{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:14:32Z","timestamp":1792660472737,"version":"4.5.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0116721","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T21:16:59Z","timestamp":1423257419000},"page":"e0116721","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Catching the Missing Million: Experiences in Enhancing TB & DR-TB Detection by Providing Upfront Xpert MTB\/RIF Testing for People Living with HIV in India"],"prefix":"10.1371","volume":"10","author":[{"given":"Neeraj","family":"Raizada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep Singh","family":"Sachdeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achuthan","family":"Sreenivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhangi","family":"Kulsange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhey Shyam","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Dewan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Boehme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinnambedu Nainarappan","family":"Paramsivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"ref1","unstructured":"UNAIDS report on the global AIDS epidemic (2013) Global report, Page no 4; Available: http:\/\/www.unaids.org\/en\/media\/unaids\/contentassets\/documents\/epidemiology\/2013\/gr2013\/UNAIDS_Global_Report_2013_en.pdf<\/ext-link>"},{"key":"ref2","unstructured":"TB HIV Facts 2012\u20132013, Available: http:\/\/www.who.int\/hiv\/topics\/tb\/tbhiv_facts_2013\/en\/<\/ext-link>. Accessed 2014 May 20."},{"issue":"2","key":"ref3","first-page":"247","article-title":"National estimate of HIV sero prevalence among tuberculosis patients","volume":"14","author":"P Dewan","year":"2010","journal-title":"India. International Journal of Tuberculosis and Lung Disease"},{"key":"ref4","unstructured":"World Health Organization, Global Tuberculosis report (2013), page no 9, Available: http:\/\/apps.who.int\/iris\/bitstream\/10665\/91355\/1\/9789241564656_eng.pdf?ua=1<\/ext-link>"},{"key":"ref5","unstructured":"WHO policy on collaborative TB\/HIV activities (2012) Guidelines for national programmes and other stakeholders (2012), Available: http:\/\/whqlibdoc.who.int\/publications\/2012\/9789241503006_eng.pdf<\/ext-link>"},{"key":"ref6","unstructured":"Agarwal S, Roy D, Chauhan LS. Book Chapter 16 TB-HIV Co-infection: A Lethal Combination, Available: http:\/\/tbcindia.nic.in\/pdfs\/Tuberculosis%20Control%20in%20India16.pdf<\/ext-link>"},{"key":"ref7","article-title":"Guidelines for Implementing Collaborative TB and HIV Programme Activities","author":"N Hargreaves","year":"2003"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1056\/NEJMoa0907488","article-title":"An algorithm for tuberculosis screening and diagnosis in people with HIV","volume":"362","author":"KP Cain","year":"2010","journal-title":"N Engl J Med"},{"key":"ref9","unstructured":"Centres for Disease Control and Prevention, Morbidity and Mortality weekly report (MMWR Weekly) \/ Vol.61\/ No.26 \/, July 06, 2012. Available: http:\/\/www.cdc.gov\/mmwr\/preview\/mmwrhtml\/mm6126a3.htm?s_cid=mm6126a3_w<\/ext-link>"},{"key":"ref10","unstructured":"World Health Organization (2009) Pathways to better diagnostics for tuberculosis: a blueprint for the development of TB diagnostics by the new diagnostics working group of the Stop TB Partnership."},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1128\/JCM.01958-12","article-title":"The Diagnostic Performance of the GenoType MTBDRplus Version 2 Line Probe Assay Is Equivalent to That of the Xpert MTB\/RIF Assay","volume":"50","author":"M Barnard","year":"2012","journal-title":"J. Clin. Microbiol."},{"key":"ref12","unstructured":"World health Organization Policy update (2013) Automated Real-time Nucleic Acid Amplification Technology for Rapid and Simultaneous Detection of Tuberculosis and Rifampicin Resistance: Xpert MTB\/RIF assay for the diagnosis of pulmonary and extra-pulmonary TB in adults and children. Policy Update WHO\/HTM\/TB\/2013.16. Available: http:\/\/apps.who.int\/iris\/bitstream\/10665\/112472\/1\/9789241506335_eng.pdf?ua=1<\/ext-link>"},{"key":"ref13","unstructured":"Central TB Division Ministry of Health and Family Welfare, Managing the RNTCP in your area\u2014A training course (Module 1\u20134). Available: http:\/\/tbcindia.nic.in\/pdfs\/Module%201%20to%204.zip<\/ext-link>"},{"key":"ref14","unstructured":"World Health Organization, Geneva (2013) Definitions and reporting framework for tuberculosis-2013 revision. S.n. p. 3. Available: http:\/\/apps.who.int\/iris\/bitstream\/10665\/79199\/1\/9789241505345_eng.pdf<\/ext-link>"},{"key":"ref15","unstructured":"Central TB Division Ministry of Health and Family Welfare, New Delhi, India, Revised National TB Control Programme (2012) Guidelines on Programmatic Management of Drug Resitant TB (PMDT) in India. Available: http:\/\/tbcindia.nic.in\/pdfs\/Guidelines%20for%20PMDT%20in%20India%20-%20May%202012.pdf<\/ext-link>"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1164\/rccm.201101-0056OC","article-title":"Evaluation of the Xpert MTB\/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting","volume":"184","author":"G Theron","year":"2011","journal-title":"Am J Respir Crit Care Med."},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"e85478","DOI":"10.1371\/journal.pone.0085478","article-title":"Intensified Tuberculosis Case-Finding in HIV-Positive Adults Managed at Ethiopian Health Centers: Diagnostic Yield of Xpert MTB\/RIF Compared with Smear Microscopy and Liquid Culture","volume":"9","author":"TT Balcha","year":"2014","journal-title":"PLoS ONE"},{"issue":"3","key":"ref18","first-page":"220","article-title":"A retrospective study of human immunodeficiency virus infection and drug-resistant tuberculosis","volume":"1","author":"D Anastasis","year":"1997","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4172\/2332-0877.1000139","article-title":"Rifampicin Resistant Tuberculosis in a Secondary Health Institution in Nigeria, West Africa","volume":"2","author":"SO Rasaki","year":"2014","journal-title":"J Infect Dis Ther"},{"key":"ref20","unstructured":"Cox H, Hughes J, Moyo S, Daniels J, Cutsem G, et al. (2014) Reduced treatment delays for drug-resistant TB\/HIV co-infected patients with decentralized care and rapid Xpert MTB\/RIF test in Khayelitsha, South Africa. 20th International AIDS Conference, abstract MOAB0203, Melbourne, 2014. Available: http:\/\/pag.aids2014.org\/Abstracts.aspx?SID=1142&AID=8215<\/ext-link>"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"e70763","DOI":"10.1371\/journal.pone.0070763","article-title":"Anti-Tuberculosis Drug Resistance among New and Previously Treated Sputum Smear-Positive Tuberculosis Patients in Uganda: Results of the First National Survey","volume":"8","author":"D Lukoye","year":"2013","journal-title":"PLoS ONE"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"e25861","DOI":"10.1371\/journal.pone.0025861","article-title":"Self-Reported Risks for Multiple-Drug Resistance among New Tuberculosis Cases: Implications for Drug Susceptibility Screening and Treatment","volume":"6","author":"TF Brewer","year":"2011","journal-title":"PLoS ONE"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"e77712","DOI":"10.1371\/journal.pone.0077712","article-title":"Rifampicin Mono-Resistance in Mycobacterium tuberculosis in KwaZulu-Natal, South Africa: A Significant Phenomenon in a High Prevalence TB-HIV Region","volume":"8","author":"YM Coovadia","year":"2013","journal-title":"PLoS ONE"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1128\/JCM.02517-13","article-title":"GeneXpert MTB\/RIF Version G4 for Identification of Rifampin- Resistant Tuberculosis in a Programmatic Setting","volume":"52","author":"M Osman","year":"2014","journal-title":"J. Clin. Microbiol"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"e77456","DOI":"10.1371\/journal.pone.0077456","article-title":"Diagnostic Accuracy and Turnaround Time of the Xpert MTB\/RIF Assay in Routine Clinical Practice","volume":"8","author":"N Kwak","year":"2013","journal-title":"PLoS ONE"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Loannidis P, Papaventsis D, Karabela S, Nikolaou S, Panagi M, et al (2011) Cepheid GeneXpert MTB\/RIF Assay for Mycobacterium tuberculosis<\/italic> Detection and Rifampin Resistance Identification in Patients with Substantial Clinical Indications of Tuberculosis and Smear-Negative Microscopy Results; Available: http:\/\/jcm.asm.org\/content\/49\/8\/3068.long<\/ext-link>","DOI":"10.1128\/JCM.00718-11"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"e89301","DOI":"10.1371\/journal.pone.0089301","article-title":"Feasibility of Decentralised Deployment of Xpert MTB\/RIF Test at Lower Level of Health System in India","volume":"9","author":"N Raizada","year":"2014","journal-title":"PLoS ONE"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1128\/JCM.05434-11","article-title":"Evaluation of the GeneXpert MTB\/RIF Assay for Rapid Diagnosis of Tuberculosis and Detection of Rifampin Resistance in Pulmonary and Extrapulmonary Specimens","volume":"49","author":"A Z Zeka","year":"2011","journal-title":"J. Clin. Microbiol."},{"issue":"6","key":"ref29","article-title":"A comparison between the efficiency of the Xpert MTB\/RIF assay and nested PCR in identifying Mycobacterium tuberculosis during routine clinical practice","volume":"6","author":"CH Kim","year":"2014","journal-title":"Journal of Thoracic Medicine"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/archinte.163.9.1009","article-title":"The growing burden of tuberculosis: global trends and interactions with the HIV epidemic.","volume":"163","author":"EL Corbett","year":"2003","journal-title":"Arch Intern Med"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1164\/rccm.200907-0989OC","article-title":"HIV Co-infection in Multidrug- and Extensively Drug-Resistant Tuberculosis Results in High Early Mortality","volume":"181","author":"N Gandhi","year":"2010","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"ref32","unstructured":"ODonnell MR, Padayatchi N, Kvasnovsky C, Werner L, Master I, et. al (2013) Treatment Outcomes for Extensively Drug-Resistant Tuberculosis and HIV Co-infection, Volume 19, Number 3\u2014March 2013, Available: http:\/\/wwwnc.cdc.gov\/eid\/article\/19\/3\/12-0998_article<\/ext-link>"},{"key":"ref33","unstructured":"Central TB Division Ministry of Health and Family Welfare, Revised National Tuberculosis Program Annual status report-2014 (2014) Available: http:\/\/www.tbcindia.nic.in\/pdfs\/TB%20INDIA%202014.pdf<\/ext-link>. Accessed 2014 August 16."},{"issue":"1","key":"ref34","first-page":"58","article-title":"Treatment outcome of Tuberculosis and HIV Co-infection at a Tertiary Health Facility in Southeastern Nigeria","volume":"25","author":"HI Nwokeukwu","year":"2013","journal-title":"Journal of Community Medicine and Primary Health Care"},{"issue":"7","key":"ref35","doi-asserted-by":"crossref","first-page":"e21008","DOI":"10.1371\/journal.pone.0021008","article-title":"Treatment Outcome and Mortality at One and Half Year Follow-Up of HIV Infected TB Patients Under TB Control Programme in a District of South India","volume":"6","author":"S Vijay","year":"2011","journal-title":"PLoS ONE"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0116721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T18:14:30Z","timestamp":1566324870000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0116721"}},"subtitle":[],"editor":[{"given":"Pere-Joan","family":"Cardona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,2,6]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2015,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0116721","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,6]]}}}