{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T06:01:44Z","timestamp":1772258504919,"version":"3.50.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:00:00Z","timestamp":1421280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0116506","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T16:29:20Z","timestamp":1421339360000},"page":"e0116506","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":47,"title":["BMI as a Mediator of the Relationship between Muscular Fitness and Cardiometabolic Risk in Children: A Mediation Analysis"],"prefix":"10.1371","volume":"10","author":[{"given":"Ana","family":"D\u00edez-Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mairena","family":"S\u00e1nchez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Gul\u00edas-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Notario-Pacheco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Ca\u00f1ete Garc\u00eda-Prieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Arias-Palencia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Mart\u00ednez-Vizca\u00edno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,1,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity","volume":"120","author":"KG Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11892-012-0331-2","article-title":"Metabolic syndrome in youth: chimera or useful concept?","volume":"13","author":"ML Marcovecchio","year":"2013","journal-title":"Curr Diab Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1001\/archinte.1994.00420160079011","article-title":"Persistence of multiple cardiovascular risk clustering related to syndrome X from childhood to young adulthood. The Bogalusa Heart Study","volume":"154","author":"W Bao","year":"1994","journal-title":"Arch Intern Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0091-7435(03)00145-2","article-title":"Biological cardiovascular risk factors cluster in Danish children and adolescents: the European Youth Heart Study","volume":"37","author":"LB Andersen","year":"2003","journal-title":"Prev Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1161\/01.CIR.99.11.1471","article-title":"Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults. The Minneapolis Children\u2019s Blood Pressure Study","volume":"99","author":"AR Sinaiko","year":"1999","journal-title":"Circulation"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.2337\/diabetes.54.11.3252","article-title":"Insulin resistance, the metabolic syndrome, and incident cardiovascular events in the Framingham Offspring Study","volume":"54","author":"MK Rutter","year":"2005","journal-title":"Diabetes"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1161\/CIRCULATIONAHA.105.539528","article-title":"Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus","volume":"112","author":"PW Wilson","year":"2005","journal-title":"Circulation"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2337\/diacare.29.01.06.dc05-1320","article-title":"Metabolic syndrome: risk factor distribution and 18-year mortality in the multiple risk factor intervention trial","volume":"29","author":"LE Eberly","year":"2006","journal-title":"Diabetes Care"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jpeds.2005.01.055","article-title":"Evidence based physical activity for school-age youth","volume":"146","author":"WB Strong","year":"2005","journal-title":"J Pediatr"},{"key":"ref10","article-title":"Physical activity guidelines for Americans","year":"2008"},{"key":"ref11","article-title":"Global recommendations on physical activity for health","year":"2010"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/ajcn\/84.3.475","article-title":"The underappreciated role of muscle in health and disease","volume":"84","author":"RR Wolfe","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1249\/MSS.0b013e31819aaae5","article-title":"Low muscle fitness is associated with metabolic risk in youth","volume":"41","author":"J Steene-Johannessen","year":"2009","journal-title":"Med Sci Sports Exerc"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/j.1399-5448.2011.00769.x","article-title":"Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents: the HELENA study","volume":"12","author":"EG Artero","year":"2011","journal-title":"Pediatr Diabetes"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1007\/s00421-011-2286-4","article-title":"Muscular fitness and clustered cardiovascular disease risk in Australian youth","volume":"112","author":"CG Magnussen","year":"2012","journal-title":"Eur J Appl Physiol"},{"key":"ref16","article-title":"Muscle strength in youth and cardiovascular risk in young adulthood (the European Youth Heart Study)","author":"A Gr\u00f8ntved","year":"2013"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e896","DOI":"10.1542\/peds.2013-3169","article-title":"Strength capacity and cardiometabolic risk clustering in adolescents","volume":"133","author":"MD Peterson","year":"2014","journal-title":"Pediatrics"},{"key":"ref18","article-title":"Introduction to statistical mediation analysis","author":"DP MacKinnon","year":"2008"},{"key":"ref19","first-page":"427","article-title":"Protocol of a randomized cluster trial to assess the effectiveness of the MOVI-2 program on overweight prevention in schoolchildren","volume":"65","author":"V Mart\u00ednez-Vizca\u00edno","year":"2012","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/sj.ejcn.1601993","article-title":"New bioimpedance analysis system: improved phenotyping with whole-body analysis","volume":"58","author":"A Pietrobelli","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.2337\/dc09-2049","article-title":"Validity of a single-factor model underlying the metabolic syndrome in children: a confirmatory factor analysis","volume":"33","author":"V Mart\u00ednez-Vizca\u00edno","year":"2010","journal-title":"Diabetes Care"},{"key":"ref22","article-title":"Handbook for the EUROFIT tests of physical fitness","year":"1993"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/HCR.0b013e3182642688","article-title":"Effects of muscular strength on cardiovascular risk factors and prognosis","volume":"32","author":"EG Artero","year":"2012","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/02640418808729800","article-title":"The multistage 20 metre shuttle run test for aerobic fitness","volume":"6","author":"LA L\u00e9ger","year":"1988","journal-title":"J Sports Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0022-3476(85)80501-1","article-title":"Clinical longitudinal standards for height and height velocity for North American children","volume":"107","author":"JM Tanner","year":"1985","journal-title":"J Pediatr"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.2047-6310.2012.00064.x","article-title":"Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity","volume":"7","author":"TJ Cole","year":"2012","journal-title":"Pediatr Obes"},{"key":"ref27","first-page":"467","article-title":"Normalizing physical performance tests for body size: a proposal for standardization","volume":"19","author":"S Jaric","year":"2005","journal-title":"J Strength Cond Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations","volume":"51","author":"RM Baron","year":"1986","journal-title":"J Pers Soc Psychol"},{"key":"ref29","first-page":"290","article-title":"Asymptotic confidence intervals for indirect effects in structural equation models","author":"M Sobel","year":"1982"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"a439","DOI":"10.1136\/bmj.a439","article-title":"Association between muscular strength and mortality in men: prospective cohort study","volume":"337","author":"JR Ruiz","year":"2008","journal-title":"BMJ"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e4759","DOI":"10.1136\/bmj.e4759","article-title":"Cardiovascular disease risk in healthy children and its association with body mass index: systematic review and meta-analysis","volume":"345","author":"C Friedemann","year":"2012","journal-title":"BMJ"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1097\/HJH.0b013e328277597f","article-title":"Body fat is associated with blood pressure in school-aged girls with low cardiorespiratory fitness: the European Youth Heart Study","volume":"25","author":"JR Ruiz","year":"2007","journal-title":"J Hypertens"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1038\/oby.2008.259","article-title":"Cardiovascular risk in 26,008 European overweight children as established by a multicenter database","volume":"16","author":"D I\u2019Allemand","year":"2008","journal-title":"Obesity (Silver Spring)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.2337\/db11-0425","article-title":"Fatty acids, obesity, and insulin resistance: time for a reevaluation","volume":"60","author":"F Karpe","year":"2011","journal-title":"Diabetes"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2337\/dc13-0416","article-title":"Obesity as a mediator of the influence of cardiorespiratory fitness on cardiometabolic risk: a mediation analysis","volume":"37","author":"A D\u00edez-Fern\u00e1ndez","year":"2014","journal-title":"Diabetes Care"},{"key":"ref36","first-page":"581","article-title":"Lipid and metabolic profiles in adolescents are affected more by physical fitness than physical activity (AVENA study)","volume":"60","author":"E Garc\u00eda-Artero","year":"2007","journal-title":"Rev Esp Cardiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s40279-014-0196-4","article-title":"The health benefits of muscular fitness for children and adolescents: a systematic review and meta-analysis","volume":"44","author":"JJ Smith","year":"2014","journal-title":"Sports Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/17477160600962864","article-title":"Muscular strength and cardiorespiratory fitness is associated with higher insulin sensitivity in children and adolescents","volume":"1","author":"AC Benson","year":"2006","journal-title":"Int J Pediatr Obes"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00421-004-1076-7","article-title":"Movement performance and body size: the relationship for different groups of tests","volume":"92","author":"G Markovic","year":"2004","journal-title":"Eur J Appl Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1519\/JSC.0b013e3181ddb03d","article-title":"Assessing muscular strength in youth: usefulness of standing long jump as a general index of muscular fitness","volume":"24","author":"J Castro-Pi\u00f1ero","year":"2010","journal-title":"J Strength Cond Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0116506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T15:21:04Z","timestamp":1566228064000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0116506"}},"subtitle":[],"editor":[{"given":"Joseph","family":"Devaney","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,1,15]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,1,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0116506","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,15]]}}}