{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:03:33Z","timestamp":1777064613638,"version":"3.51.4"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0116711","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T18:51:53Z","timestamp":1424199113000},"page":"e0116711","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Time-Course Effect of Electrical Stimulation on Nerve Regeneration of Diabetic Rats"],"prefix":"10.1371","volume":"10","author":[{"given":"Yu-Ching","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Hong","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Chia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherng-Jyh","family":"Ke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Hsu","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueh-Sheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1097\/PRS.0000000000000226","article-title":"Nerve conduits for peripheral nerve surgery","volume":"133","author":"A Pabari","year":"2014","journal-title":"Plast Reconstr Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.1016\/j.biomaterials.2014.04.064","article-title":"Neural tissue engineering options for peripheral nerve regeneration","volume":"35","author":"X Gu","year":"2014","journal-title":"Biomaterials"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3171\/2014.4.JNS131260","article-title":"The effect of stem cells in bridging peripheral nerve defects: a meta-analysis","volume":"121","author":"CA Hundepool","year":"2014","journal-title":"J Neurosurg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e94054","DOI":"10.1371\/journal.pone.0094054","article-title":"Comprehensive evaluation of peripheral nerve regeneration in the acute healing phase using tissue clearing and optical microscopy in a rodent model","volume":"9","author":"Y Jung","year":"2014","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ijsu.2014.03.018","article-title":"Functional effect of local administration of glial derived neurotrophic factor combined with inside-out artery graft on sciatic nerve regeneration in rat","volume":"12","author":"N Ghayemi","year":"2014","journal-title":"Int J Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.expneurol.2008.01.020","article-title":"Immediate electrical stimulation enhances regeneration and reinnervation and modulates spinal plastic changes after sciatic nerve injury and repair","volume":"211","author":"M Viv\u00f3","year":"2008","journal-title":"Exp Neurol"},{"key":"ref7","first-page":"168","article-title":"Thirty minutes of low intensity electrical stimulation promotes nerve regeneration after sciatic nerve crush injury in a rat mode","volume":"110","author":"MS Alrashdan","year":"2010","journal-title":"Acta Neurol Belg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1590\/S1413-35552011005000008","article-title":"High-voltage electrical stimulation improves nerve regeneration after sciatic crush injury","volume":"15","author":"RM Teodori","year":"2011","journal-title":"Rev Bras Fisioter"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e105045","DOI":"10.1371\/journal.pone.0105045","article-title":"Electrical stimulation promotes regeneration of defective peripheral nerves after delayed repair intervals lasting under one month","volume":"9","author":"C Xu","year":"2014","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.expneurol.2009.09.020","article-title":"Brief post-surgical electrical stimulation accelerates axon regeneration and muscle reinnervation without affecting the functional measures in carpal tunnel syndrome patients","volume":"223","author":"T Gordon","year":"2010","journal-title":"Exp Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"046002","DOI":"10.1088\/1741-2560\/11\/4\/046002","article-title":"Neurite outgrowth on electrospun PLLA fibers is enhanced by exogenous electrical stimulation","volume":"11","author":"AN Koppes","year":"2014","journal-title":"J Neural Eng"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1111\/ejn.12370","article-title":"Electrical stimulation accelerates nerve regeneration and functional recovery in delayed peripheral nerve injury in rats","volume":"38","author":"J Huang","year":"2013","journal-title":"Eur J Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/B978-0-12-420045-6.00005-5","article-title":"Electrical stimulation for promoting peripheral nerve regeneration","volume":"109","author":"K Haastert-Talini","year":"2013","journal-title":"Int Rev Neurobiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0014-2999(95)00718-0","article-title":"Presynaptic deficit of sympathetic nerves: a cause for disturbed sciatic nerve blood flow responsiveness in diabetic rats","volume":"296","author":"T Van Buren","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1046\/j.1460-9568.2000.01341.x","article-title":"Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons","volume":"12","author":"AA Al-Majed","year":"2000","journal-title":"Eur J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02740621","article-title":"The cellular and molecular basis of peripheral nerve regeneration","volume":"14","author":"SY Fu","year":"1997","journal-title":"Mol Neurobiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0266-7681(98)80117-4","article-title":"Neurotrophins, neurons and peripheral nerve regeneration","volume":"23","author":"Q Yin","year":"1998","journal-title":"J Hand Surg Br"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1469-7580.1999.19410001.x","article-title":"Peripheral nerve regeneration and neurotrophic factors","volume":"194","author":"G Terenghi","year":"1999","journal-title":"J Anat"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/brain\/awu031","article-title":"Regeneration of diabetic axons is enhanced by selective knockdown of the PTEN gene","volume":"137","author":"B Singh","year":"2014","journal-title":"Brain"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/jdi.12115","article-title":"Impaired nerve fiber regeneration in axotomized peripheral nerves in streptozotocin-diabetic rats","volume":"4","author":"N Nishida","year":"2013","journal-title":"J Diabetes Investig"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"191632","DOI":"10.1155\/2012\/191632","article-title":"Chinese medicine in diabetic peripheral neuropathy: experimental research on nerve repair and regeneration","volume":"2012","author":"Y Piao","year":"2012","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e74029","DOI":"10.1371\/journal.pone.0074029","article-title":"Secretoneurin gene therapy improves blood flow in an ischemia model in type 1 diabetic mice by enhancing therapeutic neovascularization","volume":"8","author":"W Schgoer","year":"2013","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mce.2013.07.011","article-title":"Cilostazol improves the response to ischemia in diabetic mice by a mechanism dependent on PPAR\u03b3","volume":"381","author":"F Biscetti","year":"2013","journal-title":"Mol Cell Endocrinol"},{"key":"ref24","first-page":"437","article-title":"Current-modulated electrical stimulation as a treatment for peripheral nerve regeneration in diabetic rats","volume":"32","author":"YC Lin","year":"2014","journal-title":"Restor Neurol Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e79078","DOI":"10.1371\/journal.pone.0079078","article-title":"High-frequency electrical stimulation can be a complementary therapy to promote nerve regeneration in diabetic rats","volume":"8","author":"CH Kao","year":"2013","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/TA.0b013e31822d233c","article-title":"Electrical stimulation improves peripheral nerve regeneration in streptozotocin-induced diabetic rats","volume":"72","author":"CH Yao","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1177\/1545968310376758","article-title":"Timing of applying electrical stimulation is an important factor deciding the success rate and maturity of regenerating rat sciatic nerves","volume":"24","author":"CC Yeh","year":"2010","journal-title":"Neurorehabil Neural Repair"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1097\/TA.0b013e318182351a","article-title":"Use of electrical stimulation at different current levels to promote recovery after peripheral nerve injury in rats","volume":"67","author":"MC Lu","year":"2009","journal-title":"J Trauma"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.brainres.2007.10.044","article-title":"Calcitonin gene-related peptide dynamics in rat dorsal root ganglia and spinal cord following different sciatic nerve injuries","volume":"1187","author":"LF Zheng","year":"2008","journal-title":"Brain Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/00061198-200308000-00003","article-title":"Estimating Normal Optic Nerve Axon Numbers in Non-Human Primate Eyes","volume":"12","author":"G Cull","year":"2003","journal-title":"J Glaucoma"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/mus.21564","article-title":"Diabetic neuropathy: electrophysiological and morphological study of peripheral nerve degeneration and regeneration in transgenic mice that express IFNbeta in beta cells","volume":"41","author":"A Seraf\u00edn","year":"2010","journal-title":"Muscle Nerve"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/dmrr.716","article-title":"Regenerative failure of diabetic nerves bridging transection injuries","volume":"23","author":"DW Zochodne","year":"2007","journal-title":"Diabetes Metab Res Rev"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1085-9489.2005.0010205.x","article-title":"Impaired peripheral nerve regeneration in diabetes mellitus","volume":"10","author":"JM Kennedy","year":"2005","journal-title":"J Peripher Nerv Syst"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0022-510X(93)90026-U","article-title":"An animal model of chronic ischemic neuropathy with proliferative changes of nerve microvessel wall","volume":"120","author":"H Yasuda","year":"1993","journal-title":"J Neurol Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1152\/japplphysiol.00766.2002","article-title":"Inflammatory cells in rat skeletal muscle are elevated after electrically stimulated contractions","volume":"194","author":"TJ McLoughlin","year":"2003","journal-title":"J Appl Physio"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e32881","DOI":"10.1371\/journal.pone.0032881","article-title":"COMP-angiopoietin-1 recovers molecular biomarkers of neuropathy and improves vascularisation in sciatic nerve of ob\/ob mice","volume":"7","author":"J Kosacka","year":"2012","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/BF00400938","article-title":"Vascular factors in diabetic neuropathy","volume":"37","author":"S Tesfaye","year":"1994","journal-title":"Diabetologia"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1093\/brain\/123.10.2118","article-title":"The regenerative deficit of peripheral nerves inexperimental diabetes: its extent, timing and possible mechanisms","volume":"123","author":"JM Kennedy","year":"2000","journal-title":"Brain"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/NEN.0b013e31817e23f4","article-title":"Impaired prosaposinsecretion during nerve regeneration in diabetic rats and protection of nerveregeneration by a prosaposin-derived peptide","volume":"67","author":"CG Jolivalt","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1097\/WNR.0b013e32833283e6","article-title":"Olmesartan medoxomil ameliorates sciatic nerve regeneration in diabetic rats","volume":"20","author":"H Nakamura","year":"2009","journal-title":"Neuroreport"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"A87","DOI":"10.1227\/01.NEU.0000335653.52938.F2","article-title":"Invited review: festschrift edition of neurosurgery peripheral nervous system as a conduit for delivering therapies for diabetic neuropathy, amyotrophic lateral sclerosis, and nerve regeneration","volume":"65","author":"T Federici","year":"2009","journal-title":"Neurosurgery"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1254\/jphs.12R02CP","article-title":"The mechanism of calcitonin gene-related peptide-containing nerve innervation","volume":"119","author":"N Hashikawa-Hobara","year":"2012","journal-title":"J Pharmacol Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1460-9568.1996.tb01269.x","article-title":"Regulation of motoneuronal calcitonin gene-related peptide (CGRP) during axonal growth and neuromuscular synaptic plasticity induced by botulinum toxin in rats","volume":"8","author":"O Tarabal","year":"1996","journal-title":"Eur J Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1006\/exnr.1999.7149","article-title":"Increased calcitonin gene-related peptide immunoreactivity in gracile nucleus after partial sciatic nerve injury: age-dependent and originating from spared sensory neurons","volume":"159","author":"W Ma","year":"1999","journal-title":"Exp Neurol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/NEN.0b013e3181d26487","article-title":"Aldose reductase deficiency improves Wallerian degeneration and nerve regeneration in diabetic thy1-YFP mice","volume":"69","author":"YS Chen","year":"2010","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/B978-0-12-410499-0.00007-1","article-title":"Role of inflammation and cytokines in peripheral nerve regeneration","volume":"108","author":"P Dubov\u00fd","year":"2013","journal-title":"Int Rev Neurobiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0165-0270(94)00156-B","article-title":"Interpreting nerve morphometry data after experimental traumatic lesions","volume":"58","author":"L de Medinaceli","year":"1995","journal-title":"J Neurosci Methods"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/micr.20483","article-title":"Role of timing in assessment of nerve regeneration","volume":"28","author":"MJ Brenner","year":"2008","journal-title":"Microsurgery"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0116711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T07:42:39Z","timestamp":1717746159000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0116711"}},"subtitle":[],"editor":[{"given":"Jui-Yang","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,17]]},"references-count":48,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0116711","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,17]]}}}