{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:06:44Z","timestamp":1757704004894},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0115897","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T14:40:40Z","timestamp":1422628840000},"page":"e0115897","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Osteocyte-Derived Insulin-Like Growth Factor I Is Not Essential for the Bone Repletion Response in Mice"],"prefix":"10.1371","volume":"10","author":[{"given":"Kin-Hing William","family":"Lau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Baylink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilda H.-C.","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"ref1","first-page":"115","article-title":"Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis","volume":"21","author":"SC Manolagas","year":"2000","journal-title":"Endocr Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1146\/annurev.bioeng.8.061505.095721","article-title":"Biomechanical and molecular regulation of bone remodeling","volume":"8","author":"AG Robling","year":"2006","journal-title":"Annu Rev Biomed Eng"},{"key":"ref3","first-page":"1921","article-title":"Effects of short-term calcium depletion and repletion on biochemical markers of bone turnover in young adult women","volume":"83","author":"K Akesson","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/BF02061954","article-title":"Bone repletion in calcium deficient rats fed a high calcium diet","volume":"9","author":"M Stauffer","year":"1972","journal-title":"Calcif Tissue Res"},{"key":"ref5","first-page":"R190","article-title":"Regulation of bone repletion in rats subjected to varying low-calcium stress","volume":"246","author":"RH Drivdahl","year":"1984","journal-title":"Am J Physiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s002239900225","article-title":"High bone turnover is associated with low bone mass and spinal fracture in postmenopausal women","volume":"60","author":"P Ravn","year":"1997","journal-title":"Calcif Tissue Int"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1007\/s00198-012-1915-z","article-title":"Osteocyte regulation of bone mineral: a little give and take","volume":"23","author":"GJ Atkins","year":"2012","journal-title":"Osteoporos Int"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.bone.2007.12.224","article-title":"Osteocytes, mechanosensing and Wnt signaling","volume":"42","author":"LF Bonewald","year":"2008","journal-title":"Bone"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bone.2007.09.047","article-title":"Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading","volume":"42","author":"L You","year":"2008","journal-title":"Bone"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jbmr.320","article-title":"The amazing osteocyte","volume":"26","author":"LF Bonewald","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF02555907","article-title":"A model of osteon closure in cortical bone","volume":"47","author":"E Polig","year":"1990","journal-title":"Calcif Tissue Int"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"6267","DOI":"10.1093\/emboj\/cdg599","article-title":"Osteocyte control of bone formation via sclerostin, a novel BMP antagonist","volume":"22","author":"DG Winkler","year":"2003","journal-title":"EMBO J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1038\/nm.2452","article-title":"Evidence for osteocyte regulation of bone homeostasis through RANKL expression","volume":"17","author":"T Nakashima","year":"2011","journal-title":"Nat Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"J Xiong","year":"2011","journal-title":"Nat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrendo.2011.218","article-title":"Skeletal secretion of FGF-23 regulates phosphate and vitamin D metabolism","volume":"8","author":"LD Quarles","year":"2012","journal-title":"Nat Rev Endocrinol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bone.2013.01.046","article-title":"Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia","volume":"54","author":"JQ Feng","year":"2013","journal-title":"Bone"},{"key":"ref17","first-page":"30","article-title":"Bone growth factors","author":"S Mohan","year":"1991","journal-title":"Clin Orthop Relat Res:"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1172\/JCI118137","article-title":"Effects of rhIGF-I administration on bone turnover during short-term fasting","volume":"96","author":"SK Grinspoon","year":"1995","journal-title":"J Clin Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1210\/endo-127-3-1033","article-title":"Expression of insulin-like growth factor I stimulates normal somatic growth in growth hormone-deficient transgenic mice","volume":"127","author":"RR Behringer","year":"1990","journal-title":"Endocrinology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1210\/en.2002-220948","article-title":"Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms","volume":"144","author":"S Mohan","year":"2003","journal-title":"Endocrinology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1359\/jbmr.060610","article-title":"Role of IGF-I signaling in regulating osteoclastogenesis","volume":"21","author":"Y Wang","year":"2006","journal-title":"J Bone Miner Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/1874467211205020135","article-title":"Insulin like growth factor-I: a critical mediator of the skeletal response to parathyroid hormone","volume":"5","author":"DD Bikle","year":"2012","journal-title":"Curr Mol Pharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/jbmr.304","article-title":"PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling","volume":"26","author":"Y Rhee","year":"2011","journal-title":"J Bone Miner Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"20122","DOI":"10.1074\/jbc.M112.441360","article-title":"Parathyroid hormone (PTH)\/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH","volume":"288","author":"V Saini","year":"2013","journal-title":"J Biol Chem"},{"key":"ref25","first-page":"E937","article-title":"Osteocytic expression of mRNA for c-fos and IGF-I: an immediate early gene response to an osteogenic stimulus","volume":"270","author":"JM Lean","year":"1996","journal-title":"Am J Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bone.2012.09.027","article-title":"Disruption of the insulin-like growth factor-1 gene in osteocytes impairs developmental bone growth in mice","volume":"52","author":"MH Sheng","year":"2013","journal-title":"Bone"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"E271","DOI":"10.1152\/ajpendo.00092.2013","article-title":"Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity","volume":"305","author":"KH Lau","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1152\/ajplegacy.1973.225.2.269","article-title":"Decreased bone formation, mineralization, and enhanced resorption in calcium-deficient rats","volume":"225","author":"M Stauffer","year":"1973","journal-title":"Am J Physiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1093\/jn\/124.6.874","article-title":"Bone repair in calcium-deficient rats: comparison of xylitol+calcium carbonate with calcium carbonate, calcium lactate and calcium citrate on the repletion of calcium","volume":"124","author":"MM Hamalainen","year":"1994","journal-title":"J Nutr"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1210\/en.2003-0745","article-title":"Lack of insulin-like growth factor I exaggerates the effect of calcium deficiency on bone accretion in mice","volume":"144","author":"Y Kasukawa","year":"2003","journal-title":"Endocrinology"},{"key":"ref31","first-page":"93","article-title":"Bone cell and hormone changes during bone repletion","volume":"101","author":"CC Liu","year":"1982","journal-title":"Prog Clin Biol Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0221-8747(82)90019-4","article-title":"Acute reduction in osteoclast number during bone repletion","volume":"4","author":"CC Liu","year":"1982","journal-title":"Metab Bone Dis Relat Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF02555874","article-title":"Evaluation of the usefulness of serum phosphatases and osteocalcin as serum markers in a calcium depletion-repletion rat model","volume":"48","author":"H Tanimoto","year":"1991","journal-title":"Calcif Tissue Int"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1210\/endo-97-2-283","article-title":"Increases in number and size of osteoclasts in response to calcium or phosphorus deficiency in the rat","volume":"97","author":"ER Thompson","year":"1975","journal-title":"Endocrinology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S8756-3282(97)00277-9","article-title":"Effects of calcium depletion and repletion on serum insulin-like growth factor I and binding protein levels in weanling rats","volume":"22","author":"A Yoo","year":"1998","journal-title":"Bone"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S8756-3282(01)00693-7","article-title":"Regulation of bone volume is different in the metaphyses of the femur and vertebra of C3H\/HeJ and C57BL\/6J mice","volume":"30","author":"MH Sheng","year":"2002","journal-title":"Bone"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1681\/ASN.2011101006","article-title":"Calcium deficiency reduces circulating levels of FGF23","volume":"23","author":"ME Rodriguez-Ortiz","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"ref38","first-page":"358","article-title":"Downregulation of SOST\/sclerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes","author":"T Bellido","year":"2006","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"44005","DOI":"10.1074\/jbc.M208265200","article-title":"Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization","volume":"277","author":"M Zhang","year":"2002","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/jbmr.5650110905","article-title":"Down-regulation of the receptor for parathyroid hormone (PTH) and PTH-related peptide by PTH in primary fetal rat osteoblasts","volume":"11","author":"JW Jongen","year":"1996","journal-title":"J Bone Miner Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.2174\/138945011131400212","article-title":"Novel targets of vitamin D activity in bone: action of the vitamin D receptor in osteoblasts, osteocytes and osteoclasts","volume":"14","author":"JW Ryan","year":"2013","journal-title":"Curr Drug Targets"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"29809","DOI":"10.1074\/jbc.M113.485938","article-title":"Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes","volume":"288","author":"Y Rhee","year":"2013","journal-title":"J Biol Chem"},{"key":"ref43","first-page":"en20141046","article-title":"Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes","author":"AN Ben-Awadh","year":"2014","journal-title":"Endocrinology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"9576","DOI":"10.1074\/jbc.M509205200","article-title":"Up-regulation of the Wnt, estrogen receptor, insulin-like growth factor-I, and bone morphogenetic protein pathways in C57BL\/6J osteoblasts as opposed to C3H\/HeJ osteoblasts in part contributes to the differential anabolic response to fluid shear","volume":"281","author":"KH Lau","year":"2006","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bone.2013.07.022","article-title":"Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling","volume":"57","author":"SA Lloyd","year":"2013","journal-title":"Bone"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0115897","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T06:53:09Z","timestamp":1566283989000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0115897"}},"subtitle":[],"editor":[{"given":"Pierre J","family":"Marie","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0115897","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]}}}