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Washington, D.C.: National Academies Press. Available: http:\/\/www.nap.edu\/catalog.php?record_id=12660<\/ext-link>. Accessed 9 May 2014."},{"key":"ref9","first-page":"546","article-title":"The precautionary principle and emerging biological risks: lessons from swine flu and HIV in blood products","volume":"117","author":"MA Stoto","year":"2002","journal-title":"Public Health Rep Wash DC 1974"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/jama.1996.03530270081036","article-title":"Cooperation between government and industry in combating a perceived emerging pandemic. The 1976 swine influenza vaccination program","volume":"275","author":"MR Hilleman","year":"1996","journal-title":"JAMA J Am Med Assoc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1093\/aje\/kws197","article-title":"Surveillance for adverse events following receipt of pandemic 2009 H1N1 vaccine in the Post-Licensure Rapid Immunization Safety Monitoring (PRISM) System, 2009-2010","volume":"175","author":"WK Yih","year":"2012","journal-title":"Am J Epidemiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1542\/peds.2010-1722L","article-title":"Immunization-safety monitoring systems for the 2009 H1N1 monovalent influenza vaccination program","volume":"127","author":"DA Salmon","year":"2011","journal-title":"Pediatrics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3201\/eid1906.121478","article-title":"Pandemic influenza planning, United States, 1978\u20132008","volume":"19","author":"J Iskander","year":"2013","journal-title":"Emerg Infect Dis"},{"key":"ref14","unstructured":"Pandemic Influenza Preparedness and Response: A WHO Guidance Document (2009) Geneva: World Health Organization. Available: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK143062\/<\/ext-link>. Accessed 26 August 2013."},{"key":"ref15","unstructured":"Institute of Medicine (US) Forum on Microbial Threats (2005) The Threat of Pandemic Influenza: Are We Ready? Workshop Summary. Knobler SL, Mack A, Mahmoud A, Lemon SM, editors Washington (DC): National Academies Press (US). Available: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK22156\/<\/ext-link>. Accessed 26 August 2013."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4161\/hv.7.1.13740","article-title":"The 2009 H1N1 influenza pandemic: a case study of how modeling can assist all stages of vaccine decision-making","volume":"7","author":"BY Lee","year":"2011","journal-title":"Hum Vaccin"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Wagner M, Tsui F, Cooper G, Espino JU, Harkema H, et al<\/etal>..<\/bold> (2011) Probabilistic, Decision-theoretic Disease Surveillance and Control. Online J Public Health Inform 3. doi:10.5210\/ojphi.v3i3.3798<\/ext-link>.","DOI":"10.5210\/ojphi.v3i3.3798"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/aje\/kwq497","article-title":"Planning for the control of pandemic influenza A (H1N1) in Los Angeles County and the United States","volume":"173","author":"DL Chao","year":"2011","journal-title":"Am J Epidemiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e19515","DOI":"10.1371\/journal.pone.0019515","article-title":"The global transmission and control of influenza","volume":"6","author":"E Kenah","year":"2011","journal-title":"PloS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3934\/mbe.2011.8.123","article-title":"Modelling the strategies for age specific vaccination scheduling during influenza pandemic outbreaks","volume":"8","author":"DH Knipl","year":"2011","journal-title":"Math Biosci Eng MBE"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1186\/1471-2458-11-932","article-title":"Vaccination against 2009 pandemic H1N1 in a population dynamical model of Vancouver, Canada: timing is everything","volume":"11","author":"JM Conway","year":"2011","journal-title":"BMC Public Health"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1016\/j.vaccine.2010.05.002","article-title":"A computer simulation of vaccine prioritization, allocation, and rationing during the 2009 H1N1 influenza pandemic","volume":"28","author":"BY Lee","year":"2010","journal-title":"Vaccine"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1126\/science.1177373","article-title":"The transmissibility and control of pandemic influenza A (H1N1) virus","volume":"326","author":"Y Yang","year":"2009","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1126\/science.1175570","article-title":"Optimizing influenza vaccine distribution","volume":"325","author":"J Medlock","year":"2009","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e387","DOI":"10.1371\/journal.pmed.0030387","article-title":"A comparative analysis of influenza vaccination programs","volume":"3","author":"S Bansal","year":"2006","journal-title":"PLoS Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e1002964","DOI":"10.1371\/journal.pcbi.1002964","article-title":"Optimal vaccine allocation for the early mitigation of pandemic influenza","volume":"9","author":"L Matrajt","year":"2013","journal-title":"PLoS Comput Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1186\/1471-2458-12-977","article-title":"School closure as an influenza mitigation strategy: how variations in legal authority and plan criteria can alter the impact","volume":"12","author":"MA Potter","year":"2012","journal-title":"BMC Public Health"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1007\/s11524-011-9603-4","article-title":"The role of subway travel in an influenza epidemic: a New York City simulation","volume":"88","author":"P Cooley","year":"2011","journal-title":"J Urban Health Bull N Y Acad Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/1471-2458-11-353","article-title":"Would school closure for the 2009 H1N1 influenza epidemic have been worth the cost?: a computational simulation of Pennsylvania","volume":"11","author":"ST Brown","year":"2011","journal-title":"BMC Public Health"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/aje\/kwh092","article-title":"Containing pandemic influenza with antiviral agents","volume":"159","author":"IM Longini Jr","year":"2004","journal-title":"Am J Epidemiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e2606","DOI":"10.1371\/journal.pone.0002606","article-title":"Effective, robust design of community mitigation for pandemic influenza: a systematic examination of proposed US guidance","volume":"3","author":"VJ Davey","year":"2008","journal-title":"PloS One"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1073\/pnas.0706849105","article-title":"Modeling targeted layered containment of an influenza pandemic in the United States","volume":"105","author":"ME Halloran","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1126\/science.1115717","article-title":"Containing pandemic influenza at the source","volume":"309","author":"IM Longini Jr","year":"2005","journal-title":"Science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/pds.2323","article-title":"The Food and Drug Administration's Post-Licensure Rapid Immunization Safety Monitoring program: strengthening the federal vaccine safety enterprise","volume":"21","author":"M Nguyen","year":"2012","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/EDE.0b013e31829dde59","article-title":"Medical product safety surveillance: how many databases to use?","volume":"24","author":"JC Maro","year":"2013","journal-title":"Epidemiol Camb Mass"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1016\/j.vaccine.2012.05.052","article-title":"Febrile events including convulsions following the administration of four brands of 2010 and 2011 inactivated seasonal influenza vaccine in NZ infants and children: the importance of routine active safety surveillance","volume":"30","author":"H Petousis-Harris","year":"2012","journal-title":"Vaccine"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.amepre.2011.04.004","article-title":"H1N1 and Seasonal Influenza Vaccine Safety in the Vaccine Safety Datalink Project","volume":"41","author":"GM Lee","year":"2011","journal-title":"Am J Prev Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.vaccine.2012.01.027","article-title":"Signal identification and evaluation for risk of febrile seizures in children following trivalent inactivated influenza vaccine in the Vaccine Safety Datalink Project, 2010\u20132011","volume":"30","author":"A Tse","year":"2012","journal-title":"Vaccine"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Dodd CN, Romio SA, Black S, Vellozzi C, Andrews N, et al<\/etal>..<\/bold> (2013) International collaboration to assess the risk of Guillain Barr\u00e9 Syndrome following Influenza A (H1N1) 2009 monovalent vaccines. Vaccine. doi:10.1016\/j.vaccine.2013.06.032<\/ext-link>.","DOI":"10.1016\/j.vaccine.2013.06.032"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(12)62189-8","article-title":"Association between Guillain-Barr\u00e9 syndrome and influenza A (H1N1) 2009 monovalent inactivated vaccines in the USA: a meta-analysis","volume":"381","author":"DA Salmon","year":"2013","journal-title":"Lancet"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1287\/mnsc.15.5.215","article-title":"A New Product Growth for Model Consumer Durables","volume":"15","author":"FM Bass","year":"1969","journal-title":"Manag Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijresmar.2009.12.012","article-title":"Innovation diffusion and new product growth models: A critical review and research directions","volume":"27","author":"R Peres","year":"2010","journal-title":"Int J Res Mark"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0048-7333(99)00092-X","article-title":"Models of technology diffusion","volume":"29","author":"P Geroski","year":"2000","journal-title":"Res Policy"},{"key":"ref44","unstructured":"Keeney RL, Raiffa H (1976) Decisions with multiple objectives: preferences and value tradeoffs. New York: Wiley. 569 p."},{"key":"ref45","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1186\/1471-2458-12-938","article-title":"Barriers to pandemic influenza vaccination and uptake of seasonal influenza vaccine in the post-pandemic season in Germany","volume":"12","author":"MM B\u00f6hmer","year":"2012","journal-title":"BMC Public Health"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1016\/j.vaccine.2011.06.107","article-title":"Factors associated with uptake of vaccination against pandemic influenza: a systematic review","volume":"29","author":"A Bish","year":"2011","journal-title":"Vaccine"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"D3","DOI":"10.1016\/j.vaccine.2010.08.024","article-title":"The 2009\u20132010 influenza pandemic: effects on pandemic and seasonal vaccine uptake and lessons learned for seasonal vaccination campaigns","volume":"28","author":"GA Poland","year":"2010","journal-title":"Vaccine"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e11226","DOI":"10.1371\/journal.pone.0011226","article-title":"Intent to receive pandemic influenza A (H1N1) vaccine, compliance with social distancing and sources of information in NC, 2009","volume":"5","author":"JA Horney","year":"2010","journal-title":"PloS One"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Keeney RL (2013) Foundations for Group Decision Analysis. Decis Anal. Available: http:\/\/da.journal.informs.org\/content\/early\/2013\/03\/13\/deca.2013.0265<\/ext-link>. Accessed 21 August 2013.","DOI":"10.1287\/deca.2013.0265"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11166-011-9121-5","article-title":"A theorem for Bayesian group decisions","volume":"43","author":"RL Keeney","year":"2011","journal-title":"J Risk Uncertain"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1016\/j.vaccine.2014.05.055","article-title":"The impact of pandemic A(H1N1)pdm09 influenza and vaccine-associated adverse events on parental attitudes and influenza vaccine uptake in young children","volume":"32","author":"CC Blyth","year":"2014","journal-title":"Vaccine"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1016\/j.vaccine.2011.06.075","article-title":"Pandemic influenza A (H1N1) vaccination in The Netherlands: parental reasoning underlying child vaccination choices","volume":"29","author":"M Bults","year":"2011","journal-title":"Vaccine"},{"key":"ref53","unstructured":"European Medicines Agency (2010) Benefit-risk methodology project: Work package 2 report: Applicability of current tools and processes for regulatory benefit-risk assessment. London, UK: European Medicines Agency. Available: http:\/\/www.ema.europa.eu\/ema\/index.jsp?curl=pages\/special_topics\/document_listing\/document_listing_000314.jsp&mid=WC0b01ac0580223ed6<\/ext-link>. Accessed 12 June 2014."},{"key":"ref54","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.publhealth.23.100901.140513","article-title":"HALYS and QALYS and DALYS, Oh My: similarities and differences in summary measures of population Health","volume":"23","author":"MR Gold","year":"2002","journal-title":"Annu Rev Public Health"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e000016","DOI":"10.1136\/bmjopen-2010-000016","article-title":"Epidemiological study of severe febrile reactions in young children in Western Australia caused by a 2010 trivalent inactivated influenza vaccine","volume":"1","author":"PK Armstrong","year":"2011","journal-title":"BMJ Open"},{"key":"ref56","unstructured":"Yih WK, Sandhu S, Nguyen MD, Zichittella L, McMahill-Walraven CN, et al<\/etal>..<\/bold> (2013) Accessing the Freshest Feasible Data for Conducting Active Influenza Vaccine Safety Surveillance. Mini-Sentin. Available: http:\/\/www.mini-sentinel.org\/work_products\/PRISM\/Mini-Sentinel_PRISM_Active-Influenza-Vaccine-Safety-Surveillance-Protocol.pdf<\/ext-link>. 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