{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:17:37Z","timestamp":1791919057207,"version":"4.3.4"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T00:00:00Z","timestamp":1419897600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0115809","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T18:53:57Z","timestamp":1419965637000},"page":"e115809","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Role of High Mobility Group Box 1 (HMGB1) in SCA17 Pathogenesis"],"prefix":"10.1371","volume":"9","author":[{"given":"Li-Ching","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiung-Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin-Rong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Tsan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guey-Jen","family":"Lee-Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2014,12,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1146\/annurev.bi.65.070196.004005","article-title":"Biochemistry and structural biology of transcription factor IID (TFIID)","volume":"65","author":"SK Burley","year":"1996","journal-title":"Annu Rev Biochem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/0092-8674(90)90681-4","article-title":"Analysis of structure-function relationships of yeast TATA box binding factor TFIID","volume":"61","author":"M Horikoshi","year":"1990","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/j.1460-2075.1994.tb06366.x","article-title":"The N-terminal domain of the human TATA-binding protein plays a role in transcription from TATA-containing RNA polymerase II and III promoters","volume":"13","author":"A Lescure","year":"1994","journal-title":"EMBO J"},{"key":"ref4","first-page":"1182","article-title":"\u201cCryptic\u201d repeating triplets of purines and pyrimidines (cRRY(i)) are frequent and polymorphic: analysis of coding cRRY(i) in the proopiomelanocortin (POMC) and TATA-binding protein (TBP) genes","volume":"52","author":"B Gostout","year":"1993","journal-title":"Am J Hum Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1001\/archneur.59.4.623","article-title":"Trinucleotide repeats in 202 families with ataxia: a small expanded (CAG)n allele at the SCA17 locus","volume":"59","author":"I Silveira","year":"2002","journal-title":"Arch Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1212\/01.WNL.0000094123.09098.A0","article-title":"Intergenerational instability and marked anticipation in SCA-17","volume":"61","author":"F Maltecca","year":"2003","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1093\/hmg\/8.11.2047","article-title":"A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?","volume":"8","author":"R Koide","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/hmg\/10.14.1441","article-title":"SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein","volume":"10","author":"K Nakamura","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"17136","DOI":"10.1016\/S0021-9258(17)32531-0","article-title":"The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein","volume":"269","author":"H Ge","year":"1994","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1002\/j.1460-2075.1996.tb00878.x","article-title":"HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation","volume":"15","author":"V Zappavigna","year":"1996","journal-title":"EMBO J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/bies.950150807","article-title":"A signature for the HMG-1 box DNA-binding proteins","volume":"15","author":"D Landsman","year":"1993","journal-title":"Bioessays"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1074\/jbc.274.3.1628","article-title":"High mobility group protein 1 interacts specifically with the core domain of human TATA box-binding protein and interferes with transcription factor IIB within the pre-initiation complex","volume":"274","author":"M Sutrias-Grau","year":"1999","journal-title":"J Biol Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"32597","DOI":"10.1074\/jbc.M011792200","article-title":"The binding interaction of HMG-1 with the TATA-binding protein\/TATA complex","volume":"276","author":"D Das","year":"2001","journal-title":"J Biol Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature00858","article-title":"Release of chromatin protein HMGB1 by necrotic cells triggers inflammation","volume":"418","author":"P Scaffidi","year":"2002","journal-title":"Nature"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1074\/jbc.M306793200","article-title":"Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein","volume":"279","author":"JS Park","year":"2004","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1083\/jcb.200911078","article-title":"Endogenous HMGB1 regulates autophagy","volume":"190","author":"D Tang","year":"2010","journal-title":"J Cell Biol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1089\/ars.2010.3666","article-title":"High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress","volume":"15","author":"D Tang","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.4049\/jimmunol.1202472","article-title":"Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates","volume":"190","author":"HJ Min","year":"2013","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pneurobio.2011.08.013","article-title":"Autophagy and polyglutamine diseases","volume":"97","author":"M Jimenez-Sanchez","year":"2012","journal-title":"Prog Neurobiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/ncb1553","article-title":"Proteome analysis of soluble nuclear proteins reveals that HMGB1\/2 suppress genotoxic stress in polyglutamine diseases","volume":"9","author":"ML Qi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cca.2008.10.013","article-title":"Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis","volume":"400","author":"LC Lee","year":"2009","journal-title":"Clin Chim Acta"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cca.2009.12.002","article-title":"SCA17 repeat expansion: mildly expanded CAG\/CAA repeat alleles in neurological disorders and the functional implications","volume":"411","author":"CM Chen","year":"2010","journal-title":"Clin Chim Acta"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/hmg\/11.9.1137","article-title":"Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin","volume":"11","author":"A Wyttenbach","year":"2002","journal-title":"Hum Mol Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","article-title":"Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4","volume":"26","author":"R Scherz-Shouval","year":"2007","journal-title":"EMBO J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.biocel.2004.05.009","article-title":"LC3 conjugation system in mammalian autophagy","volume":"36","author":"I Tanida","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1046\/j.1440-1789.2000.00350.x","article-title":"Interaction of expanded polyglutamine stretches with nuclear transcription factors leads to aberrant transcriptional regulation in polyglutamine diseases","volume":"20","author":"T Shimohata","year":"2000","journal-title":"Neuropathology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1038\/nn2011","article-title":"Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration","volume":"10","author":"MJ Friedman","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1093\/brain\/awr146","article-title":"Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor","volume":"134","author":"S Huang","year":"2011","journal-title":"Brain"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e35302","DOI":"10.1371\/journal.pone.0035302","article-title":"Role of the CCAAT-binding protein NFY in SCA17 pathogenesis","volume":"7","author":"LC Lee","year":"2012","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/cdd.2009.144","article-title":"Essential role of the unfolded protein response regulator GRP78\/BiP in protection from neuronal apoptosis","volume":"17","author":"M Wang","year":"2010","journal-title":"Cell Death Differ"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0968-0004(98)01201-8","article-title":"Role of the CCAAT-binding protein CBF\/NF-Y in transcription","volume":"23","author":"SN Maity","year":"1998","journal-title":"Trends Biochem Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0378-1119(99)00368-6","article-title":"The molecular biology of the CCAAT-binding factor NF-Y","volume":"239","author":"R Mantovani","year":"1999","journal-title":"Gene"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1093\/nar\/gkp067","article-title":"HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha","volume":"37","author":"M Stros","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"N Mizushima","year":"2008","journal-title":"Nature"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"B Levine","year":"2008","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/brain\/awp292","article-title":"Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3","volume":"133","author":"FM Menzies","year":"2010","journal-title":"Brain"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/jmcb\/mjq005","article-title":"Polyglutamine diseases: where does toxicity come from? what is toxicity? where are we going?","volume":"2","author":"T Takahashi","year":"2010","journal-title":"J Mol Cell Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0115809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T16:41:59Z","timestamp":1650904919000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0115809"}},"subtitle":[],"editor":[{"given":"Vladimir V.","family":"Kalinichenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,30]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0115809","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,30]]}}}