{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T07:20:59Z","timestamp":1789543259297,"version":"build-2803163510"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0116316","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T18:51:00Z","timestamp":1425667860000},"page":"e0116316","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Variability in the Effect of 5-HTTLPR on Depression in a Large European Population: The Role of Age, Symptom Profile, Type and Intensity of Life Stressors"],"prefix":"10.1371","volume":"10","author":[{"given":"Gabriella","family":"Juhasz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Gonda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Hullam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Eszlari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judit","family":"Lazary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorottya","family":"Pap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Petschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Francis William","family":"Deakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian Muir","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Antal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Peter","family":"Lesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyorgy","family":"Bagdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/mp.2011.182","article-title":"The dappled nature of causes of psychiatric illness: replacing the organic-functional\/hardware-software dichotomy with empirically based pluralism","volume":"17","author":"KS Kendler","year":"2012","journal-title":"Mol Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.neuron.2014.01.027","article-title":"The genetics of major depression","volume":"81","author":"J Flint","year":"2014","journal-title":"Neuron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.274.5292.1527","article-title":"Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region","volume":"274","author":"KP Lesch","year":"1996","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/mp.2012.19","article-title":"The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis","volume":"18","author":"SE Murphy","year":"2013","journal-title":"Mol Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/nn1964","article-title":"Long story short: the serotonin transporter in emotion regulation and social cognition","volume":"10","author":"T Canli","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref6","first-page":"174","article-title":"Gene-environment interaction and the genetics of depression","volume":"29","author":"KP Lesch","year":"2004","journal-title":"J Psychiatry Neurosci"},{"key":"ref7","first-page":"453","article-title":"A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders","volume":"1","author":"DA Collier","year":"1996","journal-title":"Mol Psychiatry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/sj.mp.4000949","article-title":"Early experience and serotonin transporter gene variation interact to influence primate CNS function","volume":"7","author":"AJ Bennett","year":"2002","journal-title":"Mol Psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/sj.mp.4001157","article-title":"Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates","volume":"7","author":"M Champoux","year":"2002","journal-title":"Mol Psychiatry"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1083968","article-title":"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene","volume":"301","author":"A Caspi","year":"2003","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1001\/archgenpsychiatry.2010.189","article-title":"The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation","volume":"68","author":"K Karg","year":"2011","journal-title":"Arch Gen Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1001\/jama.2009.878","article-title":"Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis","volume":"301","author":"N Risch","year":"2009","journal-title":"JAMA"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/mp.2012.21","article-title":"A mega-analysis of genome-wide association studies for major depressive disorder","volume":"18","author":"S Ripke","year":"2013","journal-title":"Mol Psychiatry"},{"key":"ref14","first-page":"131","article-title":"The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis","volume":"13","author":"R Uher","year":"2008","journal-title":"MolPsychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/1471-244X-13-304","article-title":"Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression","volume":"13","author":"RC Culverhouse","year":"2013","journal-title":"BMC Psychiatry"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrg2764","article-title":"Gene\u2014environment-wide association studies: emerging approaches","volume":"11","author":"D Thomas","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref17","first-page":"762","article-title":"The CREB1-BDNF-NTRK2 Pathway in Depression: Multiple Gene-Cognition-Environment Interactions","volume":"69","author":"G Juhasz","year":"2011","journal-title":"BiolPsychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.biopsych.2008.03.030","article-title":"New evidence for the association of the serotonin transporter gene (SLC6A4) haplotypes, threatening life events, and depressive phenotype","volume":"64","author":"J Lazary","year":"2008","journal-title":"Biological Psychiatry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1038\/npp.2009.19","article-title":"CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms","volume":"34","author":"G Juhasz","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref20","article-title":"Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version","author":"MB First","year":"2002"},{"key":"ref21","unstructured":"Derogatis LR (1993) BSI: Brief Symptom Inventory: Administration, Scoring, and Procedures Manual. Minneapolis: National Computer Systems Pearson,Inc."},{"key":"ref22","first-page":"189","article-title":"The List of Threatening Experiences: a subset of 12 life event categories with considerable long-term contextual threat","volume":"15","author":"T Brugha","year":"1985","journal-title":"PsycholMed"},{"key":"ref23","first-page":"1132","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","volume":"151","author":"DP Bernstein","year":"1994","journal-title":"AmJPsychiatry"},{"key":"ref24","first-page":"67","article-title":"DNA from buccal swabs recruited by mail: evaluation of storage effects on long-term stability and suitability for multiplex polymerase chain reaction genotyping","volume":"33","author":"B Freeman","year":"2003","journal-title":"BehavGenet"},{"key":"ref25","article-title":"R: A language and environment for statistical computing","author":"RC Team","year":"2013"},{"key":"ref26","unstructured":"Antal P, Hullam,G., Gezsi,A., Millinghoffer,A. (2006) Learning complex Bayesian network features for classification. Proceedings of the third European Workshop on Probabilistic Graphical Models. Prague, Czech Republic. pp. 9\u201316."},{"key":"ref27","first-page":"273","article-title":"Beyond Structural Equation Modeling: model properties and effect size from a Bayesian viewpoint. An example of complex phenotype\u2014genotype associations in depression","volume":"14","author":"G Hullam","year":"2012","journal-title":"Neuropsychopharmacol Hung"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1126\/science.1094068","article-title":"Inferring cellular networks using probabilistic graphical models","volume":"303","author":"N Friedman","year":"2004","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrg2615","article-title":"Bayesian statistical methods for genetic association studies","volume":"10","author":"M Stephens","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref30","first-page":"382","article-title":"Bayesian Model Averaging","volume":"14","author":"D. Hoeting JAM","year":"1999","journal-title":"A Tutorial. Statistical Science"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1080\/03610929608831853","article-title":"Bayesian model averaging and model selection for Markov equivalence classes of acyclic digraphs","volume":"25","author":"D Madigan","year":"1996","journal-title":"Communications in Statistics-Theory and Methods"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.tips.2011.02.013","article-title":"Personalized medicine can pave the way for the safe use of CB(1) receptor antagonists","volume":"32","author":"J Lazary","year":"2011","journal-title":"Trends Pharmacol Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1748-1716.2011.02402.x","article-title":"CB1 receptor antagonists: new discoveries leading to new perspectives","volume":"205","author":"E Kirilly","year":"2012","journal-title":"Acta Physiol (Oxf)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00406-008-0842-7","article-title":"Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population","volume":"259","author":"X Gonda","year":"2009","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.psychres.2006.05.014","article-title":"High anxiety and migraine are associated with the s allele of the 5HTTLPR gene polymorphism","volume":"149","author":"X Gonda","year":"2007","journal-title":"Psychiatry Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1176\/appi.ajp.2010.09101452","article-title":"Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits","volume":"167","author":"A Caspi","year":"2010","journal-title":"Am J Psychiatry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1176\/appi.ajp.2011.10111699","article-title":"Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress","volume":"169","author":"EM Drabant","year":"2012","journal-title":"Am J Psychiatry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jad.2011.03.010","article-title":"Serotonin transporter gene moderates childhood maltreatment&apos;s effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results","volume":"135","author":"R Uher","year":"2011","journal-title":"J Affect Disord"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2008.04.009","article-title":"Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction","volume":"111","author":"GW Brown","year":"2008","journal-title":"J Affect Disord"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1017\/S0033291709992121","article-title":"Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: a test of the stress sensitization hypothesis in a population-based sample of adults","volume":"40","author":"KA McLaughlin","year":"2010","journal-title":"Psychol Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"SA Montgomery","year":"1979","journal-title":"BrJ Psychiatry"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1192\/bjp.141.5.518","article-title":"The Clinical Anxiety Scale: an instrument derived from the Hamilton Anxiety Scale","volume":"141","author":"RP Snaith","year":"1982","journal-title":"BrJ Psychiatry"},{"key":"ref43","first-page":"213","article-title":"A new clinical evidence-based gene-environment interaction model of depression","volume":"14","author":"G Bagdy","year":"2012","journal-title":"Neuropsychopharmacol Hung"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1517\/17530059.2013.821979","article-title":"Biomarkers for personalised treatment in psychiatric diseases","volume":"7","author":"G Bagdy","year":"2013","journal-title":"Expert Opin Med Diagn"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.coph.2011.02.008","article-title":"Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional GxG and GxE differences in health and disease","volume":"11","author":"DL Murphy","year":"2011","journal-title":"Curr Opin Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0116316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T06:19:31Z","timestamp":1589005171000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0116316"}},"subtitle":[],"editor":[{"given":"H. Sunny","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,3,6]]},"references-count":45,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,3,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0116316","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,6]]}}}