{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:23:20Z","timestamp":1762323800830},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T00:00:00Z","timestamp":1426118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0115657","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T17:49:26Z","timestamp":1426182566000},"page":"e0115657","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["A Randomised, Double Blind Trial of N-Acetylcysteine for Hearing Protection during Stapes Surgery"],"prefix":"10.1371","volume":"10","clinical-trial-number":[{"clinical-trial-number":"nct00525551","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Dan","family":"Bagger-Sj\u00f6b\u00e4ck","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Str\u00f6mb\u00e4ck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Hakizimana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Plue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malou","family":"Hultcrantz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Papatziamos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Smeds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Danckwardt-Lilliestr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sten","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Tideholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Fridberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,3,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3109\/14992027.2012.707334","article-title":"Ear diseases and other risk factors for hearing impairment among adults: An epidemiological study","volume":"51","author":"S Hannula","year":"2012","journal-title":"Int J Audiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2273.1992.tb01004.x","article-title":"The prevalence of middle ear disease in the adult British population","volume":"17","author":"GG Browning","year":"1992","journal-title":"Clin Otolaryngol All Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"944","DOI":"10.3109\/00016489.2012.677859","article-title":"High frequency hearing following stapes surgery","volume":"132","author":"K Str\u00f6mb\u00e4ck","year":"2012","journal-title":"Acta Otolaryngol"},{"key":"ref4","first-page":"36","article-title":"The effect of stapes surgery on high frequency hearing in patients with otosclerosis","volume":"20","author":"SE Meyer","year":"1999","journal-title":"Am J Otol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/000348948609500402","article-title":"Air conduction thresholds after myringoplasty and stapes surgery: a conventional and high frequency audiometric comparison","volume":"95","author":"IW Mair","year":"1986","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/MAO.0b013e318172d6a3","article-title":"High-Frequency Sensorineural Hearing Loss After Stapedectomy","volume":"29","author":"M Bauchet St Martin","year":"2008","journal-title":"Otol Neurotol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/MAO.0b013e318161ab0f","article-title":"Outcome and lack of prognostic factors in stapes surgery","volume":"29","author":"J-M Gerard","year":"2008","journal-title":"Otol Neurotol"},{"key":"ref8","first-page":"267","article-title":"Transient depression of inner ear function after stapedotomy: Skeeter versus CO2 laser technique","volume":"65","author":"T Somers","year":"2007","journal-title":"Adv Otorhinolaryngol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000276097","article-title":"Pre- and postoperative high-freqeuncy audiometry in otosclerosis","volume":"52","author":"RA Tange","year":"1990","journal-title":"ORL"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0194-5998(96)70046-3","article-title":"Hearing loss as a complication of stapes surgery","volume":"115","author":"WJ Mann","year":"1998","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.anl.2011.07.009","article-title":"Effect of the stapedotomy technique on early post-operative hearing results\u2014Preliminary results","volume":"39","author":"T Just","year":"2012","journal-title":"Auris Nasus Larynx"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.3109\/00016489.2011.600725","article-title":"Evaluation of the noise generated by otological electrical drills and suction during cadaver surgery","volume":"131","author":"X Yin","year":"2011","journal-title":"Acta Otolaryngol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.aud.0000191942.36672.f3","article-title":"The role of oxidative stress in noise-induced hearing loss","volume":"27","author":"D Henderson","year":"2006","journal-title":"Ear Hear"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1080\/00016480601110188","article-title":"Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration","volume":"127","author":"EC Bielefeld","year":"2007","journal-title":"Acta Otolaryngol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2004.02.005","article-title":"Dose and time-dependent protection of the antioxidant N-L-acetylcysteine against impulse noise trauma","volume":"192","author":"M Duan","year":"2004","journal-title":"Hear Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0006-8993(02)04205-1","article-title":"Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea","volume":"966","author":"Y Ohinata","year":"2003","journal-title":"Brain Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0006-8993(97)01156-6","article-title":"Role of glutathione in protection against noise-induced hearing loss","volume":"784","author":"T Yamasoba","year":"1998","journal-title":"Brain Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.heares.2009.08.010","article-title":"Permanent and transient effects of locally delivered n-acetyl cysteine in a guinea pig model of cochlear implantation","volume":"259","author":"H Eastwood","year":"2010","journal-title":"Hear Res"},{"key":"ref19"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1517\/14728214.2011.552427","article-title":"Emerging treatments for noise-induced hearing loss","volume":"16","author":"N Oishi","year":"2011","journal-title":"Exp Op Emerg Drugs"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.4103\/1463-1741.90317","article-title":"Increased vitamin plasma levels in Swedish military personnel treated with nutrients prior to automatic weapon training","volume":"13","author":"CG Le Prell","year":"2011","journal-title":"Noise Health"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3766\/jaaa.17.4.5","article-title":"Efficacy of the antioxidant N-acetylcysteine (NAC) in protecting ears exposed to loud music","volume":"17","author":"S Kramer","year":"2006","journal-title":"J Am Acad Audiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.heares.2010.07.005","article-title":"N-Acetyl-cysteine against noise-induced temporary threshold shift in male workers","volume":"269","author":"CY Lin","year":"2010","journal-title":"Hear Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1365-2125.2001.01305.x","article-title":"Risk factors in the development of adverse reactions to N-acetylcysteine in patients with paracetamol poisoning","volume":"51","author":"LE Schmidt","year":"2001","journal-title":"Br J Clin Pharm"},{"key":"ref25","first-page":"70","article-title":"Protective effects of N-acetylcysteine on noise-induced hearing loss in guinea pigs","volume":"29","author":"AR Fetoni","year":"2009","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/S1474-4422(13)70160-1","article-title":"Tinnitus: causes and clinical management","volume":"12","author":"B Langguth","year":"2013","journal-title":"Lancet Neurology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/15563650802665587","article-title":"Adverse reactions associated with acetylcysteine","volume":"47","author":"EA Sandilands","year":"2009","journal-title":"Clin Toxicol"},{"key":"ref28","author":"AF Zuur","year":"2009"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.heares.2006.10.006","article-title":"Mechanisms of noise-induced hearing loss indicate multiple methods of prevention","volume":"226","author":"CG Le Prell","year":"2007","journal-title":"Hearing Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00606662","article-title":"Pharmacokinetics of N-Acetylcysteine in man","volume":"31","author":"L Borgstr\u00f6m","year":"1986","journal-title":"Eur J Clin Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0115657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:42:51Z","timestamp":1588970571000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0115657"}},"subtitle":[],"editor":[{"given":"Berthold","family":"Langguth","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,12]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0115657","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,12]]}}}