{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:09:43Z","timestamp":1762866583319},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0116562","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T18:49:46Z","timestamp":1424890186000},"page":"e0116562","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Frostbite Protection in Mice Expressing an Antifreeze Glycoprotein"],"prefix":"10.1371","volume":"10","author":[{"given":"Martin","family":"Heisig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Mattessich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Rembisz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Acar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen J.","family":"Booth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Neelakanta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erol","family":"Fikrig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,2,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0959-440X(97)80154-6","article-title":"Antifreeze proteins","volume":"7","author":"PL Davies","year":"1997","journal-title":"Curr Opin Struct Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1126\/science.163.3871.1073","article-title":"Freezing resistance in some Antarctic fishes","volume":"163","author":"AL DeVries","year":"1969","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0300-9629(82)90261-4","article-title":"Antifreeze agents of terrestrial arthropods","volume":"73","author":"JG Duman","year":"1982","journal-title":"Comparative Biochemistry and Physiology Part A: Physiology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00360-008-0286-4","article-title":"How insects survive the cold: molecular mechanisms-a review","volume":"178","author":"MS Clark","year":"2008","journal-title":"J Comp Physiol B"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1007\/s00018-009-8320-6","article-title":"The bugs that came in from the cold: molecular adaptations to low temperatures in insects","volume":"66","author":"D Doucet","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.ph.54.030192.003155","article-title":"Natural freeze tolerance in ectothermic vertebrates","volume":"54","author":"KB Storey","year":"1992","journal-title":"Annu Rev Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/cphy.c130007","article-title":"Molecular biology of freezing tolerance","volume":"3","author":"KB Storey","year":"2013","journal-title":"Compr Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/07388550801891152","article-title":"Properties, potentials, and prospects of antifreeze proteins","volume":"28","author":"S Venketesh","year":"2008","journal-title":"Crit Rev Biotechnol"},{"key":"ref9","first-page":"223","article-title":"Structures and ice-binding faces of the alanine-rich type I antifreeze proteins","volume":"88","author":"SN Patel","year":"2010","journal-title":"Biochem Cell Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1529\/biophysj.107.125328","article-title":"Direct visualization of spruce budworm antifreeze protein interacting with ice crystals: basal plane affinity confers hyperactivity","volume":"95","author":"N Pertaya","year":"2008","journal-title":"Biophys J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1529\/biophysj.106.096297","article-title":"Fluorescence microscopy evidence for quasi-permanent attachment of antifreeze proteins to ice surfaces","volume":"92","author":"N Pertaya","year":"2007","journal-title":"Biophys J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1073\/pnas.1213603110","article-title":"Microfluidic experiments reveal that antifreeze proteins bound to ice crystals suffice to prevent their growth","volume":"110","author":"Y Celik","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3168\/jds.S0022-0302(06)72068-9","article-title":"Ice recrystallization inhibition in ice cream as affected by ice structuring proteins from winter wheat grass","volume":"89","author":"A Regand","year":"2006","journal-title":"J Dairy Sci"},{"key":"ref14","unstructured":"Daniel A, Oldroyd JR (2000) Ice confection containing antifreeze protein. Google Patents."},{"key":"ref15","unstructured":"De Boishebert Virgi Des C, Wille HJE, Vieira JB (2008) Ice-structuring peptides of lactic origin. Google Patents."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cryobiol.2004.02.009","article-title":"Subzero nonfreezing cryopresevation of rat hearts using antifreeze protein I and antifreeze protein III","volume":"48","author":"G Amir","year":"2004","journal-title":"Cryobiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1016\/j.healun.2004.11.003","article-title":"Improved viability and reduced apoptosis in sub-zero 21-hour preservation of transplanted rat hearts using anti-freeze proteins","volume":"24","author":"G Amir","year":"2005","journal-title":"J Heart Lung Transplant"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.athoracsur.2003.04.004","article-title":"Prolonged 24-hour subzero preservation of heterotopically transplanted rat hearts using antifreeze proteins derived from arctic fish","volume":"77","author":"G Amir","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/mrd.20799","article-title":"Cryogenic effect of antifreeze protein on transgenic mouse ovaries and the production of live offspring by orthotopic transplantation of cryopreserved mouse ovaries","volume":"75","author":"H Bagis","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1387-2656(00)06019-1","article-title":"Biotechnological applications of plant freezing associated proteins","volume":"6","author":"G Breton","year":"2000","journal-title":"Biotechnol Annu Rev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s11626-010-9383-2","article-title":"Lessons from nature for preservation of mammalian cells, tissues, and organs","volume":"47","author":"KG Brockbank","year":"2011","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1126\/science.295.5557.1015","article-title":"New prospects for putting organs on ice","volume":"295","author":"J Kaiser","year":"2002","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1006\/bbrc.1994.1512","article-title":"Freezing of mammalian livers with glycerol and antifreeze proteins","volume":"200","author":"B Rubinsky","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1006\/jsre.2000.6053","article-title":"Successful nonfreezing, subzero preservation of rat liver with 2,3-butanediol and type I antifreeze protein","volume":"96","author":"KA Soltys","year":"2001","journal-title":"J Surg Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.cryobiol.2005.10.010","article-title":"Effects of synthetic antifreeze glycoprotein analogue on islet cell survival and function during cryopreservation","volume":"52","author":"S Matsumoto","year":"2006","journal-title":"Cryobiology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2174\/138920306779025576","article-title":"Applications of type I antifreeze proteins: studies with model membranes &amp; cryoprotectant properties","volume":"7","author":"SR Inglis","year":"2006","journal-title":"Curr Protein Pept Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1002\/jsfa.4473","article-title":"Antifreeze glycoprotein agents: structural requirements for activity","volume":"91","author":"PA Carvajal-Rondanelli","year":"2011","journal-title":"J Sci Food Agric"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1002\/cbic.201000509","article-title":"Design and synthesis of antifreeze glycoproteins and mimics","volume":"11","author":"J Garner","year":"2010","journal-title":"Chembiochem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1039\/c0sc00194e","article-title":"Synthesis and antifreeze activity of fish antifreeze glycoproteins and their analogues","volume":"1","author":"R Peltier","year":"2010","journal-title":"Chemical Science"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.3390\/md11062013","article-title":"Antifreeze peptides and glycopeptides, and their derivatives: potential uses in biotechnology","volume":"11","author":"JK Bang","year":"2013","journal-title":"Mar Drugs"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1073\/pnas.94.8.3817","article-title":"Convergent evolution of antifreeze glycoproteins in Antarctic notothenioid fish and Arctic cod","volume":"94","author":"L Chen","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1172\/JCI42868","article-title":"Anaplasma phagocytophilum induces Ixodes scapularis ticks to express an antifreeze glycoprotein gene that enhances their survival in the cold","volume":"120","author":"G Neelakanta","year":"2010","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e33447","DOI":"10.1371\/journal.pone.0033447","article-title":"Expression of Ixodes scapularis antifreeze glycoprotein enhances cold tolerance in Drosophila melanogaster","volume":"7","author":"G Neelakanta","year":"2012","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1249\/JSR.0b013e3182578783","article-title":"Cold weather issues in sideline and event management","volume":"11","author":"JA McMahon","year":"2012","journal-title":"Curr Sports Med Rep"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.celrep.2014.09.034","article-title":"Antivirulence properties of an antifreeze protein","volume":"9","author":"M Heisig","year":"2014","journal-title":"Cell Rep"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-immunol-030409-101311","article-title":"The sterile inflammatory response","volume":"28","author":"KL Rock","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/MEJ.0b013e3282bf6ed0","article-title":"Frostbite: management options","volume":"15","author":"G Roche-Nagle","year":"2008","journal-title":"Eur J Emerg Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jen.2005.07.002","article-title":"Frostbite: case report, practical summary of ED treatment","volume":"31","author":"R McGillion","year":"2005","journal-title":"J Emerg Nurs"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/pgmj.2008.068635","article-title":"Cold damage to the extremities: frostbite and non-freezing cold injuries","volume":"85","author":"C Imray","year":"2009","journal-title":"Postgrad Med J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.jvs.2013.03.012","article-title":"Current medical and surgical management of Raynaud&apos;s syndrome","volume":"57","author":"GJ Landry","year":"2013","journal-title":"J Vasc Surg"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, et al. (2014) Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med.","DOI":"10.1038\/nm.3588"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Zhang X, Goncalves R, Mosser DM (2008) The isolation and characterization of murine macrophages. Curr Protoc Immunol Chapter 14: Unit 14.11.","DOI":"10.1002\/0471142735.im1401s83"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0116562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T19:35:57Z","timestamp":1651347357000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0116562"}},"subtitle":[],"editor":[{"given":"Andreas","family":"Bergmann","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,25]]},"references-count":42,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0116562","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,25]]}}}