{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T10:59:55Z","timestamp":1793012395631,"version":"4.5.0"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0116009","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T18:52:54Z","timestamp":1425667974000},"page":"e0116009","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":69,"title":["Therapeutic Effects of Human Multilineage-Differentiating Stress Enduring (MUSE) Cell Transplantation into Infarct Brain of Mice"],"prefix":"10.1371","volume":"10","author":[{"given":"Tomohiro","family":"Yamauchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Shichinohe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohiro","family":"Houkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Dezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/jcbfm.2011.187","article-title":"Stem cell therapy for cerebral ischemia: from basic science to clinical applications","volume":"32","author":"K Abe","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.55782\/ane-2013-1921","article-title":"Bone marrow stromal cell transplantation for ischemic stroke\u2014its multi-functional feature","volume":"73","author":"S Kuroda","year":"2013","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/sj.bmt.1705757","article-title":"Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury","volume":"40","author":"AM Parr","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/mp3005148","article-title":"Mesenchymal stem cell-based therapy","volume":"10","author":"V Mundra","year":"2013","journal-title":"Molecular pharmaceutics"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.trsl.2009.07.006","article-title":"Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson&apos;s disease","volume":"155","author":"NK Venkataramana","year":"2010","journal-title":"Transl Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.STR.0000247888.25985.62","article-title":"Cell transplantation therapy for stroke","volume":"38","author":"T Bliss","year":"2007","journal-title":"Stroke"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1179\/1743132813Y.0000000210","article-title":"Therapeutic applications of bone marrow-derived stem cells in ischemic stroke","volume":"35","author":"L Wang","year":"2013","journal-title":"Neurol Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.pneurobio.2010.12.002","article-title":"Functional recovery after severe CNS trauma: current perspectives for cell therapy with bone marrow stromal cells","volume":"93","author":"J Vaquero","year":"2011","journal-title":"Prog Neurobiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s12264-013-1431-y","article-title":"Bone marrow stromal cells as a therapeutic treatment for ischemic stroke","volume":"30","author":"Z Yang","year":"2014","journal-title":"Neurosci Bull"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000320486","article-title":"Bone marrow stromal cell transplantation attenuates cognitive dysfunction due to chronic cerebral ischemia in rats","volume":"30","author":"H Shichinohe","year":"2010","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.neulet.2007.02.092","article-title":"Bone marrow stromal cells of transgenic mice can improve the cognitive ability of an Alzheimer&apos;s disease rat model","volume":"417","author":"QY Wu","year":"2007","journal-title":"Neurosci Lett"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3390\/cells1041045","article-title":"Regenerative Effects of Mesenchymal Stem Cells: Contribution of Muse Cells, a Novel Pluripotent Stem Cell Type that Resides in Mesenchymal Cells","volume":"1","author":"S Wakao","year":"2012","journal-title":"Cells"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1073\/pnas.0911647107","article-title":"Unique multipotent cells in adult human mesenchymal cell populations","volume":"107","author":"Y Kuroda","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9875","DOI":"10.1073\/pnas.1100816108","article-title":"Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts","volume":"108","author":"S Wakao","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1089\/scd.2013.0473","article-title":"Human adipose tissue possesses a unique population of pluripotent stem cells with nontumorigenic and low telomerase activities: potential implications in regenerative medicine","volume":"23","author":"F Ogura","year":"2014","journal-title":"Stem Cells Dev"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.6030\/1939-067X-3.1.28","article-title":"A Reproducible and Simple Model of Permanent Cerebral Ischemia in CB-17 and SCID Mice","volume":"3","author":"A Taguchi","year":"2010","journal-title":"J Exp Stroke Transl Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1440-1789.2003.00496.x","article-title":"Migration and differentiation of nuclear fluorescence-labeled bone marrow stromal cells after transplantation into cerebral infarct and spinal cord injury in mice","volume":"23","author":"JB Lee","year":"2003","journal-title":"Neuropathology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/01.STR.17.3.472","article-title":"Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination","volume":"17","author":"JB Bederson","year":"1986","journal-title":"Stroke"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/jcbfm.1990.47","article-title":"A Semiautomated method for measuring brain infarct volume","volume":"10","author":"RA Swanson","year":"1990","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.brainresprot.2004.04.004","article-title":"In vivo tracking of bone marrow stromal cells transplanted into mice cerebral infarct by fluorescence optical imaging","volume":"13","author":"H Shichinohe","year":"2004","journal-title":"Brain Res Brain Res Protoc"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1073\/pnas.042678299","article-title":"Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery","volume":"99","author":"CP Hofstetter","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1440-1789.2012.01335.x","article-title":"Timing and cell dose determine therapeutic effects of bone marrow stromal cell transplantation in rat model of cerebral infarct","volume":"33","author":"M Kawabori","year":"2013","journal-title":"Neuropathology: official journal of the Japanese Society of Neuropathology"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Shichinohe H, Ishihara T, Takahashi K, Tanaka Y, Miyamoto M, et al. (2014) Bone Marrow Stromal Cells Rescue Ischemic Brain by Trophic Effects and Phenotypic Change Toward Neural Cells. Neurorehabil Neural Repair.","DOI":"10.1177\/1545968314525856"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.brainres.2007.08.091","article-title":"Role of SDF-1\/CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral infarct","volume":"1183","author":"H Shichinohe","year":"2007","journal-title":"Brain Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2004.02.072","article-title":"Bone marrow grafts restore cerebral blood flow and blood brain barrier in stroke rats","volume":"1010","author":"CV Borlongan","year":"2004","journal-title":"Brain Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1097\/00004647-200009000-00006","article-title":"Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice","volume":"20","author":"Y Li","year":"2000","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/neu.1994.11.187","article-title":"The rotarod test: an evaluation of its effectiveness in assessing motor deficits following traumatic brain injury","volume":"11","author":"RJ Hamm","year":"1994","journal-title":"J Neurotrauma"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1254\/jphs.11013FP","article-title":"Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia","volume":"116","author":"K Takasaki","year":"2011","journal-title":"J Pharmacol Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nprot.2013.076","article-title":"Isolation, culture and evaluation of multilineage-differentiating stress-enduring (Muse) cells","volume":"8","author":"Y Kuroda","year":"2013","journal-title":"Nat Protoc"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1161\/STROKEAHA.112.655803","article-title":"Cerebrovascular disease and mechanisms of cognitive impairment: evidence from clinicopathological studies in humans","volume":"43","author":"RN Kalaria","year":"2012","journal-title":"Stroke"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/jcbfm.2012.185","article-title":"Assessing post-stroke behavior in mouse models of focal ischemia","volume":"33","author":"M Balkaya","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/pin.12129","article-title":"Muse cells, newly found non-tumorigenic pluripotent stem cells, reside in human mesenchymal tissues","volume":"64","author":"S Wakao","year":"2014","journal-title":"Pathol Int"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0116009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T17:33:57Z","timestamp":1717781637000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0116009"}},"subtitle":[],"editor":[{"given":"Eva","family":"Mezey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,6]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0116009","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,6]]}}}