.00087.x","article-title":"Lipopeptide vaccines illustrate the potential role of subtype-crossreactive T cells in the control of highly virulent influenza","volume":"3","author":"WC Ng","year":"2009","journal-title":"Influenza and Other Respiratory Viruses"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.4049\/jimmunol.1201574","article-title":"Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity antibodies in the absence of neutralizing antibodies","volume":"190","author":"S Jegaskanda","year":"2013","journal-title":"Journal of Immunology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nm.3443","article-title":"Broadly neutralizing hemagglutinin stalk-specific antibodies require FcgammaR interactions for protection against influenza virus in vivo","volume":"20","author":"DJ DiLillo","year":"2014","journal-title":"Nature Medicine"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/intimm\/11.9.1431","article-title":"Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response","volume":"11","author":"L Harling-McNabb","year":"1999","journal-title":"International Immunology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1128\/IAI.43.2.457-462.1984","article-title":"Relative immunogenicity of the cold-adapted influenza virus A\/Ann Arbor\/6\/60 (A\/AA\/6\/60-ca), recombinants of A\/AA\/6\/60-ca, and parental strains with similar surface antigens","volume":"43","author":"GA Tannock","year":"1984","journal-title":"Infection and Immunity"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.4049\/jimmunol.169.9.4905","article-title":"Highly immunogenic and totally synthetic lipopeptides as self-adjuvanting immunocontraceptive vaccines","volume":"169","author":"W Zeng","year":"2002","journal-title":"Journal of Immunology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1006\/viro.1994.1073","article-title":"Conserved determinants for CD4+ T cells within the light chain of the H3 hemagglutinin molecule of influenza virus","volume":"198","author":"DC Jackson","year":"1994","journal-title":"Virology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0092-8674(86)90019-X","article-title":"The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides","volume":"44","author":"AR Townsend","year":"1986","journal-title":"Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0042-6822(86)90222-9","article-title":"Antigenic determinants of influenza virus hemagglutinin. XII. the epitopes of a synthetic peptide representing the C-terminus of HA1","volume":"155","author":"DC Jackson","year":"1986","journal-title":"Virology"},{"key":"ref29","unstructured":"Kendal AP, Pereira PM, Skehel JJ (1982) Concepts and procedures for laboratory-based influenza surveillance. Atlanta, GA: US Department of Health and Human Services, CDC."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2174\/156720105774370258","article-title":"Lipid-based self-adjuvanting vaccines","volume":"2","author":"LE Brown","year":"2005","journal-title":"Current Drug Delivery"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.molimm.2010.10.003","article-title":"Lipidation of intact proteins produces highly immunogenic vaccine candidates","volume":"48","author":"W Zeng","year":"2011","journal-title":"Molecular Immunology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.4049\/jimmunol.1100486","article-title":"Soluble proteins induce strong CD8+ T cell and antibody responses through electrostatic association with simple cationic or anionic lipopeptides that target TLR2","volume":"187","author":"BY Chua","year":"2011","journal-title":"Journal of Immunology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"7770","DOI":"10.1128\/JVI.00241-09","article-title":"Evaluation of Vaccines for H5N1 Influenza Virus in Ferrets Reveals the Potential for Protective Single-Shot Immunization","volume":"83","author":"D Middleton","year":"2009","journal-title":"Journal of Virology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/j.vaccine.2010.12.044","article-title":"The development of vaccine viruses against pandemic A(H1N1) influenza","volume":"29","author":"JS Robertson","year":"2011","journal-title":"Vaccine"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1056\/NEJMp1304661","article-title":"Global concerns regarding novel influenza A (H7N9) virus infections","volume":"368","author":"TM Uyeki","year":"2013","journal-title":"The New England Journal of Medicine"},{"key":"ref36","first-page":"1","article-title":"Major Challenges in Providing an Effective and Timely Pandemic Vaccine for Influenza A(H7N9)","author":"MT Osterholm","year":"2013","journal-title":"Journal of the American Medical Association"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0092-8674(88)90514-4","article-title":"Enhanced recognition of a modified peptide antigen by cytotoxic T cells specific for influenza nucleoprotein","volume":"52","author":"HC Bodmer","year":"1988","journal-title":"Cell"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1084\/jem.175.5.1221","article-title":"Extracellular processing of peptide antigens that bind class I major histocompatibility molecules","volume":"175","author":"LA Sherman","year":"1992","journal-title":"The Journal of Experimental Medicine"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0115356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T02:18:45Z","timestamp":1598581125000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0115356"}},"subtitle":[],"editor":[{"given":"Suryaprakash","family":"Sambhara","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,18]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0115356","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,18]]}}}