{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:58:24Z","timestamp":1772103504121,"version":"3.50.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T00:00:00Z","timestamp":1419984000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0115916","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T18:53:15Z","timestamp":1420051995000},"page":"e115916","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Soluble AXL: A Possible Circulating Biomarker for Neurofibromatosis Type 1 Related Tumor Burden"],"prefix":"10.1371","volume":"9","author":[{"given":"Gunnar","family":"Johansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Chun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Yuan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiung-Fei","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Tai","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Liang","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Tin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Jen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2014,12,31]]},"reference":[{"key":"ref1","unstructured":"Friedman J, Gutmann D, MacCollin M, Riccardi V (1999) Neurofibromatosis-Phenotype, Natural History and Pathogensis. Baltimore, MA: The John Hopkins University Press."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<31::AID-AJMG7>3.0.CO;2-W","article-title":"Plexiform neurofibromas","volume":"89","author":"BR Korf","year":"1999","journal-title":"Am J Med Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1086\/320121","article-title":"Mortality in neurofibromatosis 1: an analysis using U.S. death certificates","volume":"68","author":"S Rasmussen","year":"2001","journal-title":"Am J Hum Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1158\/1078-0432.CCR-07-1305","article-title":"High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization","volume":"14","author":"KK Mantripragada","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0065-230X(08)00002-X","article-title":"TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer","volume":"100","author":"RM Linger","year":"2008","journal-title":"Adv Cancer Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1523\/JNEUROSCI.16-06-02012.1996","article-title":"Identification of Gas6 as a growth factor for human Schwann cells","volume":"16","author":"R Li","year":"1996","journal-title":"J Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1210\/en.2007-0039","article-title":"Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells","volume":"148","author":"SM Nielsen-Preiss","year":"2007","journal-title":"Endocrinology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/BF02303537","article-title":"Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors","volume":"1","author":"TM Weiner","year":"1994","journal-title":"Ann Surg Oncol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1038\/sj.onc.1203957","article-title":"The protein tyrosine kinase family of the human genome","volume":"19","author":"DR Robinson","year":"2000","journal-title":"Oncogene"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1038\/sj.onc.1210173","article-title":"A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors","volume":"26","author":"D Mahadevan","year":"2007","journal-title":"Oncogene"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1158\/0008-5472.CAN-08-4490","article-title":"Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL","volume":"69","author":"L Liu","year":"2009","journal-title":"Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/glia.10340","article-title":"CD44-independent hepatocyte growth factor\/c-Met autocrine loop promotes malignant peripheral nerve sheath tumor cell invasion in vitro","volume":"45","author":"W Su","year":"2004","journal-title":"Glia"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0046-8177(97)90060-5","article-title":"Hepatocyte growth factor and c-MET in benign and malignant peripheral nerve sheath tumors","volume":"28","author":"UN Rao","year":"1997","journal-title":"Hum Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1074\/jbc.270.2.551","article-title":"The transforming receptor tyrosine kinase, Axl, is post-translationally regulated by proteolytic cleavage","volume":"270","author":"JP O'Bryan","year":"1995","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1111\/j.1538-7836.2010.03752.x","article-title":"Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood","volume":"8","author":"C Ekman","year":"2010","journal-title":"J Thromb Haemost"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1158\/1078-0432.CCR-08-2514","article-title":"Differential expression of Axl and Gas6 in renal cell carcinoma reflecting tumor advancement and survival","volume":"15","author":"A Gustafsson","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1158\/0008-5472.CAN-05-3330","article-title":"Large-Scale Molecular Comparison of Human Schwann Cells to Malignant Peripheral Nerve Sheath Tumor Cell Lines and Tissues","volume":"66","author":"SJ Miller","year":"2006","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1158\/0008-5472.CAN-07-2734","article-title":"Tissue Inhibitor of Metalloproteinase-3 via Oncolytic Herpesvirus Inhibits Tumor Growth and Vascular Progenitors","volume":"68","author":"YY Mahller","year":"2008","journal-title":"Cancer Research"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1158\/1535-7163.MCT-07-2335","article-title":"Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors","volume":"7","author":"G Johansson","year":"2008","journal-title":"Mol Cancer Ther"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/09553009314550251","article-title":"Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients","volume":"63","author":"WK Dahlberg","year":"1993","journal-title":"Int J Radiat Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/1097-4547(20000901)61:5<524::AID-JNR7>3.0.CO;2-Z","article-title":"Long-term culture and characterization of human neurofibroma-derived Schwann cells","volume":"61","author":"T Rosenbaum","year":"2000","journal-title":"J Neurosci Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1158\/0008-5472.CAN-10-0833","article-title":"H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM","volume":"70","author":"MW Chen","year":"2010","journal-title":"Cancer Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"13571","DOI":"10.1074\/jbc.275.18.13571","article-title":"Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart","volume":"275","author":"LJ De Windt","year":"2000","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0092-8674(92)90407-4","article-title":"Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis","volume":"69","author":"J DeClue","year":"1992","journal-title":"Cell"},{"key":"ref25","first-page":"1085","article-title":"Efficient preparation of highly pure chlorin e6 and its photodynamic anti-cancer activity in a rat tumor model","volume":"22","author":"YH Moon","year":"2009","journal-title":"Oncol Rep"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0021-9258(18)70225-1","article-title":"Methods for the isolation of glycolytic intermediated by column chromatography with ion exchange resins","volume":"234","author":"GR Bartlett","year":"1959","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.phrs.2003.12.015","article-title":"Enhanced photodynamic antitumor effect on gastric cancer by a novel photosensitive stealth liposome","volume":"50","author":"Y Namiki","year":"2004","journal-title":"Pharmacol Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/lsm.20754","article-title":"Improved photodynamic inactivation of gram-positive bacteria using hematoporphyrin encapsulated in liposomes and micelles","volume":"41","author":"T Tsai","year":"2009","journal-title":"Lasers Surg Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/lsm.22124","article-title":"Photodynamic inactivation of chlorin e6-loaded CTAB-liposomes against Candida albicans","volume":"45","author":"YT Yang","year":"2013","journal-title":"Lasers Surg Med"},{"key":"ref30","first-page":"9518","article-title":"Phase II study of erlotinib in metastatic or unresectable malignant peripheral nerve sheath tumors (MPNST)","volume":"2006","author":"KH Albritton","year":"2006","journal-title":"Journal of Clinical Oncology, ASCO Annual Meeting Proceedings Part I Vol 24, No 18S (June 20 Supplement)"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/labinvest.3700591","article-title":"Imatinib mesylate inhibits cell invasion of malignant peripheral nerve sheath tumor induced by platelet-derived growth factor-BB","volume":"87","author":"M Aoki","year":"2007","journal-title":"Lab Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1172\/JCI7610","article-title":"Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models","volume":"105","author":"J DeClue","year":"2000","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/(SICI)1097-4652(199811)177:2<334::AID-JCP15>3.0.CO;2-9","article-title":"Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB","volume":"177","author":"A Badache","year":"1998","journal-title":"J Cell Physiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"9621","DOI":"10.1016\/S0021-9258(18)98395-X","article-title":"Identification of a soluble receptor for platelet-derived growth factor in cell-conditioned medium and human plasma","volume":"268","author":"J Tiesman","year":"1993","journal-title":"J Biol Chem"},{"key":"ref35","first-page":"103","article-title":"Soluble epidermal growth factor receptor (sEGFR\/sErbB1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancer","volume":"12","author":"AT Baron","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/(SICI)1097-4652(199609)168:3<737::AID-JCP27>3.0.CO;2-U","article-title":"Cleavage and release of a soluble form of the receptor tyrosine kinase ARK in vitro and in vivo","volume":"168","author":"M Costa","year":"1996","journal-title":"J Cell Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"7570","DOI":"10.1158\/0008-5472.CAN-10-1267","article-title":"AXL is an essential factor and therapeutic target for metastatic ovarian cancer","volume":"70","author":"EB Rankin","year":"2010","journal-title":"Cancer Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/onc.2012.587","article-title":"Axl\/Gas6\/NFkappaB signalling in schwannoma pathological proliferation, adhesion and survival","volume":"33","author":"S Ammoun","year":"2014","journal-title":"Oncogene"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0119975","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T00:00:00Z","timestamp":1426550400000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0115916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T19:43:42Z","timestamp":1650915822000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0115916"}},"subtitle":[],"editor":[{"given":"Raffaele A.","family":"Calogero","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2014,12,31]]},"references-count":38,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2014,12,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0115916","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,31]]}}}