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Human Papillomaviruses. Lyon: World Health Organization (2005)."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1349-7006.1994.tb02911.x","article-title":"High frequency of p53 abnormality in laryngeal cancers of heavy smokers and its relation to human papillomavirus infection","volume":"85","author":"T Suzuki","year":"1994","journal-title":"Jpn J Cancer Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1288\/00005537-199408000-00016","article-title":"Lack of synergistic association between human papillomavirus and ras gene point mutation in laryngeal carcinomas","volume":"104","author":"K Shidara","year":"1994","journal-title":"Laryngoscope"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/00019606-199506000-00008","article-title":"Human papillomavirus infection in the malignant and premalignant head and neck epithelium","volume":"4","author":"P Fouret","year":"1995","journal-title":"Diagn Mol Pathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/(SICI)1096-9071(199803)54:3<186::AID-JMV8>3.0.CO;2-1","article-title":"Human papillomavirus DNA sequences and p53 over-expression in laryngeal squamous cell carcinomas in Northeast China","volume":"54","author":"XL Ma","year":"1998","journal-title":"J Med Virol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1002\/(SICI)1097-0142(19990501)85:9%3C1903::AID-CNCR4%3E3.0.CO;2-6","article-title":"Human papillomavirus and prognoses of patients with cancers of the upper aerodigestive tract","volume":"85","author":"J Pintos","year":"1999","journal-title":"Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1097\/MLG.0b013e31816a7135","article-title":"Recurrent respiratory papillomatosis: a review","volume":"118","author":"CS Derkay","year":"2008","journal-title":"Laryngoscope"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/LGT.0b013e3182472947","article-title":"Prevalence of human papillomavirus types in invasive vulvar cancers and vulvar intraepithelial neoplasia 3 in the United States before vaccine introduction","volume":"16","author":"JW Gargano","year":"2012","journal-title":"J Low Genit Tract Dis"},{"key":"ref14","unstructured":"Fritz A, Percy C, Shanmugaratnam K, Sobin L, Parkin DM, <etal>et al<\/etal>.<bold>.<\/bold> (2000) The International Classification of Diseases for Oncology, 3rd Edition. Geneva: World Health Organization."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.humpath.2005.03.010","article-title":"Tissues from population-based cancer registries: a novel approach to increasing research potential","volume":"36","author":"MT Goodman","year":"2005","journal-title":"Hum Pathol"},{"key":"ref16","unstructured":"Young JL Jr, Roffers SD, Ries LAG, Fritz AG, Hurlbut AAeditors (2001) SEER Summary Staging Manual - 2000: Codes and Coding Instructions. Bethesda, MD: National Cancer Institute."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jmoldx.2011.03.007","article-title":"Efficient DNA extraction for HPV genotyping in formalin-fixed, paraffin-embedded tissues","volume":"13","author":"M Steinau","year":"2011","journal-title":"J Mol Diagn"},{"key":"ref18","first-page":"1","article-title":"Human papillomaviruses. IARC Monograph","volume":"90","year":"2007","journal-title":"Eval Carcinog Risks Hum"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.vaccine.2006.05.115","article-title":"Chapter 1: HPV in the etiology of human cancer","volume":"24S3","author":"N Munoz","year":"2006","journal-title":"Vaccine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/000348949510400601","article-title":"Gender differences in cancer of the larynx","volume":"104","author":"MS Kokoska","year":"1995","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/lary.20509","article-title":"Human papillomavirus in early laryngeal carcinoma","volume":"119","author":"JL Baumann","year":"2009","journal-title":"The Laryngoscope"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1177\/0194599811434482","article-title":"Human Papillomavirus Outcomes in an Access-to-Care Laryngeal Cancer Cohort","volume":"146","author":"JK Stephen","year":"2012","journal-title":"Otolaryngology-Head and Neck Surgery"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/jnci\/85.6.465","article-title":"Racial differences in risk of oral and pharyngeal cancer: alcohol, tobacco, and other determinants","volume":"85","author":"GL Day","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jnci\/djn025","article-title":"Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers","volume":"100","author":"ML Gillison","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/s10552-011-9792-x","article-title":"An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies","volume":"22","author":"JH Lubin","year":"2011","journal-title":"Cancer Causes Control"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/ije\/dyp350","article-title":"Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium","volume":"39","author":"JE Heck","year":"2010","journal-title":"Int J Epidemiol"},{"key":"ref27","unstructured":"Piccirillo JF, Costas I (2007) Chapter 8 Larynx. In: Ries LAG YJ, Keel GE, Eisner MP, Lin YD, Horner M-J, editor. SEER Survival Monograph: Cancer Survival Among Adults: US SEER Program, 1988\u20132001, Patient and Tumor Characteristics Bethesda, MD.: National Cancer Institute, SEER Program."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1001\/archotol.1991.01870180117023","article-title":"Carcinoma of the larynx. Changing incidence in women","volume":"117","author":"DP DeRienzo","year":"1991","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.canep.2011.02.003","article-title":"Gender differences in the incidence of laryngeal and hypopharyngeal cancers in Spain","volume":"35","author":"DL de Souza","year":"2011","journal-title":"Cancer Epidemiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"7033","DOI":"10.7314\/APJCP.2013.14.11.7033","article-title":"Laryngeal cancer in Kazakhstan - ethnic, age and gender differences over time","volume":"14","author":"N Igissinov","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref31","unstructured":"Lortet-Tieulent J, Renteria E, Sharp L, Weiderpass E, Comber H, <etal>et al<\/etal>.<bold>.<\/bold> (2013) Convergence of decreasing male and increasing female incidence rates in major tobacco-related cancers in Europe in 1988\u20132010. Eur J Cancer."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1200\/JCO.2011.36.4596","article-title":"Human papillomavirus (HPV) and rising oropharyngeal cancer incidence in the United States","volume":"29","author":"AK Chaturvedi","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djn011","article-title":"Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial","volume":"100","author":"C Fakhry","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/0029-7844(95)00045-S","article-title":"Prognostic significance of human papillomavirus DNA in vulvar carcinoma","volume":"85","author":"BJ Monk","year":"1995","journal-title":"Obstet 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Schwartz","year":"2001","journal-title":"Otolaryngol Head Neck Surg"},{"key":"ref42","first-page":"755","article-title":"Human papilloma virus and p53 in head and neck cancer: clinical correlates and survival","volume":"2","author":"DJ Haraf","year":"1996","journal-title":"Clin Cancer Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/00001622-199905000-00010","article-title":"Human papillomavirus in head and neck squamous cell carcinoma: are some head and neck cancers a sexually transmitted disease?","volume":"11","author":"ML Gillison","year":"1999","journal-title":"Curr Opin Oncol"},{"key":"ref44","first-page":"1663","article-title":"Mutations in the p53 gene and human papillomavirus infection as significant prognostic factors in squamous cell carcinomas of the oral cavity","volume":"12","author":"I 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