{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:24:17Z","timestamp":1772115857964,"version":"3.50.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:00:00Z","timestamp":1421798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0116340","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T19:59:42Z","timestamp":1421870382000},"page":"e0116340","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Association of INSIG2 Polymorphism with Overweight and LDL in Children"],"prefix":"10.1371","volume":"10","author":[{"given":"Anne-Marie","family":"Kaulfers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjan","family":"Deka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Dolan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3945\/ajcn.2009.27525","article-title":"Relation of body mass index and skinfold thicknesses to cardiovascular disease risk factors in children: the Bogalusa Heart Study","volume":"90","author":"DS Freedman","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/aje\/kwf219","article-title":"Body mass index in adolescence in relation to total mortality: 32-year follow-up of 227,000 Norwegian boys and girls","volume":"157","author":"A Engeland","year":"2003","journal-title":"Am J Epidemiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1542\/peds.2007-2329C","article-title":"Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report","volume":"120","author":"SE Barlow","year":"2007","journal-title":"Pediatrics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.1124779","article-title":"A common genetic variant is associated with adult and childhood obesity","volume":"312","author":"A Herbert","year":"2006","journal-title":"Science"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1038\/sj.ijo.0803657","article-title":"Obesity and polymorphisms in genes regulating human adipose tissue","volume":"31","author":"I Dahlman","year":"2007","journal-title":"Int J Obes (Lond)"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1073\/pnas.162488899","article-title":"Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins","volume":"99","author":"D Yabe","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1172\/JCI25614","article-title":"Schoenheimer effect explained\u2014feedback regulation of cholesterol synthesis in mice mediated by Insig proteins","volume":"115","author":"LJ Engelking","year":"2005","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1210\/jc.2007-1850","article-title":"Insulin-induced gene 2 involvement in human adipocyte metabolism and body weight regulation","volume":"93","author":"S Krapivner","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s10038-008-0317-8","article-title":"INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese","volume":"53","author":"K Hotta","year":"2008","journal-title":"J Hum Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1371\/journal.pgen.0030061","article-title":"The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts","volume":"3","author":"HN Lyon","year":"2007","journal-title":"PLoS Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1126\/science.1130571","article-title":"Comment on \u201cA common genetic variant is associated with adult and childhood obesity\u201d","volume":"315","author":"D Rosskopf","year":"2007","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.diabres.2008.03.022","article-title":"A common polymorphism is associated with body mass index in Uyghur population","volume":"81","author":"J Zhang","year":"2008","journal-title":"Diabetes Res Clin Pract"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e2872","DOI":"10.1371\/journal.pone.0002872","article-title":"Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes","volume":"3","author":"CH Andreasen","year":"2008","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/oby.2007.132","article-title":"INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism","volume":"16","author":"E Boes","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2337\/db07-0970","article-title":"Identification and replication of a novel obesity locus on chromosome 1q24 in isolated populations of Cilento","volume":"57","author":"M Ciullo","year":"2008","journal-title":"Diabetes"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1126\/science.1129402","article-title":"Comment on \u201cA common genetic variant is associated with adult and childhood obesity\u201d","volume":"315","author":"C Dina","year":"2007","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00439-006-0258-2","article-title":"Lack of association between rs7566605 and obesity in a Chinese population","volume":"120","author":"Y Feng","year":"2007","journal-title":"Hum Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1471-2350-7-83","article-title":"INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families","volume":"7","author":"DH Hall","year":"2006","journal-title":"BMC Med Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1399-0004.2007.00795.x","article-title":"The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population","volume":"71","author":"J Kumar","year":"2007","journal-title":"Clin Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/oby.2007.301","article-title":"No association between rs7566605 variant and being overweight in Japanese","volume":"15","author":"M Kuzuya","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1126\/science.1130012","article-title":"Comment on \u201cA common genetic variant is associated with adult and childhood obesity\u201d","volume":"315","author":"RJ Loos","year":"2007","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1017\/S0007114508006557","article-title":"The single nucleotide polymorphism upstream of insulin-induced gene 2 (INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women","volume":"101","author":"K Oki","year":"2009","journal-title":"Br J Nutr"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/sj.mp.4001956","article-title":"Is rs7566605, a SNP near INSIG2, associated with body mass in a randomized clinical trial of antipsychotics in schizophrenia?","volume":"12","author":"T Skelly","year":"2007","journal-title":"Mol Psychiatry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1038\/sj.ijo.0803645","article-title":"INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects","volume":"31","author":"AJ Smith","year":"2007","journal-title":"Int J Obes (Lond)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/oby.2007.25","article-title":"No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population","volume":"16","author":"Y Tabara","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/oby.2008.650","article-title":"Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS)","volume":"17","author":"KS Vimaleswaran","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/S0895-3988(09)60013-1","article-title":"Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents","volume":"21","author":"HJ Wang","year":"2008","journal-title":"Biomed Environ Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/oby.2008.669","article-title":"Lack of association between a common polymorphism near the INSIG2 gene and BMI, myocardial infarction, and cardiovascular risk factors","volume":"17","author":"S Wiedmann","year":"2009","journal-title":"Obesity (Silver Spring)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ejhg.2008.8","article-title":"Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation","volume":"16","author":"L Yang","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/sj.mp.4002133","article-title":"Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?","volume":"14","author":"S Le Hellard","year":"2009","journal-title":"Mol Psychiatry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/hup.1111","article-title":"Association study of polymorphisms in insulin induced gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients","volume":"25","author":"AK Tiwari","journal-title":"Hum Psychopharmacol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jpeds.2005.01.045","article-title":"Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents","volume":"146","author":"LM Dolan","year":"2005","journal-title":"J Pediatr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature02623","article-title":"Mapping complex disease loci in whole-genome association studies","volume":"429","author":"CS Carlson","year":"2004","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00439-007-0394-3","article-title":"Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin","volume":"122","author":"P Pal","year":"2007","journal-title":"Hum Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/CIRCGENETICS.109.917039","article-title":"Fine mapping of the insulin-induced gene 2 identifies a variant associated with LDL cholesterol and total apolipoprotein B levels","volume":"3","author":"R Do","year":"2010","journal-title":"Circ Cardiovasc Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0116340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T05:03:04Z","timestamp":1651035784000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0116340"}},"subtitle":[],"editor":[{"given":"Joseph","family":"Devaney","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,21]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0116340","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,21]]}}}